Psychological Medicine最新文献

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Examining psychotic experiences in two generations - findings from a rural household-based cohort study; the Lolland-Falster Health Study. 检查两代人的精神病经历——来自农村家庭队列研究的结果;Lolland-Falster健康研究
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-05-01 Epub Date: 2023-11-24 DOI: 10.1017/S0033291723003276
Martin Køster Rimvall, Erik Simonsen, Jiawei Zhang, Zorana Jovanovic Andersen, Lene Halling Hastrup, Pia Jeppesen, Stephen F Austin, Susanne Vinkel Koch
{"title":"Examining psychotic experiences in two generations - findings from a rural household-based cohort study; the Lolland-Falster Health Study.","authors":"Martin Køster Rimvall, Erik Simonsen, Jiawei Zhang, Zorana Jovanovic Andersen, Lene Halling Hastrup, Pia Jeppesen, Stephen F Austin, Susanne Vinkel Koch","doi":"10.1017/S0033291723003276","DOIUrl":"10.1017/S0033291723003276","url":null,"abstract":"<p><strong>Background: </strong>Psychotic disorders are highly heritable, yet the evidence is less clear for subclinical psychosis expression, such as psychotic experiences (PEs). We examined if PEs in parents were associated with PEs in offspring.</p><p><strong>Methods: </strong>As part of the Danish general population Lolland-Falster Health Study, families with youths aged 11-17 years were included. Both children and parents reported PEs according to the Psychotic Like Experiences Questionnaire, counting only 'definite' PEs. Parents additionally reported depressive symptoms, anxiety, and mental wellbeing. The associations between parental and child PEs were estimated using generalized estimating equations with an exchangeable correlation structure to account for the clustering of observations within families, adjusting for sociodemographic characteristics.</p><p><strong>Results: </strong>Altogether, 984 youths (mean age 14.3 years [s.d. 2.0]), 700 mothers, and 496 fathers from 766 households completed PEs-questionnaires. Offspring of parents with PEs were at an increased risk of reporting PEs themselves (mothers: adjusted risk ratio (aRR) 2.42, 95% CI 1.73-3.38; fathers: aRR 2.25, 95% CI 1.42-3.59). Other maternal problems (depression, anxiety, and poor mental well-being), but not paternal problems, were also associated with offspring PEs. In multivariate models adjusting for parental problems, PEs, but not other parental problems, were robustly associated with offspring PEs (mothers: aRR 2.25, 95% CI 1.60-3.19; fathers: aRR 2.44, 95% CI 1.50-3.96).</p><p><strong>Conclusions: </strong>The current findings add novel evidence suggesting that specific psychosis vulnerability in families is expressed at the lower end of the psychosis continuum, underlining the importance of assessing youths' needs based on psychosis vulnerability broadly within the family systems.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term diagnostic stability, predictors of diagnostic change, and time until diagnostic change of first-episode psychosis: a 21-year follow-up study. 首发精神病的长期诊断稳定性、诊断改变的预测因素和诊断改变前的时间:一项21年的随访研究
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-05-01 Epub Date: 2023-11-21 DOI: 10.1017/S0033291723003173
David Peralta, Lucía Janda, Elena García de Jalón, Lucía Moreno-Izco, Ana M Sánchez-Torres, Manuel J Cuesta, Victor Peralta
{"title":"Long-term diagnostic stability, predictors of diagnostic change, and time until diagnostic change of first-episode psychosis: a 21-year follow-up study.","authors":"David Peralta, Lucía Janda, Elena García de Jalón, Lucía Moreno-Izco, Ana M Sánchez-Torres, Manuel J Cuesta, Victor Peralta","doi":"10.1017/S0033291723003173","DOIUrl":"10.1017/S0033291723003173","url":null,"abstract":"<p><strong>Background: </strong>Although diagnostic instability in first-episode psychosis (FEP) is of major concern, little is known about its determinants. This very long-term follow-up study aimed to examine the diagnostic stability of FEP diagnoses, the baseline predictors of diagnostic change and the timing of diagnostic change.</p><p><strong>Methods: </strong>This was a longitudinal and naturalistic study of 243 subjects with FEP who were assessed at baseline and reassessed after a mean follow-up of 21 years. The diagnostic stability of DSM-5 psychotic disorders was examined using prospective and retrospective consistencies, logistic regression was used to establish the predictors of diagnostic change, and survival analysis was used to compare time to diagnostic change across diagnostic categories.</p><p><strong>Results: </strong>The overall diagnostic stability was 47.7%. Schizophrenia and bipolar disorder were the most stable diagnoses, with other categories having low stability. Predictors of diagnostic change to schizophrenia included a family history of schizophrenia, obstetric complications, developmental delay, poor premorbid functioning in several domains, long duration of untreated continuous psychosis, spontaneous dyskinesia, lack of psychosocial stressors, longer duration of index admission, and poor early treatment response. Most of these variables also predicted diagnostic change to bipolar disorder but in the opposite direction and with lesser effect sizes. There were no significant differences between specific diagnoses regarding time to diagnostic change. At 10-year follow-up, around 80% of the diagnoses had changed.</p><p><strong>Conclusions: </strong>FEP diagnoses other than schizophrenia or bipolar disorder should be considered as provisional. Considering baseline predictors of diagnostic change may help to enhance diagnostic accuracy and guide therapeutic interventions.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intergenerational transmission of ADHD behaviors: genetic and environmental pathways. 多动症行为的代际传播:遗传和环境途径。
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-05-01 Epub Date: 2023-11-03 DOI: 10.1017/S003329172300315X
Thomas H Kleppesto, Espen Moen Eilertsen, Elsje van Bergen, Hans Fredrik Sunde, Brendan Zietsch, Magnus Nordmo, Nikolai Haahjem Eftedal, Alexandra Havdahl, Eivind Ystrom, Fartein Ask Torvik
{"title":"Intergenerational transmission of ADHD behaviors: genetic and environmental pathways.","authors":"Thomas H Kleppesto, Espen Moen Eilertsen, Elsje van Bergen, Hans Fredrik Sunde, Brendan Zietsch, Magnus Nordmo, Nikolai Haahjem Eftedal, Alexandra Havdahl, Eivind Ystrom, Fartein Ask Torvik","doi":"10.1017/S003329172300315X","DOIUrl":"10.1017/S003329172300315X","url":null,"abstract":"<p><strong>Background: </strong>We investigate if covariation between parental and child attention-deficit hyperactivity disorder (ADHD) behaviors can be explained by environmental and/or genetic transmission.</p><p><strong>Methods: </strong>We employed a large children-of-twins-and-siblings sample (<i>N</i> = 22 276 parents and 11 566 8-year-old children) of the Norwegian Mother, Father and Child Cohort Study. This enabled us to disentangle intergenerational influences via parental genes and parental behaviors (i.e. genetic and environmental transmission, respectively). Fathers reported on their own symptoms and mothers on their own and their child's symptoms.</p><p><strong>Results: </strong>Child ADHD behaviors correlated with their mother's (0.24) and father's (0.10) ADHD behaviors. These correlations were largely due to additive genetic transmission. Variation in children's ADHD behaviors was explained by genetic factors active in both generations (11%) and genetic factors specific to the children (46%), giving a total heritability of 57%. There were small effects of parental ADHD behaviors (2% environmental transmission) and gene-environment correlation (3%). The remaining variability in ADHD behaviors was due to individual-specific environmental factors.</p><p><strong>Conclusions: </strong>The intergenerational resemblance of ADHD behaviors is primarily due to genetic transmission, with little evidence for parental ADHD behaviors causing children's ADHD behaviors. This contradicts theories proposing environmental explanations of intergenerational transmission of ADHD, such as parenting theories or psychological life-history theory.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic syndrome after childhood trauma: a 9-year longitudinal analysis. 儿童创伤后代谢综合征:9年纵向分析。
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-05-01 Epub Date: 2023-11-20 DOI: 10.1017/S0033291723003264
Camille Souama, Yuri Milaneschi, Femke Lamers, Christiaan H Vinkers, Erik J Giltay, Edith J Liemburg, Brenda W J H Penninx
{"title":"Metabolic syndrome after childhood trauma: a 9-year longitudinal analysis.","authors":"Camille Souama, Yuri Milaneschi, Femke Lamers, Christiaan H Vinkers, Erik J Giltay, Edith J Liemburg, Brenda W J H Penninx","doi":"10.1017/S0033291723003264","DOIUrl":"10.1017/S0033291723003264","url":null,"abstract":"<p><strong>Background: </strong>Childhood trauma (CT) has been cross-sectionally associated with metabolic syndrome (MetS), a group of biological risk factors for cardiometabolic disease. Longitudinal studies, while rare, would clarify the development of cardiometabolic dysregulations over time. Therefore, we longitudinally investigated the association of CT with the 9-year course of MetS components.</p><p><strong>Methods: </strong>Participants (<i>N</i> = 2958) from the Netherlands Study of Depression and Anxiety were assessed four times across 9 years. The CT interview retrospectively assessed childhood emotional neglect and physical, emotional, and sexual abuse. Metabolic outcomes encompassed continuous MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, blood pressure [BP], and glucose) and count of clinically elevated MetS components. Mixed-effects models estimated sociodemographic- and lifestyle-adjusted longitudinal associations of CT with metabolic outcomes over time. Time interactions evaluated change in these associations.</p><p><strong>Results: </strong>CT was reported by 49% of participants. CT was consistently associated with increased waist (<i>b</i> = 0.32, s.e. = 0.10, <i>p</i> = 0.001), glucose (<i>b</i> = 0.02, s.e. = 0.01, <i>p</i> < 0.001), and count of MetS components (<i>b</i> = 0.04, s.e. = 0.01, <i>p</i> < 0.001); and decreased HDL cholesterol (<i>b</i> = -0.01, s.e.<0.01, <i>p</i> = .020) and systolic BP (<i>b</i> = -0.33, s.e. = 0.13, <i>p</i> = 0.010). These associations were mainly driven by severe CT and unaffected by lifestyle. Only systolic BP showed a CT-by-time interaction, where CT was associated with lower systolic BP initially and with higher systolic BP at the last follow-up.</p><p><strong>Conclusions: </strong>Over time, adults with CT have overall persistent poorer metabolic outcomes than their non-maltreated peers. Individuals with CT have an increased risk for cardiometabolic disease and may benefit from monitoring and early interventions targeting metabolism.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mental health of Australians bereaved during the first two years of the COVID-19 pandemic: a latent class analysis. COVID-19 大流行头两年期间澳大利亚丧亲者的心理健康:潜类分析。
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-05-01 Epub Date: 2024-01-05 DOI: 10.1017/S0033291723003227
F Maccallum, L J Breen, J L Phillips, M R Agar, A Hosie, J Tieman, M DiGiacomo, T Luckett, J Philip, S Ivynian, S Chang, A Dadich, C H Grossman, I Gilmore, J Harlum, I Kinchin, N Glasgow, E A Lobb
{"title":"The mental health of Australians bereaved during the first two years of the COVID-19 pandemic: a latent class analysis.","authors":"F Maccallum, L J Breen, J L Phillips, M R Agar, A Hosie, J Tieman, M DiGiacomo, T Luckett, J Philip, S Ivynian, S Chang, A Dadich, C H Grossman, I Gilmore, J Harlum, I Kinchin, N Glasgow, E A Lobb","doi":"10.1017/S0033291723003227","DOIUrl":"10.1017/S0033291723003227","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic disrupted many areas of life, including culturally accepted practices at end-of-life care, funeral rites, and access to social, community, and professional support. This survey investigated the mental health outcomes of Australians bereaved during this time to determine how these factors might have impacted bereavement outcomes.</p><p><strong>Methods: </strong>An online survey indexing pandemic and bereavement experiences, levels of grief, depression, anxiety, and health, work, and social impairment. Latent class analysis (LCA) was used to identify groups of individuals who shared similar symptom patterns. Multinomial regressions identified pandemic-related, loss-related, and sociodemographic correlates of class membership.</p><p><strong>Results: </strong>1911 Australian adults completed the survey. The LCA identified four classes: low symptoms (46.8%), grief (17.3%), depression/anxiety (17.7%), and grief/depression/anxiety (18.2%). The latter group reported the highest levels of health, work, and social impairment. The death of a child or partner and an inability to care for the deceased due to COVID-19 public health measures were correlated with grief symptoms (with or without depression and anxiety). Preparedness for the person's death and levels of pandemic-related loneliness and social isolation differentiated all four classes. Unemployment was associated with depression/anxiety (with or without grief).</p><p><strong>Conclusions: </strong>COVID-19 had profound impacts for the way we lived and died, with effects that are likely to ricochet through society into the foreseeable future. These lessons learned must inform policymakers and healthcare professionals to improve bereavement care and ensure preparedness during and following future predicted pandemics to prevent negative impacts.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental health and service use of parents with and without borderline intellectual functioning. 有或没有边缘性智力功能的父母的心理健康和服务使用情况。
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-05-01 Epub Date: 2023-10-25 DOI: 10.1017/S0033291723003136
Sonya Rudra, Sally McManus, Angela Hassiotis, Afia Ali
{"title":"Mental health and service use of parents with and without borderline intellectual functioning.","authors":"Sonya Rudra, Sally McManus, Angela Hassiotis, Afia Ali","doi":"10.1017/S0033291723003136","DOIUrl":"10.1017/S0033291723003136","url":null,"abstract":"<p><strong>Background: </strong>People with borderline intellectual functioning (BIF) encounter greater social adversities than the general population and have an increased prevalence of mental illness. However, little is known about the socio-demographic characteristics and mental health of parents with BIF.</p><p><strong>Methods: </strong>A secondary data analysis of the Adult Psychiatric Morbidity Survey 2014 was conducted. Logistic regression models were fitted to compare differences in socio-demographic, mental health and service-use characteristics between parents and non-parents with and without BIF, and to investigate if the relationship between parent status and mental health outcomes was modified by BIF status, sex, and employment.</p><p><strong>Results: </strong>Data from 6872 participants was analyzed; 69.1% were parents. BIF parents had higher odds of common mental disorder, severe mental illness, post-traumatic stress disorder, self-harm/suicide and were more likely to see their General Practitioner (GP) and to receive mental health treatment than non-BIF parents. BIF parents did not have a higher prevalence of mental health problems than BIF non-parents. Being a parent, after adjusting for BIF status and other confounders, was associated with increased odds of having a common mental disorder, visits to see a GP and treatment for mental health. Female parents had higher odds of treatment for mental health problems.</p><p><strong>Conclusions: </strong>Being a parent is associated with elevated rates of common mental disorders. There is a higher burden of mental health problems and service use in people with BIF. A greater provision of specialist support services including ascertainment is indicated for this group.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
24-Hour warning signs for adolescent suicide attempts. 青少年自杀未遂的24小时警告标志。
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-05-01 Epub Date: 2023-11-10 DOI: 10.1017/S0033291723003112
Cheryl A King, Polly Y Gipson Allen, Sheikh Iqbal Ahamed, Michael Webb, T Charles Casper, David Brent, Jacqueline Grupp-Phelan, T Alexander Rogers, Alejandra Arango, Nadia Al-Dajani, Taylor C McGuire, Courtney L Bagge
{"title":"24-Hour warning signs for adolescent suicide attempts.","authors":"Cheryl A King, Polly Y Gipson Allen, Sheikh Iqbal Ahamed, Michael Webb, T Charles Casper, David Brent, Jacqueline Grupp-Phelan, T Alexander Rogers, Alejandra Arango, Nadia Al-Dajani, Taylor C McGuire, Courtney L Bagge","doi":"10.1017/S0033291723003112","DOIUrl":"10.1017/S0033291723003112","url":null,"abstract":"<p><strong>Background: </strong>Little is known about <i>when</i> youth may be at greatest risk for attempting suicide, which is critically important information for the parents, caregivers, and professionals who care for youth at risk. This study used adolescent and parent reports, and a case-crossover, within-subject design to identify 24-hour warning signs (WS) for suicide attempts.</p><p><strong>Methods: </strong>Adolescents (<i>N</i> = 1094, ages 13 to 18) with one or more suicide risk factors were enrolled and invited to complete bi-weekly, 8-10 item text message surveys for 18 months. Adolescents who reported a suicide attempt (survey item) were invited to participate in an interview regarding their thoughts, feelings/emotions, and behaviors/events during the 24-hours prior to their attempt (case period) and a prior 24-hour period (control period). Their parents participated in an interview regarding the adolescents' behaviors/events during these same periods. Adolescent or adolescent and parent interviews were completed for 105 adolescents (81.9% female; 66.7% White, 19.0% Black, 14.3% other).</p><p><strong>Results: </strong>Both parent and adolescent reports of suicidal communications and withdrawal from social and other activities differentiated case and control periods. Adolescent reports also identified feelings (self-hate, emotional pain, rush of feelings, lower levels of rage toward others), cognitions (suicidal rumination, perceived burdensomeness, anger/hostility), and serious conflict with parents as WS in multi-variable models.</p><p><strong>Conclusions: </strong>This study identified 24-hour WS in the domains of cognitions, feelings, and behaviors/events, providing an evidence base for the dissemination of information about signs of proximal risk for adolescent suicide attempts.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long-term effectiveness of a personality-targeted substance use prevention program on aggression from adolescence to early adulthood 以人格为目标的药物使用预防计划对青少年至成年早期攻击行为的长期效果
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-04-29 DOI: 10.1017/s0033291724000989
Siobhan Lawler, Emma L. Barrett, Maree Teesson, Erin Kelly, Katrina E. Champion, Jennifer Debenham, Anna Smout, Cath Chapman, Tim Slade, Patricia J. Conrod, Nicola C. Newton, Lexine Stapinski
{"title":"The long-term effectiveness of a personality-targeted substance use prevention program on aggression from adolescence to early adulthood","authors":"Siobhan Lawler, Emma L. Barrett, Maree Teesson, Erin Kelly, Katrina E. Champion, Jennifer Debenham, Anna Smout, Cath Chapman, Tim Slade, Patricia J. Conrod, Nicola C. Newton, Lexine Stapinski","doi":"10.1017/s0033291724000989","DOIUrl":"https://doi.org/10.1017/s0033291724000989","url":null,"abstract":"<span>Background</span><p>Addressing aggressive behavior in adolescence is a key step toward preventing violence and associated social and economic costs in adulthood. This study examined the secondary effects of the personality-targeted substance use preventive program <span>Preventure</span> on aggressive behavior from ages 13 to 20.</p><span>Methods</span><p>In total, 339 young people from nine independent schools (<span>M</span> age = 13.03 years, <span>s.d.</span> = 0.47, range = 12–15) who rated highly on one of the four personality traits associated with increased substance use and other emotional/behavioral symptoms (i.e. impulsivity, anxiety sensitivity, sensation seeking, and negative thinking) were included in the analyses (<span>n</span> = 145 in Preventure, <span>n</span> = 194 in control). Self-report assessments were administered at baseline and follow-up (6 months, 1, 2, 3, 5.5, and 7 years). Overall aggression and subtypes of aggressive behaviors (proactive, reactive) were examined using multilevel mixed-effects analysis accounting for school-level clustering.</p><span>Results</span><p>Across the 7-year follow-up period, the average yearly reduction in the frequency of aggressive behaviors (<span>b</span> = −0.42; 95% confidence interval [CI] −0.64 to −0.20; <span>p</span> &lt; 0.001), reactive aggression (<span>b</span> = −0.22; 95% CI 0.35 to −0.10; <span>p</span> = 0.001), and proactive aggression (<span>b</span> = −0.14; 95% CI −0.23 to −0.05; <span>p</span> = 0.002) was greater for the Preventure group compared to the control group.</p><span>Conclusions</span><p>The study suggests a brief personality-targeted intervention may have long-term impacts on aggression among young people; however, this interpretation is limited by imbalance of sex ratios between study groups.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140811312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis 健康行为在抑郁、焦虑与癌症发病率之间关系中的中介作用:个体参与者数据荟萃分析
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-04-29 DOI: 10.1017/s0033291724000850
Kuan-Yu Pan, Lonneke van Tuijl, Maartje Basten, Judith J. M. Rijnhart, Alexander de Graeff, Joost Dekker, Mirjam I. Geerlings, Adriaan Hoogendoorn, Adelita V. Ranchor, Roel Vermeulen, Lützen Portengen, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Monika Hollander, Martijn Huisman, Anke Huss, Melanie R. Keats, Almar A. L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, Nolwenn Noisel, Yves Payette, Brenda W. J. H. Penninx, Susan Picavet, Ina Rissanen, Annelieke M. Roest, Judith G. M. Rosmalen, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Alison Teyhan, Emma L. Twait, Kimberly D. van der Willik, Femke Lamers
{"title":"The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis","authors":"Kuan-Yu Pan, Lonneke van Tuijl, Maartje Basten, Judith J. M. Rijnhart, Alexander de Graeff, Joost Dekker, Mirjam I. Geerlings, Adriaan Hoogendoorn, Adelita V. Ranchor, Roel Vermeulen, Lützen Portengen, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Monika Hollander, Martijn Huisman, Anke Huss, Melanie R. Keats, Almar A. L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, Nolwenn Noisel, Yves Payette, Brenda W. J. H. Penninx, Susan Picavet, Ina Rissanen, Annelieke M. Roest, Judith G. M. Rosmalen, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Alison Teyhan, Emma L. Twait, Kimberly D. van der Willik, Femke Lamers","doi":"10.1017/s0033291724000850","DOIUrl":"https://doi.org/10.1017/s0033291724000850","url":null,"abstract":"<span>Background</span><p>Although behavioral mechanisms in the association among depression, anxiety, and cancer are plausible, few studies have empirically studied mediation by health behaviors. We aimed to examine the mediating role of several health behaviors in the associations among depression, anxiety, and the incidence of various cancer types (overall, breast, prostate, lung, colorectal, smoking-related, and alcohol-related cancers).</p><span>Methods</span><p>Two-stage individual participant data meta-analyses were performed based on 18 cohorts within the Psychosocial Factors and Cancer Incidence consortium that had a measure of depression or anxiety (<span>N</span> = 319 613, cancer incidence = 25 803). Health behaviors included smoking, physical inactivity, alcohol use, body mass index (BMI), sedentary behavior, and sleep duration and quality. In stage one, path-specific regression estimates were obtained in each cohort. In stage two, cohort-specific estimates were pooled using random-effects multivariate meta-analysis, and natural indirect effects (i.e. mediating effects) were calculated as hazard ratios (HRs).</p><span>Results</span><p>Smoking (HRs range 1.04–1.10) and physical inactivity (HRs range 1.01–1.02) significantly mediated the associations among depression, anxiety, and lung cancer. Smoking was also a mediator for smoking-related cancers (HRs range 1.03–1.06). There was mediation by health behaviors, especially smoking, physical inactivity, alcohol use, and a higher BMI, in the associations among depression, anxiety, and overall cancer or other types of cancer, but effects were small (HRs generally below 1.01).</p><span>Conclusions</span><p>Smoking constitutes a mediating pathway linking depression and anxiety to lung cancer and smoking-related cancers. Our findings underline the importance of smoking cessation interventions for persons with depression or anxiety.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140811338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A longitudinal network analysis of suicide risk factors among service members and veterans sampled for suicidal ideation or attempt. 对有自杀倾向或企图自杀的军人和退伍军人的自杀风险因素进行纵向网络分析。
IF 6.9 2区 医学
Psychological Medicine Pub Date : 2024-04-23 DOI: 10.1017/S0033291724000734
April R Smith, Lauren N. Forrest, Shruti S. Kinkel-Ram, William Grunewald, S. D. Tubman, Aaron M. Esche, Cheri Levinson
{"title":"A longitudinal network analysis of suicide risk factors among service members and veterans sampled for suicidal ideation or attempt.","authors":"April R Smith, Lauren N. Forrest, Shruti S. Kinkel-Ram, William Grunewald, S. D. Tubman, Aaron M. Esche, Cheri Levinson","doi":"10.1017/S0033291724000734","DOIUrl":"https://doi.org/10.1017/S0033291724000734","url":null,"abstract":"BACKGROUND\u0000Suicidal thoughts and behaviors are elevated among active-duty service members (ADSM) and veterans compared to the general population. Hence, it is a priority to examine maintenance factors underlying suicidal ideation among ADSM and veterans to develop effective, targeted interventions. In particular, interpersonal risk factors, hopelessness, and overarousal have been robustly connected to suicidal ideation and intent.\u0000\u0000\u0000METHODS\u0000To identify the suicidal ideation risk factors that are most relevant, we employed network analysis to examine between-subjects (cross-sectional), contemporaneous (within seconds), and temporal (across four hours) group-level networks of suicidal ideation and related risk factors in a sample of ADSM and veterans (participant n = 92, observations n = 10 650). Participants completed ecological momentary assessment (EMA) surveys four times a day for 30 days, where they answered questions related to suicidal ideation, interpersonal risk factors, hopelessness, and overarousal.\u0000\u0000\u0000RESULTS\u0000The between-subjects and contemporaneous networks identified agitation, not feeling close to others, and ineffectiveness as the most central symptoms. The temporal network revealed that feeling ineffective was most likely to influence other symptoms in the network over time.\u0000\u0000\u0000CONCLUSION\u0000Our findings suggest that ineffectiveness, low belongingness, and agitation are important drivers of moment-to-moment and longitudinal relations between risk factors for suicidal ideation in ADSM and veterans. Targeting these symptoms may disrupt suicidal ideation.","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":6.9,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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