Polimery w medycynie最新文献

{"title":"Cytotoxicity of cleaning agents for ocular prostheses.","authors":"Marcelo Coelho Goiato,&nbsp;Agda Marobo Andreotti,&nbsp;Fernanda Pereira De Caxias,&nbsp;Emily Vivianne Freitas Da Silva,&nbsp;Letícia De Oliveira Gonçalves,&nbsp;Sandra Helena Penha De Oliveira,&nbsp;Victor Gustavo Balera Brito,&nbsp;Clóvis Lamartine De Moraes Melo Neto,&nbsp;Daniela Micheline Dos Santos","doi":"10.17219/pim/163118","DOIUrl":"https://doi.org/10.17219/pim/163118","url":null,"abstract":"<p><strong>Background: </strong>Polymethylmethacrylate (PMMA) is the most used material for the manufacturing of eye prostheses.</p><p><strong>Objectives: </strong>To investigate the cytotoxicity of different cleaning agents for ocular prostheses on human conjunctival cells.</p><p><strong>Material and methods: </strong>Six groups of specimens were created (saline, soap, 4% chlorhexidine, hydrogen peroxide, 1% triclosan, and citronella oil). Three specimens were made for each disinfectant at each disinfection period (1, 7, 15, 30, 60, and 90 days), totaling 108 specimens. Thus, the specimens were disinfected, with different disinfectants, for different periods of time. After each disinfection process, the specimens were washed with sterile distilled water. A human conjunctival cell line was grown on the acrylic resin specimens and then cytotoxicity tests (MTT and Neutral Red (NR)) were performed. A negative control (untreated cell cultures) and positive control (Tween 20) were created. Two-way analysis of variance (ANOVA) and Bonferroni test were performed (p < 0.05).</p><p><strong>Results: </strong>For the MTT and NR tests, when there was a significant difference between the disinfectant and negative control, the disinfectant generated a significant reduction in cell proliferation most of the time.</p><p><strong>Conclusions: </strong>All reductions in cell proliferation caused by the disinfectants were clinically acceptable. All disinfectants tested in this study were found to be non-cytotoxic to human conjunctival cells.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"53 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global uses of traditional herbs for hepatic diseases and other pharmacological actions: A comprehensive review.","authors":"Akram Choudhary,&nbsp;Mohammad Noman,&nbsp;Uzma Bano,&nbsp;Jamal Akhtar,&nbsp;Yahya Shaikh,&nbsp;Mohammad Shahar Yar","doi":"10.17219/pim/165977","DOIUrl":"https://doi.org/10.17219/pim/165977","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is the 7th most common cancer and the 3rd leading cause of cancer-related death worldwide. It is resistant to the majority of chemotherapeutics and has a dismal prognosis. Hepatocellular carcinoma is a prevalent complication of chronic liver disease (CLD) in India. Primary liver cancer is the 6th most common cancer worldwide and the 4th most prevalent cause of cancer-related death. In 2018, it affected 841,000 people and caused 782,000 deaths around the world. Thus, research into the tumor cycle and its prevention through suitable herbal (Unani/Ayurvedic) medication is critical for reducing the impact of primary liver cancer. Treatment options for end-stage liver cancer are limited, necessitating costly liver transplantation, which is unavailable in most countries. Here, we present the results of a comprehensive literature survey to determine the benefits of using various herbs with liver protective and antioxidant properties. This information will be useful to researchers working on liver carcinoma and free radical scavenging, both of which are important in curbing potential carcinogens.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"53 1","pages":"81-89"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9694920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A method for evaluating the transport and energy conversion properties of polymer biomembranes using the Kedem-Katchalsky-Peusner equations.","authors":"Andrzej Ślęzak,&nbsp;Sławomir Marek Grzegorczyn,&nbsp;Anna Pilis,&nbsp;Izabella Ślęzak-Prochazka","doi":"10.17219/pim/161743","DOIUrl":"https://doi.org/10.17219/pim/161743","url":null,"abstract":"<p><strong>Background: </strong>A basic parameter in non-equilibrium thermodynamics is the production of entropy (S-entropy), which is a consequence of the irreversible processes of mass, charge, energy, and momentum transport in various systems. The product of S-entropy production and absolute temperature (T) is called the dissipation function and is a measure of energy dissipation in non-equilibrium processes.</p><p><strong>Objectives: </strong>This study aimed to estimate energy conversion in membrane transport processes of homogeneous non-electrolyte solutions. The stimulus version of the R, L, H, and P equations for the intensity of the entropy source achieved this purpose.</p><p><strong>Material and methods: </strong>The transport parameters for aqueous glucose solutions through Nephrophan® and Ultra-Flo 145 dialyser® synthetic polymer biomembranes were experimentally determined. Kedem-Katchalsky-Peusner (KKP) formalism was used for binary solutions of non-electrolytes, with Peusner coefficients introduced.</p><p><strong>Results: </strong>The R, L, H, and P versions of the equations for the S-energy dissipation were derived for the membrane systems based on the linear non-equilibrium Onsager and Peusner network thermodynamics. Using the equations for the S-energy and the energy conversion efficiency factor, equations for F-energy and U-energy were derived. The S-energy, F-energy and U-energy were calculated as functions of osmotic pressure difference using the equations obtained and presented as suitable graphs.</p><p><strong>Conclusions: </strong>The R, L, H, and P versions of the equations describing the dissipation function had the form of second-degree equations. Meanwhile, the S-energy characteristics had the form of second-degree curves located in the 1st and 2nd quadrants of the coordinate system. These findings indicate that the R, L, H, and P versions of S-energy, F-energy and U-energy are not equivalent for the Nephrophan® and Ultra-Flo 145 dialyser® membranes.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"53 1","pages":"25-36"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9693684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of thermal cycles and disinfection on the roughness, microhardness and color of PETG/TPU and PMMA.","authors":"Clóvis Lamartine De Moraes Melo Neto,&nbsp;Bruno Simão Bernardi,&nbsp;Stefan Fiuza De Carvalho Dekon,&nbsp;Daniela Micheline Dos Santos,&nbsp;Marcelo Coelho Goiato","doi":"10.17219/pim/159350","DOIUrl":"https://doi.org/10.17219/pim/159350","url":null,"abstract":"<p><strong>Background: </strong>Occlusal splints can protect teeth during bruxism, preventing tooth wear, as well as during sports activities, shielding them from impacts.</p><p><strong>Objectives: </strong>To verify the influence of thermal cycles and disinfection on the roughness, microhardness and color of polyethylene terephthalate glycol/thermoplastic polyurethane (PETG/TPU) and poly(methyl methacrylate) (PMMA).</p><p><strong>Material and methods: </strong>Thirty-six PETG/TPU samples and 36 PMMA samples were prepared (ø10 mm × 3 mm). Six groups were created according to the material and the disinfection method used (n = 12 each): PETG/TPU (glister), PETG/TPU (hypochlorite), PETG/TPU (soap), PMMA (glister), PMMA (hypochlorite), and PMMA (soap). Roughness, Knoop microhardness and color evaluations were performed before the experiments (T1), after thermocycling (T2) and after disinfection (T3). Three-way repeated measures analysis of variance (ANOVA) and Tukey's test were used for statistical evaluations.</p><p><strong>Results: </strong>For roughness and color, ANOVA showed statistical significance based on the interaction between thermal cycling, material and disinfectant factors. In terms of Knoop microhardness, ANOVA showed statistical significance based on the interaction between thermal cycling and material factors.</p><p><strong>Conclusions: </strong>Roughness results were clinically acceptable in all groups at all time points, except the PETG/TPU and PMMA groups disinfected with hypochlorite. Microhardness significantly increased for both materials after thermal cycling, and at all time points, the microhardness of PMMA was significantly higher than that of PETG/TPU. After thermal cycling, the color changes were clinically unacceptable in all groups.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"53 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9691743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of botanicals using molecular biotechnology.","authors":"Mohd Imran,&nbsp;Haya Majid,&nbsp;Tasha Riaz,&nbsp;Shayan Maqsood","doi":"10.17219/pim/163119","DOIUrl":"https://doi.org/10.17219/pim/163119","url":null,"abstract":"<p><p>The available information on the abundance of restorative plants on earth is incomplete, and the data regarding botanicals from various countries differ significantly. The substantial development of the worldwide natural botanical market is attributable to the expanding revenue of global drug companies trading herbal medicines. This essential type of traditional medical care is depended on by approx. 72-80% of individuals. Even though numerous restorative plants are readily used, they have never been subject to the same strict quality guidelines as conventional drugs. Nonetheless, it is vital to have specific organic, phytochemical, and molecular tools and methods for identifying restorative plant species so that traditional and novel plant products can be safely used in modern medicine. Molecular biotechnology approaches provide a reliable and accurate way to identify botanicals and can be used to ensure the safety and efficacy of plant-based products. This review explores various molecular biotechnology approaches and methods for identifying botanicals.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"53 1","pages":"69-79"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spray drying and nano spray drying as manufacturing methods of drug-loaded polymeric particles.","authors":"Dominik Strojewski,&nbsp;Anna Krupa","doi":"10.17219/pim/152230","DOIUrl":"https://doi.org/10.17219/pim/152230","url":null,"abstract":"<p><p>In this review, benefits and drawbacks of the process of spray drying and nano spray drying with regard to the manufacturing of polymeric particles for pharmaceutical applications are discussed. Spray drying has been used for many years in the food, chemical and pharmaceutical industries for converting liquids into solids, in order to form products of uniform appearance. The construction of spray dryer enables to atomize the liquid into small droplets, which ensures a large surface area for heat and mass transfer, and significantly shortens the processing. Each droplet dries to an individual solid microparticle of characteristic features that can be tailored by optimizing formulation variables and critical process parameters. Since spray drying technology is easy to scale up and can be used for drying almost any drug in a solution or suspension, there are numerous examples of products in clinical use, in which this process has been successfully applied to improve drug stability, enhance bioavailability or control its release rate. In recent years, nano spray drying technology has been proposed as a method for lab-scale manufacturing of nanoparticles. Such an approach is of particular interest at early stages of drug development, when a small amount of new chemical entities is available. Here, the nebulization technique is used for feed atomization, while laminar gas flow in the drying chamber ensures gentle drying conditions. Moreover, electrostatic collectors have gradually replaced cyclone separators, ensuring high effectiveness in producing solid nanoparticles, even if a small volume of the sample is processed.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"52 2","pages":"101-111"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10417246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Talinum triangulare (Jacq.) Willd. mucilage and pectin in the formulation of ibuprofen microspheres.","authors":"Olufunke Dorothy Akin-Ajani,&nbsp;Temiloluwa Mary Hassan,&nbsp;Oluwatoyin Adepeju Odeku","doi":"10.17219/pim/153520","DOIUrl":"https://doi.org/10.17219/pim/153520","url":null,"abstract":"<p><strong>Background: </strong>Mucilage and pectin are both natural polymers with the advantages of availability and biodegradability. Microspheres made from biodegradable polymers can break down naturally after performing their tasks.</p><p><strong>Objectives: </strong>The study aimed to use mucilage and pectin from the leaves of Talinum triangulare (Jacq.) Willd. as polymer matrices for the formulation of microspheres, with ibuprofen as the model drug.</p><p><strong>Material and methods: </strong>Both polymers were examined under a microscope and evaluated using measurements of viscosity, density, flow properties, swelling power, elemental analysis, Fourier-transform infrared spectroscopy (FTIR), and the degree of esterification (DE) for pectin. The microspheres were prepared using the ionotropic gelation method and alginate:mucilage/pectin at ratios of 1:1 and 1:2. They were assessed for swellability, drug entrapment effectiveness and drug release profile.</p><p><strong>Results: </strong>The mucilage particles were ovoid while pectin particles were irregularly shaped. Pectin had higher particle, bulk and tapped densities than mucilage, while mucilage had a higher swelling power and a better flow than pectin. Talinum triangulare pectin is a low-methoxyl pectin with a DE of 7.14%. The FTIR spectra showed no interaction between the polymers and ibuprofen. The surface morphology of the microspheres without ibuprofen was smooth, while those with ibuprofen revealed a spongy-like mesh. The swelling power of the microspheres was higher in phosphate buffer with a pH of 7.2 than in distilled water. The entrapment efficiency ranged within 39.57-60.43% w/w, with microspheres containing alginate:mucilage/pectin ratio of 1:1 having higher entrapment efficiency. Microspheres with polymer at a ratio of 1:1 provided a longer release (>2 h), while microspheres with polymer blend of 1:2 provided an immediate release of ibuprofen.</p><p><strong>Conclusions: </strong>The polymers of T. triangulare could be used as matrices in microsphere formulations.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"52 2","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10416809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irvingia gabonensis (O'Rorke) Bail polymer matrix system for controlled drug delivery.","authors":"Bernard O Patani,&nbsp;Olufunke Dorothy Akin-Ajani,&nbsp;Arul Kumaran,&nbsp;Oluwatoyin Adepeju Odeku","doi":"10.17219/pim/153521","DOIUrl":"https://doi.org/10.17219/pim/153521","url":null,"abstract":"<p><strong>Background: </strong>Irvingia gabonensis kernel polymer has gained attention in drug delivery systems because of its compatibility and degradation under natural and physiological conditions.</p><p><strong>Objectives: </strong>This study aimed to evaluate Irvingia gabonensis polymer as a matrix system for the controlled delivery of ibuprofen in comparison to xanthan gum and hydroxypropylmethylcellulose (HPMC).</p><p><strong>Material and methods: </strong>Irvingia gabonensis polymer was extracted using established methods and dried using the ovenand freeze-drying methods. Ibuprofen tablets were prepared by direct compression and the effects of polymer concentration (10-50%), excipients (lactose, microcrystalline cellulose and dicalcium phosphate dihydrate) and polymers (xanthan gum and HPMC) on the mechanical and drug release properties of the tablets were evaluated. Density measurements and the Heckel and Kawakita equations were used to determine the compression properties of the tablets. Friability, crushing strength and the crushing strength-friability ratio (CSFR) were used to evaluate the mechanical properties of the tablets, while dissolution times were used to evaluate drug release from the matrices. The drug release mechanisms were determined by fitting the dissolution data into classic kinetic equations.</p><p><strong>Results: </strong>Irvingia gabonensis polymer deformed plastically with a fast onset and a high amount of plastic deformation compared with xanthan gum and HPMC. This polymer was directly compressible and formed intact non-disintegrating tablets; the mechanical and dissolution properties of Irvingia gabonensis polymer tablets generally decreased with increasing concentration of ibuprofen. The ranking of dissolution times was xanthan gum > freeze-dried Irvingia gabonensis > HPMC > oven-dried Irvingia gabonensis. The addition of the excipients improved the mechanical properties of the tablets, aided ibuprofen release, and altered the release kinetics, which was largely defined by the Korsmeyer-Peppas model. Increasing the proportion of xanthan gum and HPMC in the matrices resulted in a decreased amount of ibuprofen released after 9 h, with xanthan gum having a greater effect.</p><p><strong>Conclusions: </strong>Irvingia gabonensis polymer matrices may be effective in the preparation of controlled release tablets, and their right combination with xanthan gum or HPMC could provide a time-independent release for longer durations.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"52 2","pages":"67-76"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10416810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of glaze and chlorhexidine on physical and mechanical properties of bis-acryl resin: An in situ study.","authors":"Betina Chairelo Commar,&nbsp;Marcelle Danelon,&nbsp;Paulo Augusto Panitente,&nbsp;Emily Vivianne Freitas Da Silva,&nbsp;Sandro Basso Bitencourt,&nbsp;Valentim Adelino Ricrdo Barão,&nbsp;Clóvis Lamartine De Moraes Melo Neto,&nbsp;Marcelo Coelho Goiato,&nbsp;Daniela Micheline Dos Santos","doi":"10.17219/pim/156868","DOIUrl":"https://doi.org/10.17219/pim/156868","url":null,"abstract":"<p><strong>Background: </strong>Temporary prosthesis protects the oral tissues, in addition to providing aesthetic look and masticatory function until a definitive prosthesis is manufactured.</p><p><strong>Objectives: </strong>To evaluate the effect of glaze and 0.12% chlorhexidine (CHX) on the physical and mechanical properties of bis-acryl, and to evaluate the antimicrobial efficacy of CHX.</p><p><strong>Material and methods: </strong>Eighty specimens of bis-acryl resin were made. Over 40 of them the glaze was applied. One specimen with and 1 specimen without glaze were placed in niches of an appliance manufactured for each patient. Each of the 20 volunteers received 2 devices. Initially, the volunteers used one device and treated it with sucrose for 7 days (control), and later they used the other device and treated it with sucrose and CHX for 7 days (test). Color, microhardness, roughness, surface energy, and insoluble extracellular polysaccharides (EPS) tests were performed. All results were submitted to the Tukey's test, with the exception of the EPS results, which were submitted to the Student's t test.</p><p><strong>Results: </strong>The ΔE00 of the unglazed control group was significantly higher than that of the unglazed test group. In all groups, a significant decrease in microhardness occurred over time. At both times, the glaze significantly increased the microhardness of the specimens (in all the glazed groups). At the final time, the test glaze group showed significantly higher microhardness compared with the control glaze group. Roughness in the groups without glaze increased significantly with CHX treatment over time. At both times, the glaze generated a significant reduction in roughness in the control and test groups. There was a significant reduction in surface energy over time in all groups. In most comparisons, the glazed groups showed significantly higher surface energy values compared with the unglazed control group. At the final time point, the unglazed test group showed a significantly higher surface energy value than the unglazed control group; and the glazed test group showed a significantly higher surface energy value compared with the glazed control group. The resins that received CHX had a significantly lower amount of biofilm.</p><p><strong>Conclusions: </strong>Color values were clinically acceptable in all tested groups. At both time points, the roughness values were clinically acceptable only in the glazed groups. Glaze increased the microhardness of the specimens. Microhardness and surface energy were reduced over time in all groups. Chlorhexidine can help prevent microhardness degradation. Glaze and CHX can increase surface energy. Chlorhexidine reduced the amount of bacterial biofilm.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"52 2","pages":"93-99"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10419061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy conversion in Textus Bioactiv Ag membrane dressings using Peusner's network thermodynamic descriptions.","authors":"Kornelia M Batko,&nbsp;Izabella Ślęzak-Prochazka,&nbsp;Sławomir Marek Grzegorczyn,&nbsp;Anna Pilis,&nbsp;Paweł Dolibog,&nbsp;Andrzej Ślęzak","doi":"10.17219/pim/153522","DOIUrl":"https://doi.org/10.17219/pim/153522","url":null,"abstract":"<p><strong>Background: </strong>The Textus Bioactiv Ag membrane is an active dressing for the treatment of chronic wounds such as venous stasis ulcers and burns.</p><p><strong>Objectives: </strong>Determination of the transport and internal energy conversion properties of the Textus Bioactiv Ag membrane using the Kedem-Katchalsky-Peusner model. This model introduces the coefficients Lij necessary to calculate the degree of coupling (lij, QL), energy conversion efficiency (eij), dissipated energy (S-energy), free energy (F-energy), and internal energy (U-energy).</p><p><strong>Material and methods: </strong>The research material was the Textus Bioactiv Ag membrane that is used as an active dressing in the treatment of difficult-to-heal wounds, and KCl aqueous solutions. The research methods employed Peusner's formalism of network thermodynamics and Kedem and Katchalsky's thermodynamics of membrane processes. To calculate the Lij coefficients, we used hydraulic conductivity (Lp), diffusion conductivity (ů) and reflection (ó) coefficients to perform experimental measurements in different conditions.</p><p><strong>Results: </strong>The Lp coefficient for the Textus Bioactiv Ag membrane is nonlinearly dependent on the average concentrations of the solutions. In turn, the ů and ó coefficients are nonlinearly dependent on the differences in osmotic pressures (Äđ). An increase in the Äđ causes the Textus Bioactiv Ag membrane to become more permeable and less selective for KCl solutions. The coefficients of Peusner (Lij), couplings (lij, QL), energy conversion efficiency (eij), S-energy, F-energy, and U-energy also depend nonlinearly on Äđ. Our results showed that for higher concentrations of KCl solutions transported through the Textus Bioactiv Ag membrane, the coupling and energy conversion coefficients were greater for larger Äđ up to their maximum values for large Äđ. Coupling of the membrane structure with the electrolyte flux through the membrane is observed for Äđ greater than 10 kPa.</p><p><strong>Conclusions: </strong>Textus Bioactiv Ag membrane dressings possess the properties of a solution component separator as well as an internal energy converter.</p>","PeriodicalId":20355,"journal":{"name":"Polimery w medycynie","volume":"52 2","pages":"57-66"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10783786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}