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QJM: An International Journal of Medicine最新文献

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Explainable machine learning prediction of 1-year kidney function progression among patients with type 2 diabetes mellitus and chronic kidney disease: a retrospective study. 可解释的机器学习预测2型糖尿病和慢性肾病患者1年肾功能进展：一项回顾性研究
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-24 DOI: 10.1093/qjmed/hcaf101
Jinyi Wu, Qi Gao, Ming Tian, Shuangping Tan, Junwu Dong, Honglan Wei
{"title":"Explainable machine learning prediction of 1-year kidney function progression among patients with type 2 diabetes mellitus and chronic kidney disease: a retrospective study.","authors":"Jinyi Wu, Qi Gao, Ming Tian, Shuangping Tan, Junwu Dong, Honglan Wei","doi":"10.1093/qjmed/hcaf101","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf101","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop and validate a risk prediction model for 1-year CKD progression in patients with T2DM and CKD by employing various machine learning (ML) algorithms.</p><p><strong>Methods: </strong>This study included a total of 12,151 patients with T2DM and CKD with estimated glomerular filtration rate (eGFR) between 30 and 59.9 mL/min/1.73 m2 from a tertiary hospital in Wuhan, enrolled between 2012 and 2024. The cohort was divided into a training set of 5,954 patients, an internal validation set of 2,552 patients, and an external validation set of 3,645 patients. We developed 1-year CKD progression risk prediction models using 10 different machine learning algorithms. CKD progression was defined as a decline in eGFR by more than 30% from baseline and/or a reduction in eGFR to below 15 mL/min/1.73 m2. The SHAP (SHapley Additive exPlanations) method was utilized to explain the predictions of a model.</p><p><strong>Results: </strong>Among the 10 ML models, the XGBoost model achieved the best predictive performance for 1-year progression of kidney function with an AUC of 0.906 in the internal validation set and 0.768 in the external validation set. The final predictive model incorporating only nine variables has been implemented into a web application to enhance its usability in clinical settings.</p><p><strong>Conclusion: </strong>Our findings suggest that the XGBoost model may serve as a valuable decision-support tool for predicting kidney function decline in patients with T2DM and CKD.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteogenesis imperfecta.
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-23 DOI: 10.1093/qjmed/hcaf099
Rimesh Pal, Varun Singla, Sanjay K Bhadada
{"title":"Osteogenesis imperfecta.","authors":"Rimesh Pal, Varun Singla, Sanjay K Bhadada","doi":"10.1093/qjmed/hcaf099","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf099","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
X-linked Ichthyosis. x连锁鱼鳞癣。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-21 DOI: 10.1093/qjmed/hcaf070
Chunyan Cao, Yiheng Zeng, Jiewen Zhang
{"title":"X-linked Ichthyosis.","authors":"Chunyan Cao, Yiheng Zeng, Jiewen Zhang","doi":"10.1093/qjmed/hcaf070","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf070","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Impact of intravenous laser irradiation of blood on cognitive function and molecular pathways in long COVID patients: a pilot study. 纠正：静脉激光照射血液对长期COVID患者认知功能和分子通路的影响：一项初步研究。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-18 DOI: 10.1093/qjmed/hcaf083
{"title":"Correction to: Impact of intravenous laser irradiation of blood on cognitive function and molecular pathways in long COVID patients: a pilot study.","authors":"","doi":"10.1093/qjmed/hcaf083","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf083","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roth Spots in Acute Myeloid Leukemia: Unveiling the Ocular Window to Systemic Disease. 急性髓系白血病中的罗斯斑：揭示全身性疾病的眼部窗口。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-17 DOI: 10.1093/qjmed/hcaf100
Vipin Rana, Kanwaljeet Singh, Amit Nandan Tripathi, Ranjit Goenka, Ashish Markan, Raihan Mondal
{"title":"Roth Spots in Acute Myeloid Leukemia: Unveiling the Ocular Window to Systemic Disease.","authors":"Vipin Rana, Kanwaljeet Singh, Amit Nandan Tripathi, Ranjit Goenka, Ashish Markan, Raihan Mondal","doi":"10.1093/qjmed/hcaf100","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf100","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Errors in the Diagnostic Process Revisited - A Formidable Personal Challenge. 重新审视诊断过程中的错误——一个可怕的个人挑战。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-17 DOI: 10.1093/qjmed/hcaf098
Ami Schattner
{"title":"Errors in the Diagnostic Process Revisited - A Formidable Personal Challenge.","authors":"Ami Schattner","doi":"10.1093/qjmed/hcaf098","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf098","url":null,"abstract":"<p><p>Recent research reveals that diagnostic errors remain alarmingly common, calamitous-often leading to serious harm or death, costly, and complex to identify, study, and prevent. Interventions to decrease diagnostic errors have mostly been focused on system changes at the institutional level, which are hard and time-consuming to implement and have demonstrated mixed results. Based on recent research of the diagnostic process and identification of recurring breakdowns preceding errors, we believe that while system improvements are underway, the burden is on the individual practitioner in each encounter, predominantly in primary care, and suggest basic, easily-adopted techniques and strategies that are likely to yield an improved accuracy of diagnosis and better follow-up.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid inferno of Graves' Disease. 甲状腺地狱格雷夫斯病。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-16 DOI: 10.1093/qjmed/hcaf096
Babu Ivan Mani, Abdus Samad Khan, Vui Heng Chong
{"title":"Thyroid inferno of Graves' Disease.","authors":"Babu Ivan Mani, Abdus Samad Khan, Vui Heng Chong","doi":"10.1093/qjmed/hcaf096","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf096","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Helicobacter pylori and Epstein-Barr virus co-infection and gastric cancer risk: A systematic review and meta-analysis. 幽门螺杆菌和eb病毒合并感染与胃癌风险的关系：一项系统综述和荟萃分析
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-15 DOI: 10.1093/qjmed/hcaf092
Ngoc-Niem Bui, Shih-Chiang Huang, Thi Nhu Le Tran, Ngoc Hien Nguyen, Hang Nga Do, Ya-Fang Chiu, Chih-Ho Lai
{"title":"Association between Helicobacter pylori and Epstein-Barr virus co-infection and gastric cancer risk: A systematic review and meta-analysis.","authors":"Ngoc-Niem Bui, Shih-Chiang Huang, Thi Nhu Le Tran, Ngoc Hien Nguyen, Hang Nga Do, Ya-Fang Chiu, Chih-Ho Lai","doi":"10.1093/qjmed/hcaf092","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf092","url":null,"abstract":"<p><strong>Background: </strong>Co-infection with Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) has been demonstrated in clinical studies; however, its association with gastric cancer (GC) remains uncertain.</p><p><strong>Aims: </strong>This study aims to assess and establish evidence linking H. pylori and EBV co-infection to an increased risk of GC development.</p><p><strong>Methods: </strong>We conducted a meta-analysis study to investigate the pooled odds ratios (OR) for individual infections and co-infections, and their association with the risk of GC development.</p><p><strong>Results: </strong>EBV infection was more frequent in patients with GC than in non-GC patients (OR 4.98, 95% confidence interval (CI) 3.17-7.85, p < 0.0001). H. pylori infection was associated with a significantly increased GC risk compared with a control group excluding gastritis cases (OR 1.42, 95% CI 1.02-1.99, p = 0.03). Nevertheless, the random-effects model revealed that the pooled odds of co-infection were significantly elevated (OR 2.57, 95% CI 1.65-4.01, p < 0.0001).</p><p><strong>Conclusions: </strong>Both H. pylori and EBV infections increase the risk of developing GC. The co-infection of H. pylori and EBV was linked to a 2.57-fold higher risk of GC, indicating the significance of incorporating both infections into diagnostic and treatment approaches for GC.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Darling tongue. 纠正：亲爱的舌头。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-12 DOI: 10.1093/qjmed/hcaf061
{"title":"Correction to: Darling tongue.","authors":"","doi":"10.1093/qjmed/hcaf061","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf061","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Case of Immunotactoid Glomerulopathy with IgG3 Lambda Staining. 罕见的IgG3 λ染色免疫样肾小球病1例。
IF 7.3 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-04-12 DOI: 10.1093/qjmed/hcaf095
Zhi-Yu Duan, Guang-Yan Cai, FengKun Chen, SuXia Wang, Xu Zhang, Yan Song
{"title":"A Rare Case of Immunotactoid Glomerulopathy with IgG3 Lambda Staining.","authors":"Zhi-Yu Duan, Guang-Yan Cai, FengKun Chen, SuXia Wang, Xu Zhang, Yan Song","doi":"10.1093/qjmed/hcaf095","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf095","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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