Postgraduate Medical Journal最新文献_第9页

Left ventricular recovery after total arterial coronary artery bypass grafting versus conventional coronary artery bypass grafting in patients with multivessel coronary artery disease and reduced left ventricular ejection fraction. 多支血管冠状动脉疾病和左心室射血分数降低患者接受全动脉冠状动脉旁路移植术和传统冠状动脉旁路移植术后的左心室恢复情况。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-16 DOI: 10.1093/postmj/qgae005

Zhi-Qin Lin, Xiujun Chen, Zheng Xu, Liang-Wan Chen, Xiao-Fu Dai

{"title":"Left ventricular recovery after total arterial coronary artery bypass grafting versus conventional coronary artery bypass grafting in patients with multivessel coronary artery disease and reduced left ventricular ejection fraction.","authors":"Zhi-Qin Lin, Xiujun Chen, Zheng Xu, Liang-Wan Chen, Xiao-Fu Dai","doi":"10.1093/postmj/qgae005","DOIUrl":"10.1093/postmj/qgae005","url":null,"abstract":"Background: We compared total arterial revascularization (TAR) versus conventional revascularization (CR) in terms of left ventricular function recovery in patients with multivessel coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF).Methods: We conducted a retrospective cohort study of 162 consecutive patients with multivessel CAD and reduced LVEF who underwent isolated coronary artery bypass grafting at our institution between January 2013 and July 2022. We assessed left ventricular function by transthoracic echocardiography at admission, before discharge, and at follow-up of 3, 6, and 12 months, using LVEF, global longitudinal peak strain, end-diastolic volume index, and end-systolic volume index. We also evaluated mitral valve regurgitation and graft patency rate at 1 year.Results: The TAR group had a significantly higher increase in LVEF and global longitudinal peak strain, and a significantly lower decrease in end-diastolic volume index and end-systolic volume index than the CR group at 6 and 12 months after surgery. The TAR group also had a significantly lower degree of mitral valve regurgitation than the CR group at all-time points within 12 months after surgery. The TAR group had a significantly higher graft patency rate than the CR group at 12 months. There was no significant difference in hospital mortality or repeat revascularization between the groups.Conclusions: TAR was associated with better recovery of left ventricular function than CR in patients with multivessel CAD and reduced LVEF. Further studies are needed to confirm these findings in this high-risk population.","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":"671-678"},"PeriodicalIF":3.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of remimazolam tosilate on gastrointestinal hormones and gastrointestinal motility in patients undergoing gastrointestinal endoscopy with sedation: a randomized control trial. 镇静胃肠道内窥镜检查患者服用托西酸瑞马唑仑对胃肠激素和胃肠蠕动的影响：随机对照试验。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-16 DOI: 10.1093/postmj/qgae040

Tianyi Yang, Yinji Zhou, Mingshan Wang, Lina Zhang, Bing Liu, Lixin Sun, Fei Shi, Yang Yuan, Gaofeng Zhang

{"title":"Effects of remimazolam tosilate on gastrointestinal hormones and gastrointestinal motility in patients undergoing gastrointestinal endoscopy with sedation: a randomized control trial.","authors":"Tianyi Yang, Yinji Zhou, Mingshan Wang, Lina Zhang, Bing Liu, Lixin Sun, Fei Shi, Yang Yuan, Gaofeng Zhang","doi":"10.1093/postmj/qgae040","DOIUrl":"10.1093/postmj/qgae040","url":null,"abstract":"Purpose: To investigate the impacts of remimazolam tosilate on gastrointestinal hormones and motility in patients undergoing gastrointestinal endoscopy with sedation.Methods: A total of 262 American Society of Anesthesiologists Physical Status I or II patients, aged 18-65 years, scheduled for gastrointestinal endoscopy with sedation, were randomly allocated into two groups (n = 131 each): the remimazolam tosilate group (Group R) and the propofol group (Group P). Patients in Group R received 0.2-0.25 mg/Kg remimazolam tosilate intravenously, while those in Group P received 1.5-2.0 mg/kg propofol intravenously. The gastrointestinal endoscopy was performed when the Modified Observer's Assessment of Alertness/Sedation scores were ≤3. The primary endpoints included the endoscopic intestinal peristalsis rating by the endoscopist; serum motilin and gastrin levels at fasting without gastrointestinal preparation (T0), before gastrointestinal endoscopy (T1), and before leaving the Post Anesthesia Care Unit (T2); and the incidences of abdominal distension during Post Anesthesia Care Unit.Results: Compared with Group P, intestinal peristalsis rating was higher in Group R (P < .001); Group R showed increased motilin and gastrin levels at T2 compared with Group P (P < .01). There was a rise in motilin and gastrin levels at T1 and T2 compared with T0 and at T2 compared with T1 in both groups (P < .01). The incidence of abdominal distension was lower in Group R (P < .05).Conclusion: Compared with propofol used during gastrointestinal endoscopy with sedation, remimazolam tosilate mildly inhibits the serum motilin and gastrin levels, potentially facilitating the recovery of gastrointestinal motility.","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":"635-641"},"PeriodicalIF":3.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence tools in medical education beyond Chat Generative Pre-trained Transformer (ChatGPT). 人工智能工具在医学教育中的应用，超越了 Chat Generative Pre-trained Transformer (ChatGPT)。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-16 DOI: 10.1093/postmj/qgae014

Li Feng Tan, Isaac K S Ng, Desmond Teo

引用次数: 0

Use of social deprivation status in primary prevention cardiovascular risk scores: a must but a challenge. 在一级预防心血管风险评分中使用社会贫困状况：必须但也是一项挑战。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-16 DOI: 10.1093/postmj/qgae043

Dorien M Kimenai, Anoop S V Shah

引用次数: 0

Progress in the relationship between mechanical ventilation parameters and ventilator-related complications during perioperative anesthesia. 围术期麻醉期间机械通气参数与呼吸机相关并发症之间关系的研究进展。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-16 DOI: 10.1093/postmj/qgae035

Hu Yue, Tao Yong

{"title":"Progress in the relationship between mechanical ventilation parameters and ventilator-related complications during perioperative anesthesia.","authors":"Hu Yue, Tao Yong","doi":"10.1093/postmj/qgae035","DOIUrl":"10.1093/postmj/qgae035","url":null,"abstract":"Background: Mechanical ventilation, as an important respiratory support, plays an important role in general anesthesia and it is the cornerstone of intraoperative management of surgical patients. Different from spontaneous respiration, intraoperative mechanical ventilation can lead to postoperative lung injury, and its impact on surgical mortality cannot be ignored. Postoperative lung injury increases hospital stay and is related to preoperative conditions, anesthesia time, and intraoperative ventilation settings.Method: Through reading literature and research reports, the relationship between perioperative input parameters and output parameters related to mechanical ventilation and ventilator-related complications was reviewed, providing reference for the subsequent setting of input parameters of mechanical ventilation and new ventilation strategies.Results: The parameters of inspiratory pressure rise time and inspiratory time can change the gas distribution, gas flow rate and airway pressure into the lungs, but there are few clinical studies on them. It can be used as a prospective intervention to study the effect of specific protective ventilation strategies on pulmonary complications after perioperative anesthesia.Conclusion: There are many factors affecting lung function after perioperative mechanical ventilation. Due to the difference of human body, the ventilation parameters suitable for each patient are different, and the deviation of each ventilation parameter can lead to postoperative pulmonary complications. Inspiratory pressure rise time and inspiratory time will be used as the new ventilation strategy.","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":"619-625"},"PeriodicalIF":3.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A linear and reticulate crusted keratotic papulopustular eruption: a rare presentation of PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) complex. 线状和网状结痂角化性丘疹脓疱疹：PRIDE（表皮生长因子受体抑制剂引起的丘疹脓疱和/或脓疱疮、毛发生长调节异常、瘙痒和干燥）综合征的罕见表现。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-14 DOI: 10.1093/postmj/qgae104

Shreya K Gowda, Deepak Kumar Sahu, Pavithra Ayyanar, Biswanath Behera

引用次数: 0

Evaluating the McMahon score for predicting mortality in earthquake-induced rhabdomyolysis: a retrospective study. 评估麦克马洪评分对地震所致横纹肌溶解症死亡率的预测作用：一项回顾性研究。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-14 DOI: 10.1093/postmj/qgae103

Mahmut Yaman, Abdullah Şen, Hasan Mansur Durgun, Eren Eynel, Sema Belek, Şilan Göger Ülgüt, Murat Orak, Cahfer Güloğlu

{"title":"Evaluating the McMahon score for predicting mortality in earthquake-induced rhabdomyolysis: a retrospective study.","authors":"Mahmut Yaman, Abdullah Şen, Hasan Mansur Durgun, Eren Eynel, Sema Belek, Şilan Göger Ülgüt, Murat Orak, Cahfer Güloğlu","doi":"10.1093/postmj/qgae103","DOIUrl":"https://doi.org/10.1093/postmj/qgae103","url":null,"abstract":"Background: In natural disasters like earthquakes, building collapses can trap individuals, causing crush syndrome and rhabdomyolysis. This life-threatening condition often leads to acute kidney injury. We aimed to determine the effectiveness of the McMahon score in predicting mortality due to rhabdomyolysis in patients affected by the earthquake.Methods: This is a retrospective observational study. In this study, the clinical and laboratory data of patients who presented to the emergency department due to the earthquake were analyzed. The McMahon score was calculated by evaluating factors such as creatine kinase, serum creatinine levels, age, and gender.Results: The study included 151 patients, of whom 74 (49.0%) were male and 77 (51.0%) were female. In the univariate model, significant (P < .05) effectiveness was observed in differentiating between patients with and without mortality for McMahon score and the risk of acute kidney injury. At a McMahon score cutoff of 6, significant effectiveness was also observed, with an area under the curve of 0.723. At this cutoff value, the sensitivity was 80.0% and the specificity was 64.5%.Conclusions: The use of the McMahon score in emergency medicine and disaster management plays a crucial role in rapid decision-making processes due to its effectiveness in predicting mortality.","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium-glucose cotransporter 2 inhibitors and emphysematous cystitis. 钠-葡萄糖共转运体 2 抑制剂与气肿性膀胱炎。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-14 DOI: 10.1093/postmj/qgae099

Ina Dubin, Yair Glick, Ami Schattner

引用次数: 0

LLMs may improve medical communication: social science perspective. 法学硕士可改善医学交流：社会科学视角。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-11 DOI: 10.1093/postmj/qgae101

Shuo Wang, Tianyu Liu, Shotaro Kinoshita, Hiromi M Yokoyama

引用次数: 0

Unveiling the veiled: assessing Afghanistan's health policy landscape through a gendered perspective. 揭开蒙着面纱的面纱：从性别角度评估阿富汗的卫生政策状况。

IF 3.6 4区医学

Postgraduate Medical Journal Pub Date : 2024-08-05 DOI: 10.1093/postmj/qgae097

Salim Usman, Muhammad Hamza Shah

引用次数: 0