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Correction to Supporting Information for Wang et al., Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia.
IF 9.4 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1073/pnas.2504173122
{"title":"Correction to Supporting Information for Wang et al., Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia.","authors":"","doi":"10.1073/pnas.2504173122","DOIUrl":"https://doi.org/10.1073/pnas.2504173122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"e2504173122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social control drove ant evolution.
IF 9.4 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 Epub Date: 2025-03-24 DOI: 10.1073/pnas.2502664122
Timothy A Linksvayer
{"title":"Social control drove ant evolution.","authors":"Timothy A Linksvayer","doi":"10.1073/pnas.2502664122","DOIUrl":"https://doi.org/10.1073/pnas.2502664122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"e2502664122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung B cells in ectopic germinal centers undergo affinity maturation 异位生殖中心的肺 B 细胞经历亲和性成熟
IF 11.1 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 DOI: 10.1073/pnas.2416855122
Stephane M. Guillaume, William S. Foster, Isabel San Martín Molina, Emily M. Watson, Silvia Innocentin, Grant M. Kennedy, Alice E. Denton, Michelle A. Linterman
{"title":"Lung B cells in ectopic germinal centers undergo affinity maturation","authors":"Stephane M. Guillaume, William S. Foster, Isabel San Martín Molina, Emily M. Watson, Silvia Innocentin, Grant M. Kennedy, Alice E. Denton, Michelle A. Linterman","doi":"10.1073/pnas.2416855122","DOIUrl":"https://doi.org/10.1073/pnas.2416855122","url":null,"abstract":"The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and other airborne antigens can result in the formation of lymphocyte aggregates in the lung, which can harbor ectopic germinal centers (GCs). After allergen exposure, GCs that form in the lung are much smaller and less densely packed with B cells than lymph node GCs. Despite this, ectopic lung GCs support somatic hypermutation and affinity-based maturation as in lymph node GCs, and export memory B cells (MBCs) directly into the lung tissue. This demonstrates that the lung can locally diversify B cell responses and supports the generation of tissue MBC populations in situ.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"22 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate change impacts have potentially big repercussions for kids' education.
IF 9.4 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 Epub Date: 2025-03-26 DOI: 10.1073/pnas.2505073122
Saima Sidik
{"title":"Climate change impacts have potentially big repercussions for kids' education.","authors":"Saima Sidik","doi":"10.1073/pnas.2505073122","DOIUrl":"https://doi.org/10.1073/pnas.2505073122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"e2505073122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Deter-Wolf et al.: Laser-stimulated fluorescence of Chancay tattoos.
IF 9.4 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1073/pnas.2501912122
Thomas G Kaye, Judyta Bąk, Henry William Marcelo, Michael Pittman
{"title":"Reply to Deter-Wolf et al.: Laser-stimulated fluorescence of Chancay tattoos.","authors":"Thomas G Kaye, Judyta Bąk, Henry William Marcelo, Michael Pittman","doi":"10.1073/pnas.2501912122","DOIUrl":"https://doi.org/10.1073/pnas.2501912122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"e2501912122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction for Quach et al., Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis.
IF 9.4 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI: 10.1073/pnas.2504475122
{"title":"Correction for Quach et al., Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in <i>Mycobacterium tuberculosis</i>.","authors":"","doi":"10.1073/pnas.2504475122","DOIUrl":"https://doi.org/10.1073/pnas.2504475122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"e2504475122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to Supporting Information for Walters et al., Identification of FSH-regulated and estrous stage-specific transcriptional networks in mouse ovaries. 对 Walters 等人，《小鼠卵巢 FSH 调节和发情期特异性转录网络的鉴定》佐证信息的更正。
IF 9.4 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI: 10.1073/pnas.2504347122
{"title":"Correction to Supporting Information for Walters et al., Identification of FSH-regulated and estrous stage-specific transcriptional networks in mouse ovaries.","authors":"","doi":"10.1073/pnas.2504347122","DOIUrl":"https://doi.org/10.1073/pnas.2504347122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"e2504347122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
IF 11.1 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 DOI: 10.1073/pnas.2417218122
Tarik Husremović, Vanessa Meier, Lucas Piëch, Katharina M. Siess, Sumire Antonioli, Irina Grishkovskaya, Nikoleta Kircheva, Silvia E. Angelova, Karoline Wenzl, Andreas Brandstätter, Jiri Veis, Fran Miočić-Stošić, Dorothea Anrather, Markus Hartl, Linda Truebestein, Luis M. Cerron-Alvan, Martin Leeb, Bojan Žagrović, Stephan Hann, Christoph Bock, Egon Ogris, Todor Dudev, Nicholas A. T. Irwin, David Haselbach, Thomas A. Leonard
{"title":"PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor","authors":"Tarik Husremović, Vanessa Meier, Lucas Piëch, Katharina M. Siess, Sumire Antonioli, Irina Grishkovskaya, Nikoleta Kircheva, Silvia E. Angelova, Karoline Wenzl, Andreas Brandstätter, Jiri Veis, Fran Miočić-Stošić, Dorothea Anrather, Markus Hartl, Linda Truebestein, Luis M. Cerron-Alvan, Martin Leeb, Bojan Žagrović, Stephan Hann, Christoph Bock, Egon Ogris, Todor Dudev, Nicholas A. T. Irwin, David Haselbach, Thomas A. Leonard","doi":"10.1073/pnas.2417218122","DOIUrl":"https://doi.org/10.1073/pnas.2417218122","url":null,"abstract":"The phosphoinositide 3-kinase (PI3K) pathway is a major regulator of cell and organismal growth. Consequently, hyperactivation of PI3K and its downstream effector kinase, Akt, is observed in many human cancers. Pleckstrin homology domain leucine-rich repeat-containing protein phosphatases (PHLPP), two paralogous members of the metal-dependent protein phosphatase family, have been reported as negative regulators of Akt signaling and, therefore, tumor suppressors. However, the stoichiometry and identity of the bound metal ion(s), mechanism of action, and enzymatic specificity of these proteins are not known. Seeking to fill these gaps in our understanding of PHLPP biology, we unexpectedly found that PHLPP2 has no catalytic activity in vitro. Instead, we found that PHLPP2 is a pseudophosphatase with a single zinc ion bound in its catalytic center. Furthermore, we found that cancer genomics data do not support the proposed role of PHLPP1 or PHLPP2 as tumor suppressors. Phylogenetic analyses revealed an ancestral phosphatase that arose more than 1,000 Mya, but that lost activity at the base of the metazoan lineage. Surface conservation indicates that while PHLPP2 has lost catalytic activity, it may have retained substrate binding. Finally, using phylogenomics, we identify coevolving genes consistent with a scaffolding role for PHLPP2 on membranes. In summary, our results provide a molecular explanation for the inconclusive results that have hampered research on PHLPP and argue for a focus on the noncatalytic roles of PHLPP1 and PHLPP2.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"38 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In This Issue.
IF 9.4 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 DOI: 10.1073/iti1325122
{"title":"In This Issue.","authors":"","doi":"10.1073/iti1325122","DOIUrl":"https://doi.org/10.1073/iti1325122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"eiti1325122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to Supporting Information for Schmidt et al., Archaeological adhesives made from Podocarpus document innovative potential in the African Middle Stone Age.
IF 9.4 1区 综合性期刊
Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1073/pnas.2503875122
{"title":"Correction to Supporting Information for Schmidt et al., Archaeological adhesives made from <i>Podocarpus</i> document innovative potential in the African Middle Stone Age.","authors":"","doi":"10.1073/pnas.2503875122","DOIUrl":"https://doi.org/10.1073/pnas.2503875122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"e2503875122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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