Research and Practice in Thrombosis and Haemostasis最新文献_第6页

Neonatal intracardiac thrombosis secondary to transplacental transfer of maternal antiphospholipid antibodies-a case report and review of the literature 新生儿心内血栓形成继发于母体抗磷脂抗体经胎盘移植- 1例报告和文献复习

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102895

Katherine Girgulis , Leslie Skeith , Deborah Fruitman , Megan Barber , Nancy Soliman , Nicole Johnson , Macgregor Steele

{"title":"Neonatal intracardiac thrombosis secondary to transplacental transfer of maternal antiphospholipid antibodies-a case report and review of the literature","authors":"Katherine Girgulis , Leslie Skeith , Deborah Fruitman , Megan Barber , Nancy Soliman , Nicole Johnson , Macgregor Steele","doi":"10.1016/j.rpth.2025.102895","DOIUrl":"10.1016/j.rpth.2025.102895","url":null,"abstract":"<div><h3>Background</h3><div>Maternal antiphospholipid immunoglobulin (Ig) G antibodies can cross the placenta, placing neonates at uncertain risk for thrombosis. There are no previous reports of neonatal intracardiac thrombosis (ICT) in the context of anticardiolipin antibodies (aCL).</div></div><div><h3>Key Clinical Question</h3><div>What were the clinical manifestations, management, and outcomes for a mother and her child with ICT secondary to presumed transplacental transfer of aCL?</div></div><div><h3>Clinical Approach</h3><div>A 2-week-old female presented with reduced feeding and was found to be poorly perfused with significant lactic acidosis. A mobile mass was noted near the left atrial appendage on the echocardiogram and confirmed on cardiac magnetic resonance imaging. Magnetic resonance imaging of the brain was normal, with no evidence of stroke. The aCL IgG titers returned highly positive for the infant (115.3 IgG phospholipid (GPL)-Unit [U]/mL) and mother (>160 GPL-U/mL; >99th percentile local reference is ≥20 GPL-U/mL). There were no other overt risk factors for thrombosis. The infant received 6 months of enoxaparin until aCL normalized. There remains a small calcified thrombus adherent to the left atrial wall. At 2 years old, the child remains healthy with no cardiac, neurologic, nor thrombotic sequelae.</div></div><div><h3>Conclusion</h3><div>This is the first report of neonatal ICT presumed secondary to maternal aCL. The outcome was favorable with anticoagulation management. Further research is needed in the area of transplacental antiphospholipid antibody transfer, identification of neonates at risk, and optimal clinical management.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102895"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External validation of the DAYS score for suspected deep vein thrombosis 疑似深静脉血栓的DAYS评分的外部验证

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102885

Thor–David Halstensen , Camilla Hardeland , Waleed Ghanima , Vigdis Abrahamsen Grøndahl , Aliaksandr Hubin , Camilla Tøvik Jørgensen , Kerstin de Wit , Mazdak Tavoly

{"title":"External validation of the DAYS score for suspected deep vein thrombosis","authors":"Thor–David Halstensen , Camilla Hardeland , Waleed Ghanima , Vigdis Abrahamsen Grøndahl , Aliaksandr Hubin , Camilla Tøvik Jørgensen , Kerstin de Wit , Mazdak Tavoly","doi":"10.1016/j.rpth.2025.102885","DOIUrl":"10.1016/j.rpth.2025.102885","url":null,"abstract":"<div><h3>Background</h3><div>Diagnosing deep vein thrombosis (DVT) involves clinical assessment, D-dimer testing, and imaging. The DAYS score, a novel 2-item prediction tool combined with D-dimer, demonstrated promising performance but required external validation.</div></div><div><h3>Objectives</h3><div>This study aimed to validate 2 DVT prediction scores: the DAYS score and a newly developed DVT score.</div></div><div><h3>Methods</h3><div>Data were collected from a prospective Norwegian DVT management study (2015-2018; NCT02486445). The DAYS score includes 2 items (DVT most likely diagnosis and calf swelling), while the new score comprises tenderness along the deep veins and previous venous thromboembolism. DVT was considered excluded if no items were present and D-dimer was < 1.0 μg/mL or if ≥1 item was present and D-dimer was < 0.5 μg/mL. The 2-tier Wells score served as the reference. Safety was defined as the number of missed DVT cases divided by the total number of patients classified as having DVT excluded and was set at 2%.</div></div><div><h3>Results</h3><div>Among 1312 patients (median age, 64 years; IQR, 52-73 years; 55% women), 261 (20.0%) had confirmed DVT. The DAYS score excluded DVT in 455 patients (34.6%), of whom 11 were diagnosed with DVT (failure rate, 2.4 %; 95% CI, 1.2-4.2). The new score excluded DVT in 519 patients (39.6%) and missed 7 cases with confirmed DVT (failure rate, 1.3%; 95% CI, 0.5-2.8). The Wells score excluded DVT in 271 patients (20.6%), missing only 2 cases with confirmed DVT.</div></div><div><h3>Conclusion</h3><div>While both the DAYS score and the new score demonstrated low failure rates, they exceeded the predefined safety threshold.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102885"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress 血管类型的异质性与内皮细胞在剪切应力下的差异基因表达谱有关

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102894

Allaura A. Cox, Christopher James Ng

{"title":"Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress","authors":"Allaura A. Cox, Christopher James Ng","doi":"10.1016/j.rpth.2025.102894","DOIUrl":"10.1016/j.rpth.2025.102894","url":null,"abstract":"<div><h3>Background</h3><div>Endothelial cell (EC) heterogeneity is an emerging area of research in EC biology. Vein, artery, and microvascular ECs have been shown to have heterogeneity in gene expression and function, termed “vascular-type” heterogeneity in this report. In addition to this innate heterogeneity, we hypothesized that different vascular-type ECs would also demonstrate heterogeneity in their response to shear stress.</div></div><div><h3>Objectives</h3><div>We interrogated whether vascular-type ECs would demonstrate variations in transcriptional expression patterns under shear stress.</div></div><div><h3>Methods</h3><div>Human umbilical vein ECs, human pulmonary arterial ECs, and human microvascular ECs were commercially purchased and subjected to 0, 1, 4, and 10 dynes/cm<sup>2</sup> of laminar shear stress. After shear stress exposure, cellular alignment was analyzed, and RNA was extracted and evaluated via bulk RNA sequencing.</div></div><div><h3>Results</h3><div>All ECs demonstrated significant changes in alignment under shear stress. Shear stress significantly affected the transcriptomes of ECs, resulting in differential expression of genes and pathways. While several genes were differentially expressed by all 3 vascular EC types (44.2%), most differentially expressed genes were limited to 1 or 2 of the vascular types. Hemostatic and thrombotic genes were found to have differential expression patterns under conditions of shear stress, and von Willebrand factor demonstrated a pattern of vascular-type heterogeneity in response to shear stress.</div></div><div><h3>Conclusion</h3><div>Shear stress causes changes in cellular alignment and transcriptional patterns in ECs that are dependent upon underlying vascular type. Therefore, endothelial vascular-type heterogeneity can regulate response to shear stress, especially in hemostatic and thrombotic gene expression.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102894"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying and addressing underuse in hematologic care through systems-based hematology 通过以系统为基础的血液学来识别和解决血液学护理的不足

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102881

Jacob C. Cogan , Allison E. Burnett , Alexandra Power-Hays , Geoffrey D. Barnes , Ming Y. Lim

引用次数: 0

80 Thrombophilia Screening in Inpatients: A Review of Testing Appropriateness and Clinical Impact in a Tertiary Hospital in Qatar 住院患者的血栓筛查：卡塔尔一家三级医院检测适宜性和临床影响的回顾

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102801

Osama Abdelsamad , Dania Alkhiyami , Syed Yameen Hasan , Eman Alhmoud , Rasha Al Anany

引用次数: 0

158 Clinical Performance of a Novel Point-of-Care Coagulometer, the Perosphere ClotChek™, for the DOACS 用于DOACS的新型即时凝血仪Perosphere ClotChek™的临床性能

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102786

S.H. Bakhru , X. Jiang , L. Chen , D. Osmani , A. Balaj , K. Kronen , D. Mootoo , F. LaDuca , J. Ansell

引用次数: 0

190 Patient Compliance with Aspirin and Rivaroxaban Post Elective Joint Replacement Surgery: A Quality Assurance Initiative 选择性关节置换手术后患者对阿司匹林和利伐沙班的依从性：一项质量保证倡议

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102811

Laurie A. Sardo , Julia A. Bayadinova , Emma K. Sardo

引用次数: 0

144 Anticoagulation in Patients with Provoked Venous Thromboembolism: A Real-World Analysis of Clinical Characteristics, Management Strategies, and Outcomes from an Outpatient Tertiary Anticoagulation Clinic in Qatar 诱发性静脉血栓栓塞患者的抗凝治疗：卡塔尔一家三级抗凝门诊的临床特征、管理策略和结果分析

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102827

Ibtihal Mahmoud Abdallah , Asma Eltahir , Rana Moustafa Al-Adawi , Mohamed Abdelgelil , Abdul Moqeeth Mohammed , Asmaa Mohamed

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135 Real World Experience with Use of Coagulation Factor VIIa (Recombinant)-jncw (SevenFact®) at an Academic Medical Center 135在学术医疗中心使用凝血因子VIIa（重组）-jncw （SevenFact®）的真实世界经验

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102753

Alyssa R. George , Katelyn W. Sylvester , Dareen M. Kanaan , Prabashni Reddy , Jean M. Connors , Nathan T. Connell

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170 Creation of Patient Self-Managed Warfarin Program Within an Anticoagulation Clinic 170在抗凝门诊建立病人自我管理的华法林计划

IF 3.4 3区医学

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-05-01 DOI: 10.1016/j.rpth.2025.102825

Julia Kluck , Jennifer Hardman , Lisa Baumann Kreuziger , Hannah Breidenbach , Eric Mendez-Michler , Michelle Te Ronde , Jesse Kutz , Rebecca Wong

引用次数: 0