QJM: An International Journal of Medicine最新文献

{"title":"Tourniquet Test in Dengue Fever: How to Perform and Interpret?","authors":"Tuli A, Pannu Ak","doi":"10.1093/qjmed/hcaf042","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf042","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What we look for might be the wrong answer.","authors":"Oscar M P Jolobe","doi":"10.1093/qjmed/hcaf039","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf039","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous larva migrans with eccrine involvement.","authors":"Bing-Sian Lin, Wei-Ming Wang","doi":"10.1093/qjmed/hcae249","DOIUrl":"https://doi.org/10.1093/qjmed/hcae249","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indian File Pattern: A histological clue to a concealed primary malignancy.","authors":"Vignesh Nr, Shreya Srinivasan, Narayanan Baskaran, Sukanya G","doi":"10.1093/qjmed/hcaf036","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf036","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"life-saving Percutaneous Transluminal Angioplasty revascularize artificial Graft of Persistent Truncus Arteriosus.","authors":"Yen Shu Huang, Jian You Chen, Bin Li","doi":"10.1093/qjmed/hcaf023","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf023","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the Burden of Epilepsy in China from 1990 to 2021 and Its Forecast until 2044: Based on the 2021 Global Burden of Disease Study.","authors":"Zhiyong Fang, Feng Wang, Zhen Mei, Xiaofen Huang, Lin Gao, Lixian Zheng, Yuanxiang Lin, Xuequn Hu","doi":"10.1093/qjmed/hcaf037","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf037","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy is one of the most prevalent neurological disorders, but no updated analysis of its burden in China.</p><p><strong>Aims: </strong>This study provides the most up-to-date, comprehensive analysis of temporal trends and predicts future trends of idiopathic epilepsy in China.</p><p><strong>Design: </strong>Secondary analysis based on the Global Burden of Disease (GBD).</p><p><strong>Methods: </strong>GBD 2021 data were analyzed to estimate the incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) of epilepsy in China across different genders, age groups, and years. Joinpoint regression and decomposition analysis assessed temporal changes and the contributions of aging, population growth, and epidemiological changes to disease trends. The Bayesian Age-Period-Cohort (BAPC) model was used to predict age-standardized rates (ASRs) per 100,000 individuals until 2044.</p><p><strong>Results: </strong>In 2021, the ASRs of incidence, prevalence, deaths, and DALYs for epilepsy in China were 28.2 (95% uncertainty interval [UI]: 19.0-37.9), 214.7 (150.1-278.6), 0.8 (0.7-1.0), and 101.4 (72.5-139.4) per 100,000 population, respectively. The incidence and prevalence rates were 26.1% and 13.4% higher than those in 1990, while deaths and DALYs decreased by 56.6% and 43.2%, respectively, compared to 1990. The highest burden was seen in the youngest and older adults, with men more affected than women. Predictions indicate rising incidence and prevalence rates by 2044, alongside declining mortality and disability rates.</p><p><strong>Conclusion: </strong>Epilepsy poses a significant health burden in China, with increasing incidence and prevalence from 1990 to 2021, and projections indicating a continued rise through 2044. The disease burden also varies across genders, age groups, and time periods.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Democracy Good for Your Health?","authors":"Cary Wu","doi":"10.1093/qjmed/hcaf034","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf034","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seizure clusters with typical \"evolution\" in EEG.","authors":"Miharuka Yokosaki, Shuichiro Neshige, Naoki Takahashi, Shiro Aoki, Hirofumi Maruyama","doi":"10.1093/qjmed/hcaf014","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf014","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactivation of Latent Syphilis During Immunosuppressive Therapy in SLE.","authors":"Chuan-Peng Wang, Jia Zhou, Jun Li","doi":"10.1093/qjmed/hcaf019","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf019","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exome sequencing for nonimmune hydrops fetalis and clinical utility of data reanalysis.","authors":"Chang Liu, Yanlin Huang, Yunan Wang, Yan Zhang, Li Du, Lihua Yu, Hongke Ding, Fake Li, Yiming Qi, Yuan Liu, Xingwang Wang, Fangfang Guo, Ying Xiong, Xin Zhao, Liyuan Fang, Juan Geng, Anpeng Fu, Jing Wu, Aihua Yin","doi":"10.1093/qjmed/hcae187","DOIUrl":"10.1093/qjmed/hcae187","url":null,"abstract":"<p><strong>Background: </strong>Nonimmune hydrops fetalis (NIHF) presents as life-threatening fluid collections in multiple fetal compartments and may be led by numerous etiologies.</p><p><strong>Aim: </strong>To establish the diagnostic yield of exome sequencing for single-gene disorders in unexplained NIHF and to evaluate the clinical utility of data reanalysis.</p><p><strong>Methods: </strong>A series of 53 unexplained cases of NIHF were enrolled, including 39 cases met a strict definition of NIHF and 14 cases with increased nuchal translucency (NT) and/or cystic hygroma in combination with other fluid collections. Trio ES from fetal samples and parental blood was performed, and clinical reports were returned by geneticists and genetic counselors. Multidisciplinary team forums were conducted for accurate diagnoses and improved patient management. The clinical follow-up assessments were conducted, and the reanalysis was performed for cases with a non-positive result.</p><p><strong>Results: </strong>Diagnostic variants were identified in 22.6% (12/53) of the cases, and variants of potential clinical significance were detected in an additional 13.2% (7/53) of the cases. Of them, three possible diagnoses (3/41, 7.3%) were obtained during reanalysis. Notably, half of the diagnosed cases were from the group exhibiting only skin edema and increased NT and/or cystic hygroma. The diagnostic rate in this group was 42.8% (6/14), while in the classically defined NIHF group, the rate was 15.4% (6/39). The pregnancy termination and live birth rates of the cases with positive genetic testing results were found to be statistically significantly different from those with negative results (91.7% vs. 53.6% and 8.3% vs. 36.6%, P < 0.05 for both).</p><p><strong>Conclusion: </strong>ES provides high incremental diagnostic yield for NIHF after standard-of-care testing, and reevaluating non-diagnostic exomes in light of updated knowledge can maximize diagnostic yield. Identifying the etiology of NIHF facilitates prenatal diagnosis, improves the management of NIHF cases and predicts recurrence risk in future pregnancies.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":"87-96"},"PeriodicalIF":7.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}