Research and Practice in Thrombosis and Haemostasis最新文献

{"title":"EP2T7_4 Perioperative management of congenital FVII-deficiency: a retrospective study","authors":"F. Toepper, P. Brandhorst, T. Doerner, C. Sucker, A. Chamatsou, R. Hammerich, C. Dibiasi, S. Treskatsch, J. Gratz","doi":"10.1016/j.rpth.2026.106763","DOIUrl":"10.1016/j.rpth.2026.106763","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106763"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP2T7_3 Long-Term Changes in Exercise Capacity and Quality of Life After Pulmonary Embolism: Comparison of Different Therapeutic Approaches","authors":"J.D. Stubnya, H.D. Szász, D. Skultéti, A. Párkányi, M. Berczi, A. Kállai, J. Fazakas","doi":"10.1016/j.rpth.2026.106767","DOIUrl":"10.1016/j.rpth.2026.106767","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106767"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP3_T7_2 Peri-operative IV iron in major abdominal surgery in the UK: a cost impact model comparing ferric derisomaltose and ferric carboxymaltose with usual care","authors":"R. Pollock, R. Atkinson","doi":"10.1016/j.rpth.2026.106749","DOIUrl":"10.1016/j.rpth.2026.106749","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106749"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP3T2_4 Enhancing Perioperative Transfusion Practices through Simulation-Based Patient Blood Management Training","authors":"R. Mattar, J. Tohme, A. Abi Lutfallah, K. Jabbour, N. El Kassis, H. Zakaria, S. Madi-Jebara","doi":"10.1016/j.rpth.2026.106670","DOIUrl":"10.1016/j.rpth.2026.106670","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106670"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP1T1_3 Development and technical validation of an intelligent electromechanical closure for digitally controlled blood transfusion release (smart blood bag)","authors":"P. Feierabend, M. Notter, T. Schirl, T. Frietsch, D. Fischer","doi":"10.1016/j.rpth.2026.106665","DOIUrl":"10.1016/j.rpth.2026.106665","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106665"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP2T1_4 The evolution of transfusion practice in major obstetric haemorrhage : a three year experience from a UK tertiary maternity centre with placenta accreta spectrum (PAS) caseload","authors":"Z. Rajput, C. Lloyd, K. Feane, J. Uprichard","doi":"10.1016/j.rpth.2026.106682","DOIUrl":"10.1016/j.rpth.2026.106682","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106682"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of action and impact on thrombin generation of denecimig (Mim8), emicizumab, and zemocimig (NXT007): comparative analysis using sequence-identical analogs","authors":"Jacob Lund,&nbsp;Thomas Egebjerg,&nbsp;Jais Rose Bjelke,&nbsp;Mirella Ezban","doi":"10.1016/j.rpth.2026.106816","DOIUrl":"10.1016/j.rpth.2026.106816","url":null,"abstract":"<div><h3>Background</h3><div>Activated factor VIII (FVIIIa) mimetic antibodies restore hemostasis in hemophilia A by bridging FIXa and FX. Next-generation mimetics such as denecimig and zemocimig have been optimized for improved hemostatic activity following the launch of emicizumab. However, direct comparisons of available mechanistic data are limited due to heterogeneous experimental conditions.</div></div><div><h3>Objectives</h3><div>This study employed FX activation and thrombin generation assays to assess how the distinct mechanistic properties of the 3 FVIIIa mimetics translate into differences in hemostatic potential.</div></div><div><h3>Methods</h3><div>Sequence-identical analogs (SIAs) of zemocimig and emicizumab were produced recombinantly and purified. FX activation kinetics in the presence of FVIIIa mimetics were assessed across increasing FIXa concentrations, and apparent dissociation constants and specific activity were derived. Thrombin generation assays were performed in hemophilia A platelet-poor plasma triggered with tissue factor, FXIa, or both.</div></div><div><h3>Results</h3><div>Complex assembly affinity was highest for zemocimig-SIA, intermediate for emicizumab-SIA, and lowest for denecimig. In contrast, denecimig demonstrated markedly higher specific activity than both comparators, indicating distinct kinetic behavior. However, the FX activation assay represents a simplified system, and its artificial nature limits broader conclusions regarding physiological coagulation. Thrombin generation assays showed comparable thrombin generation profiles for denecimig and zemocimig-SIA, both exceeding emicizumab-SIA in potency.</div></div><div><h3>Conclusion</h3><div>These data indicate distinct mechanistic strategies among the 3 FVIIIa mimetics, with efficient complex assembly for emicizumab-SIA and zemocimig-SIA versus lower-affinity assembly but higher catalytic activity for denecimig. Despite these differences, zemocimig-SIA and denecimig exhibit comparable thrombin generation potential, supporting similar improvement in hemostatic potential relative to emicizumab-SIA.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 5","pages":"Article 106816"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148639980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating extracellular vesicle tissue factor activity is associated with disseminated intravascular coagulation in 2 cohorts of patients with sepsis","authors":"Ana T.A. Sachetto,&nbsp;Dhruva J. Dwivedi,&nbsp;Amandine Bonifay,&nbsp;Sylvie Cointe,&nbsp;Yohei Hisada,&nbsp;Françoise Dignat-George,&nbsp;Romaric Lacroix,&nbsp;Patricia C. Liaw,&nbsp;Nigel Mackman","doi":"10.1016/j.rpth.2026.106833","DOIUrl":"10.1016/j.rpth.2026.106833","url":null,"abstract":"<div><h3>Background</h3><div>Disseminated intravascular coagulation (DIC) occurs in a variety of diseases and syndromes. Platelet count, prothrombin time, and levels of fibrinogen and D-dimer are used to determine if a patient has DIC. The tissue factor (TF)/factor (F)VIIa complex plays a central role in the activation of coagulation in sepsis. In Gram-negative sepsis, lipopolysaccharide induces TF expression in monocytes and release TF-positive extracellular vesicles (EVs).</div></div><div><h3>Objective</h3><div>This study determined whether EV-TF activity is associated with DIC in patients with sepsis.</div></div><div><h3>Methods</h3><div>We studied 2 cohorts of patients with sepsis: a cohort of sequential patients that included 143 patients without DIC and 45 patients with DIC, and a cohort of selected patients that included 39 patients without DIC and 36 patients with DIC. The first cohort had longitudinal samples taken, and the second cohort had samples taken from pre-DIC patients (who developed DIC during the study). Healthy subjects were used as controls. Plasma EV-TF activity was measured using an in-house assay. We used the updated 2025 International Society on Thrombosis and Haemostasis (ISTH) DIC score.</div></div><div><h3>Results</h3><div>EV-TF activity was significantly higher in patients with sepsis than in healthy controls. There was no significant difference in the level of EV-TF activity between pre-DIC patients and patients without DIC. Importantly, EV-TF activity was associated with DIC in both cohorts of patients with sepsis. We observed a time-dependent decrease in EV-TF activity in patients with DIC.</div></div><div><h3>Conclusion</h3><div>Our study suggests that increased levels of circulating EV-TF activity contribute to the activation of coagulation in patients with sepsis.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 5","pages":"Article 106833"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148639922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative management of direct oral anticoagulant-treated patients who need urgent surgery","authors":"Stephanie Carlin,&nbsp;Alejandro Godoy,&nbsp;James Douketis","doi":"10.1016/j.rpth.2026.106836","DOIUrl":"10.1016/j.rpth.2026.106836","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 5","pages":"Article 106836"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148639937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP3T1_5 Systematic review and methodological quality assessment of platelet transfusion guidelines for thrombocytopenic patients in non-surgical, non-traumatic care settings","authors":"Y. Criel,&nbsp;H. Feys,&nbsp;E. De Buck,&nbsp;P. Vandekerckhove,&nbsp;T. Devos,&nbsp;P. Vandenberghe,&nbsp;H. Van Remoortel","doi":"10.1016/j.rpth.2026.106676","DOIUrl":"10.1016/j.rpth.2026.106676","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106676"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}