Research and Practice in Thrombosis and Haemostasis最新文献

{"title":"EP3T1_5 Systematic review and methodological quality assessment of platelet transfusion guidelines for thrombocytopenic patients in non-surgical, non-traumatic care settings","authors":"Y. Criel, H. Feys, E. De Buck, P. Vandekerckhove, T. Devos, P. Vandenberghe, H. Van Remoortel","doi":"10.1016/j.rpth.2026.106676","DOIUrl":"10.1016/j.rpth.2026.106676","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106676"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP3T6_5 Adverse events of intravenous ferric derisomaltose and ferric carboxymaltose in pregnancy and surgery: Systematic review","authors":"D. Heger, J. Volkmann, S. Weibel, J. Stoevesandt, V. Walzer, P. Kranke, P. Meybohm, S. Stangl","doi":"10.1016/j.rpth.2026.106730","DOIUrl":"10.1016/j.rpth.2026.106730","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106730"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP1T6_1 Acquired Factor XIII deficiency incidence in polytrauma","authors":"B. Abejaro Mut, A. Pajares, J. Fernandez, C. Palau, A. Moscardo, S. Bonanad, P. Argente, R. Ferrandis","doi":"10.1016/j.rpth.2026.106776","DOIUrl":"10.1016/j.rpth.2026.106776","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106776"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148646890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National trends in venous thromboembolism incidence in Ireland (2015-2022): a retrospective analysis","authors":"Richard Daly,&nbsp;Ciara Kirke,&nbsp;Cathal Hanley,&nbsp;Orla Healy,&nbsp;Barry Kevane,&nbsp;Fionnuala Ní Áinle,&nbsp;Maeve P. Crowley","doi":"10.1016/j.rpth.2026.106798","DOIUrl":"10.1016/j.rpth.2026.106798","url":null,"abstract":"<div><h3>Background</h3><div>Venous thromboembolism (VTE) affects millions globally, resulting in significant costs to patients and healthcare systems. Robust incidence data on VTE are limited, with a scarcity of national-level data in Ireland. Objectives: Determination of the crude VTE incidence in Ireland between 2015-2022; and assessment of VTE events during the COVID-19 during the pandemic, resulting in or occurring during a hospital admission.</div></div><div><h3>Methods</h3><div>This was a retrospective observational study using Hospital In-patient Enquiry data obtained from hospital admissions in Ireland from 2015 to 2022. VTE events were identified using International Classification of Disease codes and categorized into primary (reason for admission), secondary (arising during admission), and hospital-acquired VTE. Census data were used to calculate crude incidence rates. Secondary rates were calculated per 1000 in-patient discharges and per 1000 elective hip/knee arthroplasties.</div></div><div><h3>Results</h3><div>Between 2015 and 2022, 51,123 adult VTE cases were recorded, with a mean annual crude incidence of 172 per 100,000 population. The mean adult primary VTE crude incidence was 98 per 100,000 and mean annual hospital–acquired VTE rate was 9.9 per 1000 discharges. Of the primary VTE cases, 15,284 (52%) were in females. A total of 218 pediatric VTE cases were identified (0.23 per 10,000 population). Pregnancy-associated VTE accounted for 2.4 VTE events per 1000 live births. The mean incidence of VTE was 11 per 1000 elective hip/knee arthroplasties.</div></div><div><h3>Conclusion</h3><div>This national report of VTE incidence in Ireland provides data on primary and secondary VTE trends. From 2020 to 2022, increases in pediatric VTE, adult pulmonary embolism, and pregnancy-associated VTE and decreases in adult deep vein thrombosis were observed, in part due to the COVID-19 pandemic. This forms essential baseline data to inform VTE prevention, surveillance, further research, and health policy.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 5","pages":"Article 106798"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148740663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective preservation of shear-dependent platelet adhesion during microvolume storage in a compact agitation system","authors":"Tiana Pelaia,&nbsp;Yiyao C. Chen,&nbsp;Alexander Dupuy,&nbsp;Ivy Guan,&nbsp;Jianfang Ren,&nbsp;Laura Moldovan,&nbsp;Lautaro Pons,&nbsp;Andreas Ludwig,&nbsp;Xuyu Liu,&nbsp;Mike C.L. Wu,&nbsp;Lining A. Ju","doi":"10.1016/j.rpth.2026.106829","DOIUrl":"10.1016/j.rpth.2026.106829","url":null,"abstract":"<div><h3>Background</h3><div>Platelet-based applications relying on fresh samples create logistical constraints in research workflows. While the platelet storage lesion (PSL) is well described, its impact on biomechanical platelet function remains unclear, and existing systems are poorly suited to lab-based assays. The digital storage device (DSD) is a compact device designed for room temperature (20-24 °C) microvolume (600 μL) platelet storage under gentle, oscillatory agitation.</div></div><div><h3>Objectives</h3><div>To assess the capacity for the DSD to preserve platelet biomechanical (shear-dependent) and biochemical functions.</div></div><div><h3>Methods</h3><div>Platelet-rich plasma (PRP) and washed platelets (WP) were stored for up to 7 days in the DSD or statically at 2 to 6 °C. Shear-dependent platelet adhesion to von Willebrand factor was assessed using a microfluidic model. Biochemical responses were evaluated by TRAP-6–induced PAC-1 activation and ADP-induced aggregation. PSL markers were also measured.</div></div><div><h3>Results</h3><div>Shear-driven adhesion was maintained for 3 days in the DSD (WP: 93% of baseline at day 2, 97% day 3; PRP: 83% day 2, and 74% day 3) and remained GPIb-dependent. Biochemical responsiveness declined, particularly in PRP, where TRAP-6 responses decreased from 52% to 12% after 2 days and ADP aggregation from 60% to 20%. WP retained 84% to 89% TRAP-6 responsiveness over 7 days under microscopy. PSL markers increased alongside progressive glucose consumption.</div></div><div><h3>Conclusion</h3><div>The DSD supports shear-dependent platelet adhesion for 3 days of storage in both PRP and WP. In contrast, biochemical responsiveness is not maintained. This divergence highlights that distinct platelet functions are differentially affected during storage, enabling targeted interrogation of biomechanical functions.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 5","pages":"Article 106829"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148742930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Philadelphia-negative myeloproliferative neoplasms and acquired von Willebrand syndrome: only pertinent at diagnosis?","authors":"Fanny Lemarié,&nbsp;Jérémy Picard,&nbsp;Hubert Galinat,&nbsp;Simon Jaouen,&nbsp;Brigitte Pan-Petesch,&nbsp;Christophe Nicol,&nbsp;Laura Herbreteau,&nbsp;Lanig Civi,&nbsp;Laëtitia Rio,&nbsp;Wayne-Corentin Lambert,&nbsp;Vincent Olivier,&nbsp;Éric Lippert,&nbsp;Jean Christophe Ianotto","doi":"10.1016/j.rpth.2026.106858","DOIUrl":"10.1016/j.rpth.2026.106858","url":null,"abstract":"<div><h3>Background</h3><div>Philadelphia-negative myeloproliferative neoplasms (MPNs) are associated with both thrombotic and bleeding complications. Acquired von Willebrand syndrome (AVWS) is particularly reported in essential thrombocythemia (ET), and its role in bleeding risk remains uncertain.</div></div><div><h3>Objectives</h3><div>This study characterized patients with AVWS at the time of MPN diagnosis and evaluated the association with clinical events.</div></div><div><h3>Methods</h3><div>In our single-center cohort study, 178 patients diagnosed with polycythemia vera (PV), ET, or prefibrotic myelofibrosis (pre-PMF) were included. AVWS was assessed at diagnosis and was defined by a von Willebrand factor:glycoprotein IbM/von Willebrand factor:Ag ratio of &lt;0.65.</div></div><div><h3>Results</h3><div>Prevalence of AVWS was 38% in the whole cohort (46.3% in PV, 33% in ET, and 36.4% in pre-PMF cases). Patients with AVWS showed a more proliferative profile with elevated platelets, leukocytes, hematocrit, and lactate dehydrogenase levels. The incidence of AVWS increased with the number of elevated blood cell counts, particularly in patients with 3 myeloid lineages implications (OR, 6.14; 95% CI, 2.22-18.9; <em>P</em> &lt; .001). In multivariable models, female sex (OR, 2.52; 95% CI, 1.15-5.78; <em>P</em> = .02), thrombocytosis of &gt;700 × 10⁹/L (OR, 10; 95% CI, 4.48-24.3; <em>P</em> &lt; .001) and polycythemia (OR, 3.75; 95% CI, 1.54-9.61; <em>P</em> = .004) remained independently associated with AVWS. History of bleeding was significantly higher in patients with AVWS (17.65% vs 5.5%; <em>P</em> = .018). Hemorrhage-free survival and thrombosis-free survival were comparable between the 2 groups (<em>P</em> = .45 and <em>P</em> = .61, respectively). All except 1 patient corrected their ratio during follow-up.</div></div><div><h3>Conclusion</h3><div>AVWS affects over one-third of newly diagnosed patients with MPN, particularly women or those with thrombocytosis or polycythemia. These results suggest AVWS is not solely driven by extreme thrombocytosis but also by overall myeloproliferative burden.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 5","pages":"Article 106858"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148659888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP1T4_6 Limitations of Conventional Coagulation Monitoring in LMWH-Treated ICU Patients: The Added Value of Viscoelastic Testing, Particularly in COVID-19","authors":"A. Parkanyi,&nbsp;D. Skulteti,&nbsp;M. Berczi,&nbsp;J.D. Stubnya,&nbsp;H.D. Szasz,&nbsp;A. Feher,&nbsp;Z. Ivanyi,&nbsp;J. Gal,&nbsp;A. Kallai,&nbsp;J. Fazakas","doi":"10.1016/j.rpth.2026.106769","DOIUrl":"10.1016/j.rpth.2026.106769","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106769"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP1T7_1 Prevalence and consequences of coagulopathy on ECMO","authors":"R. Ferrandis,&nbsp;A. Moya,&nbsp;B. Abejaro,&nbsp;J. Fernández,&nbsp;C. Palau,&nbsp;P. Argente,&nbsp;A. Pajares","doi":"10.1016/j.rpth.2026.106770","DOIUrl":"10.1016/j.rpth.2026.106770","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106770"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP3T2_3 Morbidity, mortality and transfusion outcomes after full implementation of Patient Blood Management in cardiac surgery","authors":"B. Marques Gomes,&nbsp;D. Castro Paupério,&nbsp;D. Martins,&nbsp;P. Neves,&nbsp;D. Ferreira,&nbsp;M. Campos,&nbsp;C. Relvas Novo","doi":"10.1016/j.rpth.2026.106701","DOIUrl":"10.1016/j.rpth.2026.106701","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106701"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/j.rpth.2026.106859","DOIUrl":"10.1016/j.rpth.2026.106859","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"10 ","pages":"Article 106859"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}