Research and Practice in Thrombosis and Haemostasis最新文献

{"title":"135 Real World Experience with Use of Coagulation Factor VIIa (Recombinant)-jncw (SevenFact®) at an Academic Medical Center","authors":"Alyssa R. George , Katelyn W. Sylvester , Dareen M. Kanaan , Prabashni Reddy , Jean M. Connors , Nathan T. Connell","doi":"10.1016/j.rpth.2025.102753","DOIUrl":"10.1016/j.rpth.2025.102753","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102753"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"170 Creation of Patient Self-Managed Warfarin Program Within an Anticoagulation Clinic","authors":"Julia Kluck , Jennifer Hardman , Lisa Baumann Kreuziger , Hannah Breidenbach , Eric Mendez-Michler , Michelle Te Ronde , Jesse Kutz , Rebecca Wong","doi":"10.1016/j.rpth.2025.102825","DOIUrl":"10.1016/j.rpth.2025.102825","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102825"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"90 Evaluation of a Protocol For Heparin Initiation in Patients Transitioning from Oral Factor Xa Inhibitors","authors":"Carla E. Staresinic , Katie L. Willenborg , Stephanie D. Eickman , Kourtney A. Peterson","doi":"10.1016/j.rpth.2025.102776","DOIUrl":"10.1016/j.rpth.2025.102776","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102776"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"159 Safety and Efficacy of Direct Oral Anticoagulants in Patients with Body Mass Index ≥40 kg/m2","authors":"Anisa Bici , Denise Sutter-Long , Liza Renner , Erin Mouland , Nghi Ha","doi":"10.1016/j.rpth.2025.102819","DOIUrl":"10.1016/j.rpth.2025.102819","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102819"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"168 Fat-Specific S6 Kinase Gene Inhibition: A Novel Strategy to Improve Metabolic Health and Anticoagulation Outcomes in Diabetes-Associated Thrombosis","authors":"Siddarth Suresh","doi":"10.1016/j.rpth.2025.102822","DOIUrl":"10.1016/j.rpth.2025.102822","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102822"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding blood clot mechanical stability: the role of factor XIIIa-mediated fibrin crosslinking in rupture resistance","authors":"Ranjini K. Ramanujam ,&nbsp;Yona Lavi ,&nbsp;Lauren G. Poole ,&nbsp;John L. Bassani ,&nbsp;Valerie Tutwiler","doi":"10.1016/j.rpth.2025.102871","DOIUrl":"10.1016/j.rpth.2025.102871","url":null,"abstract":"<div><h3>Background</h3><div>Embolization, or rupture of a thrombus, is a complication of thrombosis that increases mortality risk by up to 30%. Fibrin provides mechanical and structural stability to blood clots. Activated factor (F)XIIIa (FXIIIa), a transglutaminase, catalyzes the formation of isopeptide bonds between fibrin fibers and is a crucial regulator of the mechanical properties of clots. FXIIIa deficiency is associated with an increased risk of bleeding and embolization. Although the mechanical response of clots is known to be influenced by fibrin crosslinking, its specific implications for the clinical outcomes of embolization remain unclear.</div></div><div><h3>Objectives</h3><div>Here, we characterized the influence of fibrin crosslinking on mechanical toughness (rupture resistance).</div></div><div><h3>Methods</h3><div>The extent of crosslinking was altered using iodoacetamide, which inhibits the activity of FXIIIa. Single-edge notch fracture tests were performed to examine fibrin strength, extensibility, and toughness under a constant strain rate. Viscoelastic mechanics was assessed using rheology. Confocal and scanning electron microscopy were utilized to quantify the fibrin network structure as a function of fibrin crosslinking.</div></div><div><h3>Results</h3><div>Our results revealed that increasing iodoacetamide concentration (0-0.1 mM) decreased toughness (8.6-2.3 N/m; <em>P</em> &lt; .01) and the maximum force prior to rupture (0.09-0.06 N; <em>P</em> &lt; .01), and the extensibility of the macroscale network remained unaltered (<em>P</em> &gt; .05), indicating that fibrin crosslinking toughens the clot. As anticipated, inhibition of fibrin crosslinking resulted in reduced storage modulus (stiffness) of clots (50-11 Pa; <em>P</em> &lt; .0001). Although inhibition of FXIIIa crosslinking altered the fibrin structure by reducing fibrin density and fiber length, these changes were not pronounced.</div></div><div><h3>Conclusion</h3><div>These findings reveal a significant contribution of fibrin crosslinking to the fracture toughness of fibrin clots, suggesting a role in the propensity for embolization.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102871"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of extended direct oral anticoagulant dosing strategies in patients with and without cancer from a prospective observational registry","authors":"Danielle T. Vlazny ,&nbsp;Robert D. McBane ,&nbsp;Ana I. Casanegra ,&nbsp;David O. Hodge ,&nbsp;Teresa Lang ,&nbsp;Waldemar E. Wysokinski ,&nbsp;Lisa Peterson ,&nbsp;Damon E. Houghton","doi":"10.1016/j.rpth.2025.102878","DOIUrl":"10.1016/j.rpth.2025.102878","url":null,"abstract":"<div><h3>Background</h3><div>Low-dose direct oral anticoagulants (DOACs) have been studied in randomized controlled trials for extended prevention of venous thromboembolism (VTE) after 6 months at therapeutic doses.</div></div><div><h3>Objectives</h3><div>This study examined the effectiveness, safety, and utilization of low-dose DOACs in a real-world cohort with dedicated analysis of cancer patients.</div></div><div><h3>Methods</h3><div>Consecutive patients enrolled in the Mayo Clinic VTE Registry from March 1, 2013, to December 31, 2022, were followed prospectively for VTE recurrence, major bleeding (MB), and clinically relevant non-MB (CRNMB). Patients with events during the first 3 months were excluded. After anticoagulation for 3 months with either rivaroxaban or apixaban, characteristics and outcomes of patients continuing anticoagulation were evaluated by Cox regression and a nested case-control study.</div></div><div><h3>Results</h3><div>In total, 466 patients (71% apixaban and 29% rivaroxaban) were identified on low-dose DOACs and 2273 in the full-dose group. Demographics between groups were mostly similar. Patients with active cancer as a provoking factor were less common in the overall low-dose DOAC group. In Cox regression analysis, VTE recurrence was not different between any groups. In noncancer patients, CRNMB but not MB was decreased in the low-dose group (hazard ratio [HR], 4.97; <em>P</em> &lt; .001). In patients with cancer, low-dose DOACs were protective for MB (HR, 4.48; <em>P</em> = .001) and CRNMB (HR, 6.81; <em>P</em> &lt; .001). Bleeding outcomes were the same in nested case-control analysis as well.</div></div><div><h3>Conclusion</h3><div>Dose reduction maintains low recurrence rates but also decreases bleeding, with the most pronounced effect in the cancer population.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102878"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aims","authors":"","doi":"10.1016/S2475-0379(25)00236-5","DOIUrl":"10.1016/S2475-0379(25)00236-5","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102912"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"194 The Impact of Prospective Review of Platelet Factor 4 Testing Practices for Suspected Heparin-Induced Thrombocytopenia: An Antithrombotic Stewardship Initiative","authors":"J. Harrison Badalamenti ,&nbsp;John Lindsley ,&nbsp;Jessica Crow ,&nbsp;Jessica Chasler ,&nbsp;Ivo Francischetti ,&nbsp;Rakhi Naik ,&nbsp;Michael Streiff ,&nbsp;Jennifer Yui ,&nbsp;Kathryn E. Dane","doi":"10.1016/j.rpth.2025.102766","DOIUrl":"10.1016/j.rpth.2025.102766","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102766"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"77 Antiplatelet and Anticoagulant Bleeding Risk Reduction: A Collaborative Approach","authors":"Lauren Jones ,&nbsp;Megan Grischeau ,&nbsp;Alaa Minkara ,&nbsp;Brandon Cave ,&nbsp;Briana Ballister ,&nbsp;Melissa Fontana ,&nbsp;Sandra Hedin","doi":"10.1016/j.rpth.2025.102767","DOIUrl":"10.1016/j.rpth.2025.102767","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102767"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}