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Self-organisation of early stress response in the biology of cancer 癌症生物学中早期应激反应的自我组织
Postępy Biochemii Pub Date : 2024-03-18 DOI: 10.18388/pb.2021_521
J. Erenpreisa, K. Salmina, N. Vainshelbaum, I. Inashkina, T. Freivalds
{"title":"Self-organisation of early stress response in the biology of cancer","authors":"J. Erenpreisa, K. Salmina, N. Vainshelbaum, I. Inashkina, T. Freivalds","doi":"10.18388/pb.2021_521","DOIUrl":"https://doi.org/10.18388/pb.2021_521","url":null,"abstract":"The early stress response by AP-1 (FOS/JUN), supported by upregulation of c-Myc and involved in cell-fate changes and adaptation to hostile environments, is increased in cancer. The review shows the biphasic character of this response with negative feed-back typically lasting a few hours as a feature of the genome regulation by self-organising criticality. It involves  rapid splitting of the pericentromeric heterochromatin clusters, opening of the active chromatin, and a massive transcription acceleration wave. Phylostratigraphic analysis revealed that AP-1 genes evolved in the Cambrian explosion ~500 Mya integrating the protein interaction networks of reproduction including proto-placenta intertwined with cytokine and immunity pathways, sex determination, oocyte maturation, and embryonal stemness. The peak  of this response as part of accelerated cell senescence led by AP-1 and IL-1β was found in breast cancer cell-line resistant to doxorubicin. Adaptability of aggressive cancer to treatments can be explained by emergent stress response evolutionarily protecting reproduction","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140232439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profesor Jakub Karol Parnas: 140 rocznica urodzin 雅各布-卡罗尔-帕尔纳斯教授诞辰 140 周年
Postępy Biochemii Pub Date : 2024-03-12 DOI: 10.18388/pb.2021_524
J. Barańska, A. Dżugaj, A. Szewczyk
{"title":"Profesor Jakub Karol Parnas: 140 rocznica urodzin","authors":"J. Barańska, A. Dżugaj, A. Szewczyk","doi":"10.18388/pb.2021_524","DOIUrl":"https://doi.org/10.18388/pb.2021_524","url":null,"abstract":"In 2024, it will be 140 years since the birth of Jan Karol Parnas, one of the most outstanding biochemists and one of the most outstanding Polish scientists of the first half of the 20th century. The article presents a synthetic biography of Prof. Parnas, his influence on the organization of scientific life in interwar Poland, and presents his students and collaborators who created the so-called \"The School of Parnassus\". It shows how this figure still influences the thinking of Polish biochemists about their Society and the attitude towards biochemical communities abroad, especially in Ukraine, which owes as much to Prof. Parnas as Poland does.","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140250080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNA-mediated gene regulation and the resilience of multicellular animals 微RNA介导的基因调控与多细胞动物的恢复能力
Postępy Biochemii Pub Date : 2024-02-28 DOI: 10.18388/pb.2021_515
Victor Ambros
{"title":"MicroRNA-mediated gene regulation and the resilience of multicellular animals","authors":"Victor Ambros","doi":"10.18388/pb.2021_515","DOIUrl":"https://doi.org/10.18388/pb.2021_515","url":null,"abstract":"MicroRNAs are small RNAs that enable parts of the genome to regulate the other parts of the genome by RNA::RNA complementarity. Genes that encode microRNAs function as trans-acting regulators of hundreds of other genes, primarily by inhibiting the production of protein from mRNAs to which the microRNAs can bind by base pairing. MicroRNAs and their Argonaute partner proteins constitute a regulatory complex (the miRISC) that exhibits astonishing regulatory versatility. microRNAs have been shown to perform diverse roles in genetic regulatory networks (GRNs) – to control developmental switches, to dampen gene expression noise, to coordinate multigene functional modules, and more broadly, to confer robustness and resilience to developmental and homeostatic processes. Genetic analysis reveals that the function of particular microRNAs can be conditional, such that the microRNA is required under particular environmental or physiological conditions, but relatively dispensable under other conditions. The diversity and versatility of microRNA function in animal systems reflects the many ways that miRISC can be regulated by cellular signaling pathways, and the structure-function interplay among microRNA, target, and Argonaute. ","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The p53 protein – not only the guardian of the genome p53 蛋白--不仅是基因组的守护者
Postępy Biochemii Pub Date : 2024-02-28 DOI: 10.18388/pb.2021_518
M. Rusin
{"title":"The p53 protein – not only the guardian of the genome","authors":"M. Rusin","doi":"10.18388/pb.2021_518","DOIUrl":"https://doi.org/10.18388/pb.2021_518","url":null,"abstract":"The p53 tumor suppressor protein is best known as an activator of cell cycle arrest and apoptosis. Only a fraction of p53-activated genes encode proteins affecting cellular replication and various forms of cell death (apoptosis, ferroptosis, autophagy). The p53-regulated genes can be divided into so-called the core transcriptional program, which comprises genes activated in most cell types by most activators, and into the group of genes activated in in cell- or stress-specific manner. Activation of p53 occurs via the extensive set of posttranslational modifications, which adjust its stability, interaction with other transcription regulators, and its ability to form a tetramer. Surprisingly, in mouse models, the activation of the best-studied p53 target genes encoding the inhibitor of the cell cycle (CDKN1A) or the inducers of apoptosis (e.g. NOXA, PUMA) is dispensable for protection against cancers. Thus, the non-classical functions of p53 must be studied to better understand its tumor suppressive mechanisms.","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gliwice Scientific Meetings as a forum for discussion of research projects.Personal impressions 格利维采科学会议作为讨论研究项目的论坛。
Postępy Biochemii Pub Date : 2024-02-21 DOI: 10.18388/pb.2021_516
Krzysztof Szyfter
{"title":"Gliwice Scientific Meetings as a forum for discussion of research projects.Personal impressions","authors":"Krzysztof Szyfter","doi":"10.18388/pb.2021_516","DOIUrl":"https://doi.org/10.18388/pb.2021_516","url":null,"abstract":"The article has been written for the occasion of 25 Anniversary of Gliwice Scientific Meetings (GSN). For this reason, I am going to present scientific contacts of the Institute of Oncology at Gliwice with the Institute of Human Genetics of the Polish Academy of Sciences at Poznań not only at conference occasions but also in regular research manner.","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140443258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermal factor Foxn1 as a regulator of antioxidant defense in the skin 表皮因子 Foxn1 是皮肤抗氧化防御的调节因子
Postępy Biochemii Pub Date : 2024-01-30 DOI: 10.18388/pb.2021_503
Sylwia Machcińska-Zielińska, Barbara Gawrońska-Kozak
{"title":"Epidermal factor Foxn1 as a regulator of antioxidant defense in the skin","authors":"Sylwia Machcińska-Zielińska, Barbara Gawrońska-Kozak","doi":"10.18388/pb.2021_503","DOIUrl":"https://doi.org/10.18388/pb.2021_503","url":null,"abstract":"The skin, as the largest organ of the body, is constantly exposed to environmental threats, including: injuries and oxidative stress. The thioredoxin system is one of the skin antioxidant systems , which protects cells against oxidative stress, regulates cell migration, proliferation and apoptosis, and also participates in signal transmission by regulating the activity of transcription factors. Recent studies have shown a correlation between the epidermal transcription factor Foxn1 and the thioredoxin system in mouse skin. Mass spectrometry analysis, followed by in vitro and in vivo experiments, showed that Foxn1 in keratinocytes regulates elements of the electron transport chain as well as the thioredoxin system (Txn2, Txnrd3), especially under hypoxic condition. High levels of Txnrd3 mRNA were detected for the first time in the injured skin of Foxn1+/+ mice compared to Foxn1-/- mice, and also showed that Foxn1 in keratinocytes upregulates Txnrd3 protein expression. Moreover, in silico analyzes indicated possible binding sites of the transcription factor Foxn1 in the Txn system. In conclusion, the data presented in this review identify Foxn1 as a novel component of the skin antioxidant system.","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140482256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the regeneration process of the sciatic nerve of a mouse animal model after application of freezing, crushing or electrocoagulation damage 评估小鼠动物模型坐骨神经在受到冷冻、挤压或电凝损伤后的再生过程
Postępy Biochemii Pub Date : 2024-01-30 DOI: 10.18388/pb.2021_504
Dariusz Górka, Krzysztof Suszyński, Natalia Białoń, Mikołaj Górka, Michał Trzęsicki, Kacper Zając, A. Dolińska, Filip Tomsia
{"title":"Evaluation of the regeneration process of the sciatic nerve of a mouse animal model after application of freezing, crushing or electrocoagulation damage","authors":"Dariusz Górka, Krzysztof Suszyński, Natalia Białoń, Mikołaj Górka, Michał Trzęsicki, Kacper Zając, A. Dolińska, Filip Tomsia","doi":"10.18388/pb.2021_504","DOIUrl":"https://doi.org/10.18388/pb.2021_504","url":null,"abstract":"The problem of regeneration of damaged peripheral nerves is an ongoing topic and has long been the subject of intensive research worldwide. This study examined the morphological and functional evaluation of the regeneration process within the damaged sciatic nerve, a mouse animal model. The effect of impaired expression of the TSC-1 gene on the process of nerve regeneration was evaluated, depending on the mode of damage. The research object consisted of 48, 2-month-old male TSC lines. The test group consisted of animals that underwent damage to the sciatic nerve by crushing, freezing and electrocoagulation, while the control group includes mice whose sciatic nerve was not damaged. Behavioral tests were conducted to evaluate the functional return of the limb, after 3,5,7 and 14 days. The first changes in the regeneration process of the damaged neurite are observed as early as day 3 after the injury, while on day 14 after the injury the functional return of the damaged limb was noted.","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conference report 6th National Conference "BIOTECHNOLOGY HAS MANY NAMES" 会议报告 第六届 "生物技术有多种名称 "全国会议
Postępy Biochemii Pub Date : 2024-01-24 DOI: 10.18388/pb.2021_511
Michał Rurek, Joanna Perła-Kaján, Karolina Pusiak
{"title":"Conference report 6th National Conference \"BIOTECHNOLOGY HAS MANY NAMES\"","authors":"Michał Rurek, Joanna Perła-Kaján, Karolina Pusiak","doi":"10.18388/pb.2021_511","DOIUrl":"https://doi.org/10.18388/pb.2021_511","url":null,"abstract":"<jats:p />","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139602023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics and the improvement of crop plants 表观遗传学与作物改良
Postępy Biochemii Pub Date : 2024-01-15 DOI: 10.18388/pb.2021_514
Klaudia Bernacka, M. Achrem, A. Kalinka
{"title":"Epigenetics and the improvement of crop plants","authors":"Klaudia Bernacka, M. Achrem, A. Kalinka","doi":"10.18388/pb.2021_514","DOIUrl":"https://doi.org/10.18388/pb.2021_514","url":null,"abstract":"Epigenetics is a term that refers to the changes in gene expression that are heritable and induced by DNA methylation, histones post-translational modifications, or sncRNA, not resulting from the DNA sequence rearrangements. Epigenetic modifications influence gene expression, and thus, the plasticity of plants' development and phenotype in response to external and internal factors. Until recently, the only known epigenetic modification of the DNA in eukaryotic organisms was 5-methylcytosine. The growing interest in epigenetics and the development of sensitive detection methods enabled the discovery of other modifications of the DNA nitrogenous bases, i.e., 4-methylcytosine and 6-methyladenine. However, whilst research on the 5mC distribution and role in eukaryotic organisms is widespread, analyses regarding 6mA are scarced. Nevertheless, there are indications of a potential epigenetic role of 6-methyladenine in eukaryotic genomes. Understanding epigenetic mechanisms, which are triggered in response to environmental changes, is crucial for agriculture. This review shows epigenetic mechanisms, with particular emphasis on adenine methylation in plants, as well as the role of epigenetic variation in epibreeding, affecting the improvement of agronomic traits.","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of physicochemical processes in the formation of the 3D genome and compartmentalization of the cell nucleus 物理化学过程在形成三维基因组和细胞核分区中的作用
Postępy Biochemii Pub Date : 2024-01-15 DOI: 10.18388/pb.2021_512
Sergey V. Razin
{"title":"The role of physicochemical processes in the formation of the 3D genome and compartmentalization of the cell nucleus","authors":"Sergey V. Razin","doi":"10.18388/pb.2021_512","DOIUrl":"https://doi.org/10.18388/pb.2021_512","url":null,"abstract":"The review analyzes the role of physicochemical processes in the formation of the function-dependent architecture of the cell nucleus, built on the platform of a folded genome. The main attention is paid to various forms of the phase separation process, primarily the processes of liquid-liquid phase separation and polymer-polymer phase separation. The role of these processes in the formation of chromatin compartments and maintenance of three-dimensional genome architecture is discussed in detail. The relationship between genome activity and the creation of functional compartments in the cell nucleus is also analyzed.","PeriodicalId":20341,"journal":{"name":"Postępy Biochemii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139530048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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