Psychoneuroendocrinology最新文献

{"title":"Acute stress differentially influences risky decision-making processes by sex: A hierarchical bayesian analysis.","authors":"Grant S Shields, Trey Malone, Zach J Gray","doi":"10.1016/j.psyneuen.2024.107259","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107259","url":null,"abstract":"<p><p>How does stress influence our decision-making? Although numerous studies have attempted to answer this question, their results have been inconsistent-presumably due to methodological heterogeneity. Drawing on cumulative prospect theory, we examined how acute stress influenced risky decision-making. To this end, we randomly assigned 147 participants to an acute stress induction or control condition and subsequently assessed participants' risky decision-making. We found that stress increased risky decision-making overall, but more importantly, that stress exerted multiple effects on risky decision-making processes that differed between male and female participants. For female participants, relative to the control condition, stress produced a pattern of decision-making characterized by risk seeking with respect to gains, slightly reduced loss aversion, accurate outcome probability assessment, and greater choice stochasticity. For male participants, stress, relative to the control condition, produced to a pattern of decision-making characterized by very low loss aversion and poorer outcome probability assessment. These results suggest that some of the heterogeneity in existing literature may be explainable by task differences in risk type, risk amount, and outcome certainties, and further that these effects will differ by sex. In short, stress changes how we make decisions, and it does so differently by sex.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107259"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of the hair-based nine hormones from four neuroendocrine systems.","authors":"Xuliang Hou, Xiaoli Ding, Lulu Zhao, Wei Gao, Deyi Qi, Huihua Deng","doi":"10.1016/j.psyneuen.2024.107262","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107262","url":null,"abstract":"<p><strong>Introduction: </strong>The stress response maintains the homeostasis of the body's internal environment and normal physiological activities, involving several neuroendocrine systems, such as the HPA axis, the HPG axis, the endocannabinoid system, and the melatonin system. However, studies on the intricate interactions among the four neuroendocrine systems are lacking, and it is not clear how these interactions are affected by demographic variables. The aim of this study was to investigate the network characteristics of hormonal networks comprising nine hormones from four neuroendocrine systems and how they were affected by demographic variables.</p><p><strong>Methods: </strong>252 healthy current students were recruited from Southeast University, China. The concentrations of nine hormones in their hair were measured by LC/MS methods, and hormonal network was constructed. Network analysis was used to characterize the interrelationships between hormones or neuroendocrine systems, central hormones, bridge hormones, hormonal network characteristics, and their changes in response to demographic variables.</p><p><strong>Results: </strong>Complex interactions between the HPA axis, the HPG axis, the ECS and the melatonin system formed a sparse and stable network, with cortisol and cortisone being the central hormones and melatonin as the bridge hormone. Demographic variables did not affect the overall characteristics of the network or the central hormone, but a number of specific connections in the network changed and the bridge hormones became cortisone and progesterone.</p><p><strong>Conclusion: </strong>The interactions between the four stress-related neuroendocrine systems were relatively stable and were centered and initiated by the HPA axis. Demographic variables did not affect the overall structure of the network, but influenced local features of the network, such as edge weights and bridge centrality.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107262"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does high perceived stress over the past month alter cortisol reactivity to the Trier Social Stress Test?","authors":"David Creswell, Kirk Warren Brown, Sheldon Cohen, Kasey Creswell, Peggy Zoccola, Sally Dickerson, Janine Dutcher, Sarah Wu, Brian Chin","doi":"10.1016/j.psyneuen.2024.107256","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107256","url":null,"abstract":"<p><strong>Background: </strong>Theories highlight the important role of chronic stress in remodeling HPA-axis responsivity under stress. The Perceived Stress Scale (PSS) is one of the most widely used measures of enduring stress perceptions, and no previous studies have evaluated whether greater perceptions of stress on the PSS are associated with cortisol hypo- or hyperactivity responses to the Trier Social Stress Test (TSST).</p><p><strong>Objective: </strong>To examine if high perceived stress over the past month, as measured by the PSS, alters cortisol and subjective acute stress reactivity to the TSST in healthy young adults.</p><p><strong>Methods: </strong>Five studies across three laboratories involving healthy young adults (N = 585) were conducted. Participants were exposed to the TSST, and cortisol levels and subjective stress responses were measured. Studies 1-2 served as exploratory, and Studies 3-5 as explanatory, with pre-registered hypotheses.</p><p><strong>Results: </strong>Higher PSS scores were consistently associated with greater acute subjective stress perceptions during the TSST across four out of five studies. Meta-analytic results revealed that higher perceived stress on the PSS was associated with blunted cortisol reactivity to the TSST. This cortisol hyporeactivity effect was more pronounced in studies using a combined speech and arithmetic TSST protocol compared to a speech-only protocol. Depressive symptoms did not significantly alter cortisol reactivity effects in these studies.</p><p><strong>Conclusion: </strong>Persistent high perceived stress over the past month may be associated with greater acute stress perceptions and blunted cortisol reactivity to the TSST. These findings highlight the potential importance of persistent perceived stress in HPA-axis responses to acute stress in healthy young adults, with potential implications for understanding stress-related health risks. Further research is needed to explore the underlying mechanisms and extend findings to diverse populations.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107256"},"PeriodicalIF":3.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-derived appetite regulating hormones across the anorexia nervosa spectrum.","authors":"Maged Muhammed, Helen Burton-Murray, Franziska Plessow, Kendra R Becker, Lauren Breithaupt, Meghan Lauze, Meghan Slattery, Hang Lee, Jennifer J Thomas, Kamryn T Eddy, Elizabeth A Lawson, Madhusmita Misra","doi":"10.1016/j.psyneuen.2024.107257","DOIUrl":"10.1016/j.psyneuen.2024.107257","url":null,"abstract":"<p><strong>Background: </strong>Appetite-regulating hormones are implicated in anorexia nervosa (AN) pathophysiology, however, data are limited for appetite-regulating hormones across the AN weight spectrum. We aimed to investigate fasting and post-prandial concentrations of appetite-regulating hormones - peptide YY (PYY), cholecystokinin (CCK), and ghrelin - among adolescent and young adult females across the AN weight spectrum, specifically those with AN and Atypical AN, and healthy controls (HC).</p><p><strong>Methods: </strong>Participants (N = 95; ages 11-22 years) included 33 with AN, 25 with Atypical AN, and 37 HC. AN was differentiated from Atypical AN by BMI < 10th percentile for age and sex (if <18 years) or < 18.5 kg/m²(if ≥18 years). Blood samples were collected fasting and 30, 60 and 120 minutes following a standardized meal to assess total PYY, CCK, and total ghrelin concentrations.</p><p><strong>Results: </strong>Median fasting and post-prandial PYY concentrations were significantly higher in AN vs. HC with medium differences (p = .001-.006, r = .34-.43). Atypical AN had significantly higher PYY concentrations compared to HC at T-0 (p = .027, r = .29) only, and did not significantly differ from concentrations in AN (p = .105-.413, r = .11-.22). Area under the curve (AUC; p = .001; r = .41) and peak PYY concentrations (p = .003; r = .41) were also significantly higher in AN vs. HC with medium differences. There were no significant differences in fasting (p = .885) or post-prandial (p = .846-.993) CCK concentrations across groups. AN and Atypical AN each had significantly higher ghrelin concentrations than HC with small to medium effect (AN vs HC p = .004-.025, r = .27-.36; Atypical AN vs HC p = .004-.033; r = .28-.28).</p><p><strong>Conclusions: </strong>Higher peak postprandial concentrations of anorexigenic PYY in AN (compared to HC) may facilitate dietary restriction and contribute to maintenance of lower weight. Lack of CCK suppression in AN is maladaptive in the context of undernutrition. Despite continued restriction, ghrelin is adaptively higher in AN overall and may not be differentiated by weight status.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107257"},"PeriodicalIF":3.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unfavourable glucose metabolism is associated with functional somatic disorders. A cross-sectional general population-based study: The DanFunD study.","authors":"Thomas Meinertz Dantoft, Sine Wanda Jørgensen, Kaare Bro Wellnitz, Eva Ørnbøl, Lise Gormsen, Per Fink, Allan Linneberg, Niklas Rye Jørgensen, Marie Weinreich Petersen, Anne Ahrendt Bjerregaard, Torben Jørgensen","doi":"10.1016/j.psyneuen.2024.107258","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107258","url":null,"abstract":"<p><strong>Objectives: </strong>Several studies have observed associations between unfavorable levels of blood glucose metabolic markers (i.e., fasting glucose, fasting insulin, glycated hemoglobin (HbA1c), and insulin resistance (HOMA-IR)) and functional somatic disorder (FSD). However, such associations have not yet been systematically analyzed in a general population-based sample using various FSD delimitations simultaneously. The aim of this study was to assess whether an unfavorable glucose metabolism is associated with FSD.</p><p><strong>Design: </strong>Cross-sectional population-based study SETTING: Ten municipalities in the western part of greater Copenhagen area in Denmark PARTICIPANTS: A total of 8183 men and women aged 18-76 years were included. Various delimitations of FSD, i.e., chronic fatigue (CF), chronic widespread pain (CWP), irritable bowel (IB), and bodily distress syndrome (BDS), were measured using validated self-administrated questionnaires. In a stratified subsample, BDS was also assessed by diagnostic interviews.</p><p><strong>Outcome measures: </strong>Logistic regression models were estimated for each delimitation of FSD as outcome and fasting glucose, fasting insulin, HbA1c, and estimated insulin resistance. Results were adjusted for age, sex (model 1), lifestyle, and social factors (model 2) and presented as odds ratios (OR) with 95 % confidence intervals (CI).</p><p><strong>Results: </strong>When only adjusting for sex and age, positive associations were found between all FSD delimitations and glucose, insulin, and HbA1c, except for between IB and HbA1c. Positive associations were also found between all questionnaire-based BDS groups, and men with BDS confirmed by diagnostic interviews and elevated insulin resistance. After adjusting for lifestyle and social factors, associations remained significant between both CF and glucose and HbA1c and between multi-organ BDS and glucose and HbA1c. Further, CF, single-organ BDS, multi-organ BDS, and women with overall-BDS also remained associated with increased levels of insulin resistance.</p><p><strong>Conclusion: </strong>FSD seems to be associated with especially an increase in plasma insulin levels and increased levels of insulin resistance. Elevated levels of blood glucose and HbA1c among all FSD groups could also completely be explained by unhealthy lifestyle. Prospective studies are needed for further clarification of the clinical relevance of this observation.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107258"},"PeriodicalIF":3.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance links dysbiosis of gut microbiota with cognitive impairment in first-episode drug-naïve schizophrenia.","authors":"Xiuxia Yuan, Yu Zhang, Lijuan Pang, Xiaoyun Zhang, Yulin Kang, Gangrui Hei, Xue Li, Xueqin Song","doi":"10.1016/j.psyneuen.2024.107255","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107255","url":null,"abstract":"<p><p>This study aimed to explore the relationship among gut microbiota imbalance, the homeostasis model of assessment of insulin resistance (HOMA-IR) and cognitive impairments in patients with schizophrenia (SCZ). We conducted a case-control study involving 189 first-episode, drug-naïve SCZ patients and 115 healthy controls (HCs). Main methods adopted included metagenomics analysis, glucose metabolism assessment, and cognitive function evaluation using the MATRICS Consensus Cognitive Battery (MCCB). Fecal microbiota composition was analyzed via high-throughput sequencing of 16S ribosomal RNA. Patients with SCZ showed a higher likelihood of developing IR (23 %), compared to HCs (12 %). The IR group exhibited significantly higher levels of fasting blood glucose (FBG), fasting insulin (FINS), HOMA-IR, and homeostasis model assessment-β (HOMA-β), while showing lower insulin sensitivity index (ISI) levels (all p < 0.05). Patients with IR demonstrated lower scores in working memories (WM), verbal learning (HVLT) and reasoning and problem solving (RPS), compared to those without IR. Additionally, microbiota analysis revealed that IR patients had higher abundance of Negativicutes, Streptococcaceae, Enterobacteriaceae, Lachnoclostridium, Dialister, Klebsiella, and Enterobacter, and lower abundance of Flavonifractor and Rikenellaceae. Notably, Negativicutes, Streptococcaceae, Lachnoclostridium, Flavonifractor, and Rikenellaceae were shared between SCZ and IR conditions. Mediation analysis indicated that the relative abundance of Streptococcaceae have an indirect effect on WM through HOMA-IR (β=-0.148, SE=0.067, 95 %CI=-0.280 to -0.020). The study suggests that IR may play a mediating role in the relationship between gut microbiota dysbiosis and cognitive impairments in patients with SCZ, which could point to potential new avenues for therapeutic interventions.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107255"},"PeriodicalIF":3.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Share-the-load vs bring-your-own-judge: The effects of friends on social evaluative stress in early adolescence.","authors":"Clarissa R Filetti, Nikola C Tsakonas, Bonny Donzella, Kathleen M Thomas, Megan R Gunnar","doi":"10.1016/j.psyneuen.2024.107254","DOIUrl":"10.1016/j.psyneuen.2024.107254","url":null,"abstract":"<p><strong>Objective: </strong>Parental attachment figures effectively buffer their children's cortisol responses to a socially evaluative stressor, the Trier Social Stress Test (TSST), by providing instrumental and emotional support during the preparation period. The effectiveness of parents as stress buffers wanes in adolescence as youth increase their reliance on peers for support. Yet, in a previous study, when peers played the same supportive role as parents, the cortisol response to the TSST was amplified. Here we asked if the role the friend plays matters. We hypothesized that the support of a friend would reduce the cortisol response to the TSST if they were also undergoing the stressor; while friend support would increase the cortisol response if they were only there for support and were not also undergoing the stressor.</p><p><strong>Method: </strong>235 youth ages 11.2-15.1 years were tested in the TSST-OL, an on-line version of the TSST task. Saliva samples were obtained for cortisol determination at multiple timepoints. In this pre-registered study, youth were randomly assigned, stratified by age, sex assigned at birth and pubertal status (early/later), to one of the following conditions: 1) Alone, 2) Unfamiliar Peer - Both Tested, 3) Friend as Supporter, 4) Friend - Both Tested.</p><p><strong>Results: </strong>Area under the curve from intercept (AUCi) for the initial reactivity phase was significantly different by group, matching our pre-registered prediction that friend support would reduce reactivity if both friends were undergoing the stressor, but increase it if the friend providing support did not also undergo the stressor. Recovery did not differ by condition.</p><p><strong>Conclusions: </strong>The effect of friends as stress buffers varies by the role the friend plays. In the case of the TSST, a social evaluative stressor, support from a friend buffers cortisol reactivity if the friend is also experiencing the stressor; but increases cortisol reactivity if they are just there as a support. Simply being with a supportive friend does not shield the adolescent from reacting with a neuroendocrine stress response to the stress of social evaluation.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107254"},"PeriodicalIF":3.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol and ACTH response to Dex/CRH testing and 24-hour urine free cortisol levels in women with and without premenstrual dysphoric disorder.","authors":"Constance X Zou, Gioia M Guerrieri, Pedro E Martinez, Xiaobai Li, Rivka Ben Dor, Rhasaan T M Bovell, Jessica M Naredo Rojas, Peggy McCluggage, Natalie Kress, Lynnette K Neiman, David R Rubinow, Peter J Schmidt","doi":"10.1016/j.psyneuen.2024.107250","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107250","url":null,"abstract":"<p><p>Hyperactive and hyperreactive HPA axis functions are frequently reported in depressive disorders, particularly in major depression. However, research into HPA axis function in women with premenstrual dysphoric disorder (PMDD), which is also classified as a depressive disorder, has shown inconsistent results. This study aimed to characterize the HPA axis in women with PMDD using the combined dexamethasone suppression and CRH stimulation (Dex/CRH) test, alongside measurements of 24-hour urine free cortisol (UFC). We enrolled 26 women with prospectively confirmed PMDD and 25 asymptomatic controls (ACs), testing them during the mid-follicular and luteal phases of the menstrual cycle. The primary outcomes included serial plasma cortisol and ACTH levels, their area-under-the-curve (AUC), and 24-hour UFC levels. We utilized a mixed model to compare serial cortisol and ACTH levels, and the Wilcoxon Signed Rank test for comparing UFC levels and cortisol and ACTH AUC. No significant effects related to diagnosis or menstrual cycle phase were observed on plasma cortisol or ACTH levels (from time 0 to +75 minutes), nor on the AUCs of plasma cortisol or ACTH (p > 0.05 for all comparisons). Notably, the PMDD group displayed significantly lower 24-hour UFC levels compared to the AC group during both the follicular and luteal phases (p = 0.0004 and p = 0.0007, respectively). The observed hyposecretion of cortisol in the PMDD group suggests a pathophysiology distinct from other depressive disorders, possibly aligning more closely with stress disorders such as PTSD. The unique symptom profile of PMDD, marked by significant irritability and a more rapid response to antidepressant treatment than is typical in major depression, further supports considering an alternative classification.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107250"},"PeriodicalIF":3.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPA axis dysregulation and postpartum depression and anxiety symptoms in breastfeeding vs bottle-feeding parents.","authors":"Katharine E Bruce, Kathryn Wouk, Karen M Grewen, Brenda Pearson, Samantha Meltzer-Brody, Alison M Stuebe, Anna E Bauer","doi":"10.1016/j.psyneuen.2024.107253","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107253","url":null,"abstract":"<p><strong>Objective: </strong>Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been implicated in the pathogenesis of perinatal mood disorders. Further, HPA axis response is known to be blunted during breastfeeding. We hypothesized that 1) postpartum depression/anxiety symptoms would be associated with HPA axis dysregulation, indexed by loss of expected adrenocorticotropic hormone (ACTH)-cortisol coupling, and 2) this association would vary by method of infant feeding.</p><p><strong>Methods: </strong>Participants (N=222) intending to breastfeed were recruited in their 3rd trimester of pregnancy. During a lab visit at 2 months postpartum, depression and anxiety symptoms were assessed (Beck Depression Inventory score ≥14 and/or Speilberger State-Trait Anxiety Inventory score ≥40). Participants then breast or bottle-fed their infants as they would at home. After a 10-minute rest, participants completed the Trier Social Stress Test (TSST), a standardized stressor involving speech and math tasks. Blood ACTH and cortisol were measured 10 minutes after feeding, during each task, and at 10, 20, and 30 minutes of recovery. Multilevel models evaluated whether coupling of ACTH at time j with cortisol at time j+1 differed between those with and without depression/anxiety symptoms, and whether differences varied by feeding method.</p><p><strong>Results: </strong>Of 205 participants who completed the TSST, 44 had depression/anxiety symptoms at 2-months postpartum. Depression/anxiety symptoms were associated with reduced ACTH-cortisol coupling (adjusted beta: -0.03; p-value: 0.03). Among those who breastfed, those with depression/anxiety showed greater blunting of ACTH-cortisol coupling than those without (adjusted beta: -0.04; p-value: 0.02), while those who bottle-fed had similar coupling patterns regardless of depression/anxiety symptoms (adjusted beta: -0.01; p-value: 0.87).</p><p><strong>Conclusion: </strong>HPA axis response was blunted in those with postpartum depression/anxiety symptoms, and blunting varied by method of infant feeding. Findings support HPA axis dysregulation in perinatal mood and anxiety disorders. Future research should explore how method of infant feeding influences the relationship between perinatal mood disorders and HPA axis dysregulation. Elucidating the mechanistic pathways underlying perinatal mood disorders can aid in the development of better diagnostic and treatment strategies.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107253"},"PeriodicalIF":3.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of single testosterone administration and stress induction on steroid hormone levels in hair","authors":"Hana H. Kutlikova ,&nbsp;Christoph Eisenegger ,&nbsp;Aniko Krumbholz ,&nbsp;Igor Riečanský ,&nbsp;Claus Lamm ,&nbsp;Boris B. Quednow","doi":"10.1016/j.psyneuen.2024.107252","DOIUrl":"10.1016/j.psyneuen.2024.107252","url":null,"abstract":"<div><div>Hair steroid analysis is increasingly recognized for its ability to capture cumulative hormone secretion, thought to reflect an individual’s response to long-term environmental conditions. Despite its growing use, the influence of single, isolated events on hair steroid concentrations remains underexplored. Our study therefore examined the effects of a single-dose transdermal testosterone administration (150 mg) and acute laboratory stress induction on hair testosterone and cortisol levels in a randomized, between-subject, placebo-controlled, and double-blind design. Liquid chromatography-tandem mass spectrometry analysis revealed a significant increase in hair testosterone levels seven weeks post-testosterone administration, underscoring the efficacy of hair analysis in detecting single-use hormone intake. Moreover, we observed a significant elevation in hair cortisol levels seven weeks post-exposure to the laboratory somatic stressor (Cold pressor test), highlighting the efficacy of hair analysis in capturing experimentally induced hormonal responses. The exploration of contextual factors revealed that individuals in committed relationships exhibited lower levels of both hair cortisol and testosterone compared to those who were single or in uncommitted relationships.</div><div>Our study provides new insights into the sensitivity of hair analysis for detecting hormonal changes following single-dose hormone administration and experimentally induced short-term stress events. The exploratory findings emphasize the importance of individual contextual factors in influencing hair hormone concentrations and lay the groundwork for further investigation into the dynamics of cumulative hair hormone measurements.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107252"},"PeriodicalIF":3.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}