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Micropatterning and Its Applications in Biomedical Research*: Micropatterning and Its Applications in Biomedical Research* 微图案及其在生物医学研究中的应用*:微图案及其在生物医学研究中的应用*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-23 DOI: 10.3724/SP.J.1206.2011.00228
D. Ren, M. Cui, Yiqiu Xia, Zheng You
{"title":"Micropatterning and Its Applications in Biomedical Research*: Micropatterning and Its Applications in Biomedical Research*","authors":"D. Ren, M. Cui, Yiqiu Xia, Zheng You","doi":"10.3724/SP.J.1206.2011.00228","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00228","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85749402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The Functional Roles of microRNA: The Functional Roles of microRNA microRNA的功能作用:microRNA的功能作用
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-23 DOI: 10.3724/SP.J.1206.2012.00469
Haitao Luo, Yi Zhao
{"title":"The Functional Roles of microRNA: The Functional Roles of microRNA","authors":"Haitao Luo, Yi Zhao","doi":"10.3724/SP.J.1206.2012.00469","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00469","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78997043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Crystal Structures of N-terminal Domain of Human Hsp90 With ATP Analogues Reveal The Functional Regulation of Hsp90*: Crystal Structures of N-terminal Domain of Human Hsp90 With ATP Analogues Reveal The Functional Regulation of Hsp90* 人Hsp90 n端结构域的晶体结构与ATP类似物揭示了Hsp90*的功能调控:人Hsp90 n端结构域的晶体结构与ATP类似物揭示了Hsp90*的功能调控
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-23 DOI: 10.3724/SP.J.1206.2011.00611
Jian Li, Lihua（孙丽华） Sun, Chunyan Xu, F. Yu, Huan Zhou, L. Tang, Jianhua He
{"title":"Crystal Structures of N-terminal Domain of Human Hsp90 With ATP Analogues Reveal The Functional Regulation of Hsp90*: Crystal Structures of N-terminal Domain of Human Hsp90 With ATP Analogues Reveal The Functional Regulation of Hsp90*","authors":"Jian Li, Lihua（孙丽华） Sun, Chunyan Xu, F. Yu, Huan Zhou, L. Tang, Jianhua He","doi":"10.3724/SP.J.1206.2011.00611","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00611","url":null,"abstract":"Heat shock protein 90 (Hsp90) is essential for folding, maturation and stabilization of many important proteins, which are involved in cell cycle regulation, signal transduction, and cell growth regulation. The highly conserved N-terminal domain contains an ATP binding cleft and thus is responsible for the catalytic activity of Hsp90. In order to further study the function and structure of Hsp90, the N-terminal of the human Hsp90 was cocrystallized with AMPPNP and ATP gamma S. The cocrystallization experiments were carried out at 277K using the hanging drop vapor-diffusion method, X-ray diffraction data were collected on beamline 17U at the SSRF and the structures were solved by molecular replacement. The densities of the two nucleotides were captured and the interactions between Hsp90(N) and nucleotides were clearly described. We confirmed that the gamma-phosphate of ATP gamma S was not hydrolyzed by Hsp90(N). The position of S 1 and ATP lid in human Hsp90(N)-AMPPNP differs significantly from that of the structure of yeast Hsp90-AMPPNP. By analyzing the structure of human Hsp90(N)-AMPPNP, we found that the interactions of E18-K100 and N40-D127 block the moving of Si and ATP lid, and then prevent the dimerization of Hsp90(N). This reflects the complexity and coordination of Hsp90 on the regulation of the function.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82093662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Structure and Function of SPLUNC1：Novel Class of Innate Immune Protective Molecules*: The Structure and Function of SPLUNC1：Novel Class of Innate Immune Protective Molecules* SPLUNC1的结构和功能:一类新的先天免疫保护分子*:SPLUNC1的结构和功能:一类新的先天免疫保护分子*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-23 DOI: 10.3724/SP.J.1206.2011.00436
Xiaowei Guo, Pang Chen, Li Xiayu, L. Xiaoling, Liu Guiyuan
{"title":"The Structure and Function of SPLUNC1：Novel Class of Innate Immune Protective Molecules*: The Structure and Function of SPLUNC1：Novel Class of Innate Immune Protective Molecules*","authors":"Xiaowei Guo, Pang Chen, Li Xiayu, L. Xiaoling, Liu Guiyuan","doi":"10.3724/SP.J.1206.2011.00436","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00436","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84250489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Fluorescent Protein Pair for Dual-color Two-photon Laser Scanning Microscopy*: A Novel Fluorescent Protein Pair for Dual-color Two-photon Laser Scanning Microscopy* 用于双色双光子激光扫描显微镜的新型荧光蛋白对*：用于双色双光子激光扫描显微镜*的新型荧光蛋白对
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-23 DOI: 10.3724/SP.J.1206.2012.00027
Song Yang, Yan Teng, P. Xu
{"title":"A Novel Fluorescent Protein Pair for Dual-color Two-photon Laser Scanning Microscopy*: A Novel Fluorescent Protein Pair for Dual-color Two-photon Laser Scanning Microscopy*","authors":"Song Yang, Yan Teng, P. Xu","doi":"10.3724/SP.J.1206.2012.00027","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00027","url":null,"abstract":"Dual-color two-photon laser scanning microscopy is a useful method for simultaneously studying the expression, localization and trafficking of two different proteins in tissues. Because most two-photon microscopes only use a single wavelength excitation laser, simultaneously exciting multiple fluorescent proteins remains a challenge. Here, we present mAmetrine and mKate2, which can be used as a novel fluorescent protein pair in dual-color two-photon imaging by taking advantage of the large Stokes shift of mAmetrine and high brightness of mKate2. Both proteins have high two-photon absorption efficiencies and can be simultaneously excited at an optical wavelength of 765 nm. Dual-color two-photon imaging using this protein pair is highly effective in living cells.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73367716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Brief Analysis of Subcellular Distribution and Physiological Functions of Plant Aquaporins*: A Brief Analysis of Subcellular Distribution and Physiological Functions of Plant Aquaporins* 植物水通道蛋白亚细胞分布与生理功能的简要分析*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-23 DOI: 10.3724/SP.J.1206.2011.00617
Yongqi Pang, Gao-qi Wang, Xucheng Wang, Jia Chen, Xuecheng Wang
{"title":"A Brief Analysis of Subcellular Distribution and Physiological Functions of Plant Aquaporins*: A Brief Analysis of Subcellular Distribution and Physiological Functions of Plant Aquaporins*","authors":"Yongqi Pang, Gao-qi Wang, Xucheng Wang, Jia Chen, Xuecheng Wang","doi":"10.3724/SP.J.1206.2011.00617","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00617","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81985927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
JNK3 Cooperates With RelA/p65 to Decrease Bel-7402 Cell Adhesion Upon The Inhibition of NF-κB Pathway*: JNK3 Cooperates With RelA/p65 to Decrease Bel-7402 Cell Adhesion Upon The Inhibition of NF-κB Pathway* JNK3与RelA/p65协同抑制NF-κB通路降低Bel-7402细胞粘附*:JNK3与RelA/p65协同抑制NF-κB通路降低Bel-7402细胞粘附*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-15 DOI: 10.3724/SP.J.1206.2012.00041
Qiang Li, Q. Han, Donghang Yu, Liu-Jun Tang, Jian Wang, Xiao-hui Wang, Wang-xiang Xu, Y. Zhan, Li Chang-Yan, Changhui Ge, Miao Yu, Xiao-Ming Yang
{"title":"JNK3 Cooperates With RelA/p65 to Decrease Bel-7402 Cell Adhesion Upon The Inhibition of NF-κB Pathway*: JNK3 Cooperates With RelA/p65 to Decrease Bel-7402 Cell Adhesion Upon The Inhibition of NF-κB Pathway*","authors":"Qiang Li, Q. Han, Donghang Yu, Liu-Jun Tang, Jian Wang, Xiao-hui Wang, Wang-xiang Xu, Y. Zhan, Li Chang-Yan, Changhui Ge, Miao Yu, Xiao-Ming Yang","doi":"10.3724/SP.J.1206.2012.00041","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00041","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78420845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NOR1 Regulates Morphogenetic Cell Behavior in vitro Coincident With Inhibition of a Non-canonical Wnt-signaling Cascade*: NOR1 Regulates Morphogenetic Cell Behavior in vitro Coincident With Inhibition of a Non-canonical Wnt-signaling Cascade* NOR1调节体外形态发生细胞行为并抑制非典型wnt信号级联*:NOR1调节体外形态发生细胞行为并抑制非典型wnt信号级联*
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-15 DOI: 10.3724/SP.J.1206.2012.00012
Bo Xiang, Wen Wang, Wen-juan Li, Ke Tang, Zhaoyang Zeng, L. Xiaoling, Liu Guiyuan
{"title":"NOR1 Regulates Morphogenetic Cell Behavior in vitro Coincident With Inhibition of a Non-canonical Wnt-signaling Cascade*: NOR1 Regulates Morphogenetic Cell Behavior in vitro Coincident With Inhibition of a Non-canonical Wnt-signaling Cascade*","authors":"Bo Xiang, Wen Wang, Wen-juan Li, Ke Tang, Zhaoyang Zeng, L. Xiaoling, Liu Guiyuan","doi":"10.3724/SP.J.1206.2012.00012","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00012","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74492098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Model System for Analyzing Behavioral Preference and Plasticity in Drosophila Egg-Laying 果蝇产卵行为偏好与可塑性分析模型系统
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-15 DOI: 10.3724/SP.J.1206.2011.00522
Wang Yijin, Wen Sheng-yun, Gong Haiyun, Gong Zhefeng, 龚哲峰, Liu Li, 刘力
{"title":"A Model System for Analyzing Behavioral Preference and Plasticity in Drosophila Egg-Laying","authors":"Wang Yijin, Wen Sheng-yun, Gong Haiyun, Gong Zhefeng, 龚哲峰, Liu Li, 刘力","doi":"10.3724/SP.J.1206.2011.00522","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00522","url":null,"abstract":"Understanding the connection between sensory input and motor output is challenging.There is a need for good model systems to evaluate the molecular and neural mechanism of animal behavior.Here we show a new system for analyzing preference and plasticity of Drosophila egg-laying behavior.We found that selection of egg-laying site in flies is a good model to investigate the food preference in Drosophila.On sugar food with lower concentration,flies showed significant preference that was reduced upon the inhibition of olfactory pathway.Moreover,to examine the plasticity of egg-laying behavior,a new learning paradigm was devised.We associated light-dark cycle of egg-laying with different food conditions and found that flies could maintain egg-laying memory at least 3 days after training.This egg-laying system provides the basis for further study of molecular and neural mechanism underlying the relationship between environment and behavior.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85724338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Novel Substitution of The Heme-binding Residue Histidine-245 by Histidine-249 in Heme Oxygenase HugZ*: A Novel Substitution of The Heme-binding Residue Histidine-245 by Histidine-249 in Heme Oxygenase HugZ* 血红素加氧酶HugZ*中血红素结合残基Histidine-245被Histidine-249取代的新研究
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2012-11-15 DOI: 10.3724/SP.J.1206.2011.00513
Xihui Shen, Yonglin Hu, Dacheng Wang
{"title":"A Novel Substitution of The Heme-binding Residue Histidine-245 by Histidine-249 in Heme Oxygenase HugZ*: A Novel Substitution of The Heme-binding Residue Histidine-245 by Histidine-249 in Heme Oxygenase HugZ*","authors":"Xihui Shen, Yonglin Hu, Dacheng Wang","doi":"10.3724/SP.J.1206.2011.00513","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00513","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88672865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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