Prostaglandins, leukotrienes, and essential fatty acids最新文献

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Failure of non-selective inhibition of arachidonic acid metabolism to ameliorate hyperoxic lung injury. 非选择性抑制花生四烯酸代谢以改善高氧肺损伤的失败。
IF 3 4区 医学
J R Hageman, J Zemaitis, R B Holtzman, S E Lee, L J Smith, C E Hunt
{"title":"Failure of non-selective inhibition of arachidonic acid metabolism to ameliorate hyperoxic lung injury.","authors":"J R Hageman,&nbsp;J Zemaitis,&nbsp;R B Holtzman,&nbsp;S E Lee,&nbsp;L J Smith,&nbsp;C E Hunt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have previously reported that bronchoalveolar lavage fluid cyclo-oxygenase products of arachidonic acid (AA) metabolism increase prior to the development of significant hyperoxic lung injury. To further assess the role of AA metabolites in the development of hyperoxic lung injury, we have utilized this same model of hyperoxic lung injury and administered either indomethacin (an inhibitor of the cyclo-oxygenase pathway of AA metabolism) or dexamethasone (inhibitor of AA release). A total of 46 adult rabbits were exposed to greater than 95% oxygen for 65 hours. Fourteen animals were given either 2 or 3 mg/kg/day indomethacin, 7 served as controls: 18 animals were given either 0.5 or 1.0 mg/kg/day of dexamethasone, 7 served as controls. The surviving animals were sacrificed after 65 hours of hyperoxia and bronchoalveolar lavage of the left lung was done; the right lung was examined by light microscopy. Treatment with indomethacin or dexamethasone failed to ameliorate the hyperoxic lung injury process. However, in both the indomethacin and dexamethasone treatment groups, significant suppression of 6-keto-PGF1 alpha, a PGI2 metabolite, was observed. Some suppression of TXB2 production was observed, but there was no evidence of any decrease in leukotriene production. We postulate that failure to ameliorate hyperoxic lung injury with either indomethacin or dexamethasone therapy was related to significant suppression of PGI2, a potentially protective AA metabolite, and/or to failure to significantly decrease production of potential pathogenic participants, such as TXA2 or LTB4.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"32 3","pages":"145-53"},"PeriodicalIF":3.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14268682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measurement of sulfidopeptide leukotrienes and their metabolism in human synovial fluid of patients with rheumatoid arthritis. 类风湿关节炎患者滑液中硫肽类白三烯的测定及其代谢。
IF 3 4区 医学
Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 1988-06-01 DOI: 10.2492/JSIR1981.6.391
Y. Koshihara, T. Isono, H. Oda, S. Karube, Y. Hayashi
{"title":"Measurement of sulfidopeptide leukotrienes and their metabolism in human synovial fluid of patients with rheumatoid arthritis.","authors":"Y. Koshihara, T. Isono, H. Oda, S. Karube, Y. Hayashi","doi":"10.2492/JSIR1981.6.391","DOIUrl":"https://doi.org/10.2492/JSIR1981.6.391","url":null,"abstract":"Leukotriene (LT)C4 in the synovial fluid of patients with osteoarthritis deformans (OA) and rheumatoid arthritis (RA) was measured by radioimmunoassay (RIA) after extraction with Sep-Pak C18 cartridge. The amounts of immunoreactive LTC4 (i-LTC4) in samples from patients with OA and RA were not significantly different, being 0.198 +/- 0.018 pmol/ml (n = 11) and 0.179 +/- 0.016 pmol/ml (n = 12), respectively. After separation by high performance liquid chromatography (HPLC) and measurement by RIA, the levels of other sulfidopeptide LTs, such as LTD4 and LTE4, in synovial fluid from patients with RA were found to be significantly higher than those in fluid from patients with OA. The leukocyte number in synovial fluids did not correlate with the i-LTC4 level. The metabolic activities of these synovial fluids were determined by incubating them with 3H-LTC4 and then separating sulfidopeptide LTs by HPLC. The conversion of LTC4 to LTD4 in synovial fluids of patients with OA and RA were similar, but the dipeptidase activity converting LTD4 to LTE4 was higher in fluid from patients with RA. It is suggested that a high level of LTE4 may contribute to exudation of synovial fluid, since LTE4 increases vascular permeability.","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"43 1","pages":"113-9"},"PeriodicalIF":3.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74720249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Eicosanoids in the CNS: sources and effects. 中枢神经系统中的类二十烷酸:来源和作用。
IF 3 4区 医学
S Murphy, B Pearce
{"title":"Eicosanoids in the CNS: sources and effects.","authors":"S Murphy,&nbsp;B Pearce","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"31 3","pages":"165-70"},"PeriodicalIF":3.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetes mellitus. 必需脂肪酸在糖尿病性神经病变及其他糖尿病并发症中的作用。
IF 3 4区 医学
D F Horrobin
{"title":"The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetes mellitus.","authors":"D F Horrobin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"31 3","pages":"181-97"},"PeriodicalIF":3.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostanoids in sperm function. 精子功能中的前列腺素。
IF 3 4区 医学
C Gottlieb, M Bygdeman
{"title":"Prostanoids in sperm function.","authors":"C Gottlieb,&nbsp;M Bygdeman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"34 3","pages":"205-14"},"PeriodicalIF":3.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14198072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of eicosanoids in tumor metastasis. 类二十烷酸在肿瘤转移中的作用。
IF 3 4区 医学
A M Fulton
{"title":"The role of eicosanoids in tumor metastasis.","authors":"A M Fulton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"34 3","pages":"229-37"},"PeriodicalIF":3.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14198073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arachidonic acid metabolism by human urothelial cells: implication in aromatic amine-induced bladder cancer. 人尿路上皮细胞花生四烯酸代谢:芳香胺诱导膀胱癌的意义。
IF 3 4区 医学
T V Zenser, B B Davis
{"title":"Arachidonic acid metabolism by human urothelial cells: implication in aromatic amine-induced bladder cancer.","authors":"T V Zenser,&nbsp;B B Davis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"31 3","pages":"199-207"},"PeriodicalIF":3.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14268990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Cyclosporine A nephrotoxicity. The role of thromboxane A2. 回复:环孢素A肾毒性。血栓素A2的作用。
IF 3 4区 医学
A A Grace
{"title":"Re: Cyclosporine A nephrotoxicity. The role of thromboxane A2.","authors":"A A Grace","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"34 3","pages":"239"},"PeriodicalIF":3.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14350922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of eicosanoids in obstetrics, gynaecology and fertility. 类二十烷酸在产科、妇科和生育中的作用。
IF 3 4区 医学
J Y Jeremy, D P Mikhailidis, P Dandona
{"title":"Role of eicosanoids in obstetrics, gynaecology and fertility.","authors":"J Y Jeremy,&nbsp;D P Mikhailidis,&nbsp;P Dandona","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"34 3","pages":"193-5"},"PeriodicalIF":3.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14198070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of prostaglandins in the regulation of cell proliferation. 前列腺素在细胞增殖调控中的作用。
IF 3 4区 医学
R G Wickremasinghe
{"title":"The role of prostaglandins in the regulation of cell proliferation.","authors":"R G Wickremasinghe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"31 3","pages":"171-9"},"PeriodicalIF":3.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14180278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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