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QJM: An International Journal of Medicine最新文献

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Spider Fingers in Marfan's Syndrome. 马凡氏综合症中的蜘蛛指。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-08-05 DOI: 10.1093/qjmed/hcaf179
Samuel Chin Wei Tan, Zhao-Wei Yin, Yun-Tao Zhao
{"title":"Spider Fingers in Marfan's Syndrome.","authors":"Samuel Chin Wei Tan, Zhao-Wei Yin, Yun-Tao Zhao","doi":"10.1093/qjmed/hcaf179","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf179","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Donor-Derived Atherosclerosis. Donor-Derived动脉粥样硬化。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-08-05 DOI: 10.1093/qjmed/hcaf178
Junyan Zhang, Zhongxiu Chen, Yong He, Minggang Zhou
{"title":"Donor-Derived Atherosclerosis.","authors":"Junyan Zhang, Zhongxiu Chen, Yong He, Minggang Zhou","doi":"10.1093/qjmed/hcaf178","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf178","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence-the death of hypothesis-led research? 人工智能——假设主导研究的死亡？
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-08-01 DOI: 10.1093/qjmed/hcaf174
Stuart D Rosen, Karl J Friston
{"title":"Artificial intelligence-the death of hypothesis-led research?","authors":"Stuart D Rosen, Karl J Friston","doi":"10.1093/qjmed/hcaf174","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf174","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ramsay Hunt Syndrome. 拉姆齐·亨特综合症。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-08-01 DOI: 10.1093/qjmed/hcaf173
Yoshitaka Tomoda, Yuichiro Shimoyama
{"title":"Ramsay Hunt Syndrome.","authors":"Yoshitaka Tomoda, Yuichiro Shimoyama","doi":"10.1093/qjmed/hcaf173","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf173","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated Mycobacterium chelonae infection Predominantly Involving the Facial Region of an Immunocompromised Elderly Patient. 弥散性龟分枝杆菌感染主要累及面部免疫功能低下的老年患者。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-08-01 DOI: 10.1093/qjmed/hcaf176
Yosuke Sazumi, Hideharu Hagiya, Shinnosuke Fukushima, Jumpei Uchiyama, Poowadon Muenraya, Satoru Sugihara, Yoshio Kawakami, Shin Morizane, Kohei Oguni, Fumio Otsuka
{"title":"Disseminated Mycobacterium chelonae infection Predominantly Involving the Facial Region of an Immunocompromised Elderly Patient.","authors":"Yosuke Sazumi, Hideharu Hagiya, Shinnosuke Fukushima, Jumpei Uchiyama, Poowadon Muenraya, Satoru Sugihara, Yoshio Kawakami, Shin Morizane, Kohei Oguni, Fumio Otsuka","doi":"10.1093/qjmed/hcaf176","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf176","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stocker's Line. 储料器的路线。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-08-01 DOI: 10.1093/qjmed/hcaf177
Shagun Korla, G C Rajput
{"title":"Stocker's Line.","authors":"Shagun Korla, G C Rajput","doi":"10.1093/qjmed/hcaf177","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf177","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Value of First-Degree Atrioventricular Block in Aortic Valve Endocarditis. 一级房室传导阻滞对主动脉瓣心内膜炎的预后价值。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-07-31 DOI: 10.1093/qjmed/hcaf175
Samuel Chin Wei Tan, Zhao-Wei Yin, Yun-Tao Zhao
{"title":"Prognostic Value of First-Degree Atrioventricular Block in Aortic Valve Endocarditis.","authors":"Samuel Chin Wei Tan, Zhao-Wei Yin, Yun-Tao Zhao","doi":"10.1093/qjmed/hcaf175","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf175","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paradoxical Hemoglobin Drop Post-Transfusion: Hyperhemolysis in Delta-Beta Thalassemia with Macrophage Activation Syndrome. 输血后反常的血红蛋白下降：伴有巨噬细胞激活综合征的地中海贫血的高溶血。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-07-31 DOI: 10.1093/qjmed/hcaf168
Sandeep Rao Kordcal, Sarthak Kain, Amandeep Singh, Manish Soneja, Naval K Vikram, Hem Pandey, Tulika Seth
{"title":"Paradoxical Hemoglobin Drop Post-Transfusion: Hyperhemolysis in Delta-Beta Thalassemia with Macrophage Activation Syndrome.","authors":"Sandeep Rao Kordcal, Sarthak Kain, Amandeep Singh, Manish Soneja, Naval K Vikram, Hem Pandey, Tulika Seth","doi":"10.1093/qjmed/hcaf168","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf168","url":null,"abstract":"<p><p>Hyperhaemolysis syndrome (HHS) is a rare, severe complication of transfusion characterised by a paradoxical drop in haemoglobin (Hb) levels post-transfusion, often below pre-transfusion values. Most reported cases are in patients with sickle cell disease and it has been rarely reported in other haemoglobinopathies. We report a case of HHS in a newly diagnosed delta-beta thalassaemia patient, manifesting as macrophage activation syndrome (MAS), successfully managed with intravenous immunoglobulin (IVIG), corticosteroids, rituximab, and erythropoietin. A 19-year-old female presented with fever, jaundice, and hepatosplenomegaly three weeks after a blood transfusion. Investigations revealed microcytic anaemia, elevated LDH and indirect bilirubin, and HPLC findings suggestive of delta-beta thalassaemia. She developed haemolysis and a paradoxical Hb drop after subsequent transfusions, along with reticulocytopenia. Alloimmunisation was initially absent but anti-E and anti-K antibodies were subsequently detected. Despite antigen-matched transfusions, haemolysis persisted, raising suspicion for HHS. She was managed with IVIG, methylprednisolone, erythropoietin, and rituximab, resulting in initial improvement in haemoglobin levels, which subsequently declined again. She then developed fever and leukocytosis without evidence of infection, and a high HScore raised suspicion for macrophage activation syndrome (MAS). Dexamethasone was initiated, leading to defervescence, normalisation of the reticulocyte count, and a significant rise in haemoglobin. She was discharged in stable condition and remained well at 6-month follow-up. This case highlights hyperhaemolysis syndrome (HHS) as a potential complication in patients with haemoglobinopathies. Although its exact pathogenesis remains unclear, macrophage activation appears to play an important role. Early recognition and timely initiation of appropriate immunotherapy can lead to favourable outcomes.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Necrolytic Migratory Erythema with Neuroendocrine Tumors. 坏死性迁移性红斑伴神经内分泌肿瘤。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-07-30 DOI: 10.1093/qjmed/hcaf172
Jiayi Sun, Xiuzu Song
{"title":"Necrolytic Migratory Erythema with Neuroendocrine Tumors.","authors":"Jiayi Sun, Xiuzu Song","doi":"10.1093/qjmed/hcaf172","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf172","url":null,"abstract":"<p><p>A 31-year-old woman with a benign medical history presented with a beefy tongue and an erythematous rash. Evaluation revealed elevated urine glucose levels and the presence of a neuroendocrine tumor. A diagnosis of necrolytic migratory erythema associated with a neuroendocrine tumor was made.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal Tuberculosis Following Intravesical Bacillus Calmette-Guérin Therapy. 膀胱内卡介苗-谷氨酰胺治疗后的肾结核。
IF 6.4 4区 医学
QJM: An International Journal of Medicine Pub Date : 2025-07-28 DOI: 10.1093/qjmed/hcaf169
Kohei Oguni, Hideharu Hagiya, Fumio Otsuka
{"title":"Renal Tuberculosis Following Intravesical Bacillus Calmette-Guérin Therapy.","authors":"Kohei Oguni, Hideharu Hagiya, Fumio Otsuka","doi":"10.1093/qjmed/hcaf169","DOIUrl":"https://doi.org/10.1093/qjmed/hcaf169","url":null,"abstract":"","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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