Pneumologia最新文献_第9页

Is VEGF a potential therapeutic target in asthma? VEGF是哮喘的潜在治疗靶点吗?

Pneumologia Pub Date : 2014-10-01

Rushaine Smith

引用次数: 0

[Ethical issues of medical journals and beyond]. [医学期刊及其他领域的伦理问题]。

Pneumologia Pub Date : 2014-10-01

Florin Mihălţan

引用次数: 0

[Tiotropium in asthma--a new opportunity?]. [替托品治疗哮喘——一个新的机会?]。

Pneumologia Pub Date : 2014-10-01

Florin Mihălţan, Ruxandra Ulmeanu

引用次数: 0

Alpha-1 antitrypsin deficiency, SZ phenotype: a rare type of a rare disease. Case report. α -1抗胰蛋白酶缺乏症，SZ型:一种罕见的疾病。病例报告。

Pneumologia Pub Date : 2014-10-01

Ana-Maria Nebunoiu, Oana Claudia Deleanu, Ileana Rohan, Florin Mihălţan, Joanna Chorostowska-Wynimko, Ruxandra Ulmeanu

{"title":"Alpha-1 antitrypsin deficiency, SZ phenotype: a rare type of a rare disease. Case report.","authors":"Ana-Maria Nebunoiu, Oana Claudia Deleanu, Ileana Rohan, Florin Mihălţan, Joanna Chorostowska-Wynimko, Ruxandra Ulmeanu","doi":"","DOIUrl":"","url":null,"abstract":"Alpha-1 antitrypsin deficiency is one of the genetic diseases with a clear impact on the structure and function of the lung, rarely diagnosed and treated. We present the case of a 51-year-old female patient, heavy smoker, known with chronic obstructive pulmonary disease (COPD) for 12 years, untreated, who was hospitalized for the first time in our clinic having symptoms of a severe COPD exacerbation. She has significant cardiac disease (rheumatic mitral disease, with previous episodes of pulmonary edema and cardiac arrest) and hepatitis B. The patient is hypoxic, with severe mixed ventilatory dysfunction. During the hospitalisation she received treatment of the exacerbation and after that she received recommendation of chronic inhaled bronchodilator and corticosteroid treatment. The test for alpha-1 antitrypsin deficiency has detected a plasma of 63 mg/dl, SZ phenotype. The patient returns for a second evaluation. Functional tests are significantly improved (despite inconsistent treatment) with the impressive improvement of FEV7 values and identification by plethysmography of a restrictive syndrome. Echocardiography identifies mitral valve changes likely rheumatic, severe pulmonary hypertension. Computer tomography was performed, highlighting discrete interstitial changes and denying the existence of emphysema. Marked increase in FEV1 values supported adding bronchial asthma to the list of diagnosis and recommendation to continue inhaled corticosteroid combination bronchodilator as treatment. The particularity of the case is the rare phenotype, association of asthma and COPD as the clinical manifestation and the presence of comorbidities, which complicates the diagnosis and prognosis.","PeriodicalId":20345,"journal":{"name":"Pneumologia","volume":"63 4","pages":"218-23"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33039981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term effects of nocturnal continuous positive airway pressure therapy in patients with resistant hypertension and obstructive sleep apnea. 顽固性高血压合并阻塞性睡眠呼吸暂停患者夜间持续气道正压治疗的远期疗效。

Pneumologia Pub Date : 2014-10-01

Ştefan M Frenţ, Voicu M Tudorache, Carmen Ardelean, Stefan Mihăicuţă

{"title":"Long-term effects of nocturnal continuous positive airway pressure therapy in patients with resistant hypertension and obstructive sleep apnea.","authors":"Ştefan M Frenţ, Voicu M Tudorache, Carmen Ardelean, Stefan Mihăicuţă","doi":"","DOIUrl":"","url":null,"abstract":"Obstructive sleep apnea (OSA) is often linked to high blood pressure and has a particularly high prevalence in patients with resistant hypertension. The effect of continuous positive airway pressure (CPAP) therapy on blood pressure (BP) values has been evaluated in several short-term clinical trials with conflicting results. Our aim was to investigate the role of long-term CPAP treatment in achieving BP control in patients who associate OSA and resistant hypertension. We have included in the study 33 patients with resistant hypertension, diagnosed with OSA in our sleep lab. Data was collected initially and after a mean follow-up period of 4 years. Patients were divided into 2 groups according to the use of CPAP therapy. Patients under CPAP therapy (n = 12) exhibited a higher reduction in both systolic and diastolic pressure and BP control was achieved in 75% of cases, while patients without CPAP treatment (n = 21) remained with refractory hypertension in proportion of 90.5%. A de-escalation of antihypertensive drug regimen by discontinuation of 1 or more drugs was observed in 41.6% (n = 5) of patients from CPAP group and in the other 33.4% (n = 4) the medication remained unchanged, but BP control was reached. Using a direct logistic regression model for examining the impact of different confounders on the probability of diagnosis of resistant hypertension at follow-up, the only statistically significant predictor found was the lack of CPAP usage.","PeriodicalId":20345,"journal":{"name":"Pneumologia","volume":"63 4","pages":"204, 207-11"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33039974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term gender-specific evolution of blood pressure under CPAP therapy in hypertensive patients with obstructive sleep apnea syndrome. 阻塞性睡眠呼吸暂停综合征高血压患者在CPAP治疗下血压的长期性别特异性演变。

Pneumologia Pub Date : 2014-10-01

Oana Claudia Deleanu, Andra Elena Mălăuţ, Anca Donoaica, Ana-Maria Nebunoiu, Florin Mihălţan

{"title":"Long-term gender-specific evolution of blood pressure under CPAP therapy in hypertensive patients with obstructive sleep apnea syndrome.","authors":"Oana Claudia Deleanu, Andra Elena Mălăuţ, Anca Donoaica, Ana-Maria Nebunoiu, Florin Mihălţan","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Reduction of blood pressure (BP) under CPAP treatment in patients with obstructive sleep apnea syndrome (OSAS) associating hypertension (HT) is controversial and short-term evolution is often measured using the sphygmomanometer.Purpose: To study the variation in BP (sphygmomanometer and Holter) after 3 and 6 months of CPAP in OSAS patients associating hypertension.Methods: We applied the exclusion criteria (hypoventilation, respiratory diseases, secondary hypertension, antihypertensive treatment modification during study, non-compliance) on 96 consecutive patients (SPSS 17.0: Chi test, T-test).Results: 15 hypertensive patients (8.53 years from diagnosis) with OSAS succeeded six months of following: 3 women (20%), 12 men (80%) were comparable as age, body mass index and Epworth score; women had more severe OSAS. Sphygmomanometer measuring in men showed a decrease in systolic BP (SBP) (142 ± 8.9 to 128.7 ± 11.7 mmHg, p = 0.005) and diastolic BP (DBP) (82 ± 17.19 to 69.1 ± 6.6 mmHg, p = 0.040) at three months of treatment. Women had no changes at 3 and 6 months of assessment using the sphygmomanometer. BP Holter showed no significant changes in men; women exhibit a significant increase in maximum DBP/24 hours (104 ± 13.4 to 169.5 ± 27.5 mmHg, p = 0.034) and mean daytime DBP/24 hours (100 ± 14.1 to 166 ± 32.5 mmHg, p = 0.046) from 3 to 6 months. No group presents dipper status change to 3 or 6 months.Conclusions: The trend in both groups of increase in BP for 3 to 6 months is explained by the natural evolution of an old HT history. Long time monitoring using Holter device is more accurate in assessing cardiovascular risk.","PeriodicalId":20345,"journal":{"name":"Pneumologia","volume":"63 4","pages":"212-7"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33039976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[23-th Congress of Romanian Pneumology Society, 2014-- competition between generations]. [第23届罗马尼亚肺病学会大会，2014-代际竞争]。

Pneumologia Pub Date : 2014-10-01

Florin Mihălţan

引用次数: 0

Serum CA-125 level in patients with chronic obstructive pulmonary disease with and without pulmonary hypertension. 慢性阻塞性肺疾病伴和不伴肺动脉高压患者血清CA-125水平

Pneumologia Pub Date : 2014-07-01

Mohammad Hossein Rahimi-Rad, Parvaneh Rahimi, Behzad Rahimi, Mahdia Gholamnaghad

{"title":"Serum CA-125 level in patients with chronic obstructive pulmonary disease with and without pulmonary hypertension.","authors":"Mohammad Hossein Rahimi-Rad, Parvaneh Rahimi, Behzad Rahimi, Mahdia Gholamnaghad","doi":"","DOIUrl":"","url":null,"abstract":"Background: Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating disease and is going to be the 3rd most common cause of death worldwide. Pulmonary hypertension (PH) has severely bad influence on prognosis in COPD patients. Hence, early diagnosis of it is important for appropriate therapy. Echocardiography is used for this purpose, which requires cardiologist and expensive equipment which may not be available anywhere. CA-125, a biomarker of ovarian cancer, has shown to be associated with left ventricular failure. We aimed to show the relationship between CA-125 levels and PH in patients with COPD.Methods: Ninety patients with stable COPD were enrolled into the study. Levels of CA-725 were measured from venous blood, and in the same day systolic pulmonary artery pressure (sPAP) was measured by transthoracic echocardiography.Results: Of 90 Patients 57 had PH and 39 had not. Patients with PH had significantly higher CA- 125 levels compared with controls (mean 39.15 U/ mL vs. 24.22 U/mL, P < 0.04). Levels of CA-125 were correlated with sPAP (r=017, P=0.01).Conclusions: The CA-125 biomarker can be used to identify COPD patients with pulmonary hypertension. Since it is cheap and easily available it can help in centers with less access to echocardiography.","PeriodicalId":20345,"journal":{"name":"Pneumologia","volume":"63 3","pages":"164-6"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32833375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Conventional and molecular diagnosis in a group of patients with drug-resistant tuberculosis]. [一组耐药结核病患者的常规和分子诊断]。

Pneumologia Pub Date : 2014-07-01

Roxana Mindru, Victor Spînu, Cristina Popa, Elena Botezatu, Ruxandra Spătaru

{"title":"[Conventional and molecular diagnosis in a group of patients with drug-resistant tuberculosis].","authors":"Roxana Mindru, Victor Spînu, Cristina Popa, Elena Botezatu, Ruxandra Spătaru","doi":"","DOIUrl":"","url":null,"abstract":"Worldwide, although the incidence of the sensitive/susceptible tuberculosis diminished, the number of drug resistant tuberculosis is growing. The bacteriological diagnosis, genetic and phenotypic, becomes essential for the epidemic control. The resistance appears as a phenotypic expression of mutations from M. tuberculosis genome. The mutations that appear for Rifampicin are in region rpoB, for Isoniazid in region katG and inhA, for Ethambutol-embB, Quinolone-gyrA, Aminoglicozid and Cyclical Peptides-rrs. To follow the concordance of results of drug sensitivity test (DST) through phenotypic and genetic method, we analyzed a group of 40 patients with TB-DR. We performed drug susceptibility testing on Lowenstein-Jensen medium according to the instructions of the manufacturer. The strains were tested indirect genetic too, Genotype MTBDR plus forl INH and RIF and Genotype MTBDRsl for the second line drugs. The concordance between genetic method and the phenotypic method is 95%, 5% from the patients have different sensitivity to INH and RIF, butphenotypical they are resistant, meaning that they have other mutations undetected by the strip. The most common mutation in region rpoB is MUT3 (52%) associating the absence of band W8. Mutations in the region rpoB MUT1 and MUT2A are 12.5%, and 15% respectively. For high resistance to INH, the mostcommon isMUT1 forkatG 95% and forlow resistance to INHMUTI from region inhA-30%. For the second line drugs, the most frequent concordance between genetic method andphenotypic method is for EMB, of 30%, geneticallyspeaking the strains display no mutation in region embB, but are resistantin phenotypic method. For FQ, KAN, AMKand CAP the concordance between the two methods is of 100% to all tested strains. In conclusion, genetic methods have high sensitivity, they are fast and shorten significantly the diagnosis time.","PeriodicalId":20345,"journal":{"name":"Pneumologia","volume":"63 3","pages":"168-73"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32833377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

["From empathy to malpractice"-- a different kind of conference of the Romanian Society of Pneumology]. [“从同理心到医疗事故”——罗马尼亚肺炎学会的另一种会议]。

Pneumologia Pub Date : 2014-07-01

Florin Mihălţan, Ioana Munteanu

引用次数: 0