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Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer. 甲基巴多洛酮通过靶向hZnT1阻断Zn2+的外排，抑制宫颈癌的增殖转移。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-05 DOI: 10.1093/procel/pwaf044
Yaxin Wang, Qinqin Liang, Shengjian Liang, Yuanyue Shan, Sai Shi, Xiaoyu Zhou, Ziyu Wang, Zhili Xu, Duanqing Pei, Mingfeng Zhang, Zhiyong Lou, Binghong Xu, Sheng Ye
{"title":"Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer.","authors":"Yaxin Wang, Qinqin Liang, Shengjian Liang, Yuanyue Shan, Sai Shi, Xiaoyu Zhou, Ziyu Wang, Zhili Xu, Duanqing Pei, Mingfeng Zhang, Zhiyong Lou, Binghong Xu, Sheng Ye","doi":"10.1093/procel/pwaf044","DOIUrl":"https://doi.org/10.1093/procel/pwaf044","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure, identification and characterization of the RibD-enolase complex in Francisella. 弗朗西斯菌ribd -烯醇化酶复合物的结构、鉴定和表征。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-05 DOI: 10.1093/procel/pwaf045
Xiaoyu Liu, Daniel L Clemens, Bai-Yu Lee, Roman Aguirre, Marcus A Horwitz, Z Hong Zhou
{"title":"Structure, identification and characterization of the RibD-enolase complex in Francisella.","authors":"Xiaoyu Liu, Daniel L Clemens, Bai-Yu Lee, Roman Aguirre, Marcus A Horwitz, Z Hong Zhou","doi":"10.1093/procel/pwaf045","DOIUrl":"10.1093/procel/pwaf045","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer. 更正：全基因组CRISPR筛选鉴定了肝癌中DOCK1抑制和二甲双胍之间的合成致死性。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-06-04 DOI: 10.1093/procel/pwaf036
{"title":"Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer.","authors":"","doi":"10.1093/procel/pwaf036","DOIUrl":"https://doi.org/10.1093/procel/pwaf036","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in gene and cellular therapeutic approaches for Huntington's disease. 亨廷顿氏症基因和细胞治疗方法的进展。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-28 DOI: 10.1093/procel/pwae042
Xuejiao Piao, Dan Li, Hui Liu, Qing Guo, Yang Yu
{"title":"Advances in gene and cellular therapeutic approaches for Huntington's disease.","authors":"Xuejiao Piao, Dan Li, Hui Liu, Qing Guo, Yang Yu","doi":"10.1093/procel/pwae042","DOIUrl":"10.1093/procel/pwae042","url":null,"abstract":"<p><p>Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG trinucleotide repeats in the Huntingtin gene (HTT) located on chromosome 4. It is transmitted in an autosomal dominant manner and is characterized by motor dysfunction, cognitive decline, and emotional disturbances. To date, there are no curative treatments for HD have been developed; current therapeutic approaches focus on symptom relief and comprehensive care through coordinated pharmacological and nonpharmacological methods to manage the diverse phenotypes of the disease. International clinical guidelines for the treatment of HD are continually being revised in an effort to enhance care within a multidisciplinary framework. Additionally, innovative gene and cell therapy strategies are being actively researched and developed to address the complexities of the disorder and improve treatment outcomes. This review endeavours to elucidate the current and emerging gene and cell therapy strategies for HD, offering a detailed insight into the complexities of the disorder and looking forward to future treatment paradigms. Considering the complexity of the underlying mechanisms driving HD, a synergistic treatment strategy that integrates various factors-such as distinct cell types, epigenetic patterns, genetic components, and methods to improve the cerebral microenvironment-may significantly enhance therapeutic outcomes. In the future, we eagerly anticipate ongoing innovations in interdisciplinary research that will bring profound advancements and refinements in the treatment of HD.</p>","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":"307-337"},"PeriodicalIF":13.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov-Arnold network and data augmentation. MultiKano：基于Kolmogorov-Arnold网络和数据增强的单细胞多组学数据的自动细胞类型标注工具。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-28 DOI: 10.1093/procel/pwae069
Siyu Li, Xinhao Zhuang, Songbo Jia, Songming Tang, Liming Yan, Heyang Hua, Yuhang Jia, Xuelin Zhang, Yan Zhang, Qingzhu Yang, Shengquan Chen
{"title":"MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov-Arnold network and data augmentation.","authors":"Siyu Li, Xinhao Zhuang, Songbo Jia, Songming Tang, Liming Yan, Heyang Hua, Yuhang Jia, Xuelin Zhang, Yan Zhang, Qingzhu Yang, Shengquan Chen","doi":"10.1093/procel/pwae069","DOIUrl":"10.1093/procel/pwae069","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":"374-380"},"PeriodicalIF":13.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1. 趋化素受体CMKLR1和GPR1的独特配体识别和信号传导的结构见解。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-28 DOI: 10.1093/procel/pwae073
Xiaowen Lin, Lechen Zhao, Heng Cai, Xiaohua Chang, Yuxuan Tang, Tianyu Luo, Mengdan Wu, Cuiying Yi, Limin Ma, Xiaojing Chu, Shuo Han, Qiang Zhao, Beili Wu, Maozhou He, Ya Zhu
{"title":"Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1.","authors":"Xiaowen Lin, Lechen Zhao, Heng Cai, Xiaohua Chang, Yuxuan Tang, Tianyu Luo, Mengdan Wu, Cuiying Yi, Limin Ma, Xiaojing Chu, Shuo Han, Qiang Zhao, Beili Wu, Maozhou He, Ya Zhu","doi":"10.1093/procel/pwae073","DOIUrl":"10.1093/procel/pwae073","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":"381-385"},"PeriodicalIF":13.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Advances in gene and cellular therapeutic approaches for Huntington's disease. 更正：亨廷顿氏病基因和细胞治疗方法的进展。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-28 DOI: 10.1093/procel/pwaf005
{"title":"Correction to: Advances in gene and cellular therapeutic approaches for Huntington's disease.","authors":"","doi":"10.1093/procel/pwaf005","DOIUrl":"10.1093/procel/pwaf005","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":"386"},"PeriodicalIF":13.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic implications of synonymous gene recoding: Insights into mechanisms controlling protein biogenesis and activity. 同义基因重新编码的治疗意义：洞察控制蛋白质生物发生和活性的机制。
IF 21.1 1区 生物学
Protein & Cell Pub Date : 2025-05-25 DOI: 10.1093/procel/pwaf028
Brian C Lin,Katarzyna I Jankowska,Upendra K Katneni,Randilu Amarasinghe,Nigam Padhiar,Nobuko Hamasaki-Katagiri,Wells W Wu,Haojie Zhu,Hideki Taguchi,Arnab Ghosh,David D Holcomb,Je-Nie Phue,Sarah E Fumagalli,Darón I Freedberg,Ofer Kimchi,Rong-Fong Shen,Anton A Komar,Zuben E Sauna,Chava Kimchi-Sarfaty
{"title":"Therapeutic implications of synonymous gene recoding: Insights into mechanisms controlling protein biogenesis and activity.","authors":"Brian C Lin,Katarzyna I Jankowska,Upendra K Katneni,Randilu Amarasinghe,Nigam Padhiar,Nobuko Hamasaki-Katagiri,Wells W Wu,Haojie Zhu,Hideki Taguchi,Arnab Ghosh,David D Holcomb,Je-Nie Phue,Sarah E Fumagalli,Darón I Freedberg,Ofer Kimchi,Rong-Fong Shen,Anton A Komar,Zuben E Sauna,Chava Kimchi-Sarfaty","doi":"10.1093/procel/pwaf028","DOIUrl":"https://doi.org/10.1093/procel/pwaf028","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":"16 1","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility. 核磷酸肌醇-p53信号体在细胞运动调节中的作用。
IF 21.1 1区 生物学
Protein & Cell Pub Date : 2025-05-22 DOI: 10.1093/procel/pwaf043
Xiaoting Hou,Yu Chen,Bo Zhou,Fengting Liu,Lingyun Dai,Chunbo Chen,Noah D Carrillo,Vincent L Cryns,Richard A Anderson,Jichao Sun,Mo Chen
{"title":"The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility.","authors":"Xiaoting Hou,Yu Chen,Bo Zhou,Fengting Liu,Lingyun Dai,Chunbo Chen,Noah D Carrillo,Vincent L Cryns,Richard A Anderson,Jichao Sun,Mo Chen","doi":"10.1093/procel/pwaf043","DOIUrl":"https://doi.org/10.1093/procel/pwaf043","url":null,"abstract":"Dysregulation of p53 and phosphoinositide (PIPn) signaling are both key drivers of oncogenesis and metastasis. Our recent findings reveal a previously unrecognized interaction between these pathways, converging in the nucleus to form a PIPn-p53 signalosome that modulates nuclear AKT activation and downstream signaling, thereby influencing cancer cell survival and motility. This review examines recent insights into nuclear PIPn signaling in the context of established roles for p53 in cell dynamics and migration while also deliberating current research on how nuclear PIPns interact with p53 to form signalosomes that affect cell motility. We emphasize the critical role of PIPns in stabilizing p53 and activating de novo nuclear AKT signaling, which subsequently modulates key motility-related pathways. Understanding the unique operation and function of the PIPn-p53 signalosome in nuclear phosphatidylinositol 3-kinase (PI3K)-AKT activation offers novel therapeutic strategies for controlling cancer metastasis by targeting pertinent interactions and events.","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":"31 1","pages":""},"PeriodicalIF":21.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. 校正：SIRT7作为异染色质稳定剂拮抗人类干细胞衰老。
IF 13.6 1区 生物学
Protein & Cell Pub Date : 2025-05-20 DOI: 10.1093/procel/pwaf031
{"title":"Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer.","authors":"","doi":"10.1093/procel/pwaf031","DOIUrl":"https://doi.org/10.1093/procel/pwaf031","url":null,"abstract":"","PeriodicalId":20790,"journal":{"name":"Protein & Cell","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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