Protein & Cell最新文献

MANF is essential for astrocyte survival in the monkey brain. MANF对猴子大脑中星形胶质细胞的存活至关重要。

IF 12.8 1区生物学

Protein & Cell Pub Date : 2026-05-03 DOI: 10.1093/procel/pwag031

Tingting Xing, Laiqiang Chen, Xuezhi Duan, Yiran Zhang, Yiyang Qin, Jinpan Lin, Eshu Ruan, Tingting Guo, Changcheng Ye, Jiating He, Suien Xie, Jiawei Zhang, Xichen Song, Wei Huang, Bang Li, Weili Yang, Shihua Li, Xiao-Jiang Li, Su Yang

引用次数: 0

Human embryo editing: Ten years of breakthroughs and challenges. 人类胚胎编辑：十年的突破与挑战。

IF 12.8 1区生物学

Protein & Cell Pub Date : 2026-05-03 DOI: 10.1093/procel/pwag030

Yitong Zhou, Dongchun Xie, Chenhui Ding, Wenlian Wu, Tianqi Cao, Qianyi Liu, David L Keefe, Canquan Zhou, Junjiu Huang

引用次数: 0

Plasma proteomic signatures of childhood adversity. 童年逆境的血浆蛋白质组学特征。

IF 21.1 1区生物学

Protein & Cell Pub Date : 2026-04-22 DOI: 10.1093/procel/pwag028

Jiening Yu,Duoduo Fu,Xucheng Wu,Weijing Gao,Hongwei Chen,Xueqing Jia,Fan Pu,Yanjie Zhao,Kaili Sun,Liming Zhang,Wen Wang,Huiqian Huang,Anna Dearman,Zuyun Liu

引用次数: 0

Next-generation skin wound healing related disease models with integration of immune cells. 结合免疫细胞的新一代皮肤创面愈合相关疾病模型。

IF 21.1 1区生物学

Protein & Cell Pub Date : 2026-04-08 DOI: 10.1093/procel/pwag013

Yutong Yuan,Shan Zhu,Yuanbo Liu,Yu Yao,Jing Zhang,Xiaoran Li,Yuan Gao,Zilin Zhang,Boyang Song,Jun Ouyang,Juan Zhang,Qiwei L,Zaozao Chen,Zhonze Gu,Ningbei Yin,Nuo Si

{"title":"Next-generation skin wound healing related disease models with integration of immune cells.","authors":"Yutong Yuan,Shan Zhu,Yuanbo Liu,Yu Yao,Jing Zhang,Xiaoran Li,Yuan Gao,Zilin Zhang,Boyang Song,Jun Ouyang,Juan Zhang,Qiwei L,Zaozao Chen,Zhonze Gu,Ningbei Yin,Nuo Si","doi":"10.1093/procel/pwag013","DOIUrl":"https://doi.org/10.1093/procel/pwag013","url":null,"abstract":"Impaired wound healing and pathological scarring remain major clinical challenges, with immune cell dysregulation being a key driver of disease progression. Conventional in vitro models fail to recapitulate human immune responses, limiting their translational relevance. In recent years, advances in tissue engineering and microfluidic technologies have driven growing efforts to incorporate immune cells into in vitro models, thereby improving their ability to mimic pathological microenvironments. Among these, organ-on-a-chip technology stands out for its capacity to replicate dynamic perfusion, mechanical stimulation, and multicellular crosstalk-features critical for modeling immune-mediated wound repair. This review systematically summarizes recent progress in immune cell-integrated models of aberrant wound healing, including two-dimensional co-cultures, three-dimensional static cultures, organoid systems, and organ-on-a-chip platforms. We highlight core strategies for immune cell integration and their roles in recapitulating key pathological processes such as inflammation and fibrosis. Despite ongoing challenges in cell source stability, model standardization, and long-term culture viability, emerging strategies (e.g., organ-on-a-chip combined with three-dimensional bioprinting or modular design) offer new opportunities for creating biomimetic, high-throughput platforms for wound research. This review aims to facilitate the adoption of immune-integrated in vitro models in wound healing research, deepen mechanistic understanding of immune-driven pathology, and accelerate the development of precision therapeutics.","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":"18 1","pages":""},"PeriodicalIF":21.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CTCF's loop-independent functions prevail over chromatin looping in the acute degradation system. 在急性降解系统中，CTCF的环无关功能优于染色质环。

IF 12.8 1区生物学

Protein & Cell Pub Date : 2026-04-01 DOI: 10.1093/procel/pwaf087

Gongcheng Hu, Binrui Ji, Jie Zhang, Yanjiang Liu, Yuli Lu, Xiuqin Wang, Huawei Ren, Junzhi Liao, Hongjie Yao

引用次数: 0

rhMG53 induces pharmacological preconditioning by acting as an agonistic ligand of c-met. rhMG53通过作为c-met的激动性配体诱导药理学预处理。

IF 21.1 1区生物学

Protein & Cell Pub Date : 2026-03-31 DOI: 10.1093/procel/pwag022

Shuo Zhang,Xiaohu Zeng,Li Jin,Xie Peng,Yan Zhang,Xinli Hu,Fengxiang Lv,Rui-Ping Xiao

引用次数: 0

Correction to: The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility. 更正：核磷酸肌醇-p53信号体参与细胞运动的调节。

IF 21.1 1区生物学

Protein & Cell Pub Date : 2026-03-27 DOI: 10.1093/procel/pwaf105

引用次数: 0

Patient‑specific profiling of TCR‑T cell efficacy enabled by a rapid and standardized reporter system. 通过快速和标准化的报告系统实现TCR - T细胞疗效的患者特异性分析。

IF 12.8 1区生物学

Protein & Cell Pub Date : 2026-03-26 DOI: 10.1093/procel/pwag027

Li Lu, Mengmeng Wei, Xiangxing Kong, Chenggang Hong, Wenhui Wei, Yulu Chen, Yuxin Zhu, Minghui He, Yushen Lin, Chaoqun Pan, Shuangshuang Liu, Jianqing Yu, Bo Yang, Zhan Zhou, Ji Cao, Wenbin Zhao

引用次数: 0

Organelle-anchored translation factories: the roles of neuronal RBP condensates in organizing local protein synthesis in neurological diseases. 细胞器锚定的翻译工厂：神经系统疾病中神经元RBP凝聚物在组织局部蛋白质合成中的作用

IF 12.8 1区生物学

Protein & Cell Pub Date : 2026-03-25 DOI: 10.1093/procel/pwag026

Semin Park, Hari Lim, Jin-A Lee

{"title":"Organelle-anchored translation factories: the roles of neuronal RBP condensates in organizing local protein synthesis in neurological diseases.","authors":"Semin Park, Hari Lim, Jin-A Lee","doi":"10.1093/procel/pwag026","DOIUrl":"https://doi.org/10.1093/procel/pwag026","url":null,"abstract":"Neurons face a fundamental proteostasis challenge: synapses and axons located far from the soma must rapidly remodel their proteome during activity, stress, and development. While local protein synthesis has long been recognized as essential for meeting these demands, classical models largely focused on ribonucleoprotein (RNP) granules as autonomous carriers of translationally silent mRNAs, treating membranous organelles as parallel logistics or metabolic systems. Recent work overturns this view, revealing that endosomes, lysosomes, axonal endoplasmic reticulum, mitochondria, and their contact sites actively function as mobile translation platforms. In this review, we propose an RBP-centered framework in which phase-separated condensates physically tether specific mRNA cohorts to organelle surfaces, coupling mRNA transport, translational control, and organelle dynamics into a unified network. By organizing recent discoveries into functional modules-long-range transport, localized translation, and stress buffering-this neuron-focused framework identifies organelle-anchored translation factories as a unifying principle of synaptic proteostasis and a broadly applicable design paradigm for highly polarized cells.","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA-triggered AIM2 condensation orchestrates immune activation and regulation. dna触发的AIM2缩合协调免疫激活和调节。

IF 12.8 1区生物学

Protein & Cell Pub Date : 2026-03-25 DOI: 10.1093/procel/pwag024

Quanjin Li, Xiaohan Geng, Huiwen Yan, Zhaolong Li, Miao Shi, Ziqi Zhu, Tongxin Niu, Chunqiu Zhao, Kaile Shu, Yina Gao, Han Feng, Songqing Liu, Qiuyao Jiang, Pengcheng Bu, Dong Li, Pu Gao

{"title":"DNA-triggered AIM2 condensation orchestrates immune activation and regulation.","authors":"Quanjin Li, Xiaohan Geng, Huiwen Yan, Zhaolong Li, Miao Shi, Ziqi Zhu, Tongxin Niu, Chunqiu Zhao, Kaile Shu, Yina Gao, Han Feng, Songqing Liu, Qiuyao Jiang, Pengcheng Bu, Dong Li, Pu Gao","doi":"10.1093/procel/pwag024","DOIUrl":"https://doi.org/10.1093/procel/pwag024","url":null,"abstract":"The innate immune sensor AIM2 detects cytosolic DNA and initiates inflammatory responses, yet its activation mechanism remains incompletely understood. Here, we show that AIM2 undergoes liquid-liquid phase separation upon DNA binding, forming dynamic condensates both in vitro and in cells. These condensates serve as platforms for inflammasome and PANoptosome assembly, promoting immune activation across multiple pathways. Direct structural determination from condensates reveals the assembly of active-form ASC filaments. Mechanistically, liquid-phase condensation is governed by multivalent interactions involving different AIM2 domains, including previously uncharacterized regions and species-specific elements. In vitro and in vivo assays show that mutants specifically disrupting condensation impair immune complex assembly, cell death initiation, antimicrobial defense, and intestinal homeostasis. Moreover, AIM2-DNA condensates function as regulatory hubs targeted by host- and pathogen-derived factors to balance immune homeostasis or facilitate immune evasion. These findings establish liquid-phase condensation as a fundamental mechanism of AIM2 activation and a potential therapeutic target.","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0