Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering最新文献_第2页

An Inductive Transfer Learning Approach using Cycle-consistent Adversarial Domain Adaptation with Application to Brain Tumor Segmentation 基于循环一致对抗域自适应的归纳迁移学习方法在脑肿瘤分割中的应用

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375948

Y. Tokuoka, Shuji Suzuki, Yohei Sugawara

{"title":"An Inductive Transfer Learning Approach using Cycle-consistent Adversarial Domain Adaptation with Application to Brain Tumor Segmentation","authors":"Y. Tokuoka, Shuji Suzuki, Yohei Sugawara","doi":"10.1145/3375923.3375948","DOIUrl":"https://doi.org/10.1145/3375923.3375948","url":null,"abstract":"With recent advances in supervised machine learning for medical image analysis applications, the annotated medical image datasets of various domains are being shared extensively. Given that the annotation labelling requires medical expertise, such labels should be applied to as many learning tasks as possible. However, the multi-modal nature of each annotated image renders it difficult to share the annotation label among diverse tasks. In this work, we provide an inductive transfer learning (ITL) approach to adopt the annotation label of the source domain datasets to tasks of the target domain datasets using Cycle-GAN based unsupervised domain adaptation (UDA). To evaluate the applicability of the ITL approach, we adopted the brain tissue annotation label on the source domain dataset of Magnetic Resonance Imaging (MRI) images to the task of brain tumor segmentation on the target domain dataset of MRI. The results confirm that the segmentation accuracy of brain tumor segmentation improved significantly. The proposed ITL approach can make significant contribution to the field of medical image analysis, as we develop a fundamental tool to improve and promote various tasks using medical images.","PeriodicalId":20457,"journal":{"name":"Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91098939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Muscle Synergy Analysis on Upper Limb Movements of Human Arms 人体上肢运动的肌肉协同分析

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375940

Hanlin Chen, F. Qin, Jiankang Wu

引用次数: 0

Towards Quantifying Genetic Interactions Among Tumor Suppressor Genes in Breast Cancer 乳腺癌肿瘤抑制基因间基因相互作用的定量研究

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375935

Wenhao Jiang, Qixuan Zhong

引用次数: 0

DMBA Induction Increases H-Ras Gene Expression and Decreases CD8 Count in Sprague Dawley Rats DMBA诱导增加大鼠H-Ras基因表达，降低CD8计数

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375942

T. Hidayati, Indrayanti, Sagiran

{"title":"DMBA Induction Increases H-Ras Gene Expression and Decreases CD8 Count in Sprague Dawley Rats","authors":"T. Hidayati, Indrayanti, Sagiran","doi":"10.1145/3375923.3375942","DOIUrl":"https://doi.org/10.1145/3375923.3375942","url":null,"abstract":"Introduction: DMBA is carcinogenic-immunosuppressant. This study was conducted to investigate the immunosuppressant effect of dimethylbenzanthracene (DMBA) on H-Ras expression, hemogram, and CD8 count I Sprague Dawley (SD) rats. Methods: We divided the test animals into three groups. The normal group received standard food and drink. We induced the DMBA group with 10x20mg/kg BW DMBA for five weeks. The solvent group received standard feeding and corn oil solutions. We conducted dissection and data retrieval in week 27. The immunosuppressant effects of DMBA are measured by number leukocytes and CD8CTL. The number of CD8 is determined by the flow cytometer. The H-Ras gene expression is assessed using densitometry after PCR. The mean intergroup difference was calculated using ANOVA. Result: The results showed that DMBA administration increases H-Ras gene expression and decreases CD8 count (p<0.05). 10x20 mg/kg BW DMBA administration decrease leukocytes and platelet (p<0.05). Conclusion: A dose of 10x20 mg/kg BW DMBA decreased CD8, leukocytes, and platelet number, while it increased H-Ras gene expression in SD rats.","PeriodicalId":20457,"journal":{"name":"Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73647029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of Trunk Rotation and Backrest Activity on Lumbar sEMG Activities, Body Pressure Distribution and Sitting Discomfort during Sitting 躯干旋转和靠背活动对腰椎肌电信号活动、体压分布和坐姿不适的影响

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375941

Zhiping Liu

{"title":"Effects of Trunk Rotation and Backrest Activity on Lumbar sEMG Activities, Body Pressure Distribution and Sitting Discomfort during Sitting","authors":"Zhiping Liu","doi":"10.1145/3375923.3375941","DOIUrl":"https://doi.org/10.1145/3375923.3375941","url":null,"abstract":"The purpose of this study was to examine the effects of trunk rotation and backrest activity on sitting discomfort, body pressure distribution and lumbar surface Electromyographic (sEMG) activities of lumbar erector spinae muscles (LES) and lumbar multifidus muscles (LMF), so as to provide a scientific basis on dynamic chair design and optimization and human-table-chair office system design. Ten healthy male subjects sat on two kinds of office chairs (one fixed dual-back chair and one movable dual-back chair), rotating 60° to the left and the right to simulate the common trunk activities of office work with the seatpan and backrest angle of 110°. Four tests were performed on each subject and sEMG activities of bilateral LES and LMF and body pressure distribution data of seatpan and backrest were statically measured. Meanwhile the Body Part Discomfort (BPD) Scale (Revised) was used to measure the subjective feelings of sitting discomfort. The results showed: (1) backrest activity did not affect marginally on LES and LMF myoelectric activities (P>.05) but trunk rotation had a significant effect on sEMG activities of left LMF (P<.01); (2) trunk rotation did not affect marginally on all the pressure variables (P>.05) but backrest activity affected marginally on average seatpan pressure (ASP), average backrest pressure (ABP) and peak backrest pressure (PBP) (P<.05); (3) low back discomfort (LBD) and total discomfort (OD) subjective ratings were significantly affected by backrest activity which had a large difference between fixed and movable dual-back chair and the latter gained a lower rating of discomfort. This study systematically utilized the combination of objective and subjective measurement to confirm that movable dual-back chairs were significantly better than fixed dual-back chairs which showed the superiority of dynamic chairs.","PeriodicalId":20457,"journal":{"name":"Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78886844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Model-based Method for Measuring Autonomic Nerve Activity and Sensitivity 一种基于模型的自主神经活动和灵敏度测量方法

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375944

Xiang'ao Meng, Zhipei Huang, Jiankang Wu

引用次数: 1

Predicting Synthetic Lethal Genetic Interactions in Breast Cancer using Decision Tree 利用决策树预测乳腺癌的合成致死基因相互作用

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375933

Zibo Yin, Bowen Qian, Guowei Yang, Li Guo

{"title":"Predicting Synthetic Lethal Genetic Interactions in Breast Cancer using Decision Tree","authors":"Zibo Yin, Bowen Qian, Guowei Yang, Li Guo","doi":"10.1145/3375923.3375933","DOIUrl":"https://doi.org/10.1145/3375923.3375933","url":null,"abstract":"Recently, a type of genetic interaction, termed synthetic lethality, is emerging as a potential promising anticancer strategy. Synthetic lethality indicates that simultaneous silencing of two complementary signaling pathways can cause cell death, while deficiency of any single gene will not show phenotype. In this study, we aimed to analyze and predict synthetic lethal genetic interactions based on decision tree in breast cancer using TCGA data. First, candidate gene pairs were collected using mutation data based on Misl algorithm, and involved genes were found in more than 2.5% total samples. Based on this method, we obtained 51,040 candidate gene pairs containing 320 genes. Second, 281 experimentally validated gene pairs were used to classify and optimize two features of mutation coverage and copy number variations (CNV) gain/loss, and the final integrated scores were used to predict synthetic lethal genetic interactions based on decision tree. Finally, candidate gene pairs were performed multi-level integrative analysis to search potential interactions, and 11,758 pairs were primarily identified. Some key gene pairs could be further screened based on drug responses and amplification features for experimentally identification, and we finally screened 5 gene pairs to perform further analysis. These results may contribute to screening and identifying synthetic lethal genetic interactions to uncover potential therapeutic target.","PeriodicalId":20457,"journal":{"name":"Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88701143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fast Multislice Chemical Exchange Saturation Transfer (CEST) MRI with Dual-channel RF Irradiation 快速多层化学交换饱和转移(CEST) MRI双通道射频辐射

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375925

Yudong Zhong, Xiaodong Zhou, Yiping P. Du, Qun Chen

{"title":"Fast Multislice Chemical Exchange Saturation Transfer (CEST) MRI with Dual-channel RF Irradiation","authors":"Yudong Zhong, Xiaodong Zhou, Yiping P. Du, Qun Chen","doi":"10.1145/3375923.3375925","DOIUrl":"https://doi.org/10.1145/3375923.3375925","url":null,"abstract":"The aim of this study is to develop a technique for rapid multislice chemical exchange saturation transfer (CEST) imaging with dual-channel radiofrequency (RF) irradiation to reduce scan time and enhance CEST contrast. Conventional CEST MRI is implemented with a long RF irradiation module, followed by fast image acquisition to obtain a steady state CEST contrast. However, it typically requires a long preparation time while producing relatively small CEST contrast. A dual-channel RF irradiation scheme is proposed including a long dual-channel RF irradiation module that establishes a steady state CEST contrast and repetitive short dual-channel secondary RF irradiation modules to maintain the contrast. The proposed method is designed to reduce the preparation time to reach steady state CEST contrast and efficiently maintain the contrast throughout signal averages and multislice acquisition. The proposed method was validated on a creatine phantom, and exhibited 31.96% higher CEST contrast than the conventional method. The proposed method, a fast multislice CEST MRI sequence with dual-channel RF irradiation module, is a promising technique with significantly improved CEST contrast and reduced scan time.","PeriodicalId":20457,"journal":{"name":"Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88782210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indexing Biosignal for Integrated Health Social Networks 索引生物信号集成健康社会网络

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375936

Yi Huang, Insu Song

引用次数: 4

Acoustic Noise Reduction of Echo Planar Imaging in Diffusion MRI 弥散MRI回波平面成像降噪研究

Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering Pub Date : 2019-11-13 DOI: 10.1145/3375923.3375937

Junwei Zhao, Zhenliang Lin, Xiaodong Zhou, Guobin Li, Jie Luo

{"title":"Acoustic Noise Reduction of Echo Planar Imaging in Diffusion MRI","authors":"Junwei Zhao, Zhenliang Lin, Xiaodong Zhou, Guobin Li, Jie Luo","doi":"10.1145/3375923.3375937","DOIUrl":"https://doi.org/10.1145/3375923.3375937","url":null,"abstract":"Acoustic noise during MR scans, generated by the gradient coil vibration, has been compromising for patient comfort and even poses risk for sensitive populations such as fetuses and infants. Although recommended noise level for neonatal MRI with hearing protection such as earplugs is 65 dBA, noise level of an MRI scan could be as high as 125-130 dB(A) at 3T. Further, hearing protection compliance for neonates using earplug could be unreliable. Single-shot echo planar imaging (EPI) has a rapid switching readout gradient waveform that is very efficient for data acquisition but also very loud. Given that EPI is widely used diffusion MRI techniques, modifications in the EPI sequence design could offer a solution that is ubiquitous across scanner platforms. In this work, we investigated the acoustic noise reduction effects of gradient waveform adjustments, echo spacing adjustments, in combination with parallel imaging. Through gradient waveform and echo spacing (ESP) adjustment, the acoustic noise was reduced by 7.5 dBA while keeping high image SNR. Besides, we validated the image consistency and ADC value accuracy quantitatively between traditional EPI-DWI sequence and the modified versions of EPI-DWI sequences in both phantom and human studies.","PeriodicalId":20457,"journal":{"name":"Proceedings of the 2019 6th International Conference on Biomedical and Bioinformatics Engineering","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89492889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0