Pure and Applied Chemistry最新文献

{"title":"Study on synthesizing the complex of sorafenib with 2-hydroxypropyl-β-cyclodextrin to enhance the anticancer activity of the drug substance","authors":"Van Cuong Bui, Thi Lan Pham, Thi Lam Nguyen, Thi Kim Chinh Tran, Thi My Hanh Le Le, Xuan Minh Vu, Irina M. Le-Deygen, Chau Anh Nguyen, Thanh Tung Mai, Raa Khimi Shuib","doi":"10.1515/pac-2024-0024","DOIUrl":"https://doi.org/10.1515/pac-2024-0024","url":null,"abstract":"This study aims to synthesize inclusion complex derived from sorafenib (Sor) and hydroxypropyl-β-cyclodextrin (HPβCD) (denoted as [Sor-HPβCD]). The complex of Sor with HPβCD has been synthesized in a mixed solvent of H<jats:sub>2</jats:sub>O-DMSO, with a DMSO volume fraction of 80 %. The results of FTIR, DSC, and UV–Vis analysis have demonstrated the success of complex formation: the intensity of some characteristic peaks for the Sor binding decreased after complex formation, indicating that a part of the guest molecule has entered the cavity of the HPβCD molecule. This is further supported by the DSC analysis results, showing the transformation of the complex’s crystalline form to an amorphous form. The phase solubility diagram study also indicates that the solubility of Sor significantly increases, approximately 7 times higher than pure Sor, after complex formation. The results of the cell growth inhibition activity test in a water environment show that the complex inhibits the growth of Hep-G2 cells with an IC<jats:sub>50</jats:sub> value of 62.4 μg/mL, while pure Sor does not exhibit activity as it is practically insoluble in water.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"3 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140297913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3-(4-methoxyphenyl) acrylic acid halts redox imbalance and modulate purinergic enzyme activity in iron-induced testicular injury","authors":"Akingbolabo Daniel Ogunlakin, Juliana Bunmi Adetunji, Matthew Iyobhebhe, Toluwanimi Ayonitemi Ajiboye, Gideon Ampoma Gyebi, Peluola Olujide Ayeni, Damilare Iyinkristi Ayokunle, Mubo Adeola Sonibare, Joel Ojogbane Onoja, Enitan O. Adesanya, Omolola Adenike Ajayi-Odoko, Oluwafemi Adeleke Ojo, Sophie Adedamola Adeyeye","doi":"10.1515/pac-2023-1201","DOIUrl":"https://doi.org/10.1515/pac-2023-1201","url":null,"abstract":"Various derivatives of cinnamic acid have been reported to possess significant activities such as antioxidant and hepatoprotective, and neuroprotective activities. Interestingly, testicular toxicity has been linked to several causes, with oxidative damage being one of the pathophysiological mechanisms. 3-(4-methoxyphenyl) acrylic acid (1), a derivative of cinnamic acid, was synthesized and then investigated for its effects on iron-induced testicular injury and oxidative stress via <jats:italic>ex vivo</jats:italic> and <jats:italic>in silico</jats:italic> studies, respectively. Evaluations were done on KAD-1’s FRAP, DPPH free radical scavenging activity, and iron chelating potential. Through the <jats:italic>ex vivo</jats:italic> incubation of tissue supernatant and 0.1 mM FeSO<jats:sub>4</jats:sub> for 30 min at 37 °C with different concentration of 1, oxidative testicular damage treatments were induced. The scavenging property of 1 increases significantly (<jats:italic>p</jats:italic> &lt; 0.05) as the concentration increases when compared with the standard quercetin. The MDA, CAT, ATPase, and ENTPDase activities were reduced when testicular damage was induced (<jats:italic>p</jats:italic> &lt; 0.05). The group treated with 30 mg/mL had the highest level of MDA. A significant rise in GSH level and activity of SOD were observed. The result obtained indicated that 1 has the potential to prevent oxidative testicular toxicity, as evidenced by its capacity to control nucleotide hydrolysis and reduce oxidative stress. Overall, the results of this experimental study point to some possible uses of 3-(4-methoxyphenyl) acrylic acid (1) in the prevention of oxidative testicular dysfunction. Therefore, 3-(4-methoxyphenyl) acrylic acid (1) would be a good product in developing a medication to alleviate male infertility.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"52 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140297810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk protein polymorphisms of Aosta Valley cattle breeds","authors":"Mathieu Merlet, Luca Vernetti-Prot, Sabina Valentini","doi":"10.1515/pac-2023-0014","DOIUrl":"https://doi.org/10.1515/pac-2023-0014","url":null,"abstract":"Cow’s milk proteins are encoded by highly polymorphic genes characterized by several mutations which result in different allelic variants. Each allelic variant has different possible effects on cheese-making properties and on human health. β-casein A1-A3-I-B, k-casein B and β-lactoglobulin B are supposed to influence milk cheese-making properties by increasing cheese or milk yield, by varying chemical parameters, by having small casein micelle size, and by influencing rennet coagulation time (RCT) and curd-firming rate (CFR). In addition, β-casein A1-B are also considered to be a risk factor for different health diseases such as ischemic heart disease (IHD), type 1 diabetes (T1D), decreased glutathione (GSH) concentration, and milk intolerance. An LC-MS method was applied to profile, for the first time, the main milk proteins genetic variants from Aosta Valley autochtonous cattle breeds. Analyses performed on milk collected from bovines of three cattle breeds (Red Pied – VRP, Black Pied – VNP and Chestnut – CAS), either from IAR experimental farm or from herds of dairy-producers in Aosta Valley region, showed quite high frequencies of β-casein A2 and A3/I, and low frequencies of β-casein A1. Moreover, low frequencies of β-casein B in VRP breed and high frequencies of the same variant in CAS, and VNP breeds have been found. As far as k-casein is concerned allelic variant B is the most diffused in VRP while allelic variant A in VNP and CAS breeds. Finally, β-lactoglobulin most diffused allelic variant for all breeds is B. Results suggest that Aosta Valley milk has good cheese-making properties and good frequencies of β-casein A2 which may be related to beneficial effects on human health. In light of these results, it is important to develop breeding programs which take into consideration milk proteins polymorphisms to further increase the milk suitability for cheese-making process and to decrease the presence of β-casein A1 and B in drinking milk which can be a risk factor for human health.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"11 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140197928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in understanding comproportionation and disproportionation in nickel catalysis","authors":"Craig S. Day","doi":"10.1515/pac-2024-0106","DOIUrl":"https://doi.org/10.1515/pac-2024-0106","url":null,"abstract":"Disproportionation and comproportionation reactions have become routinely proposed events in modern synthetic endevours that use nickel catalysts. This new found appreciation from practitioners in the field for these electron transfer reactions has largely stemmed from our improved understanding of catalytic reactions. These studies have shown evidence of the ability of nickel complexes to occupy odd and even oxidation states which are critical to dictating reactivity. Comproportionation and disproportionation reactions shuttle nickel complexes between these oxidation states and are essential to the formation of either on-cycle or off-cycle species. This review will cover these fundamental reactions, and provide information about their role in catalysis.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"231 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140205674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface tension measurement of FAP-based ionic liquid pendant drops in a high vacuum/gas cell","authors":"Julius Kim Tiongson, Imee Su Martinez","doi":"10.1515/pac-2023-1113","DOIUrl":"https://doi.org/10.1515/pac-2023-1113","url":null,"abstract":"The surface tension of ionic liquids with the tris(pentafluoroethyl)trifluorophosphate (FAP) anion were measured using a home-built surface tensiometer. A high-vacuum line was used to pre-evacuate the ionic liquids prior to analyses, ensuring that the samples were free of dissolved gases, water, and volatile impurities. Using the pendant drop method, measurements were performed in a custom-built surface tension vacuum or gas cell, in the presence of nitrogen and carbon dioxide gas. To calibrate the instrument, surface tension measurement of known liquids was also performed. Results show that the presence of saturated carbon dioxide led to the lowering of measured surface tension values, indicating the adsorption of CO<jats:sub>2</jats:sub> on the ionic liquid surface.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"18 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140198265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-based aerogel composites of coconut pith-derived carbon and chitosan for efficient anionic dye-polluted water treatment","authors":"Oanh H. Nguyen, Huy T. A. Nguyen, Luon Tan Nguyen, Nga H. N. Do, Lam Dai Tran, Viet T. Tran, Phung K. Le, Kien A. Le","doi":"10.1515/pac-2024-0102","DOIUrl":"https://doi.org/10.1515/pac-2024-0102","url":null,"abstract":"Biomass-based aerogels are of interest due to their abundant precursors, ease of functionalization, eco-friendliness, low cost, and effectiveness in dye-contaminated water treatment. Coconut pith (CP) known as a by-product after coconut processing is a sponge-like and lightweight material discarded in large volumes. For the first time, carbon micro-particles resulting from two-step treatment and pyrolysis of CP have been successfully incorporated with chitosan to produce aerogel composites by high-speed homogenization and freeze-drying. After pretreatment, holocellulose content and crystallinity index of the recovered CP pulp are respectively 75.4 and 58.6 % along with a solid recovery rate of 27.5 %. Characteristic properties of the aerogel composites are featured by their density as low as 15.23–28.17 mg/cm<jats:sup>3</jats:sup>, remarkably high porosity of 98.17–99.05 %, and Young’s modulus of 1.64–12.23 kPa. Synergistic effects of the porous network, electrostatic interactions between both amine groups in chitosan and carbon surface with methyl orange (MO) cause the as-fabricated aerogel composites to achieve an extremely high adsorption capacity of 454.13 mg/g and removal efficiency of 92.32 % at initial MO concentration of 500 mg/L. Therefore, the CP-derived carbon/chitosan aerogel composites synthesized from a feasible procedure exhibit their great potential in enhancing the value of coconut waste and dealing with dye-contaminated water pollution by simple and economical adsorption.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"30 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140198220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochar-based catalysts: a potential disposal of plant biomass from phytoremediation","authors":"Nhuan N. Doan, Ha T. Nguyen, Luan T. Nguyen, Lam D. Tran, Tuan D. Phan, Tien A. Nguyen, Linh T. T. Nguyen","doi":"10.1515/pac-2024-0105","DOIUrl":"https://doi.org/10.1515/pac-2024-0105","url":null,"abstract":"In this study, the plant biomass from the phytoremediation was recovered, prepared, and investigated catalytic ability for the α-pinene isomerization. The results show that the Fe_loaded AAL biochar can catalyze the isomerization of a-pinene, with the α-pinene conversion of 90.5 % and the selectivities for monocyclic terpenes (limonene, terpinolene and γ-terpinene) of 57.1 %, bicyclic terpene (camphene) of 24.6 %. Iron in the plant biomass from phytoremediation is considered a decisive factor that heightened the conversion of α-pinene and the yield of isomers. This research has initially opened up a new application for the plant biomass absorbing heavy metal from the phytoremediation stage to resolve contaminants efficiently.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140167170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selection of graphene as a conductive additive for biomass-based activated carbon electrode in capacitive deionization: acid-treated as a practical approach to reduce graphene content","authors":"Thi Nam Pham, Thi Thom Nguyen, Le Thanh Nguyen Huynh, Viet Hai Le, Thi Kim Ngan Nguyen, Tuan Anh Nguyen, Raa Khimi Shuib, Dai Lam Tran, Tuan Anh Nguyen","doi":"10.1515/pac-2024-0109","DOIUrl":"https://doi.org/10.1515/pac-2024-0109","url":null,"abstract":"The use of graphene (GE) as a conductive additive for activated carbon (AC) electrode in capacitive deionization (CDI) has attracted much attention due to its high electrical conductivity. However, self-agglomeration by π–π interactions between individual GE sheets required the use of high content to ensure an efficient conductive network in the electrode, which limited its practical application. This work proposed an approach to reduce the GE content in the fabrication of biomass-based activated carbon electrode for CDI application. The stacking effect of GE sheets is inhibited when GE sheets functionalize with oxygen groups via acid treatment under ultrasonic condition. This helps to reduce GE content to less than 2 wt% in the fabrication of CDI electrodes. The electrode fabricated using 2 wt% treated GE (T-GE) achieved the superior capacitance of 54 F/g, twice that of the pristine AC. The desalination process using as-prepared electrodes was evaluated by batch-mode CDI system with the initial NaCl solution of 2000 ppm and 3000 ppm at various applied voltages. The AC/T-GE 2 % electrode showed excellent performance with a desalination capacity greater than 10 mg/g, and reached an adsorption rate of 1.93 mg/g.min in both solutions under an applied voltage 1.2 V.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"1 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140167173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of chemical modification using citraconic anhydride on the stability of α-amylase from Aspergillus fumigatus","authors":"Yandri Yandri, Lupia Widya Astuti, Hendri Ropingi, Tati Suhartati, Bambang Irawan, Sutopo Hadi","doi":"10.1515/pac-2023-1138","DOIUrl":"https://doi.org/10.1515/pac-2023-1138","url":null,"abstract":"The purpose of this research is to improve the stability of α-amylase from <jats:italic>Aspergillus fumigatus</jats:italic> by chemical modification with citraconic anhydride. The α-amylase was isolated using a centrifugation technique, followed by purification using precipitation and dialysis of ammonium sulfate salt. The experimental results demonstrate that the stability of purified α-amylase is 13.41 times higher than that of the crude extract. A significant increase in the optimum temperature was also achieved, in which the optimum temperature of 50 °C was found for native α-amylase, while for modified α-amylase, the optimum temperature of 60 °C was found. Similarly, an increase in half-life was also evident, which is 38.72 min found for the native enzyme to 256.67–330.00 min for modified α-amylase, depending on the volume of citraconic anhydride used. Modification also resulted in increased free energy values (<jats:italic>ΔG</jats:italic> <jats:sub>i</jats:sub>) from 104.348 for the native enzyme to 109.585–110.281 kJ mol<jats:sup>−1</jats:sup> for modified α-amylase, indicating that modified α-amylase is stiffer than native α-amylase. The results obtained in this work demonstrate that citric anhydride is a very promising modifying agent to improve the stability and performance of α-amylase enzyme isolated from <jats:italic>A. fumigatus</jats:italic>. The findings of this study also offer an opportunity for the application of citric anhydride for other enzymes.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"24 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140156068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fluvial discharge on 137Cs in the ocean following the Fukushima Daiichi Nuclear Power Station accident","authors":"Daisuke Tsumune, Takaki Tsubono, Kazuhiro Misumi, Kazuyuki Sakuma, Yuichi Onda","doi":"10.1515/pac-2023-0902","DOIUrl":"https://doi.org/10.1515/pac-2023-0902","url":null,"abstract":"After the Fukushima Daiichi Nuclear Power Station (F1NPS) accident, <jats:sup>137</jats:sup>Cs activity concentrations have not yet decreased to pre-accident levels because of direct release from the site and fluvial discharges of <jats:sup>137</jats:sup>Cs deposited on land. It is necessary to consider dispersion processes in the coastal area to understand the impact of multiple river discharges and direct release. To achieve this goal, we carried out oceanic dispersion simulations that considered direct release and fluvial discharges and compared the results with the annual averages of observed data. We assumed that particulate <jats:sup>137</jats:sup>Cs discharged from rivers to the ocean quickly resuspended and re-leached after coagulation and precipitation, and that all of the <jats:sup>137</jats:sup>Cs was dispersed. The reproducibility of results was improved by considering fluvial discharges of particulate <jats:sup>137</jats:sup>Cs at all sites between 2013 and 2016, except near the F1NPS. In other words, particulate <jats:sup>137</jats:sup>Cs discharged from rivers was found to influence the results of ocean surface activity concentrations within a relatively short period of time. The impact of direct release was dominant for the observed <jats:sup>137</jats:sup>Cs activity concentrations adjacent to the F1NPS, which was used to estimate direct releases.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":"210 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140116520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}