Psychiatria polskaPub Date : 2024-02-28DOI: 10.12740/PP/OnlineFirst/152782
Katarzyna Gibek, Tomasz Sacha, Katarzyna Cyranka
{"title":"Side effects of treatment with tyrosine kinase inhibitors in patients with chronic myeloid leukemia and the occurrence of anxiety symptoms.","authors":"Katarzyna Gibek, Tomasz Sacha, Katarzyna Cyranka","doi":"10.12740/PP/OnlineFirst/152782","DOIUrl":"10.12740/PP/OnlineFirst/152782","url":null,"abstract":"<p><strong>Objectives: </strong>The study aims to check whether individual side effects of treatment with TKIs in patients suffering from CML may contribute to the occurrence of anxiety symptoms. In addition, it was decided to check whether there were any relationships between age, gender, duration of treatment, and the intensity of anxiety, divided by the occurrence of individual side effects.</p><p><strong>Methods: </strong>The study involved 91 patients and was conducted at the Hematology Clinic of the University Hospital in Krakow. The following questionnaires were used: created by the author, David Goldberg Questionnaire GHQ-28, and the four-dimensional 4DSQ Questionnaire.</p><p><strong>Results: </strong>The most frequently mentioned side effects of treatment were bone and joint pain, muscle cramps and pain, water retention, and fatigue. The mean duration of the disease was ten years. Our research showed that fatigue, nausea/indigestion, frequent infections, bone and joint pain, abdominal pain, and loss of appetite were the most common side effects of TKI treatment, which resulted in increased anxiety symptoms.</p><p><strong>Conclusions: </strong>The work of doctors, psychologists, and pharmaceutical companies on reducing/alleviating side effects may in the future affect a better quality of life for these patients. Early detection of severe anxiety and taking appropriate steps can prevent the emergence of more significant disorders. In addition, several years of attempts to discontinue treatment with some TKIs (imatinib and nilotinib) in patients who achieve a profound molecular response may improve their mental condition.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"25-38"},"PeriodicalIF":1.7,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10415085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatria polskaPub Date : 2024-02-28DOI: 10.12740/PP/OnlineFirst/147190
Julia Wyszomirska, Ewa Martyniak, Monika Bąk-Sosnowska, Katarzyna Piekarska-Bugiel, Artur Chwalba, Marek Krzystanek
{"title":"Exercise addiction symptoms and mental health during the forced exercises deprivation in greatest COVID-19 pandemic restrictions in Poland.","authors":"Julia Wyszomirska, Ewa Martyniak, Monika Bąk-Sosnowska, Katarzyna Piekarska-Bugiel, Artur Chwalba, Marek Krzystanek","doi":"10.12740/PP/OnlineFirst/147190","DOIUrl":"10.12740/PP/OnlineFirst/147190","url":null,"abstract":"<p><strong>Objectives: </strong>The paper describes the relationship between the symptoms of exercise addiction, behavioral strategies in situations of limited workout possibilities and mental health state in exercising individuals.</p><p><strong>Methods: </strong>The study included 391 participants, 286 women (73.1%) and 105 men (26.9%), aged 18 to 68 years. The respondents were surveyed online after 17-19 days of barriers to routine training due to greatest COVID-19 restrictions in Poland. Subjects completed the Exercise Dependence Scale, General Health Questionnaire - 28 (GHQ-28) and questionnaires enabling the collection of demographic and clinical data as well as data related to exercise behaviors.</p><p><strong>Results: </strong>The variables related to exercise addiction and some related to behavioral changes are predictors of mental health, especially in terms of anxiety, insomnia and somatic symptoms. All the introduced variables accounted for 27.4% to 43.7% of the variation in the mental health status of the subjects, depending on GHQ subscales. Breaking the restriction rules by outdoor training protected against symptoms of psychological disorders, especially in relation to somatic symptoms (Beta = -0.23; p< 0.001). Individual assessment of stress induction in a given situation was a predictor of results in all GHQ subscales, which was the strongest for symptoms of anxiety and insomnia (Beta = 0.37; p< 0.001).</p><p><strong>Conclusions: </strong>Individuals with features of exercise addiction are at risk of deterioration of their well-being during forced abstinence. In addition, the subjective level of stress induction in a given situation is an important determinant that conditions psychological well-being, especially the aggravation of depressive symptoms. People who ignore restrictions and have low levels of stress, experience lower psychological costs.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"153-168"},"PeriodicalIF":1.7,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9101712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatria polskaPub Date : 2024-02-28DOI: 10.12740/PP/OnlineFirst/155178
Lena Cichoń, Małgorzata Janas-Kozik, Artur Pałasz, Krzysztof Maria Wilczyński, Aleksandra Suszka-Świtek, Anna Żmijowska, Ireneusz Jelonek
{"title":"Predictive efficiency of phoenixin, spexin and kisspeptin neuropeptides concentration levels in diagnosis of bipolar disorder in paediatric population.","authors":"Lena Cichoń, Małgorzata Janas-Kozik, Artur Pałasz, Krzysztof Maria Wilczyński, Aleksandra Suszka-Świtek, Anna Żmijowska, Ireneusz Jelonek","doi":"10.12740/PP/OnlineFirst/155178","DOIUrl":"10.12740/PP/OnlineFirst/155178","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to assess concentrations of the following neuropeptides: phoenixin, spexin and kisspeptin in venous blood serum of children and adolescents suffering from bipolar disorder, and by this their predictive efficiency in this disorder.</p><p><strong>Methods: </strong>The study covered 75 individuals with a mean age of 15.26 years (95% CI: 14.86-15.67), of which the study group comprised of 57 individuals diagnosed with bipolar affective disorder and the control group - 18 individuals with no psychiatric diagnosis and no pharmacological treatment. Phoenixin, spexin and kisspeptin levels were determined in the peripheral venous blood serum. Neuropeptide concentrations were measured with the enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>The mean phoenixin concentration in the studied group equalled 1.57 ng/ml (95% CI: 1.35-1.79), while in the control group - 2.69 ng/ml (95% CI: 2.38-3; U Mann-Whitney test p-value < 0.05). For spexin, these results were 639.65 pg/ml (95% CI: 558.86-720.44) in the studied group, and 354.28 pg/ml (95% CI: 310.33-398.22; U Mann-Whitney test p-value < 0.05) in the control group. The observed differences were statistically significant. The mean concentration of kisspeptin levels in the studied group was 126.02 pg/ml (95% CI: 39.82-212.23; median: 59.85), while in the control group - 54.83 pg/ml (95% CI: 39.23-70.43; median: 51.3; U Mann-Whitney test p-value = 0.29), and the observed difference was not statistically significant.</p><p><strong>Conclusions: </strong>The occurrence of bipolar disorder symptoms is statistically significantly linked with a decreased phoenixin concentration and to a small degree - with an increased spexin concentration in blood serum of patients. However, it is not linked with the kisspeptin concentration.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"169-181"},"PeriodicalIF":0.9,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9198803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial.","authors":"Dominika Dudek, Jerzy A Sobański, Katarzyna Klasa","doi":"10.12740/PP/186432","DOIUrl":"10.12740/PP/186432","url":null,"abstract":"<p><p>No summary.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"58 1","pages":"3-4"},"PeriodicalIF":1.7,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The risk of anxiety disorders in women in the first year postpartum - the results from the postpartum depression prevention program ‟Next Stop: MUM\".","authors":"Magdalena Chrzan-Dętkoś, Natalia Murawska","doi":"10.12740/PP/156929","DOIUrl":"https://doi.org/10.12740/PP/156929","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of the study was to examine the severity of anxiety symptoms and the co-occurrence of anxiety disorders and mood disorders in a group of women in the first year after childbirth participating in the program for the prevention of postpartum depression.</p><p><strong>Methods: </strong>The study included 1,514 women who were screened by midwives during a patronage visit and were followed up, and 10,454 women who took part in an online screening conducted on the project website. The Edinburgh Postpartum Depression Scale was used for screening, including factor analysis to assess the anxiety subscale, and the GAD-2 questionnaire was used too.</p><p><strong>Results: </strong>The risk of anxiety disorders was observed in 9.5% of women during the patronage visit and, depending on the survey method, 21.2% (ESDP 3 A) or 13.2% (GAD-2) in the follow-up study up to 9 months postpartum. In the online study, 62.8% of women obtained results indicating a high risk of anxiety disorders. For comparison, the result of 12 points and more indicating the risk of depression was obtained by 6.3% in the first month after childbirth and 14.3% in the follow-up study. The results show that anxiety disorders and mood disorders are significantly related (r = 0.631; p < 0.01).</p><p><strong>Conclusions: </strong>The risk of having anxiety disorders after childbirth is higher or similar to that of mood disorders. It is warranted to extend screening to anxiety disorders and to develop a rapid pathway of early psychological/psychiatric intervention for women in need.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1231-1246"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Boldness, meanness and disinhibition as predictors of indirect/direct type of aggressive behavior in youth.","authors":"Krzysztof Nowakowski","doi":"10.12740/PP/158898","DOIUrl":"https://doi.org/10.12740/PP/158898","url":null,"abstract":"<p><strong>Objectives: </strong>Numerous studies show that a high level of psychopathic traits in youth is related to the propensity to use various types and forms of aggression. The presented study focuses on the relations between psychopathy and aggression, both indirect (relational) and direct in this age group. The triarchic model of psychopathy was used, according to which psychopathy is described as a configuration of boldness, meanness and disinhibition. It was assumed that boldness would be a predictor for indirect aggression and disinhibition - for the direct forms of aggressive behaviors.</p><p><strong>Methods: </strong>The sample consisted of 200 older adolescents (108 boys and 92 girls), aged 16-19. Two groups were distinguished for comparison: juveniles from youth fostering centers and youth not violating legal norms. For the measurement of the variables the following self-reports were used: Triarchic Psychopathy Measure, Indirect Aggression Scale (Aggressor Version) and Aggression Questionnaire.</p><p><strong>Results: </strong>From among the dimensions of psychopathy, the strongest predictor for both forms of aggression (indirect and direct) was disinhibition. The study also revealed the differences in the intensity of psychopathic traits and aggressive behaviors with reference to gender and institutionalization. However, the hypothesis on the relationship between boldness and indirect aggression was not confirmed.</p><p><strong>Conclusions: </strong>The results showed that disinhibition and meanness can be considered as significant personality risk factors for aggressive behaviors and violence not only in adults but also in adolescents. The study supported also the heterogeneity of the triarchic model of psychopathy itself.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1169-1179"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenhui Zhai, Mingchao Li, Zou Su, Qiuming Ji, Zijun Xiong, Yijing Zhao, Yuhong Yang, Dan Liao, Chi Li, Cairong Wang
{"title":"The effect of repetitive transcranial magnetic stimulation on the negative symptoms of chronic schizophrenia and serum brain-derived neurotrophic factor.","authors":"Wenhui Zhai, Mingchao Li, Zou Su, Qiuming Ji, Zijun Xiong, Yijing Zhao, Yuhong Yang, Dan Liao, Chi Li, Cairong Wang","doi":"10.12740/PP/153375","DOIUrl":"https://doi.org/10.12740/PP/153375","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) on the negative symptoms of chronic schizophrenia and serum brainderived neurotrophic factor (BDNF).</p><p><strong>Methods: </strong>A total of 86 patients with chronic schizophrenia hospitalised from March to October 2019 were randomly assigned to the active rTMS group or the sham rTMS group, with 43 patients in each group. All patients were administered paliperidone orally at a dose of 3-6 mg/d, and rTMS treatment was given to the active rTMS group. The Positive and Negative Syndrome Scale (PANSS) score and the serum BDNF concentration were calculated in both groups at baseline and after two and four weeks of treatment.</p><p><strong>Results: </strong>There were no statistically significant differences in the PANSS scores and serum BDNF concentrations between the two groups before treatment (p > 0.05). However, after four weeks of treatment, the change in the score on the negative symptom scale in the active rTMS group was greater than in the sham rTMS group (p < 0.05), and the serum BDNF levels in the active rTMS group were higher than in the sham rTMS group (p < 0.05).</p><p><strong>Conclusions: </strong>Four weeks of continuous rTMS treatment can effectively improve the negative symptoms of schizophrenia, and the serum concentration of BDNF increases as the duration of rTMS treatment increases.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1293-1303"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Motives of abstinence versus metacognition and self-conscious emotions in people addicted to alcohol.","authors":"Mateusz Wojtczak, Sławomir Ślaski","doi":"10.12740/PP/152400","DOIUrl":"https://doi.org/10.12740/PP/152400","url":null,"abstract":"<p><strong>Objectives: </strong>The target of the present study was to show the relationship between time and motives for maintaining abstinence and metacognitive beliefs about alcohol and self-conscious emotions.</p><p><strong>Methods: </strong>Ninety-one alcohol-dependent individuals who are currently maintaining abstinence participated in the study. Three instruments were used to measure individual variables: RALD was used to examine motives for maintaining abstinence, MPA was used to measure the level of individual metacognitive beliefs about alcohol, and SUM 5 was used to measure the level of self-conscious emotions in addicts who maintain abstinence. Correlation analyses were performed and differences in mean ranks of metacognition and self-awareness emotions were examined for the two independent samples.</p><p><strong>Results: </strong>All metacognitive beliefs were shown to negatively correlate with abstinence time. Some metacognitive beliefs were negatively associated with abstinence motives. Moreover, positive associations of self-conscious emotions and metacognitive beliefs with time and abstinence motives were found. Both metacognitive beliefs and self-conscious emotions have different mean levels depending on the duration of abstinence.</p><p><strong>Conclusions: </strong>The study revealed that both psychological constructs are related to abstinence maintenance and can be creatively used in further analyses of addiction recovery and relapse prevention.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1277-1291"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychiatria polskaPub Date : 2023-12-31DOI: 10.12740/PP/OnlineFirst/151570
Anna Julia Krupa, Krzysztof Wojtasik-Bakalarz, Marcin Siwek
{"title":"Vortioxetine - pharmacological properties and use in mood disorders. The current state of knowledge.","authors":"Anna Julia Krupa, Krzysztof Wojtasik-Bakalarz, Marcin Siwek","doi":"10.12740/PP/OnlineFirst/151570","DOIUrl":"10.12740/PP/OnlineFirst/151570","url":null,"abstract":"<p><p>Vortioxetine is an antidepressant with a unique profile of receptor activity. The pharmacodynamic spectrum of vortioxetine activity is linked to the modulation of not only serotoninergic but also noradrenergic and dopaminergic transmission. At the same time, its pharmacokinetic properties determine good tolerance and safety, which are also observed in elderly patients and those burdened with somatic comorbidity. This work aims to sum up the knowledge coming from the most recent studies assessing the efficacy of vortioxetine. The efficacy of vortioxetine in the treatment of depression was confirmed in a large number of open studies, randomized controlled studies with placebo control, and meta-analyses thereof. What is more, the latest research shows that this drug allows depressed patients to achieve not only symptomatic remission but also an improvement of anhedonia and recovery in cognitive and occupational function. Furthermore, there are studies showing that vortioxetine is efficacious in the treatment of elderly patients, as well as subjects who have experienced trauma or suffer from bipolar depression. Vortioxetine is characterized by a good tolerance profile and safety; rarely does it cause severe adverse effects.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"1109-1126"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10430373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polish adaptation and validation of the Short Inventory of Problems (SIP-2L).","authors":"Kamila Morawska, Jan Chodkiewicz","doi":"10.12740/PP/153433","DOIUrl":"https://doi.org/10.12740/PP/153433","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the research was to present the Polish adaptation and validation of the Short Inventory of Problems (SIP-2L) by Miller et al. (1995). The SIP-2L is a popular selfreport measure used to assess the negative consequences of alcohol use in 5 domains with negative consequences: physical, interpersonal, intrapersonal, social and impulse control. The adapted version of SIP assesses lifetime consequences of using alcohol.</p><p><strong>Methods: </strong>A total of 256 participants diagnosed with alcohol dependence (71 women and 185 men) completed an assessment battery that included SIP-2L and Polish versions of AUDIT, MAST and KOEP-R, which is a modified Polish adaptation of CEAQ - Comprehensive Effects of Alcohol Questionnaire.</p><p><strong>Results: </strong>Confirmatory factor analysis demonstrated the hypothesized 5-factor model produced the best fit. Reliability of the entire method (Cronbach's α = 0.868) and for all factors was satisfactory, as was convergent validity.</p><p><strong>Conclusions: </strong>The results support that the Polish version of the SIP-2L has good psychometric properties and can successfully assess the consequences of drinking among patients diagnosed with alcohol dependence.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"57 6","pages":"1263-1276"},"PeriodicalIF":1.7,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}