Preventive Nutrition and Food Science最新文献

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Inhibitory Efficacy of Cycloartenyl Ferulate against α-Glucosidase and α-Amylase and Its Increased Concentration in Gamma-Irradiated Rice (Germinated Rice). 阿魏酸环蒿烯基对γ辐照水稻(发芽水稻)α-葡萄糖苷酶和α-淀粉酶的抑制作用及其浓度升高。
Preventive Nutrition and Food Science Pub Date : 2023-06-30 DOI: 10.3746/pnf.2023.28.2.170
Sompong Sansenya, Apirak Payaka, Preecha Mansalai
{"title":"Inhibitory Efficacy of Cycloartenyl Ferulate against α-Glucosidase and α-Amylase and Its Increased Concentration in Gamma-Irradiated Rice (Germinated Rice).","authors":"Sompong Sansenya,&nbsp;Apirak Payaka,&nbsp;Preecha Mansalai","doi":"10.3746/pnf.2023.28.2.170","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.2.170","url":null,"abstract":"<p><p>Cycloartenyl ferulate is a derivative of γ-oryzanol with varied biological activity, including diabetes mellitus treatment. This research focused on improving the cycloartenyl ferulate accumulation in germinated rice by gamma irradiation under saline conditions. Moreover, the inhibitory potential of cycloartenyl ferulate against carbohydrate hydrolysis enzymes (α-glucosidase and α-amylase) was investigated through <i>in vitro</i> and <i>in silico</i> techniques. The results revealed that cycloartenyl ferulate increased in germinated rice under saline conditions upon gamma irradiation. A suitable condition for stimulating the highest cycloartenyl ferulate concentration (852.20±20.59 μg/g) in germinated rice was obtained from the gamma dose at 100 Gy and under 40 mM salt concentration. The inhibitory potential of cycloartenyl ferulate against α-glucosidase (31.31±1.43%) was higher than against α-amylase (12.72±1.11%). The inhibition mode of cycloartenyl ferulate against α-glucosidase was demonstrated as a mixed-type inhibition. A fluorescence study confirmed that the cycloartenyl ferulate interacted with the α-glucosidase's active site. A docking study revealed that cycloartenyl ferulate bound to seven amino acids of α-glucosidase with a binding energy of -8.8 kcal/mol and a higher binding potential than α-amylase (-8.2 kcal/mol). The results suggested that the gamma irradiation technique under saline conditions is suitable for stimulating γ-oryzanol, especially cycloartenyl ferulate. Furthermore, cycloartenyl ferulate demonstrated its potential as a candidate compound for blood glucose management in diabetes mellitus treatment.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/b6/pnfs-28-2-170.PMC10321442.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9810326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AGEs Blocker™ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice. AGEs阻断剂™(枸杞、无花果和韩国薄荷混合提取物)抑制无毛小鼠由链脲佐菌素诱导的糖基化引起的皮肤老化。
Preventive Nutrition and Food Science Pub Date : 2023-06-30 DOI: 10.3746/pnf.2023.28.2.134
Jin Hee Yoo, Je Sung Lee, Ji Hwan Jang, Jae In Jung, Eun Ji Kim, Su-Young Choi
{"title":"AGEs Blocker™ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice.","authors":"Jin Hee Yoo,&nbsp;Je Sung Lee,&nbsp;Ji Hwan Jang,&nbsp;Jae In Jung,&nbsp;Eun Ji Kim,&nbsp;Su-Young Choi","doi":"10.3746/pnf.2023.28.2.134","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.2.134","url":null,"abstract":"<p><p>Glycation is a cause of skin aging. This study investigated in a glycation-induced skin aging mouse model the effects on skin and mechanism of action of AGEs Blocker™ (AB), which contains goji berry, fig, and Korean mint mixed extract. This study sought to demonstrate the antiglycation effect of streptozotocin, thereby improving skin aging, by measuring advanced glycation end products (AGEs) and various skin parameters, including collagen; matrix metalloproteinases (MMPs); inflammatory cytokines; activities of oxidative enzymes; and skin wrinkles, elasticity, and hydration. This study found that skin wrinkles, elasticity, and hydration improved with AB. Particularly, the oral administration of AB suppressed AGEs, receptors of AGEs, and carboxymethyl lysine in blood and skin tissue. In addition, AB increased the activities of antioxidative enzymes, reduced inflammatory cytokines, suppressed MMP-9 expression, and increased the contents of collagen and hyaluronic acid, ultimately suppressing skin wrinkles and increasing skin elasticity and hydration. Therefore, AB can inhibit skin aging through its antiglycation effect and is thus considered a good ingredient for skin care products.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/f3/pnfs-28-2-134.PMC10321449.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9797169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical Screening, Phenolic Content, and Anti-Inflammatory Effect of Foeniculum vulgare Seed Extract. 小茴香种子提取物的植物化学筛选、酚类含量及抗炎作用。
Preventive Nutrition and Food Science Pub Date : 2023-06-30 DOI: 10.3746/pnf.2023.28.2.141
Asma Cherbal, Mouna Bouabdallah, Mouna Benhalla, Saliha Hireche, Rachid Desdous
{"title":"Phytochemical Screening, Phenolic Content, and Anti-Inflammatory Effect of <i>Foeniculum vulgare</i> Seed Extract.","authors":"Asma Cherbal,&nbsp;Mouna Bouabdallah,&nbsp;Mouna Benhalla,&nbsp;Saliha Hireche,&nbsp;Rachid Desdous","doi":"10.3746/pnf.2023.28.2.141","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.2.141","url":null,"abstract":"<p><p>Medicinal plants are promising sources of natural substances with biological functions and several drugs have been developed from traditional medicine. This study aimed to determine the chemical components of a hydromethanolic extract from <i>Foeniculum vulgare</i> seeds. Total phenolic, flavonoid, and flavonol contents were assessed, and gas chromatography-mass spectrometry (GC-MS) analysis was performed. To investigate the anti-inflammatory activity of <i>F. vulgare</i> seed hydromethanolic extract, its effects on protein denaturation, protease activity, membrane stabilization, and heat-induced hemolysis in red blood cells were evaluated <i>in vitro</i>. <i>F. vulgare</i> seed extract showed significant inhibition of protein denaturation (35.68±0.4%), protease activity (58.09±0.1%), and heat-induced hemolysis in red blood cells (9.67±0.3%) at concentrations of 200, 250, and 200 μg/mL, respectively, compared to the reference drug indomethacin (<i>P</i><0.001). This remarkable anti-inflammatory activity may be attributable to the abundance of flavonoids in the <i>F. vulgare</i> seed extract. GC-MS confirmed the presence of linalool and fatty acids (palmitic and oleic acids), which have potential anti-inflammatory activities. Therefore, the hydromethanolic extract of <i>F. vulgare</i> seeds may be a valuable anti-inflammatory candidate in the years ahead.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/44/pnfs-28-2-141.PMC10321444.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9803536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Stabilization of Rice Bran by Infrared Radiation Heating for Increased Resilience and Quality of Rice Bran Oil Production. 红外辐射加热稳定米糠以提高米糠油的回弹性和质量。
Preventive Nutrition and Food Science Pub Date : 2023-06-30 DOI: 10.3746/pnf.2023.28.2.189
Rachen Duangsi, Wiraya Krongyut
{"title":"Stabilization of Rice Bran by Infrared Radiation Heating for Increased Resilience and Quality of Rice Bran Oil Production.","authors":"Rachen Duangsi,&nbsp;Wiraya Krongyut","doi":"10.3746/pnf.2023.28.2.189","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.2.189","url":null,"abstract":"<p><p>Rice bran, a by-product of rice milling, is a valuable source of rice bran oil (RBO). However, it is prone to rancidity and must be processed quickly after rice polishing. The researchers found that rice bran stabilization with infrared radiation (IR) at 125 V and 135 V for 5∼10 min. The most promising IR treatments were 125 V for 10 min and 135 V for 5 min, which resulted in the lowest lipase activity (93∼96% inhibition) and levels of γ-oryzanol and α-tocopherol comparable to those of the untreated control. However, the color of rice bran and RBO based on L*, a*, b*, and total color difference (ΔE) and Gardner-20 mm index darkened. Upon storage of rice bran at 38°C for 8 weeks, the use of these two IR treatments completely inhibited the rise in free fatty acid (FFA) content and peroxide values throughout the storage period. In contrast, the control had a pre-storage FFA more than double that of IR-stabilized rice bran, which further increased during storage and, in the 8th week, was more than 6-fold higher than the pre-storage level. γ-oryzanol and α-tocopherol slightly decreased with storage and their levels did not differ between stabilized and unstabilized rice bran. RBO color darkening was again observed, but the color lightened with storage, especially upon treatment at 135 V for 5 min. In contrast, the color of control RBO darkened with storage. Thus, IR at 135 V for 5 min was the most promising method for rice bran stabilization, based on which commercial IR treatment instruments can be developed.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/72/pnfs-28-2-189.PMC10321441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9810324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of National Dysphagia Diet and International Dysphasia Diet Standardization Initiative Levels for Thickened Drinks Prepared with a Commercial Xanthan Gum-Based Thickener Used for Patients with Dysphagia. 用商用黄原胶基增稠剂制备的用于吞咽困难患者的增稠饮料的国家吞咽困难饮食与国际吞咽困难饮食标准化倡议水平的比较。
Preventive Nutrition and Food Science Pub Date : 2023-03-31 DOI: 10.3746/pnf.2023.28.1.83
Subin An, Wonjae Lee, Byoungseung Yoo
{"title":"Comparison of National Dysphagia Diet and International Dysphasia Diet Standardization Initiative Levels for Thickened Drinks Prepared with a Commercial Xanthan Gum-Based Thickener Used for Patients with Dysphagia.","authors":"Subin An,&nbsp;Wonjae Lee,&nbsp;Byoungseung Yoo","doi":"10.3746/pnf.2023.28.1.83","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.1.83","url":null,"abstract":"The thickness levels of fluids for patients with dysphagia are established according to the guidelines of the National Dysphagia Diet (NDD) and International Dysphagia Diet Standardization Initiative (IDDSI). The nectar- (level 2), honey- (level 3), and pudding-like (level 4) fluids in NDD are consistent with the mildly (level 2), moderately (level 3), and extremely (level 4) thick fluids in IDDSI, respectively. In this study, NDD levels were compared with IDDSI levels by estimating both the apparent viscosity (ηa,50) and the residual volume (mL) in the IDDSI syringe flow test of thickened drinks prepared with a commercial xanthan gum-based thickener at different concentrations (0.1∼3.1%, w/w). The concentration range of the thickener in thickened drinks at each IDDSI and NDD level increased in the following order: water> orange juice> milk. A small difference was noted in the range of thickener concentration in the same NDD and IDDSI levels for thickened milk when compared with other thickened drinks. These results indicate that the thickener concentration ranges of thickened drinks for the classification of NDD levels differed from those of IDDSI levels, and they appeared to be greatly influenced by the type of drink. These findings could provide useful information for practically indi-cating the reliable thickness levels by the IDDSI flow test in clinical practice.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/c9/pnfs-28-1-83.PMC10103603.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9311094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality Characteristics of Citrus Peel Jelly. 柑桔果皮果冻的品质特征。
Preventive Nutrition and Food Science Pub Date : 2023-03-31 DOI: 10.3746/pnf.2023.28.1.79
Jin-Ju Baek, Soo-In Ryu, Jean Kyung Paik
{"title":"Quality Characteristics of Citrus Peel Jelly.","authors":"Jin-Ju Baek,&nbsp;Soo-In Ryu,&nbsp;Jean Kyung Paik","doi":"10.3746/pnf.2023.28.1.79","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.1.79","url":null,"abstract":"<p><p>Citrus peels are high in flavonoids and can help with nausea, indigestion, and phlegm. Furthermore, the peel is higher in dietary fiber and phenolic compounds than the fruit. However, every year, around 40,000∼120,000 tons of citrus peels are discarded as waste. As a result, citrus peel jelly was created, which can be reused as a functional food. In this study, salinity, color, texture, and antioxidant properties were measured by adding citrus peel powder at 0%, 1%, 3%, 5%, and 7%, respectively. The salinity decreased as the amount of addition increased (<i>P</i><0.001). The L-value of chromaticity decreased significantly (<i>P</i><0.001). The a-, b-value increased significantly (<i>P</i><0.001). As the addition amount increased, the hardness decreased significantly (<i>P</i>=0.002). Total polyphenols, flavonoids, 2,2-diphenyl-1-picrylhydrazyl scavenging capacity, and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) scavenging capacity all increased statistically significantly (<i>P</i><0.001). Through this study, we confirmed the quality characteristics of citrus peel jelly. Citrus peel jelly, which is high in antioxidant activity, is expected to increase the use of peel and functional foods.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/20/14/pnfs-28-1-79.PMC10103598.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Gly-Pro-Val-Gly-Pro-Ser Peptide Fish Collagen Improves Skin Moisture and Wrinkles with Ameliorated the Oxidative Stress and Pro-inflammatory Factors in Skin Photoaging Mimic Models. Gly-Pro-Val-Gly-Pro-Ser肽鱼胶原蛋白通过改善皮肤光老化模拟模型中的氧化应激和促炎因子,改善皮肤水分和皱纹。
Preventive Nutrition and Food Science Pub Date : 2023-03-31 DOI: 10.3746/pnf.2023.28.1.50
Wonhee Cho, Jeongjin Park, Minhee Lee, Seong-Hoo Park, Jaeeun Jung, Jinhak Kim, Sangwon Eun, Jinkyung Kim
{"title":"Gly-Pro-Val-Gly-Pro-Ser Peptide Fish Collagen Improves Skin Moisture and Wrinkles with Ameliorated the Oxidative Stress and Pro-inflammatory Factors in Skin Photoaging Mimic Models.","authors":"Wonhee Cho,&nbsp;Jeongjin Park,&nbsp;Minhee Lee,&nbsp;Seong-Hoo Park,&nbsp;Jaeeun Jung,&nbsp;Jinhak Kim,&nbsp;Sangwon Eun,&nbsp;Jinkyung Kim","doi":"10.3746/pnf.2023.28.1.50","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.1.50","url":null,"abstract":"<p><p>This study aimed to investigate whether low molecular fish collagen peptide (FC) from <i>Oreochromis niloticus</i> had protective effects on skin of photoaging mimic models. We observed that FC supplementation improved antioxidant enzymes activities and regulated the pro-inflammatory cytokines [e.g., tumor necrosis factor-α, interleukin (IL)-1β, and IL-6] by reducing the protein expressions of pro-inflammatory factors IκBα, p65, and cyclooxygenase-2 in ultraviolet-B (UV-B) irradiated <i>in vitro</i> and <i>in vivo</i>. Furthermore, FC increased hyaluronic acid, sphingomyelin, and skin hydration by reg-ulating the mRNA expression of hyaluronic acid synthases 1∼3, serine palmitoyltransferase 1, delta 4-desaturase, sphingolipid 1, and protein expressions of ceramide synthase 4, matrix metalloproteinase (MMP)-1, -2, and -9. In UV-B irradiated <i>in vitro</i> and <i>in vivo</i>, FC down-regulated the protein expression of the c-Jun N-terminal kinase, c-Fos, c-Jun, and MMP pathways and up-reg-ulated that of the transforming growth factor-β receptor I, collagen type I, procollagen type I, and small mothers against decapentaplegic homolog pathways. Our results suggest that FC can be effective against UV-B induced skin photoaging by improving skin dryness and wrinkle formation through antioxidant and anti-inflammatory properties.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/b3/pnfs-28-1-50.PMC10103600.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9311093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Vaginal Infections during Pregnancy Increase Breast Milk Microbiome Alpha Diversity and Alter Taxonomic Composition. 妊娠期阴道感染增加母乳微生物组α多样性并改变分类学组成。
Preventive Nutrition and Food Science Pub Date : 2023-03-31 DOI: 10.3746/pnf.2023.28.1.1
Azka Ainun Nisaa, Chern-Ein Oon, Sasidharan Sreenivasan, Venugopal Balakrishnan, Deepa Rajendran, Jun-Jie Tan, Fatin Fazrina Roslan, Svetoslav Dimitrov Todorov, Woo-Sik Jeong, Feiyan Zhao, Nur Syafiqah Mohamad Nasir, Zakuan Zainy Deris, Heping Zhang, Yong-Ha Park, Guoxia Liu, Min-Tze Liong
{"title":"Vaginal Infections during Pregnancy Increase Breast Milk Microbiome Alpha Diversity and Alter Taxonomic Composition.","authors":"Azka Ainun Nisaa,&nbsp;Chern-Ein Oon,&nbsp;Sasidharan Sreenivasan,&nbsp;Venugopal Balakrishnan,&nbsp;Deepa Rajendran,&nbsp;Jun-Jie Tan,&nbsp;Fatin Fazrina Roslan,&nbsp;Svetoslav Dimitrov Todorov,&nbsp;Woo-Sik Jeong,&nbsp;Feiyan Zhao,&nbsp;Nur Syafiqah Mohamad Nasir,&nbsp;Zakuan Zainy Deris,&nbsp;Heping Zhang,&nbsp;Yong-Ha Park,&nbsp;Guoxia Liu,&nbsp;Min-Tze Liong","doi":"10.3746/pnf.2023.28.1.1","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.1.1","url":null,"abstract":"<p><p>We previously reported that breast milk from women with (W) or without (WO) vaginal yeast infection during pregnancy differs in its immunological and antimicrobial properties, especially against pathogenic vaginal <i>Candida</i> sp.. Here, we investigated the differences in microbiota profiles of breast milk from these groups. Seventy-two breast milk samples were collected from lactating mothers (W, n=37; WO, n=35). The DNA of bacteria was extracted from each breast milk sample for microbiota profiling by 16S rRNA gene sequencing. Breast milk from the W-group exhibited higher alpha diversity than that from the WO-group across different taxonomic levels of class (<i>P</i>=0.015), order (<i>P</i>=0.011), family (<i>P</i>=0.020), and genus (<i>P</i>=0.030). Compositional differences between groups as determined via beta diversity showed marginal differences at taxonomic levels of phylum (<i>P</i>=0.087), family (<i>P</i>=0.064), and genus (<i>P</i>=0.067). The W-group showed higher abundances of families Moraxellaceae (<i>P</i>=0.010) and Xanthomonadaceae (<i>P</i>=0.008), and their genera <i>Acinetobacter</i> (<i>P</i>=0.015), <i>Enhydrobacter</i> (<i>P</i>=0.015), and <i>Stenotrophomonas</i> (<i>P</i>=0.007). Meanwhile, the WO-group showed higher abundances of genus <i>Staphylococcus</i> (<i>P</i>=0.046) and species <i>Streptococcus infantis</i> (<i>P</i>=0.025). This study shows that, although breast milk composition is affected by vaginal infection during pregnancy, this may not pose a threat to infant growth and development.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/11/pnfs-28-1-1.PMC10103605.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Ethyl Acetate Extract of Halymenia durvillei Induced Apoptosis, Autophagy, and Cell Cycle Arrest in Colorectal Cancer Cells. 海棠乙酸乙酯提取物诱导结直肠癌细胞凋亡、自噬和细胞周期阻滞。
Preventive Nutrition and Food Science Pub Date : 2023-03-31 DOI: 10.3746/pnf.2023.28.1.69
Pathanin Chantree, Pongsakorn Martviset, Phornphan Sornchuer, Nattaya Thongsepee, Kant Sangpairoj, Krai Meemon, Nakorn Niamnont, Montakan Tamtin, Prasert Sobhon
{"title":"Ethyl Acetate Extract of <i>Halymenia durvillei</i> Induced Apoptosis, Autophagy, and Cell Cycle Arrest in Colorectal Cancer Cells.","authors":"Pathanin Chantree,&nbsp;Pongsakorn Martviset,&nbsp;Phornphan Sornchuer,&nbsp;Nattaya Thongsepee,&nbsp;Kant Sangpairoj,&nbsp;Krai Meemon,&nbsp;Nakorn Niamnont,&nbsp;Montakan Tamtin,&nbsp;Prasert Sobhon","doi":"10.3746/pnf.2023.28.1.69","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.1.69","url":null,"abstract":"<p><p>Colorectal cancer is one of the most death-dealing cancers. However, conventional cancer treatments still have side effects. Therefore, novel chemotherapeutic agents with less side effects are still in search. A marine red seaweed, <i>Halymenia durvillei</i>, is recently interested in its anticancer effects. This study investigated the anticancer effect of ethyl acetate extract of <i>H. durvillei</i> (HDEA) on HT-29 colorectal cancer cells in association with the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway. HDEA-treated HT-29 and OUMS-36 cells were used for cell viability tests by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay. The effects of HDEA on apoptosis and cell cycle were evaluated. The nuclear morphology and mitochondrial membrane potential (ΔΨm) were observed by Hoechst 33342 and JC-1 staining, respectively. The gene expression of PI3K, AKT, and mTOR genes was evaluated using a real-time semiquantitative reverse transcription-polymerase chain reaction. The corresponding protein expressions were assessed by western blot analysis. The result revealed that the cell viability of treated HT-29 cells diminished while that of OUMS-36 cells was non-significant. By the down-regulation of cyclin-dependent ki-nase 4 and cyclin D1, HDEA-treated HT-29 cells were arrested in the G0/G1 phase. By the up-regulation of cleaved poly(adenosine diphosphate-ribose) polymerase, caspase-9, caspase-8, caspase-3, and Bax, HDEA-treated HT-29 cells underwent apoptosis, but suppressed Bcl-2, disrupted nuclear morphology and ΔΨm. Furthermore, treated HT-29 cells underwent autophagy by up-regulation of light chain 3-II and beclin-1. Lastly, HDEA suppressed the expression of PI3K, AKT, and mTOR. Therefore, HDEA exerts anticancer effects against HT-29 cells, confirmed by apoptosis, autophagy, and cell cycle arrest induction via regulation of the PI3K/AKT/mTOR signaling pathway.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/d7/pnfs-28-1-69.PMC10103606.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9311097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic Effects of Combined Concurrent Training and Eri-Polyunsaturated Fatty Acid Supplementation on Bone Mineral Density, Muscle Strength, and Inflammation. 联合训练和补充eri -多不饱和脂肪酸对骨密度、肌肉力量和炎症的协同作用。
Preventive Nutrition and Food Science Pub Date : 2023-03-31 DOI: 10.3746/pnf.2023.28.1.10
Jatuporn Phoemsapthawee, Ratree Ruangthai, Piyaporn Tumnak, Andaman Klomklorm, Piyapong Prasertsri, Udomlak Sukatta, Pilanee Vaithanomsat
{"title":"Synergistic Effects of Combined Concurrent Training and Eri-Polyunsaturated Fatty Acid Supplementation on Bone Mineral Density, Muscle Strength, and Inflammation.","authors":"Jatuporn Phoemsapthawee,&nbsp;Ratree Ruangthai,&nbsp;Piyaporn Tumnak,&nbsp;Andaman Klomklorm,&nbsp;Piyapong Prasertsri,&nbsp;Udomlak Sukatta,&nbsp;Pilanee Vaithanomsat","doi":"10.3746/pnf.2023.28.1.10","DOIUrl":"https://doi.org/10.3746/pnf.2023.28.1.10","url":null,"abstract":"<p><p>Obesity has been associated with lower bone mineral density (BMD) and rapid muscle weakness. Regular exercise and polyunsaturated fatty acid (PUFA) consumption have been recognized as nonpharmaceutical approaches to increase BMD and ameliorate muscle weakness. This study aimed to determine the effects of concurrent training (CCT) and Eri-PUFA supplementation on BMD, muscular strength, and inflammation in obese adults. A total of 33 obese participants were randomly assigned to one of three groups (n=11 per group): (1) a placebo group; (2) an Eri-PUFA ingestion group (ERI); or (3) a CCT and Eri-PUFA ingestion group (CCT+ERI). The ERI and CCT+ERI groups received approximately 2.5 g of linolenic acid per day from Eri silkworm pupae. The exercise program included aerobic and resistance exercises performed under supervision three times per week for 8 weeks. Before and after the 8-week intervention, BMD, muscular strength, and inflammatory markers were measured. Only the CCT+ERI group showed a significant increase in lumbar spine BMD (5.1%, <i>P</i><0.01) and upper-body muscle strength (16.9%, <i>P</i><0.01) after the intervention, with differences between the groups. After the intervention, both the ERI and CCT+ERI groups showed a significant decrease in the monocyte-to-lymphocyte ratio (-25%, <i>P</i><0.01 and -21.4%, <i>P</i><0.05, respectively) and tumor necrosis factor-alpha (-21.6%, <i>P</i><0.05 and -19.4%, <i>P</i><0.05, respectively). These findings demonstrate that combining CCT and Eri-PUFA supplementation increases BMD and upper-body muscular strength and decreases inflammation. Although Eri-PUFA consumption did not affect BMD or muscle strength directly, it may have an additive effect on BMD by reducing inflammation.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/05/pnfs-28-1-10.PMC10103601.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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