Research and Practice in Thrombosis and Haemostasis最新文献

{"title":"Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome—insights from a UK center","authors":"Giulia Simini ,&nbsp;Andrew Innes ,&nbsp;Saravanan Vinayagam ,&nbsp;Golzar Mobayen ,&nbsp;Nilanthi Karawitage ,&nbsp;Simone Claudiani ,&nbsp;Zain Odho ,&nbsp;Mike Laffan ,&nbsp;Deepa J. Arachchillage","doi":"10.1016/j.rpth.2025.102954","DOIUrl":"10.1016/j.rpth.2025.102954","url":null,"abstract":"<div><h3>Background</h3><div>Myeloproliferative neoplasms (MPNs) represent a group of blood disorders characterized by myeloid cell proliferation and an associated increased risk of thrombosis and bleeding. Platelet count may have a direct link to these complications.</div></div><div><h3>Objectives</h3><div>To share our MPN clinic’s experience with hemostatic testing and bleeding outcomes in patients with platelets ≥ 800 × 10⁹/L.</div></div><div><h3>Methods</h3><div>This was a single-center retrospective study from May 2022 to September 2024. Clinical characteristics, treatments, and bleeding events of patients with MPN or chronic myeloid leukemia were recorded. Laboratory assessments included full blood count, renal function, coagulation profiles, platelet function test, and von Willebrand factor (VWF) assays.</div></div><div><h3>Results</h3><div>A total of 39 patients were included, majority of whom received aspirin for thrombosis prevention (76%). The study found that bleeding complications occurred in 33% of patients, with mucocutaneous bleeding being the most common. There was a trend toward bleeding in patients on aspirin (<em>P</em> = .07). However, platelet count alone did not predict bleeding risk. While some patients showed abnormal VWF function, low VWF levels were not consistently associated with increased bleeding. Interestingly, we found moderate negative correlation between baseline VWF ristocetin/antigen and activated partial thromboplastin time (<em>P</em> = .02; <em>r</em> = −.37) and prothrombin time (<em>P</em> = .009, <em>r</em> = −.45), suggesting other potential coagulation imbalances associated with bleeding diathesis in MPNs. Post cytoreduction, there was a significant increase in mean VWF ristocetin/antigen ratio (<em>P</em> = .0009).</div></div><div><h3>Conclusion</h3><div>The study illustrates the limitations of relying solely on platelet counts to estimate bleeding risk in MPN patients. Assessment of VWF activity and careful selection of antithrombotic therapy were highlighted as important considerations.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 5","pages":"Article 102954"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of heavy menstrual bleeding in a multidisciplinary young women’s clinic: a Dutch experience","authors":"Yara Dixon ,&nbsp;Bart Kabboord ,&nbsp;Carla Groenestein-Sondaal ,&nbsp;Marieke J.H.A. Kruip ,&nbsp;Carolien van der Velden ,&nbsp;Greta Mulders ,&nbsp;C. Heleen van Ommen","doi":"10.1016/j.rpth.2025.102959","DOIUrl":"10.1016/j.rpth.2025.102959","url":null,"abstract":"<div><h3>Background</h3><div>Heavy menstrual bleeding (HMB) is common in young women. It may lead to iron deficiency with or without anemia, decreased school, work, sport, and social participation, and may be the first sign of underlying bleeding disorders (BDs).</div></div><div><h3>Objectives</h3><div>To study the prevalence of BDs, initial and effective management of HMB and iron deficiency (anemia) in young women referred to a tertiary multidisciplinary HMB clinic.</div></div><div><h3>Methods</h3><div>This was a retrospective, single-center chart review evaluating patients aged ≤25 years who visited the multidisciplinary HMB clinic between March 2018 and December 2023.</div></div><div><h3>Results</h3><div>In total, 200 patients (median age, 15 years) were included. At first consultation, BD was already diagnosed in 47 (24%) patients, particularly von Willebrand disease (<em>n</em> = 27). In 32 of 153 (21%) remaining patients, a new BD was diagnosed (von Willebrand disease, <em>n</em> = 21; platelet aggregation defect, <em>n</em> = 8). Initial therapy of HMB mainly consisted of tranexamic acid with (<em>n</em> = 52, 26%) or without (<em>n</em> = 50, 30%) combined oral contraceptive pill. In 60 patients (30%), initial therapy was effective. Effective HMB management was mostly achieved with tranexamic acid combined with a combined oral contraceptive pill (<em>n</em> = 75, 38%) after a median of 1 treatment change (range, 0-10). Iron deficiency was present in 52% of patients, with approximately half having anemia. Treatment consisted of oral and/or intravenous iron supplementation in 77 patients and red blood cell transfusion in 9 patients.</div></div><div><h3>Conclusion</h3><div>BDs and iron deficiency (anemia) were common in young women with HMB. Multiple treatment strategies were needed to achieve an acceptable outcome. A multidisciplinary approach may offer complementary expertise in this patient group.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 5","pages":"Article 102959"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A brief comparison of human factor XII-Ala188 and factor XII-Pro188","authors":"Aleksandr Shamanaev,&nbsp;David Gailani","doi":"10.1016/j.rpth.2025.102957","DOIUrl":"10.1016/j.rpth.2025.102957","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 5","pages":"Article 102957"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aims & Scope","authors":"","doi":"10.1016/S2475-0379(25)00261-4","DOIUrl":"10.1016/S2475-0379(25)00261-4","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102937"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Oral Communications Abstracts","authors":"","doi":"10.1016/j.rpth.2025.102925","DOIUrl":"10.1016/j.rpth.2025.102925","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102925"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Late Breakthrough Abstracts","authors":"","doi":"10.1016/j.rpth.2025.102931","DOIUrl":"10.1016/j.rpth.2025.102931","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102931"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Poster Abstracts Part 2","authors":"","doi":"10.1016/j.rpth.2025.102930","DOIUrl":"10.1016/j.rpth.2025.102930","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102930"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Poster Abstracts Part 1","authors":"","doi":"10.1016/j.rpth.2025.102923","DOIUrl":"10.1016/j.rpth.2025.102923","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102923"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99 Nonadherence to Early Discharge in Low-Risk Pulmonary Embolism: Insights from an Anticoagulation Stewardship Program in Latin America","authors":"Santiago Méndez Salazar ,&nbsp;Paula Ruiz-Talero ,&nbsp;Oscar Muñoz ,&nbsp;Pilar Alarcón Robles ,&nbsp;Karen Navarro Pérez ,&nbsp;Alice Salamanca","doi":"10.1016/j.rpth.2025.102804","DOIUrl":"10.1016/j.rpth.2025.102804","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102804"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144202996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"186 Anticoagulation Stewardship Using a Direct Oral Anticoagulation Dashboard to Reduce Incorrect Prescribing","authors":"Jeffrey Lee ,&nbsp;Stacy Ellsworth ,&nbsp;Brian Haymart ,&nbsp;Gregory Krol ,&nbsp;Bevelry Stallings ,&nbsp;Noelle Ryan ,&nbsp;Michael Lanham ,&nbsp;Geoff Barnes ,&nbsp;Scott Kaatz","doi":"10.1016/j.rpth.2025.102762","DOIUrl":"10.1016/j.rpth.2025.102762","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102762"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}