Mutations and their consequences in the development of pancreatic cancer

Q3 Medicine
Postepy biochemii Pub Date : 2024-12-02 Print Date: 2024-12-31 DOI:10.18388/pb.2021_576
Przemysław Panek, Jarosław Rachuna, Łukasz Madej, Ryszard Tomasiuk, Aleksandra Jezela-Stanek
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引用次数: 0

Abstract

Pancreatic cancer is a common cancer with a very poor prognosis and aggressive course. The main reason for the highly unfavorable prognosis of patients with pancreatic cancer is its long-term asymptomatic development, which results in the diagnosis being made at a stage when the cancer process is significantly advanced. Despite extensive research in the field of effective diagnosis and treatment of this cancer, patient survival rates are increasing slowly and insignificantly. Pancreatic cancer cells contain many mutations, the most frequently found of which concern the KRAS, TP53, CDKN2A, SMAD4, BRCA1 and BRCA2 genes. Each of these mutations is associated with specific consequences at the molecular level and translates into further cell functioning, including uncontrolled cell division. The occurrence of specific mutations influences the planning of therapeutic procedures and patient prognosis. Many mutations are associated with a hereditary predisposition to cancer, including pancreatic cancer.

突变及其在胰腺癌发展中的影响
胰腺癌是一种常见的癌症,预后很差,病程具有侵袭性。胰腺癌患者预后非常不利的主要原因是其长期无症状发展,导致在癌症进程明显进展的阶段才做出诊断。尽管在该癌症的有效诊断和治疗领域进行了广泛的研究,但患者的生存率增长缓慢且不显著。胰腺癌细胞含有许多突变,其中最常见的突变涉及KRAS, TP53, CDKN2A, SMAD4, BRCA1和BRCA2基因。这些突变中的每一种都与分子水平上的特定后果相关,并转化为进一步的细胞功能,包括不受控制的细胞分裂。特异性突变的发生影响治疗程序的计划和患者的预后。许多突变与癌症的遗传易感性有关,包括胰腺癌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Postepy biochemii
Postepy biochemii Medicine-Medicine (all)
CiteScore
0.80
自引率
0.00%
发文量
36
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