Research and Practice in Thrombosis and Haemostasis最新文献

{"title":"64 Variation in Anticoagulant Hemorrhage Management Guidelines for Factor-Xa Inhibitors: A Survey and Analysis of U.S. Academic Institutions","authors":"Rishabh Singh , Ishan J. Tatake , Joseph Sibley , Radhika Gangaraju , Karlyn A. Martin , Rachel P. Rosovsky , Diana Marie Byrnes , Ming Y. Lim , Manila Gaddh , Jacob Cogan , Kimberley Youkhana , Lisa Baumann Kreuziger , Andrew M. Peseski","doi":"10.1016/j.rpth.2025.102813","DOIUrl":"10.1016/j.rpth.2025.102813","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102813"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"91 Making It Count: Evaluating an Intervention to Increase Usability of Factor Xa Inhibitor Anti-Xa Levels","authors":"Emily Tisler , Sara A. Zochert","doi":"10.1016/j.rpth.2025.102781","DOIUrl":"10.1016/j.rpth.2025.102781","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102781"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"103 Assessing Anticoagulation Status of a Patient with APS Using Chromogenic Factor X Testing","authors":"Katelyn N. Bell","doi":"10.1016/j.rpth.2025.102782","DOIUrl":"10.1016/j.rpth.2025.102782","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102782"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"174 Peri-Procedural Warfarin Bridging Evaluation for Patients with Atrial Fibrillation Enrolled in an Anticoagulation Management Service","authors":"Hamza H. Sinan , Katelyn W. Sylvester , Mengyan Li , Ellie M. Kang , Rebecca H. Chow , Jean M. Connors","doi":"10.1016/j.rpth.2025.102796","DOIUrl":"10.1016/j.rpth.2025.102796","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102796"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"148 Automation, Expansion and Optimization of an Emergency Department Transition of Care Program for Outpatient Management of Acute Venous Thromboembolic Disease: Experience with our Facilitating Anticoagulation for Safer Transitions (FAST) Enterprise Health","authors":"Lynda J. Thomson , Menaka Suri , Geno J. Merli , Huelena Nguyen","doi":"10.1016/j.rpth.2025.102741","DOIUrl":"10.1016/j.rpth.2025.102741","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102741"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"178 Implementation of a Warfarin Patient Self-Management Program in Patients on Chronic Warfarin Therapy","authors":"Allison Dery , Ashley Varela-Martinez , Charlene Nash , Darla Althizer","doi":"10.1016/j.rpth.2025.102745","DOIUrl":"10.1016/j.rpth.2025.102745","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102745"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68 Attributable Risk of Bleeding in Pulmonary Embolism (PE): A Comparative Study of Contemporaneous Control, Symptomatic PE, and Asymptomatic PE","authors":"Sophie Samuel , Jamie SC. Beck , Vi Tran","doi":"10.1016/j.rpth.2025.102775","DOIUrl":"10.1016/j.rpth.2025.102775","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102775"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighing the consequences: body mass index trajectories after pediatric venous thromboembolism","authors":"Julie Jaffray","doi":"10.1016/j.rpth.2025.102891","DOIUrl":"10.1016/j.rpth.2025.102891","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102891"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The factor XIa antibody osocimab strongly inhibits clotting in extracorporeal circuits with human blood and in baboons","authors":"Eslam Samaha ,&nbsp;Michael Schwameis ,&nbsp;Sabine Schranz ,&nbsp;Katarina D. Kovacevic ,&nbsp;Bruno Watschinger ,&nbsp;Martin Stoiber ,&nbsp;Christopher Wolf ,&nbsp;Michael Wallisch ,&nbsp;András Gruber ,&nbsp;Erik I. Tucker ,&nbsp;Anja Buchmüller ,&nbsp;Bernd Jilma","doi":"10.1016/j.rpth.2025.102932","DOIUrl":"10.1016/j.rpth.2025.102932","url":null,"abstract":"<div><h3>Background</h3><div>Effective anticoagulant approaches in extracorporeal circuits with little impact on hemostasis are still an unmet medical need. Targeted inhibition of activated factor (F)XI might represent an attractive alternative or addition to conventional anticoagulation.</div></div><div><h3>Objectives</h3><div>We aimed to evaluate the additional antithrombotic effect of the monoclonal anti-FXIa antibody osocimab in in vitro and in vivo models of extracorporeal circulation.</div></div><div><h3>Methods</h3><div>This study compared the additional antithrombotic effect of a novel monoclonal antibody, osocimab (anti-FXIa), with that of low-molecular-weight heparin in 3 <em>in vitro</em> models of extracorporeal blood circulation (hemodialysis [HD], left ventricular assist devices [LVADs], and extracorporeal membrane oxygenation [ECMO]). Whole blood donated by healthy volunteers was spiked with enoxaparin ± osocimab and circulated for several hours in extracorporeal circuits. The primary endpoint was time to filter clotting. Furthermore, we performed <em>in vivo</em> ECMO perfusion studies in baboons using unfractionated heparin and osocimab.</div></div><div><h3>Results</h3><div>Of 40 subjects screened, 34 (50% male; mean age, 32 years [±9 SD]) were enrolled in the study. The addition of osocimab significantly prolonged the time to filter clotting from 120 minutes (IQR, 105-150) to 180 minutes (IQR, 180-180; <em>n</em> = 10) in HD circuits, from 127 minutes (IQR, 38-210) to 180 minutes (IQR, 69-240; <em>n</em> = 12) in ECMO circuits, and from 36 minutes (IQR, 18-59) to 113 minutes (IQR, 51-120; <em>n</em> = 12) in LVAD circuits. Furthermore, it preserved fibrinogen concentrations (HD: 227 mg/dL vs 170 mg/dL; LVADs: 229 mg/dL vs 50 mg/dL; ECMO: 221 mg/dL vs 170 mg/dL) and platelet aggregation and prolonged clotting times in thromboelastometry. In baboons, osocimab significantly reduced the oxygenator’s platelet deposition and terminal fibrin content.</div></div><div><h3>Conclusion</h3><div>Osocimab effectively inhibited clotting due to extracorporeal circulation.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102932"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial heterogeneity shapes shear stress response: a transcriptomic perspective","authors":"Hanqiang Deng","doi":"10.1016/j.rpth.2025.102927","DOIUrl":"10.1016/j.rpth.2025.102927","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102927"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}