Research and Practice in Thrombosis and Haemostasis最新文献

{"title":"177 The Current Landscape of Anticoagulation (AC) Stewardship Implementation Around the World: An International Survey","authors":"Nancy L. Shapiro , Grace A. McGee , Allison E. Burnett","doi":"10.1016/j.rpth.2025.102761","DOIUrl":"10.1016/j.rpth.2025.102761","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102761"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"98 Derivation and Validation of a Pharmacogenetic-guided Warfarin Dosing Algorithm in an Arab Population Residing in Qatar","authors":"Amr Fahmi , Ahmed El Bardissy , Mohamed Saad , Mohamed Nabil , Loulia Bader , Mohamed Kassem , Ahmed Mahfouz , Osama Abdelsamad , Abdelnasser Elzouki , Hazem Elewa","doi":"10.1016/j.rpth.2025.102778","DOIUrl":"10.1016/j.rpth.2025.102778","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102778"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"93 Adherence to Direct Oral Anticoagulants among U.S. Veterans with Atrial Fibrillation in the Era of the Veteran Health Administration DOAC Population Management Tool","authors":"Arthur Allen , Shardool Patel , Brian Sauer , Bishoy Ragheb","doi":"10.1016/j.rpth.2025.102749","DOIUrl":"10.1016/j.rpth.2025.102749","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102749"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"85 Developing an Innovative Clinical Decision Support App for Enhanced Peripheral Artery Disease Management","authors":"Kelly M. Rudd , Jennifer Glen , Tim Michalski","doi":"10.1016/j.rpth.2025.102797","DOIUrl":"10.1016/j.rpth.2025.102797","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102797"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"72 Utilization of a Direct Oral Anticoagulant (DOAC) Population Management Tool (PMT): Standardizing Assessment of Liver Flags","authors":"Christina M. Bookwalter , Michelle Anderson , Heather Poepping , Julie Spenner","doi":"10.1016/j.rpth.2025.102739","DOIUrl":"10.1016/j.rpth.2025.102739","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102739"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"156 Continued Assessment of a Direct Oral Anticoagulant (DOAC) Dashboard","authors":"Nghi Ha , Nhan Hoang , Liza Renner , Erin Mouland , Michael Lanham , Geoff Barnes","doi":"10.1016/j.rpth.2025.102744","DOIUrl":"10.1016/j.rpth.2025.102744","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102744"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"89 Stroke Prevention in Atrial Fibrillation and Flutter - Targeting the Untreated Patients In Veterans Health Administration with a Pharmacists-Led, Multi-Center Electronic Health Record Intervention (SPAFF-TNT)","authors":"Arthur Allen , Jeffery Kibert , Geoffrey Barnes , Michael Dyal , Paul Varosy , David Parra , SPAFF-TNT Steering Committee","doi":"10.1016/j.rpth.2025.102770","DOIUrl":"10.1016/j.rpth.2025.102770","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102770"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombotic risk determined by ABO, F8, and VWF variants in a population-based cohort study","authors":"Eric Manderstedt ,&nbsp;Christer Halldén ,&nbsp;Christina Lind-Halldén ,&nbsp;Johan Elf ,&nbsp;Peter J. Svensson ,&nbsp;Gunnar Engström ,&nbsp;Olle Melander ,&nbsp;Aris Baras ,&nbsp;Luca A. Lotta ,&nbsp;Bengt Zöller","doi":"10.1016/j.rpth.2025.102875","DOIUrl":"10.1016/j.rpth.2025.102875","url":null,"abstract":"<div><h3>Background</h3><div>Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) plasma levels are associated with increased risk for venous thromboembolism (VTE).</div></div><div><h3>Objectives</h3><div>This study aimed to determine the thrombotic risk of rare and common variants of 27 genes linked to VWF or FVIII plasma levels in genome-wide association studies.</div></div><div><h3>Methods</h3><div>Exon sequences of 27 genes linked to plasma levels of VWF or FVIII in genome-wide association studies were analyzed for common and rare variants in 28,794 subjects without VTE (born during 1923-1950, 60% women), who participated in the Malmö Diet and Cancer study (1991-1996), with a follow-up time until 2018. Hazard ratios (HRs) were determined. <em>P</em> values were Bonferroni-corrected (<em>P</em> value = .05/27 &lt;.0019). Common variants were analyzed individually. Rare qualifying variants (&lt;0.1%) were collapsed.</div></div><div><h3>Results</h3><div>None of the 27 genes were associated with VTE in the rare variant collapsing analysis. Three common exon variants were significantly associated with VTE: rs8176719 (frameshift) in <em>ABO</em> (HR = 1.30; 95% CI, 1.20-1.42; <em>P</em> = 3.9 × 10⁻¹⁰), rs1800291 (p.Asp1260Glu) in <em>F8</em> (HR = 1.29; 95% CI, 1.08-1.55; <em>P</em> = .00046 for men; HR = 1.17; 95% CI, 1.06-1.29; <em>P</em> = .00019 for women), and rs1063856 (p.Thr789Ala) in <em>VWF</em> (HR = 1.10; 95% CI, 1.04-1.17; <em>P</em> = .00057). A risk score of these 3 variants was dose-dependently associated with VTE (5 risk alleles): HR = 2.8; 95% CI, 1.7-4.7; and <em>P</em> value = .00008. The area under the curve for VTE in receiver operating characteristics for the risk score was similar to FV Leiden (0.55 vs 0.54).</div></div><div><h3>Conclusion</h3><div>The risk score of 3 common variants in <em>VWF</em>, <em>F8</em>, and <em>AB0</em> genes is associated with VTE risk similar to FV Leiden.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102875"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"141 Heparin Management - The Ultimate Goldilocks Dilemma: A Quality Improvement Project","authors":"Malarvizhi Narayanan ,&nbsp;Sarah Lake-Wallace ,&nbsp;Samuel Akinyele ,&nbsp;Teresa Allison ,&nbsp;Julin Mathew ,&nbsp;Megan Anderson ,&nbsp;Latosha Mitchell ,&nbsp;Diane Vo ,&nbsp;Sue Thomas ,&nbsp;Nautam Ganatra","doi":"10.1016/j.rpth.2025.102806","DOIUrl":"10.1016/j.rpth.2025.102806","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102806"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"137 Real-World Implementation of Latex Immunoturbidimetric Platelet Factor 4 Assay for Heparin-Induced Thrombocytopenia Diagnosis at a Large Academic Medical Center","authors":"Dareen M. Kanaan ,&nbsp;Gabriella C. Torres ,&nbsp;Allison L. Zhang ,&nbsp;Katelyn W. Sylvester ,&nbsp;Daniel Dees ,&nbsp;Elisabeth M. Battinelli ,&nbsp;Jean M. Connors","doi":"10.1016/j.rpth.2025.102785","DOIUrl":"10.1016/j.rpth.2025.102785","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102785"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}