Psychiatric Quarterly最新文献

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National Seclusion and Restraint Trends within Child Residential Treatment Facilities: 2010-2020 in Review. 全国儿童住院治疗机构中的隔离和约束趋势:2010-2020 年回顾》(National Seclusion and Restraint Trends within Child Residential Treatment Facilities: 2010-2020 in Review.
IF 4.6 4区 医学
Psychiatric Quarterly Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1007/s11126-024-10098-3
Kathryn T Luk, Nev Jones
{"title":"National Seclusion and Restraint Trends within Child Residential Treatment Facilities: 2010-2020 in Review.","authors":"Kathryn T Luk, Nev Jones","doi":"10.1007/s11126-024-10098-3","DOIUrl":"10.1007/s11126-024-10098-3","url":null,"abstract":"<p><p>This study aimed to estimate the percentage of child RTCs utilizing seclusion and restraint (S/R) practices and examine predictors associated with increased likelihood of S/R use between 2010 and 2020. A secondary analysis of the National Mental Health Services Survey was conducted (n-range = 580-781). Facility-level client demographics and facility characteristics were examined using multi-level logistic regression. One-way ANOVA indicated that the percentage of child RTCs using S/R significantly decreased between 2010 and 2020 [F(4, 58074) = 75.62, p <.001]. A post-hoc Bonferroni test found that the percentage of facilities reporting the use of SR in 2010 was significantly higher than in 2014, 2016, 2018, and 2020 (all p <.001). Multi-level logistic regression analysis found that facility-level client demographics (percent male, white, and involuntarily committed) did not significantly predict facility use of SR in 2010, 2014, or 2016. However, facility-level characteristics of SED program (all p <.01), use of psychotropic medication (all p <.001), and facility size as measured by number of mental health beds (all p <.01) consistently predicted usage of SR in 2010 [F(11) = 68.38, p <.001], 2014 [F(12) = 74.25, p <.001], and 2016 [F(12) = 74.48, p <.001]. Facility ownership and accepting Medicare payments did not significantly predict facility usage of SR. Use of SR within child RTCs significantly declined between 2010 and 2020. Larger facilities, facilities with an SED program, and facilities that used psychotropic medications with clients were more likely to use SR practices between 2010 and 2016. More high-quality, publicly available data for monitoring S/R use in mental health services within the United States is needed.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"681-695"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Effectiveness of a Group CBT-Based Intervention Aiming to Reduce Self-Stigma and Improve Recovery-Related Outcomes in People with Severe Mental Disorders: Randomised Controlled Trial. 旨在减少严重精神障碍患者的自我污名并改善与康复相关的结果的基于 CBT 的小组干预的效果评估:随机对照试验》。
IF 2.7 4区 医学
Psychiatric Quarterly Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1007/s11126-024-10092-9
Katarzyna Frączek-Cendrowska, Piotr Świtaj, Izabela Stefaniak
{"title":"Evaluation of the Effectiveness of a Group CBT-Based Intervention Aiming to Reduce Self-Stigma and Improve Recovery-Related Outcomes in People with Severe Mental Disorders: Randomised Controlled Trial.","authors":"Katarzyna Frączek-Cendrowska, Piotr Świtaj, Izabela Stefaniak","doi":"10.1007/s11126-024-10092-9","DOIUrl":"10.1007/s11126-024-10092-9","url":null,"abstract":"<p><p>Self-stigma is a major barrier to personal and clinical recovery in people with mental illness. Although psychosocial interventions have been developed to reduce self-stigma, the exploration of group CBT-based interventions for hospitalised patients are less represented. The purpose of this trial is to investigate the effectiveness of a group CBT-based intervention aiming to reduce self-stigma and improve recovery-related outcomes such as self-esteem, stigma resistance and sense of coherence, which comes down to saying, \"I am what I am\". A total of 104 patients admitted to the inpatient therapy were recruited to participate in a randomised controlled clinical trial, and 77 participants (46 in the intervention group and 31 in the control group) completed the trial. Constructs of interest were measured before and after the intervention. The results showed that the evaluated intervention was effective in improving sense of coherence and stigma resistance, compared to treatment as usual (TAU). The level of self-stigma significantly decreased in both the intervention and control groups, but no statistically significant difference was observed between the groups. The limitations of the study include: the lack of assessment of the sustainability of the effects of therapy (follow-up), the presence of intensive interventions of the ward's programme and patients pre-qualified for the ward based on admission criteria. The intervention \"I am what I am,\" has proven to be effective, especially in increasing the level of personal resources needed to build clinical and personal recovery and to counteract the negative consequences of self-stigma.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"619-641"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risks of Long-Term Psychiatric Disease in Women with a History of Primary Infertility: A Historical Cohort Study. 有原发性不孕史的女性患长期精神病的风险:历史队列研究
IF 4.6 4区 医学
Psychiatric Quarterly Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1007/s11126-024-10095-6
Alessandra J Ainsworth, Emily Sadecki, Lauren M Kendall Rauchfuss, Hannah K Betcher, Yulian Zhao, Carin Y Smith, Elizabeth A Stewart
{"title":"Risks of Long-Term Psychiatric Disease in Women with a History of Primary Infertility: A Historical Cohort Study.","authors":"Alessandra J Ainsworth, Emily Sadecki, Lauren M Kendall Rauchfuss, Hannah K Betcher, Yulian Zhao, Carin Y Smith, Elizabeth A Stewart","doi":"10.1007/s11126-024-10095-6","DOIUrl":"10.1007/s11126-024-10095-6","url":null,"abstract":"<p><p>To examine the risks of long-term de novo psychiatric disease in women with primary infertiltiy compared to age-matched referrent women. Retrospective, population-based cohort of 1,001 women with primary infertility and 1,001 age-matched (± 1 year) referent women aged 18-50. The \"index date\" was date of first clinical note for infertility and included visits fromJanuary 1, 1980 to December 31, 1999. Baseline characteristics were collected by chart review. Outcome data was evaluated through December 31, 2020. Primary outcomes were baseline prevalence and de novo rates of subsequent psychiatric disorders including depression, anxiety, bipolar disorder, substance abuse, suicidality, and somatization evaluated by Cox proportional hazards modeling. Among women with primary infertility and referent women, the median duration of follow-up was 23.7 years. The risk of de novo psychiatric disorders was not significantly different between groups. Additionally, the risk of de novo psychiatric disorders did not significantly differ between those with isolated male factor versus isolated female factor infertility. Among women with primary infertility, the cumulative incidence of de novo depression and anxiety was significantly higher among women diagnosed with primary infertility in the 1990s compared to the 1980s. Women with primary infertility, in a historical population-based cohort, do not have a significantly different long-term risk of de novo psychiatric diagnoses compared to age-matched referent women. Our findings support the notion that infertility diagnosis and treatment present an acute period of stress and for some psychologic distress, neither of which persist or increase the risk for development of future psychiatric disease.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"643-655"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Covid-19 Anxiety Scale (CAS): A Validity and Reliability Study. Covid-19 焦虑量表(CAS):有效性和可靠性研究
IF 4.6 4区 医学
Psychiatric Quarterly Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI: 10.1007/s11126-024-10088-5
İrfan Ertekin, Özkan Görgülü
{"title":"Covid-19 Anxiety Scale (CAS): A Validity and Reliability Study.","authors":"İrfan Ertekin, Özkan Görgülü","doi":"10.1007/s11126-024-10088-5","DOIUrl":"10.1007/s11126-024-10088-5","url":null,"abstract":"<p><p>In this study, our aim was to develop a valid and reliable scale to determine the social anxiety level of people regarding COVID-19. A total of 420 people participated in the research. Explanatory and confirmatory factor analyses were used to test the validity and reliability of the scale. As a result of the explanatory factor analysis, it was determined that the scale consisted of 22 items and four sub-dimensions. These sub-dimensions were named \"negative thinking\", \"sociability\", \"fear\" and \"vaccination\". In examination of the fit indices obtained from the confirmatory factor analysis results, it was seen that the four-factor scale structure was high and acceptable. Based on these results, we concluded that the COVID-19 social anxiety scale (CAS) was valid and reliable for examining the level of social anxiety of people during the pandemic periods.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"527-542"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of Suicidal Thoughts and Suicide Attempts in People Who Gamble Based on Biological-Psychological-Social Variables: A Machine Learning Study. 基于生物-心理-社会变量预测赌博者的自杀想法和自杀企图:机器学习研究
IF 4.6 4区 医学
Psychiatric Quarterly Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1007/s11126-024-10101-x
Mohsen Mohajeri, Negin Towsyfyan, Natalie Tayim, Bita Bazmi Faroji, Mohammadreza Davoudi
{"title":"Prediction of Suicidal Thoughts and Suicide Attempts in People Who Gamble Based on Biological-Psychological-Social Variables: A Machine Learning Study.","authors":"Mohsen Mohajeri, Negin Towsyfyan, Natalie Tayim, Bita Bazmi Faroji, Mohammadreza Davoudi","doi":"10.1007/s11126-024-10101-x","DOIUrl":"10.1007/s11126-024-10101-x","url":null,"abstract":"<p><p>Recent research has shown that people who gamble are more likely to have suicidal thoughts and attempts compared to the general population. Despite the advancements made, no study to date has predicted suicide risk factors in people who gamble using machine learning algorithms. Therefore, current study aimed to identify the most critical predictors of suicidal ideation and suicidal attempts among people who gamble using a machine learning approach. An online survey conducted a cross-sectional analysis of 741 people who gamble (mean age: 25.9 ± 5.56). To predict the risk of suicide attempts and ideation, we employed a comprehensive set of 40 biological, psychological, social, and socio-demographic variables. The predictive models were developed using Logistic Regression, Random Forest (RF), robust eXtreme Gradient Boosting (XGBoost), and ensemble machine learning algorithms. Data analysis was performed using R-Studio software. Random Forest emerged as the top-performing algorithm for predicting suicidal ideation, with an impressive AUC of 0.934, sensitivity of 0.7514, specificity of 0.9885, PPV of 0.9473, and NPV of 0.9347. Across all models, dissociation, depression, and anxiety symptoms consistently emerged as crucial predictors of suicidal ideation. However, for suicide attempt prediction, all models exhibited weaker performance. XGBoost showed the best performance in this regard, with an AUC of 0.663, sensitivity of 0.78, specificity of 0.8990, PPV of 0.34, NPV of 0.984, and accuracy of 0.8918. Depressive symptoms and rumination severity were highlighted as the most important predictors of suicide attempts according to this model. These findings have important implications for clinical practice and public health interventions. Machine learning could help detect individuals prone to suicidal ideation and suicide attempts among people who gamble, assisting in creating tailored prevention programs to address future suicide risks more effectively.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"711-730"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barriers to Treatment of Mental Disorders in Saudi Arabia. 沙特阿拉伯精神障碍治疗的障碍。
IF 2.7 4区 医学
Psychiatric Quarterly Pub Date : 2024-11-30 DOI: 10.1007/s11126-024-10104-8
Sumayah Aljhani, Sultan Aldughayim, Ziyad Alsweed, Sulaiman Alherbish, Faris Alhumaid, Rayan Alismail, Saleh Alkhalaf, Ibrahim AlBahouth
{"title":"Barriers to Treatment of Mental Disorders in Saudi Arabia.","authors":"Sumayah Aljhani, Sultan Aldughayim, Ziyad Alsweed, Sulaiman Alherbish, Faris Alhumaid, Rayan Alismail, Saleh Alkhalaf, Ibrahim AlBahouth","doi":"10.1007/s11126-024-10104-8","DOIUrl":"https://doi.org/10.1007/s11126-024-10104-8","url":null,"abstract":"<p><p>Mental disorders are a global health issue affecting millions of individuals. People with mental disorders often face barriers to treatment, including stigma and discrimination, social, religious, and familial barriers, and a lack of knowledge about available treatment options. These barriers can lead to delayed or untreated mental illnesses, with serious consequences for the individuals, their families, and communities. This cross-sectional study explores the treatment barriers for different mental disorders as they significantly impact people's lives. It includes patients diagnosed with mental disorders. The data were collected from the patients or their companions attending Qassim Mental Health Hospital's outpatient clinic. We used a self-administered online questionnaire, sociodemographic variables, and the barrier to access to care evaluation (BACE) scale. Our sample included 332 adult patients with mental disorders (men, 63.9%; women, 36.1%). The mean percentage scores for stigma-, attitude-, and instrument-related barriers were 26.7%, 33.0%, and 18.7%, respectively. Younger age was associated with higher scores in all three BACE domains. Patients with psychotic disorders faced stigma- and attitude-related barriers, but not instrument-related barriers. Patients with multiple mental conditions faced increased stigma- and instrument-related barriers but not attitude-related barriers. Further longitudinal studies are required to better understand these barriers to help patients with mental conditions.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Treatment Preferences in Acute Psychosis: A Comparison of Patient and Staff Perspectives on Symptom Prioritization and Biopsychosocial Interventions. 更正:急性精神病的治疗偏好:比较患者和工作人员对症状优先级和生物心理社会干预的看法。
IF 2.7 4区 医学
Psychiatric Quarterly Pub Date : 2024-11-29 DOI: 10.1007/s11126-024-10107-5
Rabea Fischer, Steffen Moritz, Jakob Scheunemann, Matthias Nagel, Charlotte Osthues, Daniel Schöttle, Daniel Luedecke
{"title":"Correction: Treatment Preferences in Acute Psychosis: A Comparison of Patient and Staff Perspectives on Symptom Prioritization and Biopsychosocial Interventions.","authors":"Rabea Fischer, Steffen Moritz, Jakob Scheunemann, Matthias Nagel, Charlotte Osthues, Daniel Schöttle, Daniel Luedecke","doi":"10.1007/s11126-024-10107-5","DOIUrl":"https://doi.org/10.1007/s11126-024-10107-5","url":null,"abstract":"","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network Analysis of Core Symptoms of Internalizing and Externalizing Symptoms Among Children with Dyslexia in Saudi Arabia. 沙特阿拉伯阅读障碍儿童的内化和外化核心症状网络分析。
IF 2.7 4区 医学
Psychiatric Quarterly Pub Date : 2024-11-27 DOI: 10.1007/s11126-024-10105-7
Norah Alkhateeb
{"title":"Network Analysis of Core Symptoms of Internalizing and Externalizing Symptoms Among Children with Dyslexia in Saudi Arabia.","authors":"Norah Alkhateeb","doi":"10.1007/s11126-024-10105-7","DOIUrl":"https://doi.org/10.1007/s11126-024-10105-7","url":null,"abstract":"<p><p>Researches indicate that children with dyslexia are more likely to experience psychiatric symptoms throughout life compared to peers in the general population. Improving the classification of psychiatric symptoms in this population can be a valuable goal for strengthing therapeutic models. The current study aimed to evaluate the dynamic associations between internalizing and externalizing symptoms in children with dyslexia using network analysis. This cross-sectional study was conducted in Saudi Arabia from April to July 2024, involving 183 children aged 8-11 diagnosed with dyslexia, recruited through convenience sampling from local schools and clinics. The Child Behavior Checklist (CBCL) was utilized to assess a range of psychopathological symptoms, focusing on six clusters: affective problems, anxiety problems, somatic symptoms, ADHD symptoms, oppositional defiant problems, and conduct problems. Notably, \"cries a lot\" emerged as a central symptom in the affective network, while \"dependent\" was identified as the most pivotal symptom in the anxiety network. Centrality measures-betweenness, closeness, and strength-were employed to quantify the significance of each symptom. The findings suggest that these central symptoms may contribute to the development and persistence of psychiatric comorbidities in children with dyslexia. Interventions targeting these core symptoms could enhance psychological outcomes for this population. Overall, this study lays the groundwork for future research into tailored intervention strategies to address unique psychiatric comorbidities associated with dyslexia.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Network Analysis of Depression and Cognitive Impairments in Fibromyalgia: A Secondary Analysis Study. 纤维肌痛中抑郁和认知障碍的网络分析:二次分析研究
IF 2.7 4区 医学
Psychiatric Quarterly Pub Date : 2024-11-26 DOI: 10.1007/s11126-024-10106-6
Dariush Tahmasebi Aghbelaghi, Mahbobeh Jalali, Natalie Tayim, Roghayeh Kiyani
{"title":"A Network Analysis of Depression and Cognitive Impairments in Fibromyalgia: A Secondary Analysis Study.","authors":"Dariush Tahmasebi Aghbelaghi, Mahbobeh Jalali, Natalie Tayim, Roghayeh Kiyani","doi":"10.1007/s11126-024-10106-6","DOIUrl":"https://doi.org/10.1007/s11126-024-10106-6","url":null,"abstract":"<p><strong>Introduction: </strong>Fibromyalgia is a chronic condition often accompanied by cognitive impairments, such as difficulties with sustained attention, and emotional disturbances, particularly depression and anxiety. Understanding how these emotional and cognitive factors interact is crucial to improving treatment for fibromyalgia patients. This study aimed to investigate the network structure of these interactions, focusing on the relationship between depression, anxiety, and cognitive performance.</p><p><strong>Method: </strong>A total of one hundred ten participants diagnosed with fibromyalgia completed self-reported assessments of depression and anxiety, alongside cognitive performance tests. Key measures included Continuous Performance Tasks (CPT) for impulsivity and sustained attention, the Stroop Interference Index (StI), Stroop Color Naming (StC), and Stroop Word Reading (StW). Network analysis was conducted to estimate the relationships between emotional and cognitive variables and assess their centrality within the network.</p><p><strong>Results: </strong>Errors in CPT emerged as the most significant indicators of the relationship between depression and cognitive performance, with high centrality values observed for the Stroop tasks (StI, StC, and StW). Additionally, Trait Anxiety (A_T) and Beck Depression Inventory (BDI) measures showed high centrality, underscoring the critical role of emotional states in the network of cognitive and emotional variables. The centrality values for cognitive flexibility, processing speed, and inhibitory control were found to be 0.85, 0.78, and 0.72, respectively.</p><p><strong>Conclusion: </strong>This study highlights the strong association between depression symptoms and deficits in cognitive domains, emphasizing the need for integrated care approaches that address both cognitive and emotional health. Multidisciplinary treatment programs, including cognitive rehabilitation and psychological support, could improve patient outcomes by targeting the most influential variables in the cognitive-emotional network.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are S100B and VILIP-1 Involved in a Common Mechanism of Neuroinflammation in Major Depressive Disorder? S100B 和 VILIP-1 是否参与了重度抑郁症神经炎症的共同机制?
IF 2.7 4区 医学
Psychiatric Quarterly Pub Date : 2024-11-08 DOI: 10.1007/s11126-024-10102-w
Nagihan Ayaz Naycı, Aybeniz Civan Kahve, Hasan Kaya, Andaç Uzdoğan, Yağmur Darben Azarsız, Süreyya Barun, Erol Göka
{"title":"Are S100B and VILIP-1 Involved in a Common Mechanism of Neuroinflammation in Major Depressive Disorder?","authors":"Nagihan Ayaz Naycı, Aybeniz Civan Kahve, Hasan Kaya, Andaç Uzdoğan, Yağmur Darben Azarsız, Süreyya Barun, Erol Göka","doi":"10.1007/s11126-024-10102-w","DOIUrl":"https://doi.org/10.1007/s11126-024-10102-w","url":null,"abstract":"<p><p>This study aimed to evaluate the role of neuroinflammation in neuronal and glial cells in the pathophysiology of Major Depressive Disorder (MDD) through different biomarkers.S100-B and VILIP-1 levels of patients diagnosed with MDD were evaluated before and after antidepressant treatment. A total of 65 patients diagnosed with MDD and 69 healthy controls were included. Serum levels of S100B and VILIP-1 were measured at the time of diagnosis and after eight weeks antidepressant treatment and compared with healthy controls. Hamilton Depression Rating Scale (HDRS) and the Clinical Global Impression Scale (CGI) were applied to assess the severity of depression. In our study, although serum S100B levels were higher in patients before treatment compared to healthy controls, this difference was not statistically significant. Regarding VILIP-1 levels, there was no statistically significant difference between patients and healthy controls. A positive and statistically significant correlation was found between S100B and VILIP-1 levels in MDD group before the treatment. At the eighth week of treatment, a statistically significant positive correlation was also found between S100B and VILIP-1 levels. Our research is the first study to evaluate MDD through two separate biomarkers specific to glial and neuronal cells.The fact that S100B and VILIP-1 levels showed significant correlations in patients diagnosed with MDD both before and after treatment suggests that they may play a shared role in the pathophysiology of the disorder. The correlation between S100B and VILIP-1 may serve as a guide in understanding the pathophysiology of the disorder and in identifying new drug development targets.</p>","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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