Proceedings of the National Academy of Sciences of the United States of America最新文献_第7页

The effect of habitat loss and fragmentation on isolation by distance and divergence 生境丧失和破碎化对距离和散度隔离的影响

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-28 DOI: 10.1073/pnas.2410951122

Gabriele Maria Sgarlata, Tiago Maié, Tiago de Zoeten, Jordi Salmona, Rita Rasteiro, Lounès Chikhi

{"title":"The effect of habitat loss and fragmentation on isolation by distance and divergence","authors":"Gabriele Maria Sgarlata, Tiago Maié, Tiago de Zoeten, Jordi Salmona, Rita Rasteiro, Lounès Chikhi","doi":"10.1073/pnas.2410951122","DOIUrl":"https://doi.org/10.1073/pnas.2410951122","url":null,"abstract":"Natural habitats have undergone drastic changes in quality, continuity, and extent during the Pleistocene, influencing the distribution of many species. More recently, human activities have converted continuous habitats into fragmented and isolated patches. Recent meta-analyses suggest that habitat loss and fragmentation (HL&F) have negatively impacted the genetic diversity of species but very few studies have analyzed the consequences of HL&F on the spatial distribution of genetic diversity and on isolation by distance (IBD) patterns (i.e., correlations between genetic and geographical distances) observed in many species. In this work, we use spatial simulations to investigate the speed at which IBD patterns generated in continuous habitats are lost in a context of HL&F. We characterized the behavior of IBD in the case of i) instantaneous HL&F, ii) gradual (two-steps) HL&F, and iii) range expansion followed by instantaneous HL&F. In addition, we show that a spatially explicit theoretical framework based on previous IBD theoretical results can be modified and applied to a toroidal stepping-stone model undergoing HL&F. Our results suggest that IBD patterns can be maintained for long periods of time after HL&F, thus pointing to the long-term persistence of signatures associated to past habitat connectivity in the genetic diversity of many species, even if they went through major and sometimes ancient fragmentation events. This suggests that some present-day fragmented species, who still exhibit significant IBD patterns, may have been partly disconnected for very long periods, on the order of tens of thousands of years for species with long generation time.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"51 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights into the iron-sulfur cluster-dependent interaction of the autophagy receptor NCOA4 with the E3 ligase HERC2. 自噬受体NCOA4与E3连接酶HERC2的铁硫簇依赖性相互作用的机制见解。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-24 DOI: 10.1073/pnas.2510269122

Haobo Liu,Liqiang Shen,Xinyu Gong,Xindi Zhou,Yichao Huang,Yuqian Zhou,Zhenpeng Guo,Hanbo Guo,Shichao Wang,Lifeng Pan

{"title":"Mechanistic insights into the iron-sulfur cluster-dependent interaction of the autophagy receptor NCOA4 with the E3 ligase HERC2.","authors":"Haobo Liu,Liqiang Shen,Xinyu Gong,Xindi Zhou,Yichao Huang,Yuqian Zhou,Zhenpeng Guo,Hanbo Guo,Shichao Wang,Lifeng Pan","doi":"10.1073/pnas.2510269122","DOIUrl":"https://doi.org/10.1073/pnas.2510269122","url":null,"abstract":"NCOA4, a dedicated autophagy receptor for mediating selective autophagy of ferritin (ferritinophagy), plays a vital role in maintaining cellular iron homeostasis. The cellular abundance of NCOA4 is regulated by the E3 ligase HERC2 that can specifically target NCOA4 for proteasomal degradation under iron-replete conditions. However, the detailed molecular mechanism governing the iron-dependent recognition of NCOA4 by HERC2 remains elusive. Here, using multidisciplinary approaches, we systematically characterize the HERC2-binding domain (HBD) of NCOA4 and its interaction with HERC2. We uncover that NCOA4 HBD harbors a [2Fe-2S] cluster and can exist in two different states, the apo-form state and the [2Fe-2S] cluster-bound state. Moreover, we unravel that HERC2 can effectively recognize the [2Fe-2S] cluster-bound NCOA4 HBD through its Cullin-7-PARC-HERC2 (CPH) domain and iron-sulfur cluster-dependent NCOA4-binding domain (INBD) with a synergistic binding mode. The determined crystal structures of HERC2(2540-2700) and its complex with the [2Fe-2S] cluster-bound NCOA4 HBD together with relevant biochemical and cellular results not only elucidate how NCOA4 HBD specifically senses cellular iron level by binding a [2Fe-2S] cluster but also reveal the molecular basis underlying the specific interaction of HERC2 with the [2Fe-2S] cluster-bound NCOA4 HBD. In summary, our findings provide mechanistic insights into the iron-dependent turnover of NCOA4 by HERC2 and expand our understanding of the regulatory mechanism of NCOA4-mediated ferritinophagy.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"18 1","pages":"e2510269122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATP synthesis driven by atmospheric hydrogen concentrations. 大气氢浓度驱动ATP合成。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-24 DOI: 10.1073/pnas.2506353122

Sarah Soom,Stefan Urs Moning,Gregory M Cook,James P Lingford,Ashleigh Kropp,Sieu Tran,Rhys Grinter,Chris Greening,Christoph von Ballmoos

{"title":"ATP synthesis driven by atmospheric hydrogen concentrations.","authors":"Sarah Soom,Stefan Urs Moning,Gregory M Cook,James P Lingford,Ashleigh Kropp,Sieu Tran,Rhys Grinter,Chris Greening,Christoph von Ballmoos","doi":"10.1073/pnas.2506353122","DOIUrl":"https://doi.org/10.1073/pnas.2506353122","url":null,"abstract":"All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The universally conserved F1Fo-ATP synthase regenerates ATP from ADP and Pi by harnessing a transmembrane electrochemical proton gradient (pmf). Bacteria have evolved diverse pmf-forming strategies using light, organic, and inorganic energy sources. Recently, we proposed that many bacteria survive using atmospheric trace gases to produce ATP when limited for other energy sources. However, direct evidence that atmospheric energy sources are sufficient to generate pmf or drive ATP synthesis is still lacking. Here, we show that the membrane-associated hydrogen:quinone oxidoreductase Huc from Mycobacterium smegmatis can enable ATP synthesis from air. Purified Huc couples H2 oxidation to the reduction of various ubiquinone and menaquinone analogues. We designed a minimal respiratory chain in which Huc interacts with liposomes containing the nonpumping, but pmf-generating, bd-I oxidase and F1Fo-ATP synthase from Escherichia coli. Our experiments show that passive hydrogen exchange from air to solution is sufficient for the electron transfer and pmf generation required to accumulate ATP. By combining continuous culture bioenergetics measurements with theoretical calculations, we show this process is sufficient for mycobacteria to sustain pmf and ATP synthesis (two ATP molecules per H2 oxidized) for maintenance energy requirements during nutrient starvation. These findings confirm that atmospheric energy sources can be dependable 'lifeline' substrates that enable continuous energy conservation during nutrient starvation. In addition, this work provides a unique tool for ATP production in synthetic applications, which unlike other approaches is traceless without by-product accumulation.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"75 1","pages":"e2506353122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the social life of urban spaces through AI. 通过人工智能探索城市空间的社会生活。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-24 DOI: 10.1073/pnas.2424662122

Arianna Salazar-Miranda,Zhuangyuan Fan,Michael Baick,Keith N Hampton,Fabio Duarte,Becky P Y Loo,Edward Glaeser,Carlo Ratti

引用次数: 0

Optimal kinetics for catalytic cycles from a single path-sampling simulation. 从单路径采样模拟催化循环的最佳动力学。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-24 DOI: 10.1073/pnas.2500934122

Peter G Bolhuis

{"title":"Optimal kinetics for catalytic cycles from a single path-sampling simulation.","authors":"Peter G Bolhuis","doi":"10.1073/pnas.2500934122","DOIUrl":"https://doi.org/10.1073/pnas.2500934122","url":null,"abstract":"A catalyst's efficiency for accelerating a reaction rate is determined by its molecular structure and interactions with the substrate. While one can predict kinetics for a particular molecular model, tuning the (potentially many) model parameters to reach a desired or optimal kinetics for a catalytic cycle is usually considered computationally prohibitively expensive, especially in solvated systems. Here, we show for a simple model representing a minimal catalytic cycle that such optimization is possible using only one single (path-sampling) simulation, by applying a maximum caliber based path reweighting method. We compute the path ensemble for a single parameter setting of the molecular interactions and then expand the kinetic landscape around these parameters. We find that optimal catalytic turnover or efficiency is orders of magnitude improved and is achieved by relevant parameters that induce strain in the system. Thus, path-reweighting based optimization is not only capable of finding important ingredients that lead to desired kinetic rates but can also identify the mechanistic origins of the rate optimization at a fraction of the costs of a direct evaluation. We demonstrate the versatility of the methodology on a minimal model for kinase signaling. The approach promises efficient computational design of (complex) catalysts using realistic models.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"17 1","pages":"e2500934122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction for Lin et al., BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. 纠正Lin等人的说法，BRIT1/MCPH1是一种DNA损伤反应蛋白，调节Brca1-Chk1通路，与小头畸形的检查点功能障碍有关。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-24 DOI: 10.1073/pnas.2517068122

引用次数: 0

Cell type-specific purifying selection of synonymous mitochondrial DNA variation. 同义线粒体DNA变异的细胞类型特异性纯化选择。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-24 DOI: 10.1073/pnas.2505704122

Caleb A Lareau,Patrick Maschmeyer,Yajie Yin,Jacob C Gutierrez,Ryan S Dhindsa,Anne-Sophie Gribling-Burrer,Sebastian Zielinski,Yu-Hsin Hsieh,Lena Nitsch,Veronika Dimitrova,Benan Nalbant,Frank A Buquicchio,Tsion Abay,Robert R Stickels,Jacob C Ulirsch,Patrick Yan,Fangyi Wang,Zhuang Miao,Katalin Sandor,Bence Daniel,Vincent Liu,Paul L Mendez,Petra Knaus,Manpreet Meyer,William J Greenleaf,Anshul Kundaje,Redmond P Smyth,Mathias Munschauer,Leif S Ludwig,Ansuman T Satpathy

{"title":"Cell type-specific purifying selection of synonymous mitochondrial DNA variation.","authors":"Caleb A Lareau,Patrick Maschmeyer,Yajie Yin,Jacob C Gutierrez,Ryan S Dhindsa,Anne-Sophie Gribling-Burrer,Sebastian Zielinski,Yu-Hsin Hsieh,Lena Nitsch,Veronika Dimitrova,Benan Nalbant,Frank A Buquicchio,Tsion Abay,Robert R Stickels,Jacob C Ulirsch,Patrick Yan,Fangyi Wang,Zhuang Miao,Katalin Sandor,Bence Daniel,Vincent Liu,Paul L Mendez,Petra Knaus,Manpreet Meyer,William J Greenleaf,Anshul Kundaje,Redmond P Smyth,Mathias Munschauer,Leif S Ludwig,Ansuman T Satpathy","doi":"10.1073/pnas.2505704122","DOIUrl":"https://doi.org/10.1073/pnas.2505704122","url":null,"abstract":"While somatic variants are well-characterized drivers of tumor evolution, their influence on cellular fitness in nonmalignant contexts remains understudied. We identified a mosaic synonymous variant (m.7076A > G) in the mitochondrial DNA (mtDNA)-encoded cytochrome c-oxidase subunit 1 (MT-CO1, p.Gly391=), present at homoplasmy in 47% of immune cells from a healthy donor. Single-cell multiomics revealed strong, lineage-specific selection against the m.7076G allele in CD8+ effector memory T cells, but not other T cell subsets, mirroring patterns of purifying selection of pathogenic mtDNA alleles. The limited anticodon diversity of mitochondrial tRNAs forces m.7076G translation to rely on wobble pairing, unlike the Watson-Crick-Franklin pairing used for m.7076A. Mitochondrial ribosome profiling confirmed stalled translation of the m.7076G allele. Functional analyses demonstrated that the elevated translational and metabolic demands of short-lived effector T cells (SLECs) amplify dependence on MT-CO1, driving this selective pressure. These findings suggest that synonymous variants can alter codon syntax, impacting mitochondrial physiology in a cell type-specific manner.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"115 1","pages":"e2505704122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic instability and hypofunctionality of fetal Tregs allow a permissive regulatory environment for T effector memory maturation. 胎儿treg的表观遗传不稳定性和功能低下为T效应记忆成熟提供了一个宽松的调节环境。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-24 DOI: 10.1073/pnas.2506673122

Jing Yao Leong,Naomi McGovern,Archita Mishra,Martin Wasser,Pavanish Kumar,Shi Huan Tay,Sharifah Nur Hazirah,Joo Guan Yeo,Xiu Qi Tan,Nursyuhadah Sutamam,Farah Nadiah Azman,Camillus Jian Hui Chua,Phyllis ZiXuan Chen,Fauziah Ally,Charles-Antoine Dutertre,Lakshmi Ramakrishna,Su Li Poh,Liang Xie,Yiping Fan,Catherine Donner,Maria Papadopoulou,David Vermijlen,Thaschawee Arkachaisri,Jerry Kok Yen Chan,Florent Ginhoux,Salvatore Albani

{"title":"Epigenetic instability and hypofunctionality of fetal Tregs allow a permissive regulatory environment for T effector memory maturation.","authors":"Jing Yao Leong,Naomi McGovern,Archita Mishra,Martin Wasser,Pavanish Kumar,Shi Huan Tay,Sharifah Nur Hazirah,Joo Guan Yeo,Xiu Qi Tan,Nursyuhadah Sutamam,Farah Nadiah Azman,Camillus Jian Hui Chua,Phyllis ZiXuan Chen,Fauziah Ally,Charles-Antoine Dutertre,Lakshmi Ramakrishna,Su Li Poh,Liang Xie,Yiping Fan,Catherine Donner,Maria Papadopoulou,David Vermijlen,Thaschawee Arkachaisri,Jerry Kok Yen Chan,Florent Ginhoux,Salvatore Albani","doi":"10.1073/pnas.2506673122","DOIUrl":"https://doi.org/10.1073/pnas.2506673122","url":null,"abstract":"The human gestational environment is commonly perceived to be predominantly suppressive and incompatible for T effector maturation. However, evidence of a competent effector fetal environment is mounting in the field. Here, we employed a high parametric, mass cytometry-based approach to study the fetal circulatory and microenvironmental immunomes, with the aim to understand the inception and extent of fetal effector T cell priming and its relation with regulatory mechanisms. We found evidence of fetal thymic immune imprinting, coupled with both circulatory and tissue effector memory development. Correspondingly, in the regulatory compartment, we detected the presence of Tbet+Treg in fetal tissues at elevated levels compared to adult tissues. Fetal Tregs, though capable of suppression, were hyposuppressive as compared with adult counterparts. We found that a proportion of fetal Tregs lost FoxP3 commitment during proliferation and exhibited higher TCR clonotype sharing with effector T cells, indicating higher plasticity in fetal Tregs than adult. Epigenetic profiling of the FoxP3 promoter locus reveals that fetal Tregs were only partially demethylated, possibly explaining the observed instability. In summary, our data provide evidence of a regulatory environment in the 2nd trimester permissive for T effector maturation, in part contributed by the relative instability and hypofunctionality in fetal Tregs.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"98 1","pages":"e2506673122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soil nitrogen drives inverse acclimation of xylem growth cessation to rising temperature in Northern Hemisphere conifers. 土壤氮驱动北半球针叶树木质部停止生长对温度升高的反向驯化。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-24 DOI: 10.1073/pnas.2421834122

Yaling Zhang,Jian-Guo Huang,Minhuang Wang,Wenjin Wang,Feiyu Yang,Annie Deslauriers,Patrick Fonti,Eryuan Liang,Harri Mäkinen,Walter Oberhuber,Cyrille B K Rathgeber,Roberto Tognetti,Václav Treml,Bao Yang,Lihong Zhai,Serena Antonucci,Valentina Buttò,J Julio Camarero,Filipe Campelo,Katarina Čufar,Martin De Luis,Marek Fajstavr,Alessio Giovannelli,Jožica Gričar,Andreas Gruber,Vladimír Gryc,Aylin Güney,Tuula Jyske,Jakub Kašpar,Gregory King,Cornelia Krause,Audrey Lemay,Fabio Lombardi,Edurne Martinez Del Castillo,Hubert Morin,Cristina Nabais,Pekka Nöjd,Richard L Peters,Peter Prislan,Antonio Saracino,Vladimir V Shishov,Hanuš Vavrčík,Joana Vieira,Qiao Zeng,Sergio Rossi

{"title":"Soil nitrogen drives inverse acclimation of xylem growth cessation to rising temperature in Northern Hemisphere conifers.","authors":"Yaling Zhang,Jian-Guo Huang,Minhuang Wang,Wenjin Wang,Feiyu Yang,Annie Deslauriers,Patrick Fonti,Eryuan Liang,Harri Mäkinen,Walter Oberhuber,Cyrille B K Rathgeber,Roberto Tognetti,Václav Treml,Bao Yang,Lihong Zhai,Serena Antonucci,Valentina Buttò,J Julio Camarero,Filipe Campelo,Katarina Čufar,Martin De Luis,Marek Fajstavr,Alessio Giovannelli,Jožica Gričar,Andreas Gruber,Vladimír Gryc,Aylin Güney,Tuula Jyske,Jakub Kašpar,Gregory King,Cornelia Krause,Audrey Lemay,Fabio Lombardi,Edurne Martinez Del Castillo,Hubert Morin,Cristina Nabais,Pekka Nöjd,Richard L Peters,Peter Prislan,Antonio Saracino,Vladimir V Shishov,Hanuš Vavrčík,Joana Vieira,Qiao Zeng,Sergio Rossi","doi":"10.1073/pnas.2421834122","DOIUrl":"https://doi.org/10.1073/pnas.2421834122","url":null,"abstract":"Controlled experiments suggest that the seasonal build-up of nitrogen (N) limitation constrains the responses of forest autumn phenology to elevated temperatures. Therefore, rising soil N is expected to increase the delaying effects of elevated temperature on the end of the season, i.e., leaf senescence. However, the interactive effects of temperature, soil N, and aridity on xylem autumn phenology remain unknown. We conducted a wide spatial analysis from 75 conifer sites in the Northern Hemisphere and found that rising soil N increases the delaying effects of elevated temperature on the end of xylem cell wall thickening but reduced the delaying effects on the cessation of cell enlargement, especially in humid regions. The contrasting effects of elevated soil N on cell enlargement versus cell wall thickening could affect xylem cell anatomy, thereby induce changes in wood density, and induce a decoupling of stem size growth from photosynthate production. These analyses extend previous findings on forest autumn phenology by systematically investigating the spatial variation in the interactive effects of temperature and soil N on xylem autumn phenology at the cellular scale.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"53 1","pages":"e2421834122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation science aims to improve healthcare by validating effective interventions. 实施科学旨在通过验证有效的干预措施来改善医疗保健。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-23 DOI: 10.1073/pnas.2517704122

John Carey

引用次数: 0