Postepy biochemii最新文献_第6页

The importance and perspectives of antidepressant use in adjuvant therapy of glioma 抗抑郁药在胶质瘤辅助治疗中的重要性和前景

Postepy biochemii Pub Date : 2025-05-26 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_602

Agata Grabowska, Anna Bielecka-Wajdman

引用次数: 0

The role of MCPIP1 in key elements of the epithelial-mesenchymal transition signaling axis in clear cell renal cell carcinoma MCPIP1在透明细胞肾细胞癌上皮-间质转化信号轴关键元件中的作用

Postepy biochemii Pub Date : 2025-05-26 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_594

Judyta Górka, Katarzyna Miękus

{"title":"The role of MCPIP1 in key elements of the epithelial-mesenchymal transition signaling axis in clear cell renal cell carcinoma","authors":"Judyta Górka, Katarzyna Miękus","doi":"10.18388/pb.2021_594","DOIUrl":"https://doi.org/10.18388/pb.2021_594","url":null,"abstract":"Clear cell renal cell carcinoma (ccRCC) is the most common renal tumor with a highly aggressive phenotype and poor prognosis. A key process in tumor progression is epithelial-mesenchymal transition (EMT), as a result of which cells acquire the ability to metastasize. An important inducer of the EMT process is inflammation. A negative regulator of inflammation is the Monocyte Chemoattractant Protein-1 Induced Protein 1 (MCPIP1), which by regulating the immune response may contribute to inhibiting tumor progression. A specific function of the MCPIP1 protein is RNase activity regulating the level of mRNA and miRNA expression. In our studies, we investigated how the MCPIP1 protein affects the EMT process, migratory activity and the level of tumor suppressor genes in clear cell renal cell carcinoma cell lines, tumor tissues of patients and an in vivo xenotransplantation model. We have shown that MCPIP1 regulates the EMT process by preventing cells from acquiring a mesenchymal phenotype. MCPIP1, due to its RNase activity, degrades miRNA-519a-3p, miRNA-519b-3p and miRNA-520c-3p, thereby actively affecting the levels of SFRP4, KREMEN1, ZNRF3, CXXC4 and CSNK1A1 inhibitors and inhibiting the Wnt pathway by inactivating β-catenin and, consequently, inhibiting the EMT process. Furthermore, MCPIP1 regulates the level of Rho proteins, phosphorylation of FAK and Src kinases, and consequently actin remodeling. The obtained results indicate that the lack of MCPIP1 RNase activity activates genes and processes associated with the migratory activity of cancer cells. In summary, the results obtained in this doctoral thesis indicated that MCPIP1 may regulate the progression of clear cell renal cancer at various levels of proangiogenic and prometastatic factors, as well as by influencing the EMT process.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 1","pages":"1-18"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of insulin resistance on pathogenesis of cardiovascular disease 胰岛素抵抗对心血管疾病发病机制的影响

Postepy biochemii Pub Date : 2025-05-26 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_592

Angelika Skóra, Robert Jarzyna, Anna Kiersztan

引用次数: 0

Fatty acid transporters as potential diagnostic markers for colorectal cancer 脂肪酸转运蛋白作为结直肠癌的潜在诊断标志物

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_571

Wojciech Michał Jankowski, Jakub Fichna, Aleksandra Tarasiuk

引用次数: 0

Mutations and their consequences in the development of pancreatic cancer 突变及其在胰腺癌发展中的影响

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_576

Przemysław Panek, Jarosław Rachuna, Łukasz Madej, Ryszard Tomasiuk, Aleksandra Jezela-Stanek

引用次数: 0

Will a glaucoma drug revolutionize the treatment of androgenetic alopecia? On drug repurposing, when the side effect becomes a desired therapeutic outcome. 青光眼药物会给雄激素性脱发的治疗带来革命性的变化吗？当副作用成为期望的治疗结果时，重新利用药物。

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_577

Kalina Spławska, Łukasz Zybaczyński, Maciej Wierzbicki, Katarzyna Koziak

{"title":"Will a glaucoma drug revolutionize the treatment of androgenetic alopecia? On drug repurposing, when the side effect becomes a desired therapeutic outcome.","authors":"Kalina Spławska, Łukasz Zybaczyński, Maciej Wierzbicki, Katarzyna Koziak","doi":"10.18388/pb.2021_577","DOIUrl":"https://doi.org/10.18388/pb.2021_577","url":null,"abstract":"Prostaglandins are hormones found in almost all mammalian tissues. As signaling molecules, they play a key role in the regulation of many physiological processes, including hair growth cycle. The article describes the history of the discovery of prostaglandins, including the work of Professor Ryszard Gryglewski – the discoverer of prostacyclin. Particular attention was paid to the synthetic analogue of prostaglandin F2α - latanoprost. Indicated for the treatment of glaucoma, the drug is known for inducing eyelash growth as a side effect. A prodrug, latanoprost\u0000is converted to its active metabolite, latanoprost acid. Recent research demonstrated that latanoprost acid has a chance to become an effective alternative to minoxidil and finasteride - the only drugs currently registered for the treatment of androgenetic alopecia. The development of\u0000anti-alopecia drugs containing prostaglandin derivatives, including latanoprost acid, will be a much faster process compared to the traditional path of product development based on a new chemical compound.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"70 4","pages":"438-446"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacogenomics in the treatment of mental disorders. 药物基因组学在精神障碍治疗中的应用。

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_568

Wioletta Kania, Tomasz Wilanowski

引用次数: 0

The role of gut microbiota and its metabolites in obesity and diabetes 肠道菌群及其代谢产物在肥胖和糖尿病中的作用

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_569

Adrianna Raczkowska, Kinga Arak, Karolina Jaworska

引用次数: 0

Activity of flavonoids of natural origin on SARS-CoV-2 infections 天然黄酮类化合物对SARS-CoV-2感染的活性研究

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_562

Iwona Sergiel

{"title":"Activity of flavonoids of natural origin on SARS-CoV-2 infections","authors":"Iwona Sergiel","doi":"10.18388/pb.2021_562","DOIUrl":"https://doi.org/10.18388/pb.2021_562","url":null,"abstract":"Coronaviruses cause diseases of the respiratory tract, gastrointestinal tract and central nervous system, which threaten human health and contribute to economic losses. Innovative production technologies make it possible to use bioactive compounds as antiviral agents. Most fruits, vegetables and plant products contain flavonoids. Numerous studies have demonstrated the health-promoting effect of this group of compounds resulting from their antioxidant potential. The activity of an antioxidant in the body is the result of many factors that modulate the reactivity and physicochemical properties, among which the chemical structure is the most important. Bioinformatics tools using molecular modeling often precede research using in vitro and in vivo methods. The aim of this review is to present the mechanism of antiviral action of flavonoids against SARS-CoV-2, responsible for COVID-19. Studies using virtual molecular docking models were collected to test the affinity of flavonoids for key proteins of the SARS-CoV-2 virus replication cycle. Among the flavonoids with antiviral activity, the most active were apigenin, luteolin, isorhamnetin, kaempferol, myricetin, quercetin, hesperetin, naringenin and genistein. Food products with a high content of these compounds are indicated.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"70 4","pages":"483-489"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silica nanoparticles in sustainable agriculture 二氧化硅纳米颗粒在可持续农业中的应用

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_574

Renata Szymańska, Aleksandra Orzechowska, Agnieszka Trela-Makowej

{"title":"Silica nanoparticles in sustainable agriculture","authors":"Renata Szymańska, Aleksandra Orzechowska, Agnieszka Trela-Makowej","doi":"10.18388/pb.2021_574","DOIUrl":"https://doi.org/10.18388/pb.2021_574","url":null,"abstract":"The increasing population, shrinking arable land, and climate change prompt the search for new solutions in agriculture. In a sustainable approach, agriculture should be based on improving the quality and quantity of yields while maintaining biodiversity and protecting the natural environment. Nanotechnology, present in many areas of our lives, offers opportunities to support the development of sustainable agriculture on many levels. Among the numerous solutions and nanomaterials, silicon, which is a natural component of the ecosystem, deserves special attention. In its nanoparticle form, it acquires new, unique properties. This article focuses on the significant role of silicon nanoparticles in organic farming, with particular emphasis on their function as nanofertilizers. The authors analyze the impact of silicon nanoparticles on plant growth and development and their potential in mitigating the negative effects of abiotic stress factors caused by drought, salinity, and exposure to metals. Additionally, the beneficial effects of silicon nanoparticles on plants growing under biotic stress conditions induced by microorganisms such as bacteria and fungi are presented. The paper includes a review of original research results conducted in recent years in this area, as well as possible mechanisms and strategies of silicon nanoparticle action at the physiological, cellular, and molecular levels. The issue of the safety of using nanoparticles in agriculture and the prospects for their further use as a factor enhancing the resistance and productivity of crops are also discussed.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"70 4","pages":"447-461"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0