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KLF1 (Krüppel-like factor 1) as a key regulator of erythroid gene expression KLF1 （kr<s:1> ppel样因子1）是红系基因表达的关键调控因子
Postepy biochemii Pub Date : 2025-06-25 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_613
Klaudia Kulczynska-Figurny, Miroslawa Siatecka
{"title":"KLF1 (Krüppel-like factor 1) as a key regulator of erythroid gene expression","authors":"Klaudia Kulczynska-Figurny, Miroslawa Siatecka","doi":"10.18388/pb.2021_613","DOIUrl":"https://doi.org/10.18388/pb.2021_613","url":null,"abstract":"<p><p>KLF1 (Krüppel-like factor 1) is an essential transcription factor involved in almost all stages of erythropoiesis. KLF1 promotes the transition of myeloid progenitor cells towards the erythroid lineage, while inhibiting the megakaryopoietic pathway. Its expression is tissue-specific and limited to hematopoietic organs. It begins in the yolk sac, then in the liver and in bone marrow. KLF1 plays a role as a global regulator of erythrocyte development. It regulates many processes, including globin synthesis, heme, iron acquisition, red blood cell membrane antigens expression. KLF1 is composed of two domains: an N-terminal transactivation domain and a C-terminal DNA-binding domain. KLF1 is the first known transcription factor from the Kruppel-like Factor family, which currently includes 17 members. Their characteristic feature is C2H2 zinc finger motifs interacting with DNA. In addition to erythropoiesis, KLF factors play a key role in regulating gene expression of various biological processes, including cell proliferation, differentiation, and apoptosis.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"145-152"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Omics methods in plant research 植物研究中的组学方法
Postepy biochemii Pub Date : 2025-06-25 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_609
Maciej Jończyk
{"title":"Omics methods in plant research","authors":"Maciej Jończyk","doi":"10.18388/pb.2021_609","DOIUrl":"https://doi.org/10.18388/pb.2021_609","url":null,"abstract":"<p><p>The usefulness of computers in biological research has been identified already in the sixties of the twentieth century. Subsequent technical progress allowed development of high-throughput experimental methods in biology. Thanks to them, one can obtain a very large amount of data in a short time, even few days. However, with this progress came a necessity of development of data management, data quality control and analysis methods. Consequently, modern biology to a great extent rely on informatics and at the intersection of these fields emerged bioinformatics. The aim of this article is a review of modern high-throughput methods in plant science, and relevant bioinformatic tools.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"169-182"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selected aspects of the pathogenesis of depression and the mechanisms of antidepressant action of statins 抑郁症的发病机制和他汀类药物抗抑郁作用机制的选择方面
Postepy biochemii Pub Date : 2025-06-25 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_606
Bożena Gabryel
{"title":"Selected aspects of the pathogenesis of depression and the mechanisms of antidepressant action of statins","authors":"Bożena Gabryel","doi":"10.18388/pb.2021_606","DOIUrl":"https://doi.org/10.18388/pb.2021_606","url":null,"abstract":"<p><p>There is a bidirectional relationship between the occurrence of depressive disorders and cardiovascular diseases. Both depression can increase the risk of cardiovascular disease and patients with cardiovascular disease often suffer from depression. This article presents four selected pathogenic mechanisms of depression: neuroinflammation, oxidative stress, mitochondrial fragmentation disorders, and the tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway.\u0000Further research is needed on the molecular basis of the antidepressant effect of statins, the elucidation of which could help develop new therapeutic strategies for the prevention and treatment of depression associated with cardiovascular diseases.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"162-168"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of nanoparticle biosynthesis by fungi 真菌生物合成纳米颗粒的机制
Postepy biochemii Pub Date : 2025-06-25 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_598
Małgorzata Jakubiak, Monika Asztemborska
{"title":"Mechanisms of nanoparticle biosynthesis by fungi","authors":"Małgorzata Jakubiak, Monika Asztemborska","doi":"10.18388/pb.2021_598","DOIUrl":"https://doi.org/10.18388/pb.2021_598","url":null,"abstract":"<p><p>In the 21st century, nanomaterials play an increasingly important role, being used in many sectors, including: agriculture, medicine, chemical, textile, electronics and energy industries. Traditional nanoparticle (NP) synthesis methods rely on chemicals, leading to toxicity and high energy use. Green biological synthesis of NPs offers a safe, more sustainable alternative. The synthesis of NPs using fungi is an interesting, constantly developing field of research due to its simplicity, relatively low economic outlays and energy efficiency. Mycosynthesis eliminates the need for harmful chemicals. Moreover, fungi produce compounds that serve dual functions, acting as both reducing agents and stabilizers for NPs, allowing for stable, non-aggregating structures with enhanced biological activity. The variety of metabolites such as enzymes, polysaccharides, polypeptides, proteins and other macromolecules, have made fungi an excellent tool for nanoparticle synthesis. This paper reviews NP synthesis methods, with a particular focus on the use of fungi in the process.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"109-117"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prolamellar body as a distinctive model for biological membranes: structure, function, and application perspectives 前片层体作为生物膜的独特模型：结构、功能和应用前景
Postepy biochemii Pub Date : 2025-06-25 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_601
Katarzyna Tratkiewicz, Joanna Wójtowicz, Alicja Bukat, Łucja Kowalewska
{"title":"The prolamellar body as a distinctive model for biological membranes: structure, function, and application perspectives","authors":"Katarzyna Tratkiewicz, Joanna Wójtowicz, Alicja Bukat, Łucja Kowalewska","doi":"10.18388/pb.2021_601","DOIUrl":"https://doi.org/10.18388/pb.2021_601","url":null,"abstract":"<p><p>The prolamellar body (PLB) is a complex membrane structure found in plant etioplasts that exhibits a diamond-type cubic symmetry. The PLB features a unique architecture based on two independent aqueous channels of distinct geometries: the larger one remains in contact with the plastid stroma, while the smaller one serves as a precursor to the thylakoid lumen. This structure is formed through a precisely organized arrangement of lipids (mainly MGDG and DGDG), proteins (primarily LPOR), and pigments (including protochlorophyllide and carotenoids). Studies involving mutants with altered biochemical compositions, and analyses of stress factors affecting PLB organization, have clarified the roles of individual components in its formation and stabilization. The PLB’s unique features—such as its large scale (approximately 80 nm), phototransformation capability, and biocompatibility, make it a compelling model for new biomaterials, particularly in controlled-release systems. Recent advances in creating biomimetic structures inspired by the PLB have opened new avenues in nanomaterials engineering.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"118-126"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms regulating chromatin structure and alterations associated with senescence 调节与衰老相关的染色质结构和改变的机制
Postepy biochemii Pub Date : 2025-05-26 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_590
Agnieszka Gadecka, Anna Bielak-Żmijewska
{"title":"Mechanisms regulating chromatin structure and alterations associated with senescence","authors":"Agnieszka Gadecka, Anna Bielak-Żmijewska","doi":"10.18388/pb.2021_590","DOIUrl":"https://doi.org/10.18388/pb.2021_590","url":null,"abstract":"<p><p>The expected average human lifespan is constantly increasing. The negative effect of this phenomenon is more frequent incidences of age-related diseases. Experimental data have shown that cellular senescence is the cause of organismal aging. Cellular senescence is an irreversible cell cycle arrest while maintaining metabolic functions and can occur through the exhaustion of proliferative potential (replicative senescence - RS) or stress conditions (stress-induced premature senescence - SIPS). Both types of senescence cause a number of morphological changes, in particular, in the cell nucleus and gene expression. A gradual decrease of condensed heterochromatin in favor of relaxed euchromatin is observed. This is caused by the loss of histones, a disturbance of the balance between repressive and activating post-translational modifications of histones, the impairment in the activity of histone-decorating enzymes and proteins stabilizing the chromatin structure. This review detailed nuclear architecture and chromatin structure alterations during cellular senescence.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 1","pages":"61-78"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aging, β-amyloid, Alzheimer's - Opinion 衰老，β-淀粉样蛋白，老年痴呆症-意见
Postepy biochemii Pub Date : 2025-05-26 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_608
Dariusz Stępkowski, Adam Jarmuła
{"title":"Aging, β-amyloid, Alzheimer's - Opinion","authors":"Dariusz Stępkowski, Adam Jarmuła","doi":"10.18388/pb.2021_608","DOIUrl":"https://doi.org/10.18388/pb.2021_608","url":null,"abstract":"<p><p>For over 100 years, medicine has not developed an effective method for treating Alzheimer's disease (AD). Despite countless studies, successes have been rather modest. This situation requires a new approach. In the current article, the authors attempt to outline and propose, based on literature and their own research results, the directions of such an approach. We begin with the observation that the strongest risk factor for AD is the aging process of the body, organs, and cells. According to the Informational Theory of Aging, the process of amyloidogenesis, must be the result of earlier molecular events leading to epigenetic chaos. However, the use of anti-amyloid antibodies has shown some moderate successes. Economic considerations suggest, that use of antibodies will not solve the problem on a population-wide scale due to the very high cost. Therefore, small molecule inhibitors of amyloidogenesis are promising molecules for stopping AD dementia processes.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"187-190"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phase-Separating Proteins in Plants and Methods Used to Study Them 植物蛋白质的相分离及其研究方法
Postepy biochemii Pub Date : 2025-05-26 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_580
Marta Gapińska
{"title":"Phase-Separating Proteins in Plants and Methods Used to Study Them","authors":"Marta Gapińska","doi":"10.18388/pb.2021_580","DOIUrl":"https://doi.org/10.18388/pb.2021_580","url":null,"abstract":"<p><p>In order for a variety of biochemical processes to take place efficiently within the same cell, the existence of discrete areas within the cell is essential. In addition to encapsulated organelles, these include membraneless bio-molecular condensates, dynamically changing structures formed from proteins and nucleic acids. These condensates are often formed by liquid-liquid phase separation (LLPS). Numerous scientific reports in recent years have indicated that liquid-liquid phase separation (LLPS) is an important mechanism allowing plants to identify various biotic and abiotic stresses and respond to them. The following paper reviews the methods currently used to study macromolecular condensates and the function of proteins undergoing LLPS in plants.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 1","pages":"25-35"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can Molecular Biology Inspire Visual Artists? 分子生物学能启发视觉艺术家吗？
Postepy biochemii Pub Date : 2025-05-26 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_596
Adam Szewczyk, Hanna Fabczak, Dorota Dymkowska, Kinga Szydłowska, Adam Hamed, Karolina Zimna-Stelmaszewska, Katarzyna Dyjewska, Kamil Zaleski, Joanna Dudek, Jacek Martusewicz
{"title":"Can Molecular Biology Inspire Visual Artists?","authors":"Adam Szewczyk, Hanna Fabczak, Dorota Dymkowska, Kinga Szydłowska, Adam Hamed, Karolina Zimna-Stelmaszewska, Katarzyna Dyjewska, Kamil Zaleski, Joanna Dudek, Jacek Martusewicz","doi":"10.18388/pb.2021_596","DOIUrl":"https://doi.org/10.18388/pb.2021_596","url":null,"abstract":"<p><p>During the September 2024 Science Festival in Warsaw, three unique events were organized in collaboration between the Nencki Institute of Experimental Biology PAS, the Academy of Fine Arts in Warsaw, and the Marceli Nencki Foundation for the Advancement of Biological Sciences. These events focused on exploring interactions between biological sciences and visual arts. As part of this collaboration, an exhibition titled “Vibration” was presented at the Hermitage in the Royal Łazienki Park. Additionally, lectures and an exhibition titled “Can Molecular Biology Inspire Visual Artists” were held at the Nencki Institute PAS. A unique event, the “Bio-Workshop”, was organized for high school students at the Graphic Arts Department of the Academy of Fine Arts in Warsaw. In addition to recounting and detailing these events, this article presents a broader context of the interplay between art and natural sciences. The benefits of creative interdisciplinary activities are discussed, highlighting the potential for mutual inspiration between these two fields, benefiting both artists and scientists.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of spermidine in neurodegenerative diseases 亚精胺在神经退行性疾病中的治疗潜力
Postepy biochemii Pub Date : 2025-05-26 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_589
Beata Grembecka, Natalia Kaczorowska
{"title":"Therapeutic potential of spermidine in neurodegenerative diseases","authors":"Beata Grembecka, Natalia Kaczorowska","doi":"10.18388/pb.2021_589","DOIUrl":"https://doi.org/10.18388/pb.2021_589","url":null,"abstract":"<p><p>In recent years, a progressive increase in the incidence of neurodegenerative diseases has been observed. The etiology and pathophysiology of Parkinson's, Alzheimer's, and Huntington's diseases are diverse; however, universal mechanisms occurring during neurodegeneration warrant attention. Among the best-characterized are chronic inflammation, oxidative stress, and altered autophagy processes resulting from abnormal protein aggregation. Neuronal loss of structure and function is accompanied by impaired repair mechanisms. Given the lack of therapies capable of halting neurodegeneration progression, studies aimed at identifying substances that activate natural cellular repair mechanisms or mitigate factors promoting neurodegeneration are of significant importance. Recently, spermidine has attracted considerable interest from research teams worldwide. This study aims to present evidence confirming the broad spectrum of spermidine’s effects in models replicating degenerative changes in the central nervous system, highlighting its influence on mechanisms of neuronal cell death associated with neurodegenerative diseases.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 1","pages":"50-60"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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