Research and Practice in Thrombosis and Haemostasis最新文献

{"title":"129 Risk Mitigation of Gastrointestinal Bleeding in Patients Co-Prescribed Antiplatelets with Oral Anticoagulants: VISN 8 Anticoagulation Stewardship Proton Pump Inhibitor Initiative","authors":"David Parra , Jeffery L. Kibert II , Natalie R. Ciccone , Litzalee Camacho-Vega , Joseph Capriola , Jennifer L. Crowley , Joseph J. Fierro , Alida Marrero-Hernandez , Maria J. Irias , Robert D. Stewart , Jaclyn Stoppi , Elyse C. Wilson , Laura K. Vinieratos , VISN 8 Pharmacy Anticoagulation Workgroup","doi":"10.1016/j.rpth.2025.102752","DOIUrl":"10.1016/j.rpth.2025.102752","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102752"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"97 Assessment of Patient's Knowledge and Its Impact on Achieving Therapeutic International Normalized Ratio Goal","authors":"Reema Syed","doi":"10.1016/j.rpth.2025.102740","DOIUrl":"10.1016/j.rpth.2025.102740","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102740"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"63 Increased Neonatal Mortality and Increasing Rate of Cerebral Venous Sinus Thrombosis in Hospitalized Children: A Pediatric Health Information System Database Study","authors":"Jiasen He , Natalie Montanez , Stuart Fraser , Audrey Barnett , Christin Silos , Keely Smith , Lakshmi Srivaths","doi":"10.1016/j.rpth.2025.102792","DOIUrl":"10.1016/j.rpth.2025.102792","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102792"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"164 Safety and Efficacy of the Use of Direct Oral Anticoagulants in Patients with a History of Bariatric Surgery","authors":"Nicholas Shabanowitz , Kayla Popova , Michelle Schultz , Nghi Ha","doi":"10.1016/j.rpth.2025.102821","DOIUrl":"10.1016/j.rpth.2025.102821","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102821"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for management of hemophilia—why, what, and how?","authors":"Alok Srivastava , Johnny Mahlangu , Steven W. Pipe","doi":"10.1016/j.rpth.2025.102879","DOIUrl":"10.1016/j.rpth.2025.102879","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102879"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of the DAYS score for suspected deep vein thrombosis","authors":"Thor–David Halstensen ,&nbsp;Camilla Hardeland ,&nbsp;Waleed Ghanima ,&nbsp;Vigdis Abrahamsen Grøndahl ,&nbsp;Aliaksandr Hubin ,&nbsp;Camilla Tøvik Jørgensen ,&nbsp;Kerstin de Wit ,&nbsp;Mazdak Tavoly","doi":"10.1016/j.rpth.2025.102885","DOIUrl":"10.1016/j.rpth.2025.102885","url":null,"abstract":"<div><h3>Background</h3><div>Diagnosing deep vein thrombosis (DVT) involves clinical assessment, D-dimer testing, and imaging. The DAYS score, a novel 2-item prediction tool combined with D-dimer, demonstrated promising performance but required external validation.</div></div><div><h3>Objectives</h3><div>This study aimed to validate 2 DVT prediction scores: the DAYS score and a newly developed DVT score.</div></div><div><h3>Methods</h3><div>Data were collected from a prospective Norwegian DVT management study (2015-2018; NCT02486445). The DAYS score includes 2 items (DVT most likely diagnosis and calf swelling), while the new score comprises tenderness along the deep veins and previous venous thromboembolism. DVT was considered excluded if no items were present and D-dimer was &lt; 1.0 μg/mL or if ≥1 item was present and D-dimer was &lt; 0.5 μg/mL. The 2-tier Wells score served as the reference. Safety was defined as the number of missed DVT cases divided by the total number of patients classified as having DVT excluded and was set at 2%.</div></div><div><h3>Results</h3><div>Among 1312 patients (median age, 64 years; IQR, 52-73 years; 55% women), 261 (20.0%) had confirmed DVT. The DAYS score excluded DVT in 455 patients (34.6%), of whom 11 were diagnosed with DVT (failure rate, 2.4 %; 95% CI, 1.2-4.2). The new score excluded DVT in 519 patients (39.6%) and missed 7 cases with confirmed DVT (failure rate, 1.3%; 95% CI, 0.5-2.8). The Wells score excluded DVT in 271 patients (20.6%), missing only 2 cases with confirmed DVT.</div></div><div><h3>Conclusion</h3><div>While both the DAYS score and the new score demonstrated low failure rates, they exceeded the predefined safety threshold.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102885"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress","authors":"Allaura A. Cox,&nbsp;Christopher James Ng","doi":"10.1016/j.rpth.2025.102894","DOIUrl":"10.1016/j.rpth.2025.102894","url":null,"abstract":"<div><h3>Background</h3><div>Endothelial cell (EC) heterogeneity is an emerging area of research in EC biology. Vein, artery, and microvascular ECs have been shown to have heterogeneity in gene expression and function, termed “vascular-type” heterogeneity in this report. In addition to this innate heterogeneity, we hypothesized that different vascular-type ECs would also demonstrate heterogeneity in their response to shear stress.</div></div><div><h3>Objectives</h3><div>We interrogated whether vascular-type ECs would demonstrate variations in transcriptional expression patterns under shear stress.</div></div><div><h3>Methods</h3><div>Human umbilical vein ECs, human pulmonary arterial ECs, and human microvascular ECs were commercially purchased and subjected to 0, 1, 4, and 10 dynes/cm² of laminar shear stress. After shear stress exposure, cellular alignment was analyzed, and RNA was extracted and evaluated via bulk RNA sequencing.</div></div><div><h3>Results</h3><div>All ECs demonstrated significant changes in alignment under shear stress. Shear stress significantly affected the transcriptomes of ECs, resulting in differential expression of genes and pathways. While several genes were differentially expressed by all 3 vascular EC types (44.2%), most differentially expressed genes were limited to 1 or 2 of the vascular types. Hemostatic and thrombotic genes were found to have differential expression patterns under conditions of shear stress, and von Willebrand factor demonstrated a pattern of vascular-type heterogeneity in response to shear stress.</div></div><div><h3>Conclusion</h3><div>Shear stress causes changes in cellular alignment and transcriptional patterns in ECs that are dependent upon underlying vascular type. Therefore, endothelial vascular-type heterogeneity can regulate response to shear stress, especially in hemostatic and thrombotic gene expression.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102894"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitor development in nonsevere hemophilia: data from the European Haemophilia Safety Surveillance (EUHASS) registry","authors":"Kathelijn Fischer ,&nbsp;Riitta Lassila ,&nbsp;Flora Peyvandi ,&nbsp;Alexander Gatt ,&nbsp;Samantha C. Gouw ,&nbsp;Robert Hollingsworth ,&nbsp;Thierry Lambert ,&nbsp;Radek Kaczmarek ,&nbsp;Diana Carbonero Alvarez ,&nbsp;Michael Makris ,&nbsp;EUHASS participants","doi":"10.1016/j.rpth.2025.102887","DOIUrl":"10.1016/j.rpth.2025.102887","url":null,"abstract":"<div><h3>Background</h3><div>Information on inhibitor development in nonsevere hemophilia and its association with clotting factor concentrate type is limited.</div></div><div><h3>Objectives</h3><div>To assess inhibitor development in patients with nonsevere hemophilia A (HA) and hemophilia B (HB) in the European Haemophilia Safety Surveillance system.</div></div><div><h3>Methods</h3><div>Inhibitors and total treated patients are reported annually. Any exposure to concentrate per year was considered a treatment year. Incidence rates per 1000 treatment years and 95% CIs were calculated according to type of concentrate and compared using incidence rate ratios (IRRs).</div></div><div><h3>Results</h3><div>During 2008 to 2023, 90 centers reported on 36,074 (HA) and 9238 (HB) treatment years. The inhibitor rate for nonsevere HA receiving factor (F)VIII was 4.2 per 1000 treatment years (95% CI, 3.5-4.9). Inhibitors developed at median 47.5 years (P25-P75 [IQR], 17.0-69.0), after median 40 exposure days (EDs; IQR, 17-80), with 58% occurring &lt;50 EDs and 88% &lt;100 EDs. Overall, 4 of 149 (2.7%) patients in the inhibitor group were female. Only one inhibitor was reported in nonsevere HB, in a female patient (FIX 7%, after 6 EDs), resulting in an inhibitor rate of 0.1 per 1000 treatment years (95% CI, 0.0-0.6). Compared with standard half-life recombinant FVIII, inhibitor rates on both plasma-derived FVIII (IRR, 0.27; 95% CI, 0.11-0.58; <em>P</em> &lt; .001) and extended half-life FVIII (IRR, 0.18; 95% CI, 0.02-0.68; <em>P</em> = .002) were significantly reduced.</div></div><div><h3>Conclusion</h3><div>Inhibitors in nonsevere hemophilia occurred at a rate of 4.2 per 1000 treatment years in HA and 0.1 per 1000 treatment years in HB. Compared with standard half-life FVIII, inhibitor development on plasma-derived and extended half-life FVIII were reduced. These data show that inhibitor monitoring is relevant with nonsevere HA in both sexes and should be continued lifelong.</div></div>","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 4","pages":"Article 102887"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title page","authors":"","doi":"10.1016/S2475-0379(25)00228-6","DOIUrl":"10.1016/S2475-0379(25)00228-6","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102904"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"131 Evaluation of Hemoglobin Monitoring Frequency in Patients on Anticoagulation Therapy","authors":"Liana Ha ,&nbsp;Saira Mirza ,&nbsp;Alyssa E. Utz ,&nbsp;Salman Hasham ,&nbsp;Mikhail Y. Akbashev","doi":"10.1016/j.rpth.2025.102784","DOIUrl":"10.1016/j.rpth.2025.102784","url":null,"abstract":"","PeriodicalId":20893,"journal":{"name":"Research and Practice in Thrombosis and Haemostasis","volume":"9 ","pages":"Article 102784"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}