Psychiatria Danubina最新文献

{"title":"THE CLINICAL NOTION OF RESTLESSNESS AS A LINCHPIN FOR A FULL UNDERSTANDING OF THE BIPOLAR SPECTRUM.","authors":"Giuseppe Tavormina, Francesco Franza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Restlessness is the essence of the thymic disease of those who present a \"mixed picture\" in the bipolar spectrum of any form. Depressive suffering, always significant for the patient, never presents itself alone, but is always accompanied by a constant state of internal anxiety, restlessness with internal and muscular tension, depressive-irritable or depressive-apathetic-confused state, a sense of existential anguish that sometimes gives no hint of future prospects, and very frequent somatic symptoms associated with mood malaise. All this is summarized in the concept of \"Restlessness\".</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"176-179"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COGNITIVE FUNCTION EVALUATION IN PATIENTS WITH NEWLY DIAGNOSED PAROXYSMAL ATRIAL FIBRILLATION.","authors":"Olga Germanova, Yulia Reshetnikova, Daria Popova, Giuseppe Galati","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>To evaluate cognitive function of patients with newly diagnosed paroxysmal atrial fibrillation.</p><p><strong>Materials and methods: </strong>In a single-center case-control study, we undertook 24 hours ECG monitoring of 6630 patients, among whom 97 showed paroxysmal atrial fibrillation (AF) Fourteen of the AF patients have informed consent to participate in the study. All patients had additional 24 hours ECG monitoring, along with transthoracic echocardiography, volumetric sphygmography, and the Montreal Cognitive Assessment (MoCA) test.</p><p><strong>Results: </strong>The median MoCA score was 24 [22; 26], indicating mild cognitive impairment in nine of the 14 patients (64%, age 67.9 ± 8.6 y.o.). The least severe impairment was in visual-spatial perception (median 4 of 5 possible), and the most severe was in executive-functional skills (median 3 of 5). Despite the high mean arterial stiffness (CAVI > 8), there was no significant correlation with MoCA (rs = -0.256, p = 0.364). However, there was a significant negative Spearman correlation between MoCA and LV myocardial mass index (rs = -0.737, 95% CI [-0.914; -0.323], p = 0.003), indicating an association between declining cognitive function and myocardial structure.</p><p><strong>Conclusions: </strong>In most of the patients with asymptomatic paroxysmal newly revealed AF, we observed mild cognitive impairment. Increased LV-indexed mass was associated with worse cognitive function in these AF patients (rs = -0.737, 95% CI [-0.914; -0.323], p = 0.003). This observation calls for investigation of the causal mechanism whereby myocardial remodeling in AF patients may impair brain function.</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"374-378"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SUSTAINED COGNITIVE DECLINE IN MULTIPLE SCLEROSIS: INVESTIGATING THE ROLE OF WHITE MATTER LESION LOAD USING AN AI-DRIVEN BRAIN IMAGING APPROACH.","authors":"Vito Tota, Astrid Mehuys, Tanguy Vansnick, Otmane Amel, Fatma Chahbar, Lamia Mahmoudi, Sidi Ahmed Mahmoudi, Giovanni Briganti, Laurence Ris, Said Mahmoudi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system, where cognitive impairment can occur even without physical disability. The underlying mechanisms remain poorly understood. This study investigates the role of white matter lesion load (WMLL) in sustained cognitive decline (SCD) in a real-life MS cohort, using an artificial intelligence(AI)-based brain imaging approach.</p><p><strong>Methods: </strong>Patients from the CHU Helora MS database with ≥3 SDMT assessments and serial brain MRIs were included. SCD was defined as a ≥4-point or ≥10% SDMT drop, confirmed 6 months later. Patients were stratified into two groups: those with SCD (COG) and those without (N-COG). WMLL was measured using a AI-based model that provides segmentation masks. Lesion volume was calculated by multiplying segmented voxels by voxel size.</p><p><strong>Results: </strong>Of 109 eligible patients, 43 met inclusion criteria. Seven showed SCD; 36 did not. Imaging data were available for 5 COG and 21 N-COG patients. There was no significant difference in WMLL or its progression between patients with and without SCD. Fewer than half of the patients in the COG group showed an increase in WMLL over time, and those who did were older than the group average. WMLL changes were not a reliable marker of SCD. Consistent with previous findings, the COG group included more males, and disease control appeared more challenging. Vascular pathology may be misclassified by segmentation algorithms, which partially explain why the two patients with WMLL progression were older. Gray matter was not assessed, though it may play a key role in this phenomenon.</p><p><strong>Conclusion: </strong>SCD did not consistently correlate with WMLL progression. Affected patients were predominantly male, consistent with a more aggressive disease course. WMLL may also be influenced by age-related factors. Alternative imaging biomarkers are needed to explain SCD in MS.</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"321-329"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CULTURA ANIMI, HUMAN RIGHTS AND MENTAL HEALTH: A HUMANISTIC SYNTHESIS.","authors":"Miro Jakovljević","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper describes the multifaceted realm of culture of mind, human rights and mental health and essential link between them. Culture plays an important part in modulating our personalities and how we view self and world we live in, how we interact with others, and how we understand, define and promote mental health and human rights as well as how we cope with mental illness. The intellectual legacy of Ciceron's concept of cultura animi (culture of mind/soul) is today more relevant than ever. Narcissism, paranoidism, maniaism, depressiveness and nihilism today are more than individual mindsets and behavioral patterns. They are toxic cultural conditions and mindsets, modes of perception and mental orientations in the world, self-perception and interpersonal relationships. Toxic psycho-cultures refer to collective psychological and emotional climates in which harmful values, behaviors, and mental states are normalized, celebrated, or weaponized within a culture - particularly in family, political, institutional, or social environments. These psychocultures lead to alienation from oneself and others, erode mental health, civic trust, ethical norms, and human dignity/rights, often producing long-term damage across all layers of society, from family systems to global politics. Common dynamics of toxic psychocultures involves harmful behavior to be culturally acceptable (normalization), toxic emotions and beliefs spread through media and public discourse (contagion), toxic patterns are embedded in law, education, or policy (institutionalization), critical and holistic thinking and self-awareness are discouraged (suppression of reflection) and complex emotions are replaced by entitlement, admiration, suspiciousness, distrust, rage, cynicism, or numbness (emotional flattening). Empathic culture of mind involving human rights respect provides a powerful transformative vision of mental health promotion, protection and restoration.</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIGITAL INNOVATIONS IN SUICIDE PREVENTION: TOWARD A PARADIGM SHIFT.","authors":"Antonella Litta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Despite the implementation of various suicide prevention strategies - such as means restriction, school-based education and follow-up interventions - their overall effectiveness remains limited, particularly in early detection, continuity of care and user engagement. The rapid advancement of digital technologies presents a unique opportunity to transform suicide prevention by enabling timely, scalable and personalized interventions. This article presents a narrative review of emerging digital solutions for suicide prevention, based on a structured literature search (2015-2025) across PubMed, Medline and Google Scholar. Five main categories of tools were identified: (1) mobile applications, (2) empathic chatbots, (3) machine learning-based risk prediction models, (4) passive sensing combined with ecological momentary assessment (EMA), and (5) simulations and embodied conversational agents (ECAs). These technologies show significant promise in enhancing risk identification, user engagement and continuity of care. Among them, blended care models - integrating digital tools with clinician-delivered interventions - emerge as particularly effective, improving adherence, therapeutic alliance and clinical outcomes. However, challenges remain, including algorithm transparency, user dependency and ethical management of acute crises. This paper advocates for a paradigm shift in suicide prevention: from reactive, episodic approaches to proactive, data-driven and human-centered care pathways. Ensuring safety, equity, and clinical relevance will require co-designed development, rigorous validation and governance frameworks tailored to real-world mental health systems.</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"74-78"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE USE OF ARTIFICIAL INTELLIGENCE IN VISUALISING RECOVERY OF PSYCHIATRIC REHABILITATION PATIENTS: CREATING GRAPHICS AS A THERAPEUTIC TOOL.","authors":"Agata Łosiewicz, Maciej Loska, Barbara Kwaśnica, Anna Kożuch, Krzysztof Krysta","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Many psychiatric patients struggle to visualise their recovery, decreasing treatment motivation. Globally, 280 million people live with depression, 24 million with schizophrenia, and 40 million with bipolar disorder. First-line treatments achieve remission in only 30-45% of depression cases and 20-60% of schizophrenia cases, with full recovery rates at 10-20%. Artificial intelligence (AI) is increasingly applied in psychiatry for psychoeducation, symptom monitoring, and therapy support. GPT-4o is a generative AI tool producing personalised text, speech, and images. No studies have explored its use for creating recovery-focused visuals to motivate psychiatric patients. This study investigated the potential of ChatGPT-generated visuals as potential therapeutic tools.</p><p><strong>Subjects and methods: </strong>Twenty psychiatric outpatients in remission (schizophrenia, affective, developmental disorders) completed a structured questionnaire with demographic and open-ended questions on recovery expectations. Based on responses, AI-generated recovery visuals were created using GPT-4o and presented for evaluation. Attitudes towards AI were assessed before and after. Participants rated how strongly each image reflected their recovery vision and motivational impact (0-4 scale). Data were analysed using descriptive statistics, paired t-tests, Spearman's correlations, and cluster analysis (Excel, Jamovi, Python).</p><p><strong>Results: </strong>Attitudes towards AI improved post-intervention (M=1.70, SD=0.80 vs. M=2.15, SD=0.67). Ratings indicated moderate to strong reflection of personal visions (Graphic 1: M=2.80, SD=1.15; Graphic 2: M=3.25, SD=0.91). No significant differences occurred across demographic groups (p>0.05). A strong positive correlation was found between attitudes towards AI and openness to using AI visuals clinically (ρ=0.65, p=0.002). Cluster analysis identified three profiles: positive adopters (60%), sceptics (25%), and emotionally engaged but technologically sceptical (15%).</p><p><strong>Conclusions: </strong>AI-generated images were well-received, improved attitudes towards AI, and enhanced patient motivation. Integrating generative AI images into psychiatric rehabilitation may support engagement and personalised care.</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"193-200"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE INNER TYRANT AND THE LABYRINTH OF CONTROL: MEANING-MAKING AND IDENTITY CONSTRUCTION IN OBSESSIVE FUNCTIONING.","authors":"Immacolata d'Errico","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper I will bring some reflections from a post-rationalist constructivist phenomenological perspective on the Obsessive-Compulsive-Prone Style of Personality (tOCD), a style that can typically lead to an Obsessive-Compulsive Disorder (OCD), but not exclusively so.</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"184-186"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF EMOTIONS IN THE RELATIONSHIP BETWEEN CHILDHOOD TRAUMAS AND CHRONIC PAIN IN ADULTHOOD: A SCOPING REVIEW.","authors":"Camille Eugénie Dieu, Giovanni Briganti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While the relationship between post-traumatic stress disorder (PTSD) and chronic pain is increasingly highlighted, the link between childhood traumas (CT) and chronic pain in adulthood remains underexplored. Yet, it is well established that early adverse experiences (ACES) are more damaging than those experienced later in life due to ongoing neurological and psychological development. Furthermore, survivors of childhood traumas may develop more complex and multifaceted reactions than those observed in PTSD, potentially leading to Complex PTSD (CPTSD). A scoping review was conducted to explore the association between childhood traumas and chronic pain in adulthood, with a focus on identifying the psychological and biological mechanisms involved. Following PRISMA-ScR guidelines, 20 peer-reviewed articles were selected and thematically analyzed. Inclusion criteria covered empirical studies involving adult populations, published between 2005 and 2025. A strong association was found between cumulative ACEs and chronic pain, which supports the additional impacts of CPTSD compared to PTSD in chronic pain. Only three studies included focused on the specific impact of each CT and showed that emotional neglect and emotional abuse had the most persistent impact. Key mechanisms mainly included central sensitization, emotional dysregulation and affective disorders. Further studies are needed to investigate the differential impact of each childhood trauma type, including emotional neglect and abuse, and various pain conditions. These findings support the hypothesis of a specific emotional pathway from early adversity to pain chronification.</p>","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 Suppl 1","pages":"125-134"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory ratings and sensitivity to perceptual variables: Novel approach to evaluating semantic memory in mild cognitive impairment.","authors":"Dušica Filipović Đurđević, Martina Sekulić Sović, Vlasta Erdeljac, Ninoslav Mimica, Draženka Ostojić, Dubravka Kalinić, Jakša Vukojević, Aleksandar Savić","doi":"10.24869/psyd.2025.180","DOIUrl":"https://doi.org/10.24869/psyd.2025.180","url":null,"abstract":"","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 2","pages":"180-193"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of post-traumatic stress disorder: A case report.","authors":"Nurten Arslan Işık, Ulrike Maria Schneider, Bettina Grager, Jan Di Pauli","doi":"10.24869/psyd.2025.257","DOIUrl":"https://doi.org/10.24869/psyd.2025.257","url":null,"abstract":"","PeriodicalId":20760,"journal":{"name":"Psychiatria Danubina","volume":"37 2","pages":"257-261"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}