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生物化学与生物物理进展最新文献

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The Relationship Between Astrocyte-mediated Metabolism of β-Amyloid Protein and Pathogenesis of The Early Stages of Alzheimer′s Disease*: The Relationship Between Astrocyte-mediated Metabolism of β-Amyloid Protein and Pathogenesis of The Early Stages of Alzheimer′s Disease* 星形胶质细胞介导的β-淀粉样蛋白代谢与阿尔茨海默病早期发病的关系*:星形胶质细胞介导的β-淀粉样蛋白代谢与阿尔茨海默病早期发病的关系*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00134
Lu Lin, Shu‐jun Xu, Qinwen Wang
{"title":"The Relationship Between Astrocyte-mediated Metabolism of β-Amyloid Protein and Pathogenesis of The Early Stages of Alzheimer′s Disease*: The Relationship Between Astrocyte-mediated Metabolism of β-Amyloid Protein and Pathogenesis of The Early Stages of Alzheimer′s Disease*","authors":"Lu Lin, Shu‐jun Xu, Qinwen Wang","doi":"10.3724/SP.J.1206.2012.00134","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00134","url":null,"abstract":"Alzheimer′s disease(AD),which is characterized with acquired deterioration of cognitive functioning and neuronal loss,is the most common neurodegenerative disease in the elderly population.However,the pathogenesis of AD is still unclear.The accumulation of β-amyloid protein(Aβ) in the brains has been associated with pathogenesis of AD.Studies have shown that astrocytes,the most abundant cells in the central nervous system(CNS),play an important role in the cause and progression of AD by regulating the metabolism of Aβ.The present paper reviews the production,internalization and degradation of Aβ in astrocytes.Our goal is to provide updated views of the role and mechanism of astrocytes in the metabolism of Aβ and its role in pathogenesis in the early stages of Alzheimer′s disease.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87248288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Mechanism of Autophagy Regulation and The Role of Autophagy in Alzheimer′s Disease*: The Mechanism of Autophagy Regulation and The Role of Autophagy in Alzheimer′s Disease* 自噬调节机制及自噬在阿尔茨海默病中的作用*:自噬调节机制及自噬在阿尔茨海默病中的作用*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00363
Zhi‐Xue Liu, Jie Chen, De-Yi Zhang
{"title":"The Mechanism of Autophagy Regulation and The Role of Autophagy in Alzheimer′s Disease*: The Mechanism of Autophagy Regulation and The Role of Autophagy in Alzheimer′s Disease*","authors":"Zhi‐Xue Liu, Jie Chen, De-Yi Zhang","doi":"10.3724/SP.J.1206.2012.00363","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00363","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78420848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer′s Disease*: Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer′s Disease* 阿尔茨海默病中Tau过度磷酸化的内源性和外源性因素*:阿尔茨海默病中Tau过度磷酸化的内源性和外源性因素*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00365
Yan-fei Wei, Junye Miao, Y. Liu
{"title":"Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer′s Disease*: Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer′s Disease*","authors":"Yan-fei Wei, Junye Miao, Y. Liu","doi":"10.3724/SP.J.1206.2012.00365","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00365","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75743481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Metal Metabolic Homeostasis Disruption and Early Initiation of Mechanism for Alzheimer's Disease 阿尔茨海默病的金属代谢稳态破坏及早期发病机制
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00297
Zhao Baolu, 赵保路, Wan Li
{"title":"Metal Metabolic Homeostasis Disruption and Early Initiation of Mechanism for Alzheimer's Disease","authors":"Zhao Baolu, 赵保路, Wan Li","doi":"10.3724/SP.J.1206.2012.00297","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00297","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78201318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Progresses on Genetics of Predementia Phase of Alzheimer′s Disease*: Progresses on Genetics of Predementia Phase of Alzheimer′s Disease* 阿尔茨海默病痴呆前期遗传学研究进展*:阿尔茨海默病痴呆前期遗传学研究进展*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00210
J. Jia, Fen Wang, Q. Yuan, W. Qin, Yi Tnag, Xiu-mei Zuo, Yue Han
{"title":"Progresses on Genetics of Predementia Phase of Alzheimer′s Disease*: Progresses on Genetics of Predementia Phase of Alzheimer′s Disease*","authors":"J. Jia, Fen Wang, Q. Yuan, W. Qin, Yi Tnag, Xiu-mei Zuo, Yue Han","doi":"10.3724/SP.J.1206.2012.00210","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00210","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89493919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Circadian Rhythm of Melatonin and Alzheimer′s Disease*: Circadian Rhythm of Melatonin and Alzheimer′s Disease* 褪黑激素与阿尔茨海默病的昼夜节律*:褪黑激素与阿尔茨海默病的昼夜节律*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00315
Jiang-Ning Zhou, Ya‐Jing Liu
{"title":"Circadian Rhythm of Melatonin and Alzheimer′s Disease*: Circadian Rhythm of Melatonin and Alzheimer′s Disease*","authors":"Jiang-Ning Zhou, Ya‐Jing Liu","doi":"10.3724/SP.J.1206.2012.00315","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00315","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86586182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Molecular Mechanisms Underlie Alzheimer-like Tau Hyperphosphorylation and Neurodegeneration*: Molecular Mechanisms Underlie Alzheimer-like Tau Hyperphosphorylation and Neurodegeneration* 阿尔茨海默样Tau蛋白过度磷酸化和神经变性的分子机制*:阿尔茨海默样Tau蛋白过度磷酸化和神经变性的分子机制*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00333
Jian-Zhi Wang, Q. Tian
{"title":"Molecular Mechanisms Underlie Alzheimer-like Tau Hyperphosphorylation and Neurodegeneration*: Molecular Mechanisms Underlie Alzheimer-like Tau Hyperphosphorylation and Neurodegeneration*","authors":"Jian-Zhi Wang, Q. Tian","doi":"10.3724/SP.J.1206.2012.00333","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00333","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72992627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD*: Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD* MCI的神经心理障碍特点及早期发现和干预:预防和延缓AD的发病*;MCI的神经心理障碍特点及早期发现和干预:预防和延缓AD的发病*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00303
Juan Li, Jing Yu, Y. Niu
{"title":"Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD*: Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD*","authors":"Juan Li, Jing Yu, Y. Niu","doi":"10.3724/SP.J.1206.2012.00303","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00303","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81803037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer′s Disease: Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer′s Disease BACE1在阿尔茨海默病早期发病中的分子调控及其功能:BACE1在阿尔茨海默病早期发病中的分子调控及其功能
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-09-03 DOI: 10.3724/SP.J.1206.2012.00217
Tan Wang, Xiulian Sun
{"title":"Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer′s Disease: Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer′s Disease","authors":"Tan Wang, Xiulian Sun","doi":"10.3724/SP.J.1206.2012.00217","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00217","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87502921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Genomics and Genome Evolution of Mycobacterium tuberculosis*: Genomics and Genome Evolution of Mycobacterium tuberculosis* 结核分枝杆菌基因组学和基因组进化*:结核分枝杆菌基因组学和基因组进化*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-08-06 DOI: 10.3724/SP.J.1206.2011.00469
Baoshan Wan, Qiufen Zhang, Aiping Zhou, Guo-Ping Zhao, Yu-Feng Yao
{"title":"Genomics and Genome Evolution of Mycobacterium tuberculosis*: Genomics and Genome Evolution of Mycobacterium tuberculosis*","authors":"Baoshan Wan, Qiufen Zhang, Aiping Zhou, Guo-Ping Zhao, Yu-Feng Yao","doi":"10.3724/SP.J.1206.2011.00469","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00469","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83168472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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