{"title":"基础代谢率对认知能力下降的保护作用：流行病学和遗传学研究的证据。","authors":"Tianwei Meng, Changxing Liu, Boyu Wang, Chengjia Li, Jiawen Liu, Jia Chen, Yidi Ma, Rui Qie","doi":"10.1093/postmj/qgae159","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore the relationship between basal metabolic rate (BMR) and cognitive impairment and assess the potential of BMR as a protective factor against cognitive decline.</p><p><strong>Methods: </strong>This investigation initially conducted a cross-sectional study of American adults from 2011 to 2014 using data from the National Health and Nutrition Examination Survey. It examined the correlation between participants' BMR and cognitive functions, exploring the association with cognitive impairment. Subsequently, publicly available genome-wide association study data was used to examine potential causal links between genetically determined BMR and specific cognitive disorders using Mendelian randomization.</p><p><strong>Results: </strong>Cross-sectional findings revealed a significant positive correlation between higher BMR and cognitive scores. In Mendelian randomization analysis, BMR demonstrated an inverse causal relationship with Alzheimer's disease and Parkinson's dementia, suggesting BMR as a potential protective factor against these diseases. No causal links were found with vascular dementia, Lewy body dementia, and frontotemporal dementia.</p><p><strong>Conclusion: </strong>This study supports the role of BMR as a potential protective factor against Alzheimer's disease and Parkinson's dementia, suggesting that BMR may play an important role in preventing cognitive decline. However, due to the limitations of cross-sectional studies, further prospective studies and broader demographic samples are necessary to verify these results and explore underlying biological mechanisms. Key messages What is already known on this topic: Existing knowledge suggests a close relationship between BMR and health and cognitive functions, but detailed studies on its connection with specific cognitive impairments are still needed. What this study adds: This study found a significant positive correlation between higher BMR and cognitive improvement, potentially aiding in the prevention of Alzheimer's and Parkinson's dementia. How this study might affect research, practice, or policy: This finding guides public health strategies and personalized medicine, emphasizing the necessity for further research to validate BMR's protective effects.</p>","PeriodicalId":20374,"journal":{"name":"Postgraduate Medical Journal","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The protective role of basal metabolic rate in cognitive decline: evidence from epidemiological and genetic studies.\",\"authors\":\"Tianwei Meng, Changxing Liu, Boyu Wang, Chengjia Li, Jiawen Liu, Jia Chen, Yidi Ma, Rui Qie\",\"doi\":\"10.1093/postmj/qgae159\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aims to explore the relationship between basal metabolic rate (BMR) and cognitive impairment and assess the potential of BMR as a protective factor against cognitive decline.</p><p><strong>Methods: </strong>This investigation initially conducted a cross-sectional study of American adults from 2011 to 2014 using data from the National Health and Nutrition Examination Survey. It examined the correlation between participants' BMR and cognitive functions, exploring the association with cognitive impairment. Subsequently, publicly available genome-wide association study data was used to examine potential causal links between genetically determined BMR and specific cognitive disorders using Mendelian randomization.</p><p><strong>Results: </strong>Cross-sectional findings revealed a significant positive correlation between higher BMR and cognitive scores. In Mendelian randomization analysis, BMR demonstrated an inverse causal relationship with Alzheimer's disease and Parkinson's dementia, suggesting BMR as a potential protective factor against these diseases. No causal links were found with vascular dementia, Lewy body dementia, and frontotemporal dementia.</p><p><strong>Conclusion: </strong>This study supports the role of BMR as a potential protective factor against Alzheimer's disease and Parkinson's dementia, suggesting that BMR may play an important role in preventing cognitive decline. However, due to the limitations of cross-sectional studies, further prospective studies and broader demographic samples are necessary to verify these results and explore underlying biological mechanisms. Key messages What is already known on this topic: Existing knowledge suggests a close relationship between BMR and health and cognitive functions, but detailed studies on its connection with specific cognitive impairments are still needed. What this study adds: This study found a significant positive correlation between higher BMR and cognitive improvement, potentially aiding in the prevention of Alzheimer's and Parkinson's dementia. 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引用次数: 0
摘要
目的：本研究旨在探讨基础代谢率（BMR）与认知障碍之间的关系，并评估基础代谢率作为防止认知能力下降的保护因素的潜力：本研究利用美国国家健康与营养调查（National Health and Nutrition Examination Survey）的数据，对 2011 年至 2014 年的美国成年人进行了横断面研究。研究考察了参与者的血液中胆固醇含量与认知功能之间的相关性，探讨了与认知障碍之间的关联。随后，研究人员利用公开的全基因组关联研究数据，采用孟德尔随机化方法研究了由基因决定的基础代谢率与特定认知障碍之间的潜在因果关系：横断面研究结果显示，较高的血液中胆固醇含量与认知能力得分之间存在显著的正相关。在孟德尔随机分析中，基础代谢率与阿尔茨海默氏症和帕金森氏痴呆症呈反向因果关系，表明基础代谢率是预防这些疾病的潜在保护因素。而血管性痴呆、路易体痴呆和额颞叶痴呆则没有因果关系：本研究支持基础代谢率是阿尔茨海默病和帕金森痴呆症的潜在保护因素，表明基础代谢率可能在预防认知能力下降方面发挥重要作用。然而，由于横断面研究的局限性，有必要进行进一步的前瞻性研究和更广泛的人口学样本，以验证这些结果并探索潜在的生物学机制。关键信息 本主题的已知信息：现有知识表明，基础代谢率与健康和认知功能之间存在密切关系，但仍需对基础代谢率与特定认知障碍之间的关系进行详细研究。本研究的补充：这项研究发现，较高的生物量与认知能力的改善之间存在明显的正相关关系，可能有助于预防阿尔茨海默氏症和帕金森氏痴呆症。本研究对研究、实践或政策有何影响？这一发现为公共卫生策略和个性化医疗提供了指导，强调了进一步研究验证 BMR 的保护作用的必要性。
The protective role of basal metabolic rate in cognitive decline: evidence from epidemiological and genetic studies.
Purpose: This study aims to explore the relationship between basal metabolic rate (BMR) and cognitive impairment and assess the potential of BMR as a protective factor against cognitive decline.
Methods: This investigation initially conducted a cross-sectional study of American adults from 2011 to 2014 using data from the National Health and Nutrition Examination Survey. It examined the correlation between participants' BMR and cognitive functions, exploring the association with cognitive impairment. Subsequently, publicly available genome-wide association study data was used to examine potential causal links between genetically determined BMR and specific cognitive disorders using Mendelian randomization.
Results: Cross-sectional findings revealed a significant positive correlation between higher BMR and cognitive scores. In Mendelian randomization analysis, BMR demonstrated an inverse causal relationship with Alzheimer's disease and Parkinson's dementia, suggesting BMR as a potential protective factor against these diseases. No causal links were found with vascular dementia, Lewy body dementia, and frontotemporal dementia.
Conclusion: This study supports the role of BMR as a potential protective factor against Alzheimer's disease and Parkinson's dementia, suggesting that BMR may play an important role in preventing cognitive decline. However, due to the limitations of cross-sectional studies, further prospective studies and broader demographic samples are necessary to verify these results and explore underlying biological mechanisms. Key messages What is already known on this topic: Existing knowledge suggests a close relationship between BMR and health and cognitive functions, but detailed studies on its connection with specific cognitive impairments are still needed. What this study adds: This study found a significant positive correlation between higher BMR and cognitive improvement, potentially aiding in the prevention of Alzheimer's and Parkinson's dementia. How this study might affect research, practice, or policy: This finding guides public health strategies and personalized medicine, emphasizing the necessity for further research to validate BMR's protective effects.
期刊介绍：
Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.
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