Radiation Physics and Chemistry最新文献

筛选
英文 中文
Dosimetric evaluation of a chilled X-ray irradiator for high throughput insect sterilization 用于高通量昆虫灭菌的冷冻 X 射线辐照装置的剂量学评估
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-18 DOI: 10.1016/j.radphyschem.2024.112289
Andrew G. Parker , Jiaqi Lyu , William McLaughlin
{"title":"Dosimetric evaluation of a chilled X-ray irradiator for high throughput insect sterilization","authors":"Andrew G. Parker ,&nbsp;Jiaqi Lyu ,&nbsp;William McLaughlin","doi":"10.1016/j.radphyschem.2024.112289","DOIUrl":"10.1016/j.radphyschem.2024.112289","url":null,"abstract":"<div><div>The current trend away from isotopic irradiators for the Sterile Insect Technique (SIT) means that alternative systems are required. This paper describes the dosimetric assessment of a Precision X-Ray X-Rad 320 system with an integrated chilling system (SIT Module) suitable for the irradiation of chill immobilized adult mosquitoes. This system is capable of irradiating a load volume of approximately 4 L whilst maintaining a suitable temperature to maintain the insects immobile. Dose rates, dose uniformity ratios and estimated weekly throughput are presented for various configurations and energies. The throughput for chilled adult mosquitoes is sufficient for currently operational or planned mosquito sterile insect programs.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112289"},"PeriodicalIF":2.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of excitation functions of 127I(p,xn) 121,122, 123, 125,127Xe reactions, with particular reference to the production of 127Xe and 123I for medical use 评估 127I(p,xn)121、122、123、125 和 127Xe 反应的激发函数,特别是关于生产医用 127Xe 和 123I 的情况
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-18 DOI: 10.1016/j.radphyschem.2024.112331
M. Eman , N. Amjed , A. Naz , A.M. Wajid , Samar , M. Hussain , S.M. Qaim
{"title":"Evaluation of excitation functions of 127I(p,xn) 121,122, 123, 125,127Xe reactions, with particular reference to the production of 127Xe and 123I for medical use","authors":"M. Eman ,&nbsp;N. Amjed ,&nbsp;A. Naz ,&nbsp;A.M. Wajid ,&nbsp;Samar ,&nbsp;M. Hussain ,&nbsp;S.M. Qaim","doi":"10.1016/j.radphyschem.2024.112331","DOIUrl":"10.1016/j.radphyschem.2024.112331","url":null,"abstract":"<div><div>Cross section data for the formation of <sup>121,122,123,125,127</sup>Xe via proton induced reactions on <sup>127</sup>I were critically analyzed. Three nuclear model codes (TALYS 1.9, ALICE-IPPE, and EMPIRE 3.2) were used to ensure the consistency and reliability of the experimental data. Utilizing a well-developed evaluation methodology, a recommended fit for each excitation function was obtained, based on theoretical predictions of nuclear models and experimental cross sections. By using the recommended/reference results, thick target yields were calculated for each production route and its associated impurity reactions. The indirect production of the radionuclides <sup>121,122,123,125</sup>I was explored. Special attention was paid to standardization of cross section data for the production of the medically important radionuclides <sup>127</sup>Xe and <sup>123</sup>I via the routes <sup>127</sup>I(p,n)<sup>127</sup>Xe and <sup>127</sup>I(p,5n)<sup>123</sup>Xe(EC, β+)<sup>123</sup>I, respectively.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112331"},"PeriodicalIF":2.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shielding characteristics of a new epoxy resin reinforced by PbO nanoparticles and PbO micro for protection against X-ray and investigation of their cytotoxicity effects and photocatalytic activity 纳米氧化铅和微氧化铅增强的新型环氧树脂对 X 射线的屏蔽特性及其细胞毒性效应和光催化活性研究
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-17 DOI: 10.1016/j.radphyschem.2024.112324
Atefeh Omidtorshiz , Mohammad Reza Benam , Mehdi Momennezhad , Zahra Sabouri , Majid Darroudi
{"title":"Shielding characteristics of a new epoxy resin reinforced by PbO nanoparticles and PbO micro for protection against X-ray and investigation of their cytotoxicity effects and photocatalytic activity","authors":"Atefeh Omidtorshiz ,&nbsp;Mohammad Reza Benam ,&nbsp;Mehdi Momennezhad ,&nbsp;Zahra Sabouri ,&nbsp;Majid Darroudi","doi":"10.1016/j.radphyschem.2024.112324","DOIUrl":"10.1016/j.radphyschem.2024.112324","url":null,"abstract":"<div><div>In this work, for the first time, lead oxide nanoparticles (PbO-NPs) were synthesized using <em>Trigonella feonumgraecum</em> plant seeds as a stabilizer and Pb(NO<sub>3</sub>)<sub>2</sub> salt as a lead precursor. The results of the XRD pattern displayed the synthesized NPs have an orthorhombic crystalline structure. According to FESEM images, the NPs had a mean size of about 18.62 nm with a spherical morphology. Also, the cytotoxicity of NPs was evaluated on the Hep G2 cancer cell line, and the IC<sub>50</sub> value was reported as 267.07 μg/mL. Next, the photocatalytic performance of the synthesized PbO-NPs was investigated for removing methylene orange (MO) pigment under UVA light, which led to the destruction of about 94% after 120 min. Finally, to investigate the protective properties of PbO-NPs against X-ray, a polymer nanocomposite of epoxy resin/PbO-NPs was prepared with different weight percentages. In the same way, other samples were also prepared, and then their ability to attenuate X-ray was studied with an X-ray tube with a voltage of 52 kV for the palm and 80 kV for the thigh of an average person, respectively. The measurement results show that with the increasing weight percentage of the fillers, the samples' linear and mass attenuation coefficient increases, which means an increase in the efficiency of the samples in X-ray attenuation. Generally, epoxy resin/PbO-NPs samples show a better effect than other samples. Therefore, these types of shields can attract more attention due to their lightness, cost-effectiveness, and far fewer environmental hazards than common lead shields.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112324"},"PeriodicalIF":2.8,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shape memory characteristics of injection molded, cross-linked all-polyethylene composites 注塑交联全聚乙烯复合材料的形状记忆特性
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-16 DOI: 10.1016/j.radphyschem.2024.112290
Balázs Tatár , Eszter Tóth , Kolos Molnár , László Mészáros
{"title":"Shape memory characteristics of injection molded, cross-linked all-polyethylene composites","authors":"Balázs Tatár ,&nbsp;Eszter Tóth ,&nbsp;Kolos Molnár ,&nbsp;László Mészáros","doi":"10.1016/j.radphyschem.2024.112290","DOIUrl":"10.1016/j.radphyschem.2024.112290","url":null,"abstract":"<div><div>In this study, we investigated the shape memory properties of a novel self-reinforced polymer composite (SRPC). Chopped Dyneema® SK76 fibers were mixed with high-density polyethylene (HDPE) resin, and samples were produced by injection molding. To allow the fibers to keep their shape and reinforce effectively, we cross-linked them with gamma irradiation (100, 200, and 300 kGy absorbed doses). In the second step of irradiation, we irradiated the composites with doses of 50, 100, 150, and 200 kGy to give them shape memory properties. Soxhlet extractions, differential scanning calorimetry, and scanning electron microscopy revealed that the fibers cross-linked and kept their structural integrity through processing. We confirmed the reinforcing effect of the fibers with flexural tests and by dynamic mechanical analysis. In free recovery experiments, samples had recovery and fixity ratios above 79%. With the highest dose, recovery stress increased by 26%. We showed the viability of this novel method of self-reinforcement in the production of shape memory polymers (SMPs) with improved characteristics.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112290"},"PeriodicalIF":2.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examination of radiation shielding features of Bi2O3 modified Lithium Zinc Silicate glass system 检验 Bi2O3 改性硅酸锌锂玻璃体系的辐射屏蔽特性
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-16 DOI: 10.1016/j.radphyschem.2024.112291
Jaber Alyami , M.I. Sayyed , Yas Al-Hadeethi , Othman A. Fallatah , Mohammad Bahmaid
{"title":"Examination of radiation shielding features of Bi2O3 modified Lithium Zinc Silicate glass system","authors":"Jaber Alyami ,&nbsp;M.I. Sayyed ,&nbsp;Yas Al-Hadeethi ,&nbsp;Othman A. Fallatah ,&nbsp;Mohammad Bahmaid","doi":"10.1016/j.radphyschem.2024.112291","DOIUrl":"10.1016/j.radphyschem.2024.112291","url":null,"abstract":"<div><div>In this study, several radiation shielding characteristics of Bi<sub>2</sub>O<sub>3</sub> modified Lithium Zinc Silicate glass systems were reported using the Phy-X program. The mass attenuation coefficient (MAC) demonstrates a substantial energy dependency only at low energy range (0.284 MeV &lt; E &lt; 0.662 MeV), however it exhibits a slight energy dependency at high energies. It was shown that the transmission factor (TF) increases with energy, suggesting that at higher energies, more gamma rays can pass through the lithium zinc Silicate glasses. We reported the transmission factor (TF) at different thicknesses and we found that the TF at 0.347 MeV for Li25Bi0 varies between 0.92 and 0.77 for thicknesses of 0.3 and 0.9 cm respectively. Also, Li5Bi20's TF is lower than Li25Bi0's, which means that the effectiveness of the samples as shields will increase with the quantity of Bi<sub>2</sub>O<sub>3</sub> present. The TVL is decreased by the introduction of Bi<sub>2</sub>O<sub>3</sub>, with Li5Bi20 possessing the smallest TVL and being regarded as the superior absorber. The lowest TVL recorded for selected glasses are 7.608, 3.189, 2.188, 1.677 and 1.427 cm for Li25Bi0 to Li5Bi20 respectively. The TVL results showed that at 0.284 MeV, the TVL for the Li25Bi0 is 5.33 times the TVL of Li5Bi20. At 0.347 MeV, the TVL of Li25Bi0 is 4.08 times the TVL of Li5Bi20, while at 0.662 MeV the TVL of Li25Bi0 is 2.36 times the TVL of Li5Bi20. We compared the effective atomic number (Z<sub>eff</sub>) for the selected glasses with other materials and we found that all these glasses have higher Z<sub>eff</sub> than ordinary concrete, and RS-253-G18, except Li25Bi0 sample which shows lower Z<sub>eff</sub> than RS-253-G18.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112291"},"PeriodicalIF":2.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of mechanical and radiation shielding properties of Sm–Sm2O3 reinforced Al–B4C composite 研究 Sm-Sm2O3 增强 Al-B4C 复合材料的机械和辐射屏蔽性能
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-16 DOI: 10.1016/j.radphyschem.2024.112325
Yasin Gaylan , Ilker Emin Dag , Seyit Caglar , Baris Avar
{"title":"Investigation of mechanical and radiation shielding properties of Sm–Sm2O3 reinforced Al–B4C composite","authors":"Yasin Gaylan ,&nbsp;Ilker Emin Dag ,&nbsp;Seyit Caglar ,&nbsp;Baris Avar","doi":"10.1016/j.radphyschem.2024.112325","DOIUrl":"10.1016/j.radphyschem.2024.112325","url":null,"abstract":"<div><div>In this study, Al–20%B<sub>4</sub>C-x%(Sm, Sm<sub>2</sub>O<sub>3</sub>) (x = 1, 3, and 5) composites were prepared using mechanical alloying to investigate their neutron shielding and mechanical properties. After pelletizing and sintering the prepared powder composites, their microstructures were characterized using X-ray diffraction, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. Hardness, density, and corrosion tests were performed on the composites. Thermal and fast neutron shielding properties were calculated using the MCNP simulation code. Experimental measurements of neutron shielding were carried out using an Am–Be neutron source. Experimental results showed that 5% Sm-reinforced composites exhibited better neutron shielding than Sm<sub>2</sub>O<sub>3</sub>-reinforced composites at all doping ratios. Simulation calculations indicated that the highest thermal neutron shielding rate was observed in Sm-reinforced composites, while the highest fast neutron shielding rate was observed in 5% Sm<sub>2</sub>O<sub>3</sub>-reinforced composites. This research provides important data for researchers interested in developing thermal and fast neutron shielding materials.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112325"},"PeriodicalIF":2.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of proton conductivity and free volume in sulfonated polyether ether ketone electrolytes: A positron annihilation lifetime spectroscopy study 磺化聚醚醚酮电解质中质子电导率与自由体积的相关性:正电子湮灭寿命光谱研究
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-16 DOI: 10.1016/j.radphyschem.2024.112327
Muhammet Lahmuni , Mesut Yılmazoğlu , Ufuk Abaci , Ozan Coban , Ayse Yumak Yahsi , Cumali Tav , Ugur Yahsi
{"title":"Correlation of proton conductivity and free volume in sulfonated polyether ether ketone electrolytes: A positron annihilation lifetime spectroscopy study","authors":"Muhammet Lahmuni ,&nbsp;Mesut Yılmazoğlu ,&nbsp;Ufuk Abaci ,&nbsp;Ozan Coban ,&nbsp;Ayse Yumak Yahsi ,&nbsp;Cumali Tav ,&nbsp;Ugur Yahsi","doi":"10.1016/j.radphyschem.2024.112327","DOIUrl":"10.1016/j.radphyschem.2024.112327","url":null,"abstract":"<div><div>Proton-conducting polymers play a pivotal role in clean energy technologies and various industrial applications, with a significant emphasis on enhancing energy efficiency and minimizing environmental impact. Sulfonated polyether ether ketone (SPEEK), which is renowned for its proton conductivity, has emerged as a key material in electrochemical processes, notably in proton exchange membrane (PEM) fuel cells. This study investigated the proton conductivity and dielectric behavior of SPEEK electrolytes at varying degree of sulfonation (DS) of 65% and 80%, correlating these properties with free volume profiles determined by positron annihilation lifetime spectroscopy (PALS). The SPEEK-65 and SPEEK-80 electrolytes were prepared via a controlled sulfonation process and characterized by FTIR, TGA, and SEM analyses. Proton conductivity and dielectric measurements were conducted at temperatures ranging from 300 to 370 K and frequencies ranging from 20 Hz to 1 MHz. The results revealed that SPEEK-80 exhibited a maximum proton conductivity of 3.4 × 10<sup>−2</sup> S/m at 300 K and 1 MHz, which was significantly greater than the 4.38 × 10<sup>−3</sup> S/m observed for SPEEK-65 under the same conditions. PALS analysis demonstrated a notable increase in free volume with increasing DS, with SPEEK-80 showing a higher o-Ps lifetime and intensity, indicating larger free volume sizes and fractions. These findings underscore the critical interplay between DS, free volume, and proton conductivity, offering insights into optimizing SPEEK-based electrolytes for advanced electrochemical applications.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112327"},"PeriodicalIF":2.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production and evaluation of the polyester composites containing pyrite and niobium diboride for radiation protection 生产和评估含黄铁矿和二硼化铌的聚酯复合材料,用于辐射防护
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-16 DOI: 10.1016/j.radphyschem.2024.112326
Ferdi Akman , Mehmet Fatih Turhan , Hasan Oğul , Ahmet Turşucu , Taha Erdoğan , Mustafa Recep Kaçal , Hasan Polat
{"title":"Production and evaluation of the polyester composites containing pyrite and niobium diboride for radiation protection","authors":"Ferdi Akman ,&nbsp;Mehmet Fatih Turhan ,&nbsp;Hasan Oğul ,&nbsp;Ahmet Turşucu ,&nbsp;Taha Erdoğan ,&nbsp;Mustafa Recep Kaçal ,&nbsp;Hasan Polat","doi":"10.1016/j.radphyschem.2024.112326","DOIUrl":"10.1016/j.radphyschem.2024.112326","url":null,"abstract":"<div><div>The presented study focused on investigating the radiation shielding properties of polyester/pyrite/niobium diboride (FeSNbB) composites. Various gamma-ray shielding parameters were evaluated with help of a HPGe detector system. Theoretical and simulation results are further evaluated by WinXCOM, GEANT4 and FLUKA codes, and the obtained results are compared with experimental values in the energy region 59.5 keV–1332.5 keV. The prepared samples are additionally evaluated using kerma relative to air values and Exposure build-up factors. Then, for the evaluation of neutron radiation shielding, effective removal cross sections for fast neutrons were determined for FeSNbB composites. Electron attenuation efficiency (<em>AE%</em>) for the produced composites was assessed across the energy spectrum of 4 MeV–18 MeV, utilizing experimental data from a Linac machine and theoretical predictions from Eclipse TPS. The results were found to be compatible with each other. FeSNbB50 has the best shielding properties among the studied composites.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112326"},"PeriodicalIF":2.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An SSDLs calibration method for the kerma-area product meter 用于热辐射积算仪的 SSDLs 校准方法
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112299
Qian Yang, Shimeng Xu, Jie Fan
{"title":"An SSDLs calibration method for the kerma-area product meter","authors":"Qian Yang,&nbsp;Shimeng Xu,&nbsp;Jie Fan","doi":"10.1016/j.radphyschem.2024.112299","DOIUrl":"10.1016/j.radphyschem.2024.112299","url":null,"abstract":"<div><div>The kerma-area product meter (KAP meter) is mainly used for quality assurance in medical imaging research, providing dose quality assessment or dose monitoring for patients. It can be calibrated either in the laboratory or on-site. The purpose of this study is to propose a method for calibrating the KAP meter using a plane-parallel transmission ionization chamber in the SSDLs. In the range of 50 kV–150 kV, under RQR (standard radiation qualities) and RQR additional filtering conditions of the KAP meter, the correction factor <span><math><mrow><msubsup><mi>N</mi><mi>Q</mi><mi>m</mi></msubsup></mrow></math></span> of the transmission ionization chamber is calculated to select two types of KAP meters for the calibration of the transmitted beam. The collimators used to limit the size of the radiation field are respectively 50.07 mm in length, 30.03 mm in length, and 20.05 mm in radius. This method, with uncertainty not exceeding 3.0% while improving calibration efficiency, can replace the unit-specific correction of the laboratory method (Toroi et al., 2008).</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112299"},"PeriodicalIF":2.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanostructures for cancer therapeutics and diagnostics: Recent advances and future outlook 用于癌症治疗和诊断的纳米结构:最新进展与未来展望
IF 2.8 3区 物理与天体物理
Radiation Physics and Chemistry Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112295
Seifeldin Elabed, Abdelrahman Sheirf, M. Ali
{"title":"Nanostructures for cancer therapeutics and diagnostics: Recent advances and future outlook","authors":"Seifeldin Elabed,&nbsp;Abdelrahman Sheirf,&nbsp;M. Ali","doi":"10.1016/j.radphyschem.2024.112295","DOIUrl":"10.1016/j.radphyschem.2024.112295","url":null,"abstract":"<div><div>Nanotechnology holds tremendous promise for advancing cancer treatment and imaging. Various nanostructures, including liposomes, polymersomes, dendrimers, carbon nanotubes, mesoporous silica nanoparticles, and metal nanoparticles, have been extensively investigated for applications such as targeted drug delivery, thermal ablation, gene therapy, MRI contrast enhancement, fluorescence imaging, theranostics, and photoacoustic imaging. This review offers a systematic evaluation of recent advancements in nanostructure applications for cancer, covering studies from 2018 to 2023. A thorough literature searches across major databases yielded over 500 relevant studies. Key insights demonstrate improved anticancer efficacy, site-specific accumulation, reduced toxicity, and real-time therapeutic response monitoring through the use of optimized multifunctional nanostructures in preclinical cancer models. However, the majority of these nanostructures remain in preclinical or early clinical stages. Addressing critical challenges related to pharmacokinetics, tumor penetration, biocompatibility, clearance, and toxicity through detailed mechanistic studies and assessments is essential for clinical translation. Future advancements in bioinspired designs, surface modifications, combination therapies, stimuli-responsive systems, in situ activation, multimodal imaging, and integration with emerging technologies such as microfluidics and AI could significantly accelerate the clinical success of nanotherapeutics, paving the way for precise and personalized cancer care. Ultimately, this review underscores the transformative potential of nanostructures in cancer treatment and diagnostics, while highlighting the necessity of integrated and rigorous optimization to achieve breakthrough outcomes in clinical oncology.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112295"},"PeriodicalIF":2.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信