Proceedings for Annual Meeting of The Japanese Pharmacological Society最新文献_第3页

Epigenetic regulation of myeloid cell differentiation 髓细胞分化的表观遗传调控

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_3-s36-3

Kurotaki Daisuke

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引用次数: 0

Synapse formation and remodeling visualized in physiological and pathological states 突触的形成和重塑在生理和病理状态下可见

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-sl03

S. Okabe

{"title":"Synapse formation and remodeling visualized in physiological and pathological states","authors":"S. Okabe","doi":"10.1254/jpssuppl.95.0_1-sl03","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-sl03","url":null,"abstract":"The development of neuronal circuits in vivo depends on precise regulation of synapse formation, elimination, and remodeling. In vivo two-photon imaging confirmed the presence of two phases of synapse dynamics in the postnatal mouse cortex. In the first phase (until postnatal 20 days), synapse turnover is maintained to be high, while in the second phase (after three weeks postnatal), synapse dynamics are highly suppressed, leading to the maturation of the cortical neural network. The transition in synapse dynamics may underlie the pathophysiology of neurodevelopmental disorders and psychiatric diseases, but their precise mechanisms have not yet been clarified. Our laboratory has focused on (1) the diverse mechanisms in neural circuits and synapse formation, (2) the structure-function relationship in dynamic synaptic changes, and (3) the relationship between brain diseases and synaptic dysfunction. In particular, we have recently developed new tools for studying neural circuits, such as quantitative methods for analyzing the nano-structure of spine synapses and methods for measuring the molecular dynamics inside spines. Furthermore, we are applying these tools to the study of brain pathology. In this talk, I will introduce these researches and discuss the validity and prospects of understanding the pathogenesis of psychiatric disorders as synaptic dysfunction.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75518180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alleviative effect of glutamate on 5-fluorouracil-induced intestinal mucositis in mice 谷氨酸对5-氟尿嘧啶致小鼠肠道黏膜炎的缓解作用

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-ss-61

S. Jonan, Ayana Fujiwara, K. Iwata, S. Kato, K. Amagase

引用次数: 0

Induction of itch and modulation of inflammation by IL-31-responsive sensory neurons il -31反应性感觉神经元对瘙痒的诱导和炎症的调节

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-s25-1

Okada Takaharu

引用次数: 0

Resveratrol attenuates age-related muscle atrophy and motor dysfunction by promoting autophagy in mice 白藜芦醇通过促进小鼠自噬来减轻与年龄相关的肌肉萎缩和运动功能障碍

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-yia-44

R. Hosoda, A. Kuno, Ryuta Nakashima, S. Asakura, N. Iwahara, Iyori Nojima, Risa Kunimoto, Y. Horio

引用次数: 0

Interaction between new neurons and astrocytes in the post-stroke brain 脑卒中后新神经元和星形胶质细胞之间的相互作用

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_4-b-s38-4

Kaneko Naoko

引用次数: 0

Orphan G protein-coupled receptor GPR35 contributes to the pathogenesis of dextran sulfate sodium-induced colitis in mice. 孤儿G蛋白偶联受体GPR35参与了硫酸葡聚糖钠诱导小鼠结肠炎的发病机制。

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-p-056

Ayaka Kishi, Yuu Tachibana, Yui Murase, Koga Tokuyama, M. Saito, Hiroyuki Yasuda, Kenjiro Matsumoto, S. Kato

引用次数: 0

Role of extracellular vesicles in disease: a novel tool for understanding disease mechanism? 细胞外囊泡在疾病中的作用:了解疾病机制的新工具?

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-w05-2

Yoshioka Yusuke

引用次数: 0

Downregulation of astrocytic connexin43 potentiates the antidepressant-induced brain-derived neurotrophic factor expression 星形细胞连接蛋白43的下调增强了抗抑郁药诱导的脑源性神经营养因子的表达

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-yia-15

Tokunaga Nozomi, Yoki Nakamura, K. Nakashima, N. Morioka

引用次数: 0

Development of Molecule-Specific Oxidative Modification Inhibitor 分子特异性氧化修饰抑制剂的研究进展

Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_2-b-s17-2

Takashi Uehara

引用次数: 0