Psychoneuroendocrinology最新文献_第4页

Mild hyperthyroidism regulates the acute stress response in virgin female rats 轻度甲亢调节雌性大鼠急性应激反应

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-10 DOI: 10.1016/j.psyneuen.2026.107743

Flavia Judith Neira , María Belén Sánchez , Gisela Erika Pennacchio , María Cecilia Michel Lara , Mariana Elizabeth Troncoso , Marta Soaje , Graciela Alma Jahn , Juan Pablo Mackern-Oberti , Susana Ruth Valdez

{"title":"Mild hyperthyroidism regulates the acute stress response in virgin female rats","authors":"Flavia Judith Neira , María Belén Sánchez , Gisela Erika Pennacchio , María Cecilia Michel Lara , Mariana Elizabeth Troncoso , Marta Soaje , Graciela Alma Jahn , Juan Pablo Mackern-Oberti , Susana Ruth Valdez","doi":"10.1016/j.psyneuen.2026.107743","DOIUrl":"10.1016/j.psyneuen.2026.107743","url":null,"abstract":"<div><div>Hyperthyroidism (HyperT) is a thyroid disorder affecting an estimated 0.2–1.3 % of the global population. The clinical implications of this pathology are significant, particularly when considering its close association with stress-related disorders that impact vulnerable populations, especially women at reproductive age. This study investigated the modulatory role of mild HyperT on the neuroendocrine stress response in virgin female Wistar rats. Two experimental groups were evaluated: a group with induced mild hyperthyroidism (HyperT) and a virgin control group (Control), each assessed under basal (non-stress) and acute stress conditions according to the corresponding experimental protocol. We evaluated the hormonal release (corticosterone and progesterone) induced by ether vapor inhalation and restraint stress in both experimental groups. Furthermore, we quantified the gene expression of receptors for glucocorticoids, progesterone, estrogen, and thyroid hormones, as well as the prolactin receptor and its downstream signaling pathway components in the medial basal hypothalamus (MBH) and hippocampus (HpC). Mild HyperT attenuates the ether stress-induced corticosterone release while responses induced by restraint stress were similar to controls. In the MBH, HyperT increased STAT5b and glucocorticoid receptor (GR) gene expression, and significantly decreased the progesterone receptor PRB/PRA ratio. In the HpC, HyperT increased the prolactin receptor (PRLR<sub>L</sub>), STAT5b, and specific thyroid receptor isoforms (TRα2, TRβ2). Our findings demonstrate that mild hyperthyroidism differentially modulates the acute stress response depending on the stressor type, and may provide insight into the possible neurochemical mechanisms in key brain regions involved in the regulation of the stress response.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107743"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-reactive protein predicts aggression in adolescent depression: Non-suicidal self-injury moderation and immunomodulatory shift c反应蛋白预测青少年抑郁症的攻击性：非自杀性自伤调节和免疫调节转变。

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.psyneuen.2026.107756

Xiaoyuan Han , Xin Yu , Xinyuan Hu , Hailiang Huang , Guofeng Zhang , Xiangyu Chen , Ming Cha , Lingming Hu , Ningning Liu

{"title":"C-reactive protein predicts aggression in adolescent depression: Non-suicidal self-injury moderation and immunomodulatory shift","authors":"Xiaoyuan Han , Xin Yu , Xinyuan Hu , Hailiang Huang , Guofeng Zhang , Xiangyu Chen , Ming Cha , Lingming Hu , Ningning Liu","doi":"10.1016/j.psyneuen.2026.107756","DOIUrl":"10.1016/j.psyneuen.2026.107756","url":null,"abstract":"<div><div>Major depressive disorder (MDD) in adolescents is frequently accompanied by aggression and non-suicidal self-injury (NSSI), yet reliable biomarkers for predicting these behavioral risks remain limited. This study employed a combined cross-sectional and longitudinal design to investigate the role of peripheral inflammatory markers in aggression among 214 adolescent inpatients with MDD and 60 healthy controls. We found that C-reactive protein (CRP) emerged as notable independent predictor of aggressive behavior, showing a high area under the curve (AUC=0.91) in this sample, suggesting its potential discriminatory performance that warrants further validation. Notably, NSSI significantly moderated the CRP-aggression link, with a stronger association observed in patients without NSSI. Furthermore, sex-specific IL-6 elevations were identified in female NSSI⁺ patients. Longitudinal analyses revealed a dynamic \"immunomodulatory shift,\" where systemic immune-inflammation index (SII) and lymphocyte-to-monocyte ratio (LMR) transitioned from positive to negative predictors of aggression over time. These preliminary findings highlight the potential of CRP as a clinically accessible indicator for aggression risk and underscore the temporal complexity of immune–behavior interactions in adolescent depression. These preliminary findings remain to be verified through independent cohorts in future studies.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107756"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term offspring loss in lactating rats: Neurobiological and emotional consequences in a novel animal model 哺乳期大鼠长期丧失后代：一种新型动物模型的神经生物学和情感后果。

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-02-01 DOI: 10.1016/j.psyneuen.2026.107777

Luisa Demarchi , Alice Sanson, Anna-Lena Boos, Oliver J. Bosch

{"title":"Long-term offspring loss in lactating rats: Neurobiological and emotional consequences in a novel animal model","authors":"Luisa Demarchi , Alice Sanson, Anna-Lena Boos, Oliver J. Bosch","doi":"10.1016/j.psyneuen.2026.107777","DOIUrl":"10.1016/j.psyneuen.2026.107777","url":null,"abstract":"<div><div>The maternal bond is a vital social connection that supports the survival and well-being of both the caregiver and offspring. Disruption of this bond, particularly following offspring loss, can result in profound trauma with long-lasting consequences. While considerable research has focused on the impact of maternal separation on offspring development, the biological effects of offspring loss on the mother remain largely unexplored. In this study, we examined the long-term effects of offspring loss on neuroplasticity, the oxytocin (OXT) and corticotropin-releasing factor (CRF) systems, and stress-coping behaviors in Sprague-Dawley rat mothers. We examined two groups of lactating mothers: (I) a control group, in which dams remained with their pups until natural weaning, and (II) a separated group, in which all offspring were removed on lactation day 1 and the mothers experienced offspring loss until the time corresponding to weaning (19 days). Our results reveal that pup removal increased oxytocin receptor binding–most prominently in the ventromedial hypothalamus (VMH)–and reduced dendritic spine density in this brain region, without altering estrogen receptor α or calbindin cell expression. Separated mothers additionally showed elevated plasma corticosterone levels and increased passive stress-coping behaviors in the forced swim test. Remarkably, passive stress-coping behavior was rescued by central CRF receptor blockade but not by central OXT treatment, indicating that the CRF system plays a critical role in the distress response to offspring loss. These findings establish a novel rat model to investigate the neurobiological consequences of maternal stress following offspring loss.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107777"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of chronic oxytocin on gaze and pupil dynamics during live dyadic interactions in children with autism 慢性催产素对自闭症儿童双眼互动中凝视和瞳孔动态的影响

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-10 DOI: 10.1016/j.psyneuen.2026.107745

Jellina Prinsen , Nicky Daniels , Matthijs Moerkerke , Bart Boets , Kaat Alaerts

{"title":"Impact of chronic oxytocin on gaze and pupil dynamics during live dyadic interactions in children with autism","authors":"Jellina Prinsen , Nicky Daniels , Matthijs Moerkerke , Bart Boets , Kaat Alaerts","doi":"10.1016/j.psyneuen.2026.107745","DOIUrl":"10.1016/j.psyneuen.2026.107745","url":null,"abstract":"<div><div>Reciprocal gaze, the mutual exchange of eye contact, plays a key role in human communication and bonding, yet it is often experienced as challenging for individuals with autism. In recent years, administration of the neuropeptide oxytocin is increasingly considered a novel approach for supporting social experiences in children with autism, but insights regarding its effects on mutual gaze or pupil dynamics remain limited—particularly regarding how chronic, repeated dosing impacts these processes. This double-blind, randomized, placebo-controlled trial examined the effects of four weeks of chronic intranasal oxytocin administration on gaze behavior and pupil dynamics during live dyadic interactions in school-aged children with autism (aged 8–12 years, 15 oxytocin, 20 placebo). While the overall duration of fixations toward the face remained unchanged, oxytocin altered the <em>distribution</em> of gaze, resulting in a more balanced pattern of looking toward and away from the face of a live interaction partner, an effect observed only in the oxytocin group and not in the placebo group. In addition, the four-week oxytocin administration period induced a relative increase in pupil dilation, an index of sympathetic arousal and attentional engagement, with this heightened autonomic responsivity showing a moderate association with children’s self-reported feelings of secure attachment. Together, these findings indicate that repeated oxytocin administration may modulate gaze parameters in live social interactions in children with autism. While cautiously encouraging, future work will be needed to further delineate whether these changes meaningfully reflect ameliorated experience and comfort in social settings.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107745"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personality moderates the predictive value of serum serotonin for antidepressant remission in depressive disorders 人格调节血清5 -羟色胺对抑郁症抗抑郁缓解的预测价值

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-12 DOI: 10.1016/j.psyneuen.2026.107752

Jae-Min Kim , Hee-Ju Kang , Ju-Wan Kim, Min Jhon, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin

{"title":"Personality moderates the predictive value of serum serotonin for antidepressant remission in depressive disorders","authors":"Jae-Min Kim , Hee-Ju Kang , Ju-Wan Kim, Min Jhon, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin","doi":"10.1016/j.psyneuen.2026.107752","DOIUrl":"10.1016/j.psyneuen.2026.107752","url":null,"abstract":"<div><div>Blood-based biomarkers such as peripheral serotonin (5-HT) hold promise for predicting antidepressant response in depression, but findings have been inconsistent. Personality traits linked to serotonergic function may moderate this relationship. This study examined whether personality type (PT) moderates the relationship between baseline serum serotonin (s5-HT) levels and antidepressant remission at 12 weeks. In a prospective, naturalistic study, 1086 outpatients with depressive disorders received stepwise pharmacotherapy. PT was classified as resilient or vulnerable using cluster analysis of the Big Five Inventory. Baseline s5-HT was measured and analyzed as both categorical (median split) and continuous variables. Remission was defined as a Hamilton Depression Rating Scale (HAMD) score ≤ 7 at week 12. Logistic regression tested the main and interaction effects of PT and s5-HT, adjusting for covariates. No direct association was found between PT and s5-HT levels. However, higher s5-HT significantly predicted remission only in the resilient group, showing a significant PT × s5-HT interaction. These findings identify personality as a moderator of the relationship between peripheral serotonin and antidepressant response. This biopsychosocial interaction may help explain prior inconsistencies and may provide preliminary insights relevant to individualized care, pending further validation.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107752"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemotherapy-induced estradiol reduction is associated with less relief of pre-chemotherapy anxiety in breast cancer patients 化疗诱导的雌二醇减少与乳腺癌患者化疗前焦虑的缓解程度较低有关。

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-15 DOI: 10.1016/j.psyneuen.2026.107749

Ángela del Águila , Lindsay D. Strehle , Seth Adarkwah Yiadom , Sagar D. Sardesai , Nicole O. Williams , Margaret E. Gatti-Mays , Daniel G. Stover , Preeti K. Sudheendra , Robert Wesolowski , Stephanie M. Gorka , Rebecca R. Andridge , Leah M. Pyter

{"title":"Chemotherapy-induced estradiol reduction is associated with less relief of pre-chemotherapy anxiety in breast cancer patients","authors":"Ángela del Águila , Lindsay D. Strehle , Seth Adarkwah Yiadom , Sagar D. Sardesai , Nicole O. Williams , Margaret E. Gatti-Mays , Daniel G. Stover , Preeti K. Sudheendra , Robert Wesolowski , Stephanie M. Gorka , Rebecca R. Andridge , Leah M. Pyter","doi":"10.1016/j.psyneuen.2026.107749","DOIUrl":"10.1016/j.psyneuen.2026.107749","url":null,"abstract":"<div><div>Chemotherapy-induced apoptosis of mature ovarian follicles in breast cancer patients likely results in decreased circulating estradiol (E<sub>2</sub>), although this is rarely measured. Outside of cancer, sudden E<sub>2</sub> reductions (e.g., post-childbirth) are associated with increased anxiety and depressive symptoms. About half of breast cancer patients undergoing chemotherapy report anxiety and depressive symptoms, which is a major reason for discontinuing or changing chemotherapy treatment. This study examined the relationship between E<sub>2</sub> reductions and anxiety/depressive symptoms, during chemotherapy. As a secondary outcome, intolerance of uncertainty was also assessed. Blood samples and patient-reported questionnaires were collected from 77 breast cancer patients. Plasma E<sub>2</sub> concentrations were quantified using ELISA. Chemotherapy-induced reductions in circulating E<sub>2</sub> were associated with less relief from pre-chemotherapy anxiety symptoms and intolerance of uncertainty during chemotherapy, regardless of age and menopausal status. Conversely, participants whose E<sub>2</sub> concentrations did not decrease experienced relief from pre-chemotherapy anxiety symptoms and intolerance of uncertainty during chemotherapy. Similar trends were observed for depressive symptoms. These findings suggest that monitoring circulating E<sub>2</sub> levels may provide valuable mechanistical insights into patients’ psychological responses during chemotherapy and could inform more personalized approaches to supportive care.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107749"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Receiving caregiver support and its association with hair hormones in people living with Alzheimer’s disease: The role of caregivers’ perspective taking 阿尔茨海默病患者接受照顾者支持及其与毛发激素的关系：照顾者视角的作用

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-10 DOI: 10.1016/j.psyneuen.2026.107746

Meng Huo , Kyungmin Kim , Casey K. Brown , Megan Gilligan , Wen Wang

{"title":"Receiving caregiver support and its association with hair hormones in people living with Alzheimer’s disease: The role of caregivers’ perspective taking","authors":"Meng Huo , Kyungmin Kim , Casey K. Brown , Megan Gilligan , Wen Wang","doi":"10.1016/j.psyneuen.2026.107746","DOIUrl":"10.1016/j.psyneuen.2026.107746","url":null,"abstract":"<div><div>Receiving support in later life is often experienced as stressful, but for people living with dementia (PLWD) support is an unavoidable necessity for daily functioning. The current study examined the association between receiving support in this unique context and PLWD’s hair cortisol, dehydroepiandrosterone (DHEA), and DHEA-to-cortisol ratio, which serve as non-invasive, objective physiological measures that may reflect longer-term HPA-axis activity related to stress. Further, we explored whether caregivers’ perspective taking—their ability to understand PLWD’s thoughts and feelings—moderated associations between support receipt and hair hormones. Participants included 58 couples managing mild-to-moderate Alzheimer’s disease (<em>M</em><sub>age</sub> = 77.60 for PLWD; <em>M</em><sub>age</sub> = 75.48 for caregivers). PLWD self-reported the frequency of emotional and practical support received from their spousal caregivers. Hair samples were collected from the posterior vertex to assess cortisol and DHEA concentrations and were assayed using enzyme immunoassay (EIA) method. Caregivers reported their own perspective taking and both spouses’ demographic characteristics. Multiple regressions showed that receiving more frequent emotional support and less frequent practical support from spousal caregivers were associated with higher hair cortisol concentrations in PLWD. Yet, these associations were only evident if caregivers had greater perspective taking. In addition, caregiver perspective taking exacerbated the negative association between receiving emotional support and the DHEA-to-cortisol ratio. By using hair hormones, this study offers preliminary insights into PLWD’s stress-related physiological processes in the context of intensive caregiving. Findings refine our understanding of the benefits and costs of caregivers' perspective taking and inform caregiver interventions.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107746"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precommitment promotes healthier food choices under stress 预先承诺有助于在压力下选择更健康的食物

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-13 DOI: 10.1016/j.psyneuen.2026.107754

Paul A.G. Forbes , Candace M. Raio , Tobias Kalenscher

{"title":"Precommitment promotes healthier food choices under stress","authors":"Paul A.G. Forbes , Candace M. Raio , Tobias Kalenscher","doi":"10.1016/j.psyneuen.2026.107754","DOIUrl":"10.1016/j.psyneuen.2026.107754","url":null,"abstract":"<div><div>Stress can result in unhealthier food choices with detrimental consequences for our health. Precommitment is a behavioural strategy whereby individuals restrict their future choice set and can promote healthier food choices – we may forgo buying cake when grocery shopping so we are not tempted to eat it at home. Yet, it is not known whether precommitment can buffer the effects of stress on food choices by providing opportunities to avoid unhealthy food altogether, enabling healthier food choices under stress. To investigate this, we developed a novel ‘precommit-to-eat’ paradigm which involved two stages. This enabled us to first assess precommitment decisions (precommitment stage) and, subsequently, participants’ propensity to select healthier items to eat in a food choice stage (choice stage). Participants (n = 29) who all reported generally trying to eat healthily completed this two-stage paradigm twice – once under acute stress and once in a non-stressful control condition. The propensity to choose unhealthier but tastier food to eat increased with subjective stress, but this effect was counteracted by stress-related increases in precommitment. Thus, our findings show the effectiveness of precommitment under stress. This has important implications for interventions aimed at promoting healthier food choices, especially in stressful environments, that could particularly benefit individuals with lower dietary restraint.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107754"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortisol and C-reactive protein interact to predict depressive symptoms 皮质醇和c反应蛋白相互作用预测抑郁症状

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-02-06 DOI: 10.1016/j.psyneuen.2026.107780

Stacey N. Doan , Dylan J. Hoell , Thomas E. Fuller-Rowell

{"title":"Cortisol and C-reactive protein interact to predict depressive symptoms","authors":"Stacey N. Doan , Dylan J. Hoell , Thomas E. Fuller-Rowell","doi":"10.1016/j.psyneuen.2026.107780","DOIUrl":"10.1016/j.psyneuen.2026.107780","url":null,"abstract":"<div><div>A growing literature has sought to characterize the physiological correlates of depression, particularly with respect to inflammatory hypothalamic-pituitary-adrenal functioning and inflammation. These systems are intricately interrelated, but in relation to depression, have primarily been investigated independently. This study examined interactions between C-reactive protein (CRP), a widely studied inflammatory biomarker, and salivary cortisol in relation to depressive symptoms in a non-clinical sample of 18- to 25-year-olds. We analyzed data from 184 participants (<em>M</em><sub><em>age</em></sub> = 19.43 years, <em>SD</em><sub><em>age</em></sub> = 1.11, 59.8 % female) who provided dried blood spot and saliva samples, assayed for CRP and cortisol concentrations, respectively. Salivary cortisol was collected across the Trier Social Stress Task. Depressive symptoms were assessed with the Beck Depression Inventory. Covariate-adjusted linear regression models were used to test for main and interaction effects between cortisol and CRP on depressive symptoms. Controls included sex, age, parent income, race/ethnicity, BMI, and study site. In our sample, neither cortisol (<em>b</em> = −.01, <em>SE b</em> =.01, <em>p</em> = .17) nor CRP (<em>b</em> = −1.25, <em>SE</em> =.92, <em>p</em> = .18) were related to depressive symptom severity. However, there was a significant interaction effect (<em>b</em> =.04, <em>SE b</em> =.01, <em>p</em> = .001), such that cortisol reactivity was inversely related to depression among participants with low, but not moderate or high levels of CRP. Cortisol reactivity to moderate stressors appears to be beneficial, but our results suggest these benefits are attenuated by high inflammation. This indicates that inflammatory activity is an important contextual factor shaping the relationship between cortisol and depression, highlighting the utility of multi-system approaches to studying the physiological correlates of depression.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"186 ","pages":"Article 107780"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Diurnal cortisol and rumination: Examining gender differences” [Psychoneuroendocrinology 179 (2025) 107517] “每日皮质醇和反刍：检查性别差异”的更正[精神神经内分泌学179 (2025)107517]

IF 3.6 2区医学

Psychoneuroendocrinology Pub Date : 2026-04-01 Epub Date: 2026-01-30 DOI: 10.1016/j.psyneuen.2026.107774

Nathan C. Stuart , Peggy M. Zoccola , Sally S. Dickerson

引用次数: 0