Postepy biochemii最新文献

Fatty acid transporters as potential diagnostic markers for colorectal cancer 脂肪酸转运蛋白作为结直肠癌的潜在诊断标志物

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_571

Wojciech Michał Jankowski, Jakub Fichna, Aleksandra Tarasiuk

引用次数: 0

Mutations and their consequences in the development of pancreatic cancer 突变及其在胰腺癌发展中的影响

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_576

Przemysław Panek, Jarosław Rachuna, Łukasz Madej, Ryszard Tomasiuk, Aleksandra Jezela-Stanek

引用次数: 0

Will a glaucoma drug revolutionize the treatment of androgenetic alopecia? On drug repurposing, when the side effect becomes a desired therapeutic outcome. 青光眼药物会给雄激素性脱发的治疗带来革命性的变化吗？当副作用成为期望的治疗结果时，重新利用药物。

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_577

Kalina Spławska, Łukasz Zybaczyński, Maciej Wierzbicki, Katarzyna Koziak

{"title":"Will a glaucoma drug revolutionize the treatment of androgenetic alopecia? On drug repurposing, when the side effect becomes a desired therapeutic outcome.","authors":"Kalina Spławska, Łukasz Zybaczyński, Maciej Wierzbicki, Katarzyna Koziak","doi":"10.18388/pb.2021_577","DOIUrl":"https://doi.org/10.18388/pb.2021_577","url":null,"abstract":"Prostaglandins are hormones found in almost all mammalian tissues. As signaling molecules, they play a key role in the regulation of many physiological processes, including hair growth cycle. The article describes the history of the discovery of prostaglandins, including the work of Professor Ryszard Gryglewski – the discoverer of prostacyclin. Particular attention was paid to the synthetic analogue of prostaglandin F2α - latanoprost. Indicated for the treatment of glaucoma, the drug is known for inducing eyelash growth as a side effect. A prodrug, latanoprost\u0000is converted to its active metabolite, latanoprost acid. Recent research demonstrated that latanoprost acid has a chance to become an effective alternative to minoxidil and finasteride - the only drugs currently registered for the treatment of androgenetic alopecia. The development of\u0000anti-alopecia drugs containing prostaglandin derivatives, including latanoprost acid, will be a much faster process compared to the traditional path of product development based on a new chemical compound.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"70 4","pages":"438-446"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacogenomics in the treatment of mental disorders. 药物基因组学在精神障碍治疗中的应用。

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_568

Wioletta Kania, Tomasz Wilanowski

引用次数: 0

The role of gut microbiota and its metabolites in obesity and diabetes 肠道菌群及其代谢产物在肥胖和糖尿病中的作用

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_569

Adrianna Raczkowska, Kinga Arak, Karolina Jaworska

引用次数: 0

Activity of flavonoids of natural origin on SARS-CoV-2 infections 天然黄酮类化合物对SARS-CoV-2感染的活性研究

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_562

Iwona Sergiel

{"title":"Activity of flavonoids of natural origin on SARS-CoV-2 infections","authors":"Iwona Sergiel","doi":"10.18388/pb.2021_562","DOIUrl":"https://doi.org/10.18388/pb.2021_562","url":null,"abstract":"Coronaviruses cause diseases of the respiratory tract, gastrointestinal tract and central nervous system, which threaten human health and contribute to economic losses. Innovative production technologies make it possible to use bioactive compounds as antiviral agents. Most fruits, vegetables and plant products contain flavonoids. Numerous studies have demonstrated the health-promoting effect of this group of compounds resulting from their antioxidant potential. The activity of an antioxidant in the body is the result of many factors that modulate the reactivity and physicochemical properties, among which the chemical structure is the most important. Bioinformatics tools using molecular modeling often precede research using in vitro and in vivo methods. The aim of this review is to present the mechanism of antiviral action of flavonoids against SARS-CoV-2, responsible for COVID-19. Studies using virtual molecular docking models were collected to test the affinity of flavonoids for key proteins of the SARS-CoV-2 virus replication cycle. Among the flavonoids with antiviral activity, the most active were apigenin, luteolin, isorhamnetin, kaempferol, myricetin, quercetin, hesperetin, naringenin and genistein. Food products with a high content of these compounds are indicated.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"70 4","pages":"483-489"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silica nanoparticles in sustainable agriculture 二氧化硅纳米颗粒在可持续农业中的应用

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_574

Renata Szymańska, Aleksandra Orzechowska, Agnieszka Trela-Makowej

{"title":"Silica nanoparticles in sustainable agriculture","authors":"Renata Szymańska, Aleksandra Orzechowska, Agnieszka Trela-Makowej","doi":"10.18388/pb.2021_574","DOIUrl":"https://doi.org/10.18388/pb.2021_574","url":null,"abstract":"The increasing population, shrinking arable land, and climate change prompt the search for new solutions in agriculture. In a sustainable approach, agriculture should be based on improving the quality and quantity of yields while maintaining biodiversity and protecting the natural environment. Nanotechnology, present in many areas of our lives, offers opportunities to support the development of sustainable agriculture on many levels. Among the numerous solutions and nanomaterials, silicon, which is a natural component of the ecosystem, deserves special attention. In its nanoparticle form, it acquires new, unique properties. This article focuses on the significant role of silicon nanoparticles in organic farming, with particular emphasis on their function as nanofertilizers. The authors analyze the impact of silicon nanoparticles on plant growth and development and their potential in mitigating the negative effects of abiotic stress factors caused by drought, salinity, and exposure to metals. Additionally, the beneficial effects of silicon nanoparticles on plants growing under biotic stress conditions induced by microorganisms such as bacteria and fungi are presented. The paper includes a review of original research results conducted in recent years in this area, as well as possible mechanisms and strategies of silicon nanoparticle action at the physiological, cellular, and molecular levels. The issue of the safety of using nanoparticles in agriculture and the prospects for their further use as a factor enhancing the resistance and productivity of crops are also discussed.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"70 4","pages":"447-461"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoids – natural compounds with antiviral and anticancer potential 类黄酮——具有抗病毒和抗癌潜力的天然化合物

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_563

Iwona Sergiel

{"title":"Flavonoids – natural compounds with antiviral and anticancer potential","authors":"Iwona Sergiel","doi":"10.18388/pb.2021_563","DOIUrl":"https://doi.org/10.18388/pb.2021_563","url":null,"abstract":"Flavonoids are a group of plant secondary metabolites that have a number of health-promoting properties and have both preventive and therapeutic effects. Research confirms that flavonoids work, among others: antiviral and anticancer. Apigenin, luteolin, isorhamnetin, kaempferol, myricetin, quercetin, hesperetin, naringenin, epicatechin and genistein have documented antiviral activity. The discovery of the anticancer activity of flavonoids (including apigenin, naringenin, hesperetin) initiated a number of studies to identify the most active compounds against various cancers and to understand the mechanism of their action. However, the relationship between flavonoid intake and cancer risk appears to be non-linear. Available literature data suggest that flavonoids may act as therapeutic agents in the early stages of virus infection and as an anticancer agent and should be included in the daily diet by increasing the consumption of primarily fruit (chokeberry, elderberry, cherry, mandarin), vegetables (parsley, celery, onion) and herbs and spices (mint, oregano, lovage, moringa, saffron). Flavonoids present in food are transported by passive diffusion (hydrophobic aglycones) and by active transport (hydrophilic glycosides). Individual classes of flavonoids differ in the amount they appear in food, the metabolites they produce and their possible impact on health. The aim of this review is to summarize the current knowledge on the potential use of selected flavonoids in the treatment of diseases of various etiologies, with an indication of their anticancer and antiviral effects. The perspectives and possibilities of using these compounds are presented, taking into account the problems resulting from their bioavailability.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"70 4","pages":"474-482"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From bench to beadside: experimental animal models in ischemic stroke research 从工作台到码头：缺血性脑卒中研究的实验动物模型

Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI: 10.18388/pb.2021_570

Sylwia Piątek, Paulina Milewska, Ewelina Ziemlińska, Anna Malik

引用次数: 0

Vitamin C and its derivatives in maintaining the good skin condition 维生素 C 及其衍生物在保持良好皮肤状态方面的作用

Postepy biochemii Pub Date : 2024-09-17 Print Date: 2024-09-30 DOI: 10.18388/pb.2021_554

Urszula Goik

{"title":"Vitamin C and its derivatives in maintaining the good skin condition","authors":"Urszula Goik","doi":"10.18388/pb.2021_554","DOIUrl":"10.18388/pb.2021_554","url":null,"abstract":"Vitamin C is one of the most important and necessary nutrient for human health, which has great potential as cosmeceutic, which protects health and the skin good condition. Thru the collagen biosynthesis stimulation it affects to the physiology of human skin, participating in the hydroxylation process of proline and lysine, and participates in tissue reconstruction while wound healing. Deficiency of vitamin C causes irregularities in the blood vessels functioning, epidermis and dermis. Is an effective antioxidant neutralizing free radicals, prevents inflammatory and carcinogenic processes. The epidermis and dermis are most exposed to free radicals from the external environment and from the inside of the body. In inflammatory diseases of the skin, such as atopic dermatitis, psoriasis, in the proper skin the levels of vitamin C are reduced. Therefore, delivering it to the skin using cosmetic preparations is important not only for cosmetic, but also health effect. The problem associated with the introduction of vitamin C in cosmetics is its limited penetration through the stratum corneum. Current studies are focused on searching for stable compounds of ascorbic acid and new media, which will allow for better way of delivery of ascorbic acid to the dermis in the future.","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"70 3","pages":"307-314"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0