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Proceedings for Annual Meeting of The Japanese Pharmacological Society最新文献

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Generation of genetically-encoded fluorescent sensors using molecular evolution and semi-rational molecular design 利用分子进化和半理性分子设计产生遗传编码荧光传感器
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_2-b-s14-1
Kitaguchi Tetsuya
{"title":"Generation of genetically-encoded fluorescent sensors using molecular evolution and semi-rational molecular design","authors":"Kitaguchi Tetsuya","doi":"10.1254/jpssuppl.96.0_2-b-s14-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-s14-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79286063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of a novel hepatitis B antiviral drug in renal organic acid transporters 一种新型乙型肝炎抗病毒药物对肾有机酸转运体的影响
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-p-082
Misaki Ishibane, M. Kaneko, Shota Saito, Sangjon Pae, Shinpei Saito, Y. Reien, Yuri Hirayama, Hirofumi Hashimoto, N. Kuwata, H. Mitsuya, N. Anzai
{"title":"Effects of a novel hepatitis B antiviral drug in renal organic acid transporters","authors":"Misaki Ishibane, M. Kaneko, Shota Saito, Sangjon Pae, Shinpei Saito, Y. Reien, Yuri Hirayama, Hirofumi Hashimoto, N. Kuwata, H. Mitsuya, N. Anzai","doi":"10.1254/jpssuppl.95.0_1-p-082","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-p-082","url":null,"abstract":"In treatment of hepatitis B virus (HBV), it is usually difficult for us to control with emergence of drug resistance. As HBV often reactive after treatment was stopped, patients must keep it for long term. Recently, we have developed E-CFCP, as a candidate drug of HBV for patients with drug-resistant HBV. As it has high antiviral activity and the half-life also is longer, patients can take it in a once-weekly dosing. We expect that E-CFCP can greatly improve the quality of life of patients. However, effects of E-CFCP are unclear in renal. The aim of this study is to clarify the effects of E-CFCP in the kidney, especially organic acid transporter（Organic anion transporters：OATs, Organic cation transporter：OCT）. We conducted cell viability studies using mouse-derived renal cortical cells (S2, CCD, cTAL) and uptake studies using radioisotopes to determine the effects of E-CFCP on the kidneys. In cell viability studies, E-CFCP has no cytotoxicity in all cell lines. We also examined the effect of drugs at high concentration using S2 cells. E-CFCP has no cytotoxicity even at high concentrations. In the substrate uptake assay, there was no inhibition of substrate uptake by E-CFCP, the transporter is not involved in the intracellular transport of E-CFCP and is unlikely to cause cytotoxicity. In conclusion, E-CFCP, a novel HBV antiviral drug, is unlikely to cause renal damage. It may be a novel great candidate drug of HBV for patients with drug-resistant HBV.","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79374749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration of Nrf2-ARE pathway activators for the prevention and treatment of diseases Nrf2-ARE通路激活因子在疾病预防和治疗中的探索
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_4-b-s44-2
Yasuhiko Izumi
{"title":"Exploration of Nrf2-ARE pathway activators for the prevention and treatment of diseases","authors":"Yasuhiko Izumi","doi":"10.1254/jpssuppl.96.0_4-b-s44-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_4-b-s44-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79430705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Discovery to Clinical application of PACAP PACAP从发现到临床应用
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_1-cl
A. Miyata
{"title":"From Discovery to Clinical application of PACAP","authors":"A. Miyata","doi":"10.1254/jpssuppl.95.0_1-cl","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_1-cl","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81809819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological action of ATP receptors and current status of related drug development ATP受体的药理作用及其药物开发现状
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.95.0_2-sl06
Kazuhide Inoue
{"title":"Pharmacological action of ATP receptors and current status of related drug development","authors":"Kazuhide Inoue","doi":"10.1254/jpssuppl.95.0_2-sl06","DOIUrl":"https://doi.org/10.1254/jpssuppl.95.0_2-sl06","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81872063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doxorubicin did not affect the lysosomal acidification 阿霉素不影响溶酶体酸化
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-p-075
Takeya Sato, N. Toda, Masaki Saito, Masanori Yamauchi, Takaaki Abe
{"title":"Doxorubicin did not affect the lysosomal acidification","authors":"Takeya Sato, N. Toda, Masaki Saito, Masanori Yamauchi, Takaaki Abe","doi":"10.1254/jpssuppl.96.0_1-b-p-075","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-p-075","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84229544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Na+/Ca2+ exchanger type 1 functions as a “brake” of hyperactivation in hamster sperm. 1型Na+/Ca2+交换器在仓鼠精子中起着“刹车”的作用。
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_2-b-o03-3
L. Gen, Y. Ogura, Y. Ujihara, Fubito Toyama, Keitaro Hayashi, T. Fujita
{"title":"Na+/Ca2+ exchanger type 1 functions as a “brake” of hyperactivation in hamster sperm.","authors":"L. Gen, Y. Ogura, Y. Ujihara, Fubito Toyama, Keitaro Hayashi, T. Fujita","doi":"10.1254/jpssuppl.96.0_2-b-o03-3","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_2-b-o03-3","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"468 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84461876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purinergic regulation of mast cell function and allergic response via ionotropic P2X4 receptors 嘌呤能通过嗜离子性P2X4受体调控肥大细胞功能和过敏反应
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-s08-2
Kazuki Yoshida, Masa-aki Ito, I. Matsuoka
{"title":"Purinergic regulation of mast cell function and allergic response via ionotropic P2X4 receptors","authors":"Kazuki Yoshida, Masa-aki Ito, I. Matsuoka","doi":"10.1254/jpssuppl.96.0_1-b-s08-2","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-s08-2","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84507687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phospholipase C like protein PRIP1 PH-domain-containing liposomes enhance apoptotic cell death in cisplatin resistant breast cancer cells 磷脂酶C样蛋白PRIP1含ph结构域脂质体促进顺铂耐药乳腺癌细胞的凋亡细胞死亡
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-p-076
Asano Satoshi, Y. Ago, T. Kanematsu
{"title":"Phospholipase C like protein PRIP1 PH-domain-containing liposomes enhance apoptotic cell death in cisplatin resistant breast cancer cells","authors":"Asano Satoshi, Y. Ago, T. Kanematsu","doi":"10.1254/jpssuppl.96.0_1-b-p-076","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-p-076","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84529992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional structural analysis of pharmacokinetics-related membrane protein P-glycoprotein using cryo-electron microscopy 用冷冻电镜分析药代动力学相关膜蛋白p -糖蛋白的三维结构
Proceedings for Annual Meeting of The Japanese Pharmacological Society Pub Date : 2022-01-01 DOI: 10.1254/jpssuppl.96.0_1-b-ss05-1
Hamaguchi Norie, N. Adachi, T. Moriya, M. Kawasaki, Kenji Yasuda, T. Senda, Satoshi Oagasawara, T. Murata
{"title":"Three-dimensional structural analysis of pharmacokinetics-related membrane protein P-glycoprotein using cryo-electron microscopy","authors":"Hamaguchi Norie, N. Adachi, T. Moriya, M. Kawasaki, Kenji Yasuda, T. Senda, Satoshi Oagasawara, T. Murata","doi":"10.1254/jpssuppl.96.0_1-b-ss05-1","DOIUrl":"https://doi.org/10.1254/jpssuppl.96.0_1-b-ss05-1","url":null,"abstract":"","PeriodicalId":20464,"journal":{"name":"Proceedings for Annual Meeting of The Japanese Pharmacological Society","volume":"207 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85011407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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