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Lamin C conserves DNA replication factors via phase separation during oxidative stress for DNA replication recovery. 层粘连蛋白C在氧化应激过程中通过相分离保护DNA复制因子，促进DNA复制恢复。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-11 DOI: 10.1093/procel/pwaf016
Mingkang Jia, Gan Zhao, Mengjie Sun, Xiangyang Wang, He Ren, Guangwei Xin, Qing Jiang, Chuanmao Zhang
{"title":"Lamin C conserves DNA replication factors via phase separation during oxidative stress for DNA replication recovery.","authors":"Mingkang Jia, Gan Zhao, Mengjie Sun, Xiangyang Wang, He Ren, Guangwei Xin, Qing Jiang, Chuanmao Zhang","doi":"10.1093/procel/pwaf016","DOIUrl":"https://doi.org/10.1093/procel/pwaf016","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal characterization of disease-associated neurons in the entorhinal cortex-hippocampal circuit during AD progression. 阿尔茨海默病进展期间内嗅皮层-海马回路中疾病相关神经元的时空特征
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-10 DOI: 10.1093/procel/pwaf042
Yuting Ma, Juan Zhang, Hankui Liu, Dingfeng Li, Sicheng Guo, Jialuo Han, Lei Wang, Shaojun Yu, Xi Su, Yongchang Gao, Xiumei Lin, A San, Yushan Peng, Guibo Li, Hui Jiang, Wei Wang, Huanming Yang, Jian Wang, Shida Zhu, Lijian Zhao, Jianguo Zhang, Qiang Liu
{"title":"Spatiotemporal characterization of disease-associated neurons in the entorhinal cortex-hippocampal circuit during AD progression.","authors":"Yuting Ma, Juan Zhang, Hankui Liu, Dingfeng Li, Sicheng Guo, Jialuo Han, Lei Wang, Shaojun Yu, Xi Su, Yongchang Gao, Xiumei Lin, A San, Yushan Peng, Guibo Li, Hui Jiang, Wei Wang, Huanming Yang, Jian Wang, Shida Zhu, Lijian Zhao, Jianguo Zhang, Qiang Liu","doi":"10.1093/procel/pwaf042","DOIUrl":"https://doi.org/10.1093/procel/pwaf042","url":null,"abstract":"<p><p>The entorhinal cortex (EC)-hippocampal (HPC) circuit is particularly vulnerable to Alzheimer's disease (AD) pathology, yet the underlying molecular mechanisms remain unclear. By employing the high-depth sequencing strategy Smart-seq2, we tracked gene expression changes across various neuron types within this circuit at different stages of AD pathology. We observed a decrease in the extent of gene expression changes in AD versus wild-type (WT) mice as the disease advanced. Functionally, we demonstrate that both mitochondrial and ribosomal pathways were increasingly activated, while neuronal pathways were inhibited with AD progression. Our findings indicate that the reduction of EC-stellate cells disrupts Meg3-mediated energy metabolism, contributing to energy dysfunction in AD. Additionally, we identified GFAP-positive neurons as a distinct population of disease-associated neurons, exhibiting a loss of neuronal-like characteristics, alongside the emergence of glia- and stem-like features. The number of GFAP-positive neurons increased with AD progression, a trend consistently observed in both AD model mice and AD patients. In summary, this study identifies and characterizes GFAP-positive neurons as a novel subtype of disease-associated neurons in AD pathology, providing insights into their potential role in disease progression.</p>","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins. 修正：工程细胞外囊泡能够高效地递送细胞内治疗蛋白。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-06 DOI: 10.1093/procel/pwaf037
{"title":"Correction to: Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins.","authors":"","doi":"10.1093/procel/pwaf037","DOIUrl":"https://doi.org/10.1093/procel/pwaf037","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer. 甲基巴多洛酮通过靶向hZnT1阻断Zn2+的外排，抑制宫颈癌的增殖转移。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-05 DOI: 10.1093/procel/pwaf044
Yaxin Wang, Qinqin Liang, Shengjian Liang, Yuanyue Shan, Sai Shi, Xiaoyu Zhou, Ziyu Wang, Zhili Xu, Duanqing Pei, Mingfeng Zhang, Zhiyong Lou, Binghong Xu, Sheng Ye
{"title":"Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer.","authors":"Yaxin Wang, Qinqin Liang, Shengjian Liang, Yuanyue Shan, Sai Shi, Xiaoyu Zhou, Ziyu Wang, Zhili Xu, Duanqing Pei, Mingfeng Zhang, Zhiyong Lou, Binghong Xu, Sheng Ye","doi":"10.1093/procel/pwaf044","DOIUrl":"https://doi.org/10.1093/procel/pwaf044","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure, identification and characterization of the RibD-enolase complex in Francisella. 弗朗西斯菌ribd -烯醇化酶复合物的结构、鉴定和表征。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-05 DOI: 10.1093/procel/pwaf045
Xiaoyu Liu, Daniel L Clemens, Bai-Yu Lee, Roman Aguirre, Marcus A Horwitz, Z Hong Zhou
{"title":"Structure, identification and characterization of the RibD-enolase complex in Francisella.","authors":"Xiaoyu Liu, Daniel L Clemens, Bai-Yu Lee, Roman Aguirre, Marcus A Horwitz, Z Hong Zhou","doi":"10.1093/procel/pwaf045","DOIUrl":"10.1093/procel/pwaf045","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer. 更正：全基因组CRISPR筛选鉴定了肝癌中DOCK1抑制和二甲双胍之间的合成致死性。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-04 DOI: 10.1093/procel/pwaf036
{"title":"Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer.","authors":"","doi":"10.1093/procel/pwaf036","DOIUrl":"https://doi.org/10.1093/procel/pwaf036","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in gene and cellular therapeutic approaches for Huntington's disease. 亨廷顿氏症基因和细胞治疗方法的进展。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-28 DOI: 10.1093/procel/pwae042
Xuejiao Piao, Dan Li, Hui Liu, Qing Guo, Yang Yu
{"title":"Advances in gene and cellular therapeutic approaches for Huntington's disease.","authors":"Xuejiao Piao, Dan Li, Hui Liu, Qing Guo, Yang Yu","doi":"10.1093/procel/pwae042","DOIUrl":"10.1093/procel/pwae042","url":null,"abstract":"<p><p>Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG trinucleotide repeats in the Huntingtin gene (HTT) located on chromosome 4. It is transmitted in an autosomal dominant manner and is characterized by motor dysfunction, cognitive decline, and emotional disturbances. To date, there are no curative treatments for HD have been developed; current therapeutic approaches focus on symptom relief and comprehensive care through coordinated pharmacological and nonpharmacological methods to manage the diverse phenotypes of the disease. International clinical guidelines for the treatment of HD are continually being revised in an effort to enhance care within a multidisciplinary framework. Additionally, innovative gene and cell therapy strategies are being actively researched and developed to address the complexities of the disorder and improve treatment outcomes. This review endeavours to elucidate the current and emerging gene and cell therapy strategies for HD, offering a detailed insight into the complexities of the disorder and looking forward to future treatment paradigms. Considering the complexity of the underlying mechanisms driving HD, a synergistic treatment strategy that integrates various factors-such as distinct cell types, epigenetic patterns, genetic components, and methods to improve the cerebral microenvironment-may significantly enhance therapeutic outcomes. In the future, we eagerly anticipate ongoing innovations in interdisciplinary research that will bring profound advancements and refinements in the treatment of HD.</p>","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":"307-337"},"PeriodicalIF":13.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov-Arnold network and data augmentation. MultiKano：基于Kolmogorov-Arnold网络和数据增强的单细胞多组学数据的自动细胞类型标注工具。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-28 DOI: 10.1093/procel/pwae069
Siyu Li, Xinhao Zhuang, Songbo Jia, Songming Tang, Liming Yan, Heyang Hua, Yuhang Jia, Xuelin Zhang, Yan Zhang, Qingzhu Yang, Shengquan Chen
{"title":"MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov-Arnold network and data augmentation.","authors":"Siyu Li, Xinhao Zhuang, Songbo Jia, Songming Tang, Liming Yan, Heyang Hua, Yuhang Jia, Xuelin Zhang, Yan Zhang, Qingzhu Yang, Shengquan Chen","doi":"10.1093/procel/pwae069","DOIUrl":"10.1093/procel/pwae069","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":"374-380"},"PeriodicalIF":13.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1. 趋化素受体CMKLR1和GPR1的独特配体识别和信号传导的结构见解。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-28 DOI: 10.1093/procel/pwae073
Xiaowen Lin, Lechen Zhao, Heng Cai, Xiaohua Chang, Yuxuan Tang, Tianyu Luo, Mengdan Wu, Cuiying Yi, Limin Ma, Xiaojing Chu, Shuo Han, Qiang Zhao, Beili Wu, Maozhou He, Ya Zhu
{"title":"Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1.","authors":"Xiaowen Lin, Lechen Zhao, Heng Cai, Xiaohua Chang, Yuxuan Tang, Tianyu Luo, Mengdan Wu, Cuiying Yi, Limin Ma, Xiaojing Chu, Shuo Han, Qiang Zhao, Beili Wu, Maozhou He, Ya Zhu","doi":"10.1093/procel/pwae073","DOIUrl":"10.1093/procel/pwae073","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":"381-385"},"PeriodicalIF":13.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Advances in gene and cellular therapeutic approaches for Huntington's disease. 更正：亨廷顿氏病基因和细胞治疗方法的进展。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-28 DOI: 10.1093/procel/pwaf005
{"title":"Correction to: Advances in gene and cellular therapeutic approaches for Huntington's disease.","authors":"","doi":"10.1093/procel/pwaf005","DOIUrl":"10.1093/procel/pwaf005","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":"386"},"PeriodicalIF":13.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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