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QJM: An International Journal of Medicine最新文献

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Reply to "Do Large PASI Responses Reflect a Clinically Meaningful Effect of Fire Needle Therapy?" 回复“大的PASI反应是否反映了火针疗法的临床意义？”
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-16 DOI: 10.1093/qjmed/hcag246
Liu Liu, Xiao-Ying Sun, Xiao-Ning Yan, Bin Li, Xin Li
{"title":"Reply to \"Do Large PASI Responses Reflect a Clinically Meaningful Effect of Fire Needle Therapy?\"","authors":"Liu Liu, Xiao-Ying Sun, Xiao-Ning Yan, Bin Li, Xin Li","doi":"10.1093/qjmed/hcag246","DOIUrl":"https://doi.org/10.1093/qjmed/hcag246","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications for the differential diagnosis of sarcoidosis. 结节病鉴别诊断的意义。
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-16 DOI: 10.1093/qjmed/hcag241
Oscar M P Jolobe
{"title":"Implications for the differential diagnosis of sarcoidosis.","authors":"Oscar M P Jolobe","doi":"10.1093/qjmed/hcag241","DOIUrl":"https://doi.org/10.1093/qjmed/hcag241","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A missing comparator in attributing ocular risk to post-COVID herpes zoster. 将眼部风险归因于covid后带状疱疹的缺失比较。
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-16 DOI: 10.1093/qjmed/hcag243
Ercan Yılmaz, Nezihe Koker Özer, Erdem Topal
{"title":"A missing comparator in attributing ocular risk to post-COVID herpes zoster.","authors":"Ercan Yılmaz, Nezihe Koker Özer, Erdem Topal","doi":"10.1093/qjmed/hcag243","DOIUrl":"https://doi.org/10.1093/qjmed/hcag243","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Round Pneumonia. 圆的肺炎。
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-15 DOI: 10.1093/qjmed/hcag242
Mikiko Ozaki, Jun Shikama, Yoshitaka Tomoda
{"title":"Round Pneumonia.","authors":"Mikiko Ozaki, Jun Shikama, Yoshitaka Tomoda","doi":"10.1093/qjmed/hcag242","DOIUrl":"https://doi.org/10.1093/qjmed/hcag242","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond a binary FOIS threshold in acupuncture for post-stroke dysphagia. 超过二值FOIS阈值针刺治疗脑卒中后吞咽困难。
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-15 DOI: 10.1093/qjmed/hcag245
Shenfan Lang, Cong Wang
{"title":"Beyond a binary FOIS threshold in acupuncture for post-stroke dysphagia.","authors":"Shenfan Lang, Cong Wang","doi":"10.1093/qjmed/hcag245","DOIUrl":"https://doi.org/10.1093/qjmed/hcag245","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin-Like Growth Factor-1 and Atherosclerosis: Mechanistic Insights and Clinical Implications. 胰岛素样生长因子-1与动脉粥样硬化：机制和临床意义。
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-12 DOI: 10.1093/qjmed/hcag237
Lianjie Hou
{"title":"Insulin-Like Growth Factor-1 and Atherosclerosis: Mechanistic Insights and Clinical Implications.","authors":"Lianjie Hou","doi":"10.1093/qjmed/hcag237","DOIUrl":"https://doi.org/10.1093/qjmed/hcag237","url":null,"abstract":"<p><p>Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality worldwide, with persistent residual risk despite optimal management of conventional risk factors. Insulin-like growth factor-1 (IGF-1), the principal effector of the growth hormone-IGF-1 axis, exerts dose-dependent dual effects on atherogenesis, yet its clinical value remains controversial and incompletely clarified. This review provides a concise overview of the core mechanistic basis of IGF-1 in atherosclerotic pathogenesis, synthesizes key epidemiological and clinical cohort evidence on the association between circulating IGF-1 and atherosclerotic cardiovascular events, evaluates its utility as a predictive and prognostic biomarker, and systematically summarizes the translational potential of IGF-1 axis-targeted interventions. Physiological IGF-1 concentrations confer endothelial protection, anti-inflammatory effects and plaque stability, whereas deviation to either excess or deficiency accelerates atherosclerotic progression. Circulating IGF-1 exhibits a non-linear association with ASCVD risk and prognosis, with routine clinical application currently limited by assay heterogeneity and metabolic confounders. Normalization of the IGF-1 axis at physiological levels delivers measurable vascular benefits, and pathway-selective modulators represent a promising direction for future translational research.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gull-wing Appearance in Erosive Hand Osteoarthritis. 糜烂性手骨关节炎的鸥翼状表现。
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-11 DOI: 10.1093/qjmed/hcag236
Bodhibrata Banerjee, Sanjay Jain, Shefali Khanna Sharma
{"title":"Gull-wing Appearance in Erosive Hand Osteoarthritis.","authors":"Bodhibrata Banerjee, Sanjay Jain, Shefali Khanna Sharma","doi":"10.1093/qjmed/hcag236","DOIUrl":"https://doi.org/10.1093/qjmed/hcag236","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Biological Recovery Is Not Enough. 当生物恢复不够时。
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-11 DOI: 10.1093/qjmed/hcag240
Roland Rosmond
{"title":"When Biological Recovery Is Not Enough.","authors":"Roland Rosmond","doi":"10.1093/qjmed/hcag240","DOIUrl":"https://doi.org/10.1093/qjmed/hcag240","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A deceptive blue nodule: pigmented dermatofibrosarcoma protuberans. 假的蓝色结节：色素皮肤纤维肉瘤隆突。
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-10 DOI: 10.1093/qjmed/hcag234
Miao Qin, Li Li, Bin Peng
{"title":"A deceptive blue nodule: pigmented dermatofibrosarcoma protuberans.","authors":"Miao Qin, Li Li, Bin Peng","doi":"10.1093/qjmed/hcag234","DOIUrl":"https://doi.org/10.1093/qjmed/hcag234","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between PCSK9 Inhibitor Use and Risk of Incident Heart Failure in Patients With Dyslipidemia. 血脂异常患者使用PCSK9抑制剂与心力衰竭风险的关系
IF 8.9 4区 医学
QJM: An International Journal of Medicine Pub Date : 2026-09-10 DOI: 10.1093/qjmed/hcag235
Jheng-Yan Wu, Keng-Wei Lee, Sheng-Chi Huang, Hsuan-Yuan Chang, Yu-Min Lin
{"title":"Association Between PCSK9 Inhibitor Use and Risk of Incident Heart Failure in Patients With Dyslipidemia.","authors":"Jheng-Yan Wu, Keng-Wei Lee, Sheng-Chi Huang, Hsuan-Yuan Chang, Yu-Min Lin","doi":"10.1093/qjmed/hcag235","DOIUrl":"https://doi.org/10.1093/qjmed/hcag235","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate whether the use of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9is) is associated with a reduced 1-year incidence of new-onset heart failure (HF) compared to statins among patients with dyslipidemia.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the TriNetX global health research network. Adults diagnosed with dyslipidemia and initiated on either PCSK9is or statins between 2015 and 2025 were included. One-to-one propensity score matching (PSM) was applied to balance baseline characteristics. The primary outcome was new-onset HF within one year. Cox proportional hazards models were used to estimate hazard ratios (HRs), with E-values calculated to assess unmeasured confounding.</p><p><strong>Results: </strong>After PSM, 40,098 patients were included in each group. The incidence of new-onset HF was significantly lower in the PCSK9is group (1.8 vs. 2.7 per 100 person-years; HR 0.69, 95% CI 0.63-0.76; P < .001). Subgroup analyses confirmed consistent benefit across age, sex, and comorbidity strata. Secondary outcomes including all-cause mortality, hospitalization, and MACEs were also significantly reduced in the PCSK9is group. A negative control outcome showed no significant association.</p><p><strong>Conclusions: </strong>Among patients with dyslipidemia, PCSK9i use was associated with a significantly lower 1-year risk of new-onset HF and improved secondary outcomes compared to statin therapy. These findings support a potential preventive role of PCSK9is in HF, warranting further prospective studies to confirm these observations.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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