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Molecular mechanisms of mherapy resistance in ovarian cancer 卵巢癌耐药的分子机制
Postepy biochemii Pub Date : 2026-06-07 DOI: 10.18388/5djwbt46
Angelika Patelak, Julia Nowak-Niedźwiecka, Beata Machnicka
{"title":"Molecular mechanisms of mherapy resistance in ovarian cancer","authors":"Angelika Patelak, Julia Nowak-Niedźwiecka, Beata Machnicka","doi":"10.18388/5djwbt46","DOIUrl":"https://doi.org/10.18388/5djwbt46","url":null,"abstract":"<p><p>Ovarian cancer remains one of the most frequently diagnosed and lethal gynaecological malignancies. Standard treatment involves surgical cytoreduction followed by chemotherapy based on platinum compounds and taxanes. Despite initial therapeutic efficacy, many patients experience disease recurrence and develop drug resistance, posing a significant clinical challenge. This review summarises the main molecular mechanisms underlying resistance to commonly used drugs, including paclitaxel, cisplatin, and PARP inhibitors. The role of multidrug resistance (MDR), associated with the overexpression of ABC transporters and alterations in drug metabolism, is discussed. Particular attention is given to cellular mechanisms, including changes in microtubule structure, regulation of apoptosis, and activation of signalling pathways such as PI3K/AKT/mTOR. Mechanisms related to drug transport, detoxification, and DNA repair are also addressed, together with the influence of the tumour microenvironment and epigenetic modifications. Understanding these mechanisms may contribute to the development of novel therapeutic strategies.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"72 2","pages":"67-84"},"PeriodicalIF":0.0,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Riboregulation in bacteria: From simple switches to complex regulatory networks 细菌中的核糖调节：从简单的开关到复杂的调节网络
Postepy biochemii Pub Date : 2026-06-07 DOI: 10.18388/tkbrr231
Paulina Lipska, Julia Konarska, Adrianna Raczkowska, Karolina Jaworska
{"title":"Riboregulation in bacteria: From simple switches to complex regulatory networks","authors":"Paulina Lipska, Julia Konarska, Adrianna Raczkowska, Karolina Jaworska","doi":"10.18388/tkbrr231","DOIUrl":"https://doi.org/10.18388/tkbrr231","url":null,"abstract":"<p><p>Riboregulation is a key component of bacterial adaptation, as regulatory RNAs enable rapid and precise control of gene expression in response to stress and fluctuating environmental conditions. This control is exerted at the levels of transcription, translation, and mRNA stability, allowing the cell to efficiently adjust gene expression without the need to produce additional protein regulators. Regulation involves both locally acting elements (including riboswitches, thermosensors, and antisense RNAs) and in trans acting molecules primarily sRNAs which form extensive networks affecting the expression of many genes simultaneously. The multilayered nature of these systems is further enhanced by sRNA-binding proteins and RNA sponges, which modulate the availability of regulators and shape complex gene expression control networks. Modern methods like Hfq-CLASH enable better identification of these interactions in vivo. In parallel, applied research leverages these mechanisms in synthetic biology and against antibiotic resistance.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"72 2","pages":"85-98"},"PeriodicalIF":0.0,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New possibilities and perspectives for the use of fly maggots in clinical practice 蝇蛆在临床实践中应用的新可能性和前景
Postepy biochemii Pub Date : 2026-04-09 DOI: 10.18388/wq70yc30
Aleksandra Wyszyńska
{"title":"New possibilities and perspectives for the use of fly maggots in clinical practice","authors":"Aleksandra Wyszyńska","doi":"10.18388/wq70yc30","DOIUrl":"10.18388/wq70yc30","url":null,"abstract":"<p><p>Maggot therapy is a method for treating chronic, non-healing wounds using live fly larvae that consume necrotic tissue, thereby cleaning the wound. The species most commonly used is Lucilia sericata (Meigen, 1826). Although clinically applied, the method raises concerns among patients and medical staff. Current research highlights the therapeutic potential of chemical compounds in larval excretions/secretions (ES), particularly against the growing issue of antibiotic resistance, as a complement to standard antibiotic therapy. Most studies focus on ES from L. sericata, while other fly species have been less explored. Investigated groups include Calliphoridae, Muscidae, and Sarcophagidae. Studies suggest ES may have antibacterial, antifungal, antiviral, and anticancer properties. This work focuses on the less-studied species and the properties of their ES.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"72 1","pages":"37-48"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Year 2026 in Biology: A Jubilee Year 2026年：生物学的禧年
Postepy biochemii Pub Date : 2026-03-20 DOI: 10.18388/cb4tp945
Jan Barciszewski
{"title":"The Year 2026 in Biology: A Jubilee Year","authors":"Jan Barciszewski","doi":"10.18388/cb4tp945","DOIUrl":"10.18388/cb4tp945","url":null,"abstract":"<p><p></p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"72 1","pages":"49"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
140 years of the model organism Escherichia coli as the "workhorse of molecular biology and biomedicine" 模式生物大肠杆菌作为“分子生物学和生物医学的主力”的140年
Postepy biochemii Pub Date : 2026-03-10 DOI: 10.18388/k2p7j927
Beata Sokołowska
{"title":"140 years of the model organism Escherichia coli as the \"workhorse of molecular biology and biomedicine\"","authors":"Beata Sokołowska","doi":"10.18388/k2p7j927","DOIUrl":"10.18388/k2p7j927","url":null,"abstract":"<p><p>The Escherichia coli bacterium is presented from its discovery in 1885 by the German-Austrian microbiologist and pediatrician Theodor Escherich, to contemporary research using state-of-the-art experimental and bioinformatic techniques, including artificial intelligence and machine learning. E. coli accompany humans from birth as a commensal organism of the gut microbiota. However, some E. coli strains exhibit pathogenic properties, causing intestinal and extraintestinal diseases, sometimes threatening the health and even life of the host. At the same time, 140 years after the discovery of E. coli bacteria, it is the best-studied single-celled organism in the world. Molecular biologists, bacteriologists, and biochemists point to the enormous importance of E. coli as a model organism in understanding the molecular mechanisms of key life processes in both health and disease, as well as its use in industrial-scale biotechnology. That is why E. coli is called the “workhorse of molecular biology and biomedicine,” and scientists working with E. coli strains have been recognized and honored for their discoveries with numerous Nobel Prizes.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"72 1","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal secondary metabolites as a source of bioactive compounds: a modern approach to their acquisition and analysis 真菌次生代谢物作为生物活性化合物的来源：一种获取和分析的现代方法
Postepy biochemii Pub Date : 2026-01-09 DOI: 10.18388/2dqryt92
Piotr Michałowski, Katarzyna Rynarzewska, Dagmara Nowicka, Olimpia Gawrońska, Katarzyna Bielicka-Daszkiewicz
{"title":"Fungal secondary metabolites as a source of bioactive compounds: a modern approach to their acquisition and analysis","authors":"Piotr Michałowski, Katarzyna Rynarzewska, Dagmara Nowicka, Olimpia Gawrońska, Katarzyna Bielicka-Daszkiewicz","doi":"10.18388/2dqryt92","DOIUrl":"10.18388/2dqryt92","url":null,"abstract":"<p><p>Secondary metabolites, which are natural products of fungi, perform key biological functions and have applications in medicine. The production of these compounds is subject to the control of clusters of biosynthetic genes located within the genome. It has been observed that these genes can become dormant under standard culture conditions. The advent of modern genetic and epigenetic methodologies has rendered the activation of these elements possible, thus facilitating the identification of novel bioactive compounds. The present article delineates classes of metabolites, the mechanisms of their biosynthesis, and current research strategies, combining knowledge from biology, genetics, and biotechnology.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"72 1","pages":"23-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum for: The role of peroxisome proliferator-activated receptors (PPARs) in the male gonad and prostate, E. Górowska-Wójtowicz, M. Kudrycka Postepy Biochem. 71(3):208-219 过氧化物酶体增殖物激活受体（ppar）在男性性腺和前列腺中的作用[j] . Górowska-Wójtowicz .中国生物医学工程学报。71(3):208-219
Postepy biochemii Pub Date : 2026-01-08 DOI: 10.18388/pb.2025_642
Kamila Bąkowska-Żywicka
{"title":"Erratum for: The role of peroxisome proliferator-activated receptors (PPARs) in the male gonad and prostate, E. Górowska-Wójtowicz, M. Kudrycka Postepy Biochem. 71(3):208-219","authors":"Kamila Bąkowska-Żywicka","doi":"10.18388/pb.2025_642","DOIUrl":"https://doi.org/10.18388/pb.2025_642","url":null,"abstract":"","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 4","pages":"433-434"},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial rhodopsins – from structure to function and ecological adaptation 微生物紫红质-从结构到功能和生态适应
Postepy biochemii Pub Date : 2026-01-08 DOI: 10.18388/pb.2021_638
Anna Karnkowska, Małgorzata Malczewska
{"title":"Microbial rhodopsins – from structure to function and ecological adaptation","authors":"Anna Karnkowska, Małgorzata Malczewska","doi":"10.18388/pb.2021_638","DOIUrl":"10.18388/pb.2021_638","url":null,"abstract":"<p><p>Rhodopsin proteins are found in all three domains of life, and the two best-known types to date are animal and microbial rhodopsins. Animal rhodopsins are found only in animals, while microbial rhodopsins are found in microorganisms in all domains, and mainly in protists among eukaryotes. All known rhodopsins have a similar structure, consisting of seven transmembrane α-helices and a retinal ligand. Animal and microbial types do not show sequence similarity, suggesting their convergent evolution. Animal rhodopsins are responsible for vision and control of the biological clock, while microbial rhodopsins are responsible for cell phototaxis and also act as hydrogen or ion pumps. These processes may be involved in converting energy from photons into energy used by the cell. A lot more is known about rhodopsins in marine microorganisms than in freshwater ones. The differences between rhodopsins appearing in these two ecosystems can be significant because they are characterized by different environmental conditions, which lead to different optical properties, consequently affecting the sequences and structure of rhodopsins.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 4","pages":"405-412"},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum for: Genetic and Molecular Pathomechanisms of Amyotrophic Lateral Sclerosis and Therapeutic Perspectives – Current State of Knowledge, K. Kalkowski Postepy Biochem. 71(3):252-259 肌萎缩性侧索硬化症的遗传和分子病理机制及其治疗前景-目前的知识状态，K. Kalkowski后医学，71(3):252-259
Postepy biochemii Pub Date : 2026-01-08 DOI: 10.18388/pb.2025_643
Kamila Bąkowska-Żywicka
{"title":"Erratum for: Genetic and Molecular Pathomechanisms of Amyotrophic Lateral Sclerosis and Therapeutic Perspectives – Current State of Knowledge, K. Kalkowski Postepy Biochem. 71(3):252-259","authors":"Kamila Bąkowska-Żywicka","doi":"10.18388/pb.2025_643","DOIUrl":"https://doi.org/10.18388/pb.2025_643","url":null,"abstract":"","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 4","pages":"435-436"},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of components of traditional and electronic cigarettes on the induction of the EMT process in lung cancer 传统和电子烟成分对肺癌EMT诱导过程的影响
Postepy biochemii Pub Date : 2025-12-19 DOI: 10.18388/pb.2021_635
Weronika Wójtowicz, Katarzyna Raszczok, Mateusz Wierzbinka, Karolina Jankowska, Karolina Bajdak-Rusinek, Kamil Barański
{"title":"The impact of components of traditional and electronic cigarettes on the induction of the EMT process in lung cancer","authors":"Weronika Wójtowicz, Katarzyna Raszczok, Mateusz Wierzbinka, Karolina Jankowska, Karolina Bajdak-Rusinek, Kamil Barański","doi":"10.18388/pb.2021_635","DOIUrl":"10.18388/pb.2021_635","url":null,"abstract":"<p><p>Lung cancer remains one of the leading causes of cancer-related mortality worldwide and is strongly associated with tobacco smoke exposure. In recent years, electronic cigarettes have gained popularity as seemingly safer alternatives to conventional cigarettes; however, their impact on tumor biology remains controversial. A central process in lung cancer progression is the epithelial–mesenchymal transition (EMT), which promotes cellular invasion, migration, and therapy resistance. This review summarizes current evidence on how nicotine, polycyclic aromatic hydrocarbons (PAHs), carbonyl compounds, and reactive oxygen species (ROS) modulate EMT through key signaling pathways, including PI3K/AKT, MAPK/ERK, Wnt/β-catenin, Notch, and HIF-1α. Moreover, it discusses the role of thermal processes during tobacco combustion and e-liquid heating in generating carcinogenic by-products. Emerging data indicate that both traditional and electronic cigarettes release bioactive agents capable of inducing EMT, thereby contributing to lung cancer pathogenesis and revealing potential therapeutic targets.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 4","pages":"361-368"},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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