Psychoneuroendocrinology最新文献

{"title":"Cortisol, cortisone, and DHEA concentrations in newborns of mothers by maternal refugee history","authors":"Darlene A. Kertes,&nbsp;Niti Contractor","doi":"10.1016/j.psyneuen.2025.107616","DOIUrl":"10.1016/j.psyneuen.2025.107616","url":null,"abstract":"<div><div>There are currently over 72 million internally displaced refugees worldwide. Understanding the intergenerational impacts of displacement experiences is critical to understanding the lasting, hidden impacts of the effects of displacement stress and is vital to future global health initiatives. Cortisol, cortisone, and dehydroepiandrosterone (DHEA) concentrations in newborns may be particularly informative for documenting potential impacts of intergenerational transmission that build on known biological mechanisms of exposure to maternal stress and functional relevance for offspring neurodevelopment and health. The present study documents, for the first time, the relation of mothers’ experience of internal displacement with steroid hormone concentrations in newborns in a study of 93 mother-newborn dyads in a high-conflict region of the Democratic Republic of Congo. Mothers self-reported on lifetime history of forced displacement along with demographic and pregnancy risks. Newborn hair samples were collected within 30 h of birth and newborn demographic information was obtained from medical records. A lifetime history of forced displacement among mothers was associated with higher cortisol, lower DHEA, and a higher cortisol/DHEA ratio among newborns. Sensitivity analysis examining initial age at displacement provided suggestive evidence for refugee experiences during early development as especially salient for the cortisol/DHEA ratio. The results have implications for global public health that extend beyond those immediately impacted by forced migration to potential second-generation impacts.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107616"},"PeriodicalIF":3.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing longitudinal patterns of central and peripheral insulin resistance","authors":"A. Evers ,&nbsp;F. Abbasi ,&nbsp;K. Watson ,&nbsp;E. Eitan ,&nbsp;T. Robakis ,&nbsp;N. Rasgon","doi":"10.1016/j.psyneuen.2025.107608","DOIUrl":"10.1016/j.psyneuen.2025.107608","url":null,"abstract":"<div><div>Metabolic dysfunction of insulin resistance (IR) may compromise brain function decades before overt disease. We assessed biomarkers of peripheral and central IR for three years in 125 cognitively intact adults without diabetes or depression (23–61 y) to clarify their relative contributions to trajectories of metabolic and cognitive change. Peripheral IR was quantified by measuring steady-state plasma glucose (SSPG) concentration during the insulin-suppression test and ancillary metabolic indices; central IR was indexed by phosphorylated insulin-receptor-substrate-1 (p-IRS1) in neuron-derived extracellular vesicles (NDEs) isolated from plasma. Mixed-effects models controlling for age, sex and BMI showed that higher baseline SSPG concentration robustly predicted subsequent increases in HOMA-IR and fasting insulin but was unrelated to cognitive outcomes. In contrast, higher baseline NDE p-IRS1 predicted better global cognition (MMSE) over time, an effect strongest in younger participants, yet showed no association with peripheral metabolic change. Participants with concordantly low fasting insulin and C-peptide maintained roughly two-fold higher p-IRS1 than those in the highest tertiles, despite similar trajectories across visits. Neither peripheral nor central IR predicted telomere attrition. Cross-sectionally, p-IRS1 correlated inversely with SSPG concentration, BMI and leptin, suggesting compensatory brain–periphery coupling. These findings indicate that NDE-based markers capture a dimension of brain metabolic vulnerability distinct from classical peripheral measures.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"181 ","pages":"Article 107608"},"PeriodicalIF":3.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic corticosterone impaired effortful motivation and risky decision-making in mice","authors":"Michael N. Noback ,&nbsp;Adam L. Halberstadt ,&nbsp;Samuel A. Barnes ,&nbsp;M.Melissa Flesher ,&nbsp;Jared W. Young","doi":"10.1016/j.psyneuen.2025.107617","DOIUrl":"10.1016/j.psyneuen.2025.107617","url":null,"abstract":"<div><div>Elevated risky decision-making is an established feature of major depressive disorder (MDD), but is not addressed by frontline treatments. The development of cross-species models of MDD focused on risky decision-making would enable high-throughput studies of novel therapeutics targeting these deficits. Elevated cortisol is observed in people with MDD and administering cortisol to healthy patients increases risky decision-making. Thus, the goal of this study was to determine whether increasing cortisol in experimental rodents also increases risky decision-making. Here, C57BL/6 J mice (n = 30, 50 % female) were given corticosterone (the rodent equivalent of cortisol) dissolved in drinking water (35 μg/mL for 21 days). Following chronic corticosterone administration, risky decision-making (Iowa gambling task; IGT), effortful motivation (progressive ratio breakpoint task; PRBT), reinforcement learning (probabilistic reversal learning task; PRLT) and exploratory behavior (Behavioral Pattern Monitor; BPM) were assessed. Chronic corticosterone elevated risky decision making (decreased difference score) and increased inappropriate responding during punishment phases in the IGT, suggesting that the sensitivity to negative outcomes contributed to impairments in decision-making. We also observed a decrease in breakpoint in the PRBT, indicating reduced effortful motivation, and a trend-level improvement in decision-making in the PRLT. Chronic corticosterone did not affect activity or exploration (BPM). Together, these findings mirror those of clinical studies of depression, supporting the use of chronic corticosterone as a model of risk-taking in MDD. Thus, the connections between corticosterone and risky decision-making in the context of MDD can be further elucidated.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"181 ","pages":"Article 107617"},"PeriodicalIF":3.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-sensitivity C-reactive protein as an early transdiagnostic biomarker for thoughts of death in mood disorders","authors":"Laura Orsolini,&nbsp;Giulio Longo ,&nbsp;Luciano Cavallo,&nbsp;Umberto Volpe","doi":"10.1016/j.psyneuen.2025.107612","DOIUrl":"10.1016/j.psyneuen.2025.107612","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with affective disorders have been consistently found to exert chronic low-grade inflammation, particularly, increased C-reactive protein (CRP) hematic levels were observed in major depressive disorder (MDD) patients. Moreover, an association between suicidal behaviour and increased CRP hematic levels has been documented. Few studies specifically investigated all suicidality spectrum dimensions, by recruiting all affective disorders, e.g. MDD, bipolar disorder type-1 (BD-I), bipolar disorder type-2 (BD-II) and cyclothymic mood disorder (Cyc). Therefore, our study was designed to explore the association between a low-grade inflammatory state (as assessed by high-sensitivity CRP [hsCRP]) and all suicidal spectrum dimensions across affective spectrum disorders in a real-world setting.</div></div><div><h3>Methods</h3><div>A naturalistic observational cross-sectional study was carried out by retrospectively recruiting 225 adult inpatients with affective disorders (MDD, BD-I, BD-II, Cyc). As routine clinical practice, for all patients were collected: a) hsCRP levels within a full laboratory panel; b) anthropometric measures; c) short version of the MINI Suicidal Scale (MINI-5-s); d) short version of the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego (brief-TEMPS-M).</div></div><div><h3>Results</h3><div>Within the total sample, 62.2 % reported thoughts of death in the last month, while 55.6 % experienced current suicidal ideation. According to a logistic regression model, thoughts of death were significantly predicted by higher score at the depressive subscale of TEMPS-M (Exp(B) = 1.069; 95 %IC = 1.021–1.119; p = 0.005) and higher hsCRP levels (Exp(B) = 1.818; 95 %IC = 1.053–3.139; p = 0.032).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that hsCRP could potentially represent a relatively easy, cheap and early transdiagnostic inflammatory biomarker for suicidality across mood disorders, particularly among those displaying a predominant affective depressive temperament. Further studies should longitudinally explore clinical implication derived by the stratification of mood disorders according to the inflammatory pattern, as well as testing whether anti-inflammatory therapy could represent an early treatment strategy for managing suicidality risk.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"181 ","pages":"Article 107612"},"PeriodicalIF":3.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between ghrelin and social support predicts antidepressant treatment outcomes in patients with depression","authors":"Jae-Min Kim ,&nbsp;Hee-Ju Kang ,&nbsp;Ju-Wan Kim,&nbsp;Honey Kim,&nbsp;Min Jhon,&nbsp;Ju-Yeon Lee,&nbsp;Sung-Wan Kim,&nbsp;Il-Seon Shin","doi":"10.1016/j.psyneuen.2025.107609","DOIUrl":"10.1016/j.psyneuen.2025.107609","url":null,"abstract":"<div><div>We aimed to investigate the interactive effects of baseline perceived social support and serum ghrelin levels on antidepressant treatment outcomes, specifically 12-week remission and 24-month relapse, in patients with depressive disorders. This prospective naturalistic study included a large cohort of patients treated for depression under routine clinical conditions. Social support was measured using the Multidimensional Scale of Perceived Social Support, and serum ghrelin was quantified at baseline. Participants received individualized pharmacological treatments over 12 weeks (N = 1086), followed by a 24-month follow-up for relapse (N = 710). Logistic regression and interaction analyses evaluated associations between social support, ghrelin, and treatment outcomes, controlling for relevant covariates. Neither social support nor serum ghrelin independently predicted 12-week remission or 24-month relapse. However, a significant interaction emerged: lower ghrelin levels were associated with poorer outcomes exclusively in patients with low social support. These interactions were significant after adjusting for clinical and demographic covariates and were observed despite no direct correlation between ghrelin and social support. Our findings highlight the importance of considering biopsychosocial interactions in predicting antidepressant treatment outcomes. Clinically, simultaneous assessment of social support and ghrelin may enhance risk stratification and guide personalized interventions. Future research should investigate underlying mechanisms and explore interventions aimed at boosting social support to mitigate biological vulnerabilities.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"181 ","pages":"Article 107609"},"PeriodicalIF":3.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on gut microbiota consortium in the management of depression: Preclinical and clinical evidence","authors":"Simranjit Kaur ,&nbsp;Aditi Jangli ,&nbsp;Vijayasree V. Giridharan ,&nbsp;Manoj P. Dandekar","doi":"10.1016/j.psyneuen.2025.107615","DOIUrl":"10.1016/j.psyneuen.2025.107615","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a disturbing mental condition affecting millions of people globally. The gut microbiota has garnered a major attention in the neurobiology and treatments of brain disorders, including depression. In this systematic review, we emphasized how prebiotics, probiotics, synbiotics, and postbiotics treatments manage depression. We registered this review on the Open Science Framework platform (Registration number: osf.io/bu674). As per PRISMA guidelines, we obtained 224 preclinical and clinical studies from five electronic databases (PubMed, Medline, EMBASE, Cochrane Library, and Web of Science) for the period of December 2008 to February 2025. Pan-probiotic approaches showed superior mood-elevating effects compared to a single-strain intervention. The mechanistic investigations of these studies unveiled complex neuroendocrine alterations, including the increase in serotonergic neurotransmission, anti-inflammatory responses, brain-derived neurotrophic factor expression, microbial diversity, and normalization of cortisol. <em>Lactobacillus</em> and <em>Bifidobacterium</em> genera exhibited the most consistent antidepressant-like effects at 1–10 billion colony-forming units (CFU) administered for 8–10 weeks. The probiotic and prebiotic interventions also demonstrated beneficial effects across the diverse clinical subpopulations, including patients with comorbid gastrointestinal disorders, heart complications, metabolic disorders, and postpartum depression. While these findings underscore the potential of microbiota-targeted therapeutics in depression, large-scale and long-term clinical trials are needed to identify a precise probiotic strain and treatment regimen.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"181 ","pages":"Article 107615"},"PeriodicalIF":3.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental timing of index trauma exposure and accelerated epigenetic aging in United States military veterans","authors":"Amanda J.F. Tamman ,&nbsp;Sheila T. Nagamatsu ,&nbsp;Brenda Cabrera-Mendoza ,&nbsp;Lynnette A. Averill ,&nbsp;Erin C. Dunn ,&nbsp;John H. Krystal ,&nbsp;Joel Gelernter ,&nbsp;Janitza L. Montalvo-Ortiz ,&nbsp;Renato Polimanti ,&nbsp;Robert H. Pietrzak","doi":"10.1016/j.psyneuen.2025.107568","DOIUrl":"10.1016/j.psyneuen.2025.107568","url":null,"abstract":"<div><div>Trauma exposure has been linked to accelerated GrimAge, an epigenetic biomarker of premature morbidity and mortality. Building on this evidence, the present study examined whether the type and timing of index trauma exposure are differentially associated with accelerated GrimAge. Participants were 873 European American male United States military Veterans from the National Health and Resilience in Veterans Study. We investigated associations between self-reported age at index trauma, index trauma type (interpersonal violence, non-interpersonal trauma, or loss/instability/other), and accelerated GrimAge, operationalized as GrimAge exceeding chronological age by five or more years. Results revealed that interpersonal violence was associated with three-fold greater odds of accelerated GrimAge compared to other trauma types. Age at index trauma was not independently associated with accelerated GrimAge. However, we observed a significant interaction between trauma type and its developmental timing, even after adjusting for index trauma recency, cumulative trauma burden, and other potential confounders. Specifically, Veterans who were older at the time of exposure to interpersonal violence or trauma involving loss or instability had higher odds of accelerated GrimAge. In contrast, exposure to non-interpersonal trauma was more strongly associated with accelerated GrimAge when it occurred at younger ages. These results indicate that trauma type and timing jointly influence epigenetic aging in Veterans, highlighting the need for tailored interventions that address specific trauma characteristics to reduce associated long-term health risks in this population.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107568"},"PeriodicalIF":3.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purpose in life and c-reactive protein: An individual-participant meta-analysis of >50,000 adults","authors":"Angelina R. Sutin ,&nbsp;Martina Luchetti ,&nbsp;Yannick Stephan ,&nbsp;Antonio Terracciano","doi":"10.1016/j.psyneuen.2025.107614","DOIUrl":"10.1016/j.psyneuen.2025.107614","url":null,"abstract":"<div><div>Purpose in life is associated consistently with better health outcomes, which may be due in part to healthier inflammatory profiles. The present research used seven independent cohort studies (total <em>N</em> = 54,491) to evaluate the association between purpose in life and c-reactive protein (CRP), sociodemographic moderators of the association, and whether purpose is associated with elevated CRP cross-sectionally and longitudinally (three cohorts with longitudinal data). Purpose in life had a modest but consistent association with concurrent CRP (meta-analytic b=-.05, 95 % CI=-.06, −.04, p &lt; .001). The association was apparent across age, sex, race, and education, but was slightly stronger among males and relatively younger participants. Purpose was associated cross-sectionally with lower likelihood of elevated CRP defined either as CRP&gt; 3 (meta-analytic OR=.91, 95 % CI=.88,.94, <em>p</em> &lt; .001) or CRP&gt; 10 (meta-analytic OR=.86, 95 % CI=.82,.90, <em>p</em> &lt; .001). Although not apparent in all cohorts, the meta-analysis indicated that purpose was associated with lower likelihood of persistently elevated CRP&gt; 3 (meta-analytic OR=.90, 95 % CI=.828,.976, <em>p</em> = .011) and lower risk of developing elevated CRP&gt; 3 (meta-analytic HR=.92, 95 % CI=.886,.964, <em>p</em> &lt; .001) over the up to 12 years of follow-up. Purpose in life is associated with lower levels of CRP, which may be one mechanism through which purpose is associated with better health outcomes.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"181 ","pages":"Article 107614"},"PeriodicalIF":3.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood trauma combined with suicide attempts affects cognitive function and inflammation levels in drug-naive patients with major depressive disorder","authors":"Mengxin Xie ,&nbsp;Yuanyuan Liu ,&nbsp;Yifan Jing ,&nbsp;Ying Gao ,&nbsp;Yuan Liu ,&nbsp;Jie Li ,&nbsp;Fuqiang Mao","doi":"10.1016/j.psyneuen.2025.107611","DOIUrl":"10.1016/j.psyneuen.2025.107611","url":null,"abstract":"<div><h3>Background</h3><div>Childhood trauma (CT) and suicide attempts (SA) independently associate with cognitive impairment in major depressive disorder (MDD), but their interactive effect and biology mechanisms still unknown.</div></div><div><h3>Methods</h3><div>We recruited a total of 156 first-episode drug-naïve patients with MDD and 90 healthy controls (HC). Using the Childhood Trauma Questionnaire (CTQ), Beck Scale for Suicide Ideation-Chinese Version (BSI-CV), and Repeatable Battery for Assessment of Neuropsychological Status (RBANS) to assess recruited patients with MDD and HC. And we measured the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), tumor necrosis factor receptor-2 (TNFR2), catalase (CAT), glutathione reductase (GSR) and superoxide dismutase (SOD) in MDD patients using enzyme-linked immunosorbent assay (ELISA).</div></div><div><h3>Results</h3><div>MDD patients demonstrated significantly lower scores across all cognitive domains compared to HC (p &lt; 0.001). In MDD patients, a significant interaction between CT and SA history was observed for RBANS total scores (p = 0.028), immediate memory (p = 0.045), attention (p = 0.008), and TNF-α levels (p = 0.018), while CT independently affected GSR levels (p = 0.034). Stratifying MDD patients into four subgroups (CT⁺SA⁺, CT^-SA⁺, CT⁺SA^-, CT^-SA^-) revealed that the CT⁺SA⁺ group had significantly lower RBANS total scores (p = 0.01) and attention scores (p &lt; 0.001) than other subgroups. TNF-α levels showed no significant differences among four subgroups (p = 0.047).</div></div><div><h3>Conclusion</h3><div>CT and SA may synergistically exacerbate cognitive impairment, especially attention deficit, in drug-naive patients with MDD and may tend to increase TNF-α levels.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107611"},"PeriodicalIF":3.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onset of workplace conflict, incident cardiovascular disease and changes in biomarkers","authors":"Tianwei Xu ,&nbsp;Maria Nordin ,&nbsp;Eleonor I. Fransson ,&nbsp;Helena Nordenstedt ,&nbsp;Linda L. Magnusson Hanson","doi":"10.1016/j.psyneuen.2025.107610","DOIUrl":"10.1016/j.psyneuen.2025.107610","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the associations of onset of workplace conflict on incident cardiovascular disease (CVD) and changes in biomarkers.</div></div><div><h3>Methods</h3><div>The study included 2704 employees aged 18–65 years and free of workplace conflict at baseline (T₀), from the Swedish Work, Lipids, Fibrinogen study (proportion of women: 17 %). Exposure to onset of workplace conflict was ascertained at T₁ using self-reports (mean interval between T₀ and T₁: 5 years). Participants were linked to nationwide registers to ascertain incident CVD. Changes in biomarkers, including body mass index, waist-hip ratio, high-density lipoprotein cholesterol, triglycerides, glucose and fibrinogen, were measured and calculated between T₀ and T₁. Cox regressions and linear regressions were applied for analyses on conflicts in relation to CVD and conflicts in relation to changes in biomarkers, respectively. Age, sex, educational level, marital status, pre-existing comorbidities, employment contract, and shift work were adjusted for in the main analyses.</div></div><div><h3>Results</h3><div>About 10 % experienced onset of workplace conflict between T₀ and T₁. Among 2682 participants who were free from CVD at T₀, 87 CVD events were recorded (mean follow-up from T₁: 7.8 years, incidence rate: 41.5/10,000 person-year). Onset of workplace conflict at T₁ was associated with 2.42 times (95 %CI 1.42, 4.12) higher risk of developing CVD during the follow-up period. Among 877 participants with information on changes in fibrinogen, onset of workplace conflict at T₁ was associated with fibrinogen increase from T₀ to T₁ (mean difference=0.14; 95 %CI 0.02, 0.25) and onset of high fibrinogen (OR=1.41; 95 %CI 1.04,1.90). These associations were largely robust for additional adjustments, restrictions and consideration of selection bias and were not likely to be affected by reverse causation.</div></div><div><h3>Conclusions</h3><div>Onset of workplace conflict was related to higher risks of developing CVD and fibrinogen increase.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"181 ","pages":"Article 107610"},"PeriodicalIF":3.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}