Proceedings for Annual Meeting of The Japanese Pharmacological Society最新文献_第4页

Cutting edge approach using Modeling and Simulation, AI in drug development -How to boost the clinical drug development- 在药物开发中使用建模和仿真的前沿方法，人工智能-如何促进临床药物开发-

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-s28-3

Terao Kimio

{"title":"Cutting edge approach using Modeling and Simulation, AI in drug development -How to boost the clinical drug development-","authors":"Terao Kimio","doi":"10.1254/jpssuppl.95.0_2-s28-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-s28-3","url":null,"abstract":"How quickly reach the goal / establish the platform of artificial intelligence (AI) for drug development is one of the biggest issue for most of pharmaceutical company. Model informed drug development (MIDD) is applied across the drug development phase, and biology / physiology based sciences. One of the key expected outcomes by MIDD is to estimate 3 view points of RIGHT which are \"RIGHT dose\", \"RIGHT patients\", and \"RIGHT timing\". To obtain three RIGHT, it is required to demonstrate drug exposure, drug penetration, pharmacodynamic biomarker response, and clinical outcomes. Quantitative system pharmacology (QSP) model is one the tool find these \"RIGHT\" and is give us the hypothetical resolution against the research/clinical questions. Integrated into wet experimental data, genetic analysis, drug binding, metabolism, polymorphisms, biological pathways. Accurate computational power is required to establish the appropriate quality of QSP model, therefore abilities of AI is required. To implementation of AI to resolve the dedicated model, it is expected to accelerated the speed of drug development and QSP model primed to change the landscape of drug development. Company-Organized Symposium","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77677792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of TRPA1 in hypoxic response of the carotid body TRPA1在颈动脉体缺氧反应中的作用

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-p-090

Tomoya Kawamoto, Akito Nakao, Barneo José López, Y. Mori

引用次数: 0

Development of therapeutic drugs for sickle cell disease targeting a histone methyltransferase 靶向组蛋白甲基转移酶的镰状细胞病治疗药物的研究进展

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_2-b-s17-1

A. Ito

引用次数: 0

Intragingival application of Porphyromonas gingivalis-derived lipopolysaccharide induces an increase in plasma TNF-α levels in anaesthetised rats 应用牙龈卟啉单胞菌衍生的脂多糖诱导麻醉大鼠血浆TNF-α水平升高

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_2-b-p-099

Y. Aono, Koji Saito, T. Saigusa

引用次数: 0

The L-DOPA receptor GPR143 in the indirect pathways regulates an anxiety-like behavior in mice 间接通路中的左旋多巴受体GPR143调节小鼠的焦虑样行为

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-ss-12

Tajika Rei, D. Masukawa, H. Uchimura, Y. Goshima

引用次数: 0

Involvement of alteration of CD36 expression on pilocarpine-induced salivation in mouse parotid gland CD36表达改变与匹罗卡品诱导小鼠腮腺唾液分泌的关系

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_3-p-263

Keitaro Satoh, Yuta Ohno, Haruna Nagase, M. Kashimata, Kazunori Adachi

引用次数: 0

Development and application of a novel probe that realize the imaging analysis of oxytocin dynamics in brain tissue 实现脑组织内催产素动态成像分析的新型探针的研制与应用

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_yia07-1

Kaho Nakamura

引用次数: 0

Noninvasive monitoring of muscle atrophy and bone metabolic disorder using Dual energy X-ray absorptiometry (DXA) in diabetes mellitus model mouse 双能x线吸收仪(DXA)无创监测糖尿病模型小鼠肌肉萎缩和骨代谢紊乱

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-p-171

Goto Momo, Kazuhisa Kishi, Yoshiharu Tsuru, M. Hori

引用次数: 0

Establishment of SARS-CoV-2 respiratory tract infection model in CAG promoter-driven hACE2 transgenic mice CAG启动子驱动hACE2转基因小鼠SARS-CoV-2呼吸道感染模型的建立

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-p-173

Utsumi Daichi, Masamitsu N. Asaka, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, Y. Kawaoka, K. Kuba, Y. Yasutomi

{"title":"Establishment of SARS-CoV-2 respiratory tract infection model in CAG promoter-driven hACE2 transgenic mice","authors":"Utsumi Daichi, Masamitsu N. Asaka, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, Y. Kawaoka, K. Kuba, Y. Yasutomi","doi":"10.1254/jpssuppl.95.0_2-p-173","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-p-173","url":null,"abstract":"COVID-19, caused by SARS-CoV-2, has spread worldwide with dire consequence. Vaccine is just not enough to suppress to this pandemic, and it is desired to develop the prophylactic and therapeutic agents for preventing the spread of infection and severity. Therefore, it is extremely important to propose therapeutic strategies by using pathological models. In this study, we established an animal model with highly susceptible to SARS-CoV-2 via the intratracheal tract infection in CAG-promoter-driven human angiotensin-converting enzyme 2 transgenic (CAG-hACE2) mice that more than 15 copies of hACE2 genes were tandemly integrated into the mouse genome. The CAG-hACE2 mice showed several severe symptoms of SARS-CoV-2 infection, with definitive weight loss and subsequent death. Acute pneumonia with elevated cytokine and chemokine levels was observed at an early stage of infection in CAG-hACE2 mice infected with SARS-CoV-2. In the developed model, administration of remdesivir, which is antiviral agent, or injection of plasma from immunized mice prevented body weight loss and lethality due to infection with SARS-CoV-2. These results indicated that a highly susceptible model of SARS-CoV-2 infection in CAG-hACE2 mice via the intratracheal tract is suitable for evaluating antibody therapeutics and medicines.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79037632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multistep regulation of mammalian sleep by phosphorylation states of CaMKII CaMKII磷酸化状态对哺乳动物睡眠的多步骤调节

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_yia01-5

D. Tone, K. Ode, Qianhui Zhang, Hiroki R Ueda

引用次数: 0