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The role of hyperbaric oxygenation in glioma therapy - a review of experimental studies 高压氧合在神经胶质瘤治疗中的作用——实验研究综述
Postepy biochemii Pub Date : 2025-10-01 DOI: 10.18388/pb.2021_616
Weronika Wójtowicz, Magdalena Iwan, Magdalena Czarnota, Karolina Jankowska, Filip Chodań, Łukasz Wilk, Nikodem Świderski, Anna Bielecka Wajdman
{"title":"The role of hyperbaric oxygenation in glioma therapy - a review of experimental studies","authors":"Weronika Wójtowicz, Magdalena Iwan, Magdalena Czarnota, Karolina Jankowska, Filip Chodań, Łukasz Wilk, Nikodem Świderski, Anna Bielecka Wajdman","doi":"10.18388/pb.2021_616","DOIUrl":"https://doi.org/10.18388/pb.2021_616","url":null,"abstract":"<p><p>Glioma is one of the most aggressive brain tumors. Despite the progress made in recent years in better understanding the changes at the molecular level of glioma and in neuroimaging techniques, the survival rates of patients with glioma have not shown any significant improvement and only about 10% still survive the period of 5 years from the moment of diagnosis. An inherent feature of glioma is slow oxygenation of tumor areas (hypoxia), which supports its malignant nature, contributes to radio-chemo-resistance and, consequently, to relapse. Attempts to modulate the glioma microenvironment by increasing the content of cellular oxygen through the use of hyperbaric oxygen therapy (HBOT) seem to be a promising, non-invasive concept complementing the basic treatment of the tumor. Although it has been used for years with good results in specialist centers in the treatment of various diseases, such as carbon monoxide poisoning, decompression sickness in divers, difficult-to-heal wounds, hearinglossor circulatory disorders, there is currently no consistent position on the importance of hyperbaric oxygen in cancer diseases, include in glioma.\u0000This paper reviews the results of in vitro and in vivo studies and clinical trials on the potential role of hyperbaric oxygen therapy in adjuvant therapy for glioma.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 3","pages":"220-227"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The dual role of autophagy in colorectal cancer 自噬在结直肠癌中的双重作用
Postepy biochemii Pub Date : 2025-10-01 DOI: 10.18388/pb.2021_617
Julia Wojtkowicz, Zuzanna Senkowska, Karolina Niewinna, Urszula Lewandowska, Katarzyna Owczarek
{"title":"The dual role of autophagy in colorectal cancer","authors":"Julia Wojtkowicz, Zuzanna Senkowska, Karolina Niewinna, Urszula Lewandowska, Katarzyna Owczarek","doi":"10.18388/pb.2021_617","DOIUrl":"https://doi.org/10.18388/pb.2021_617","url":null,"abstract":"<p><p>In recent years, increasing attention has been devoted to cellular processes that modulate tumor progression, particularly autophagy. Current studies indicate a dual role of autophagy in the pathogenesis of colorectal cancer. In the early stages, autophagy serves a protective function by degrading damaged organelles and proteins, whereas in advanced stages, it promotes cancer cell survival. The regulation of autophagy primarily involves the PI3K/Akt/mTOR and AMPK/mTOR signalling pathways, as well as the Beclin-1/PI3K complex. Autophagy-related proteins such as LC3, p62/SQSTM1, and Beclin-1 hold significant diagnostic and prognostic value. Given the impact of autophagy on the efficacy of chemotherapy and targeted therapies, pharmacological modulation of this process has garnered increasing interest. Natural compounds, particularly polyphenols, demonstrate promising multitargeted effects on autophagy. This review comprehensively analyses the molecular mechanisms underlying autophagy in colorectal cancer and evaluates its potential as a therapeutic target.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 3","pages":"192-207"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural polysaccharides as drug delivery system in colorectal cancer therapy 天然多糖作为给药系统在结直肠癌治疗中的应用
Postepy biochemii Pub Date : 2025-10-01 DOI: 10.18388/pb.2021_610
Zuzanna Senkowska, Julia Wojtkowicz, Katarzyna Owczarek, Urszula Lewandowska, Karolina Niewinna
{"title":"Natural polysaccharides as drug delivery system in colorectal cancer therapy","authors":"Zuzanna Senkowska, Julia Wojtkowicz, Katarzyna Owczarek, Urszula Lewandowska, Karolina Niewinna","doi":"10.18388/pb.2021_610","DOIUrl":"https://doi.org/10.18388/pb.2021_610","url":null,"abstract":"<p><p>Natural polysaccharides are a promising material for the design of drug delivery systems (DDS). Due to their properties, such as biocompatibility, biodegradability, chemical modifiability, and specific interactions with target cells, polysaccharides enable the development of carriers with high selectivity and controlled release of active substances. They are particularly important in the context of targeted therapy for gastrointestinal cancers. This is especially relevant for colorectal cancer, one of the most common and deadly cancers, whose microenvironment is favorable for the use of DDS. Polysaccharides such as pectins, guar gum, cellulose, chitosan, cyclodextrins, and alginate demonstrate the ability to form encapsulates capable of effectively delivering chemotherapeutics directly to cancer cells, thereby reducing systemic toxicity. This article discusses the physicochemical properties of selected natural polysaccharides and presents examples of their clinical application in the treatment of colorectal cancer, highlighting their potential in the development of anticancer therapies.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 3","pages":"179-191"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic and Molecular Pathomechanisms of Amyotrophic Lateral Sclerosis and Therapeutic Perspectives – Current State of Knowledge 肌萎缩性侧索硬化症的遗传和分子病理机制及治疗前景-目前的知识状况
Postepy biochemii Pub Date : 2025-10-01 DOI: 10.18388/pb.2021_599
Krzysztof Kalkowski
{"title":"Genetic and Molecular Pathomechanisms of Amyotrophic Lateral Sclerosis and Therapeutic Perspectives – Current State of Knowledge","authors":"Krzysztof Kalkowski","doi":"10.18388/pb.2021_599","DOIUrl":"10.18388/pb.2021_599","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease leading to progressive degeneration of motor neurons, muscle weakness and respiratory failure. Despite intensive research, the pathomechanisms of ALS have not been fully elucidated. This article presents the current state of knowledge on the genetic and molecular mechanisms of this disease, with a focus on mutations in the SOD1, C9ORF72, TARDBP, FUS, TBK1 genes, as well as recent discoveries in this area. Key pathogenetic processes are discussed, including disruption of RNA homeostasis, oxidative stress, mitochondrial dysfunction and protein aggregation. In addition, current therapeutic strategies are reviewed, including both registered drugs, such as riluzole and edaravone, and modern approaches, such as gene therapy, antisense oligonucleotides, immunotherapy and gene editing technologies, including CRISPR/Cas9. Special attention was given to clinical trials and their potential impact on future treatment options for ALS.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 3","pages":"252-259"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glutathione deficiency and disturbances of sulfur homeostasis in the pathophysiology of schizophrenia 谷胱甘肽缺乏和硫稳态紊乱在精神分裂症病理生理中的作用
Postepy biochemii Pub Date : 2025-10-01 DOI: 10.18388/pb.2021_618
Magdalena Górny, Elżbieta Lorenc-Koci, Małgorzata Iciek
{"title":"Glutathione deficiency and disturbances of sulfur homeostasis in the pathophysiology of schizophrenia","authors":"Magdalena Górny, Elżbieta Lorenc-Koci, Małgorzata Iciek","doi":"10.18388/pb.2021_618","DOIUrl":"10.18388/pb.2021_618","url":null,"abstract":"<p><p>Schizophrenia is a mental illness characterized by positive and negative symptoms and cognitive function disorders. Animal models are used in studies of the pathophysiology of schizophrenia and in the search for new drugs. In one of the recently developed rat’s neurodevelopmental model, schizophrenic-like changes were induced by administration of buthioninesulfoximine (BSO) - an inhibitor of glutathione synthesis and a dopamine reuptake inhibitor - the compound GBR 12909 during the developmental period. Behavioral tests conducted on adult rats showed that deficits in social behavior and cognitive functions were observed in the model animals, and rats that received a combination of both compounds additionally showed positive symptoms. The usefulness of the developed model was tested by the effect of the antipsychotic drug aripiprazole and N-acetylcysteine. Behavioral tests showed that N-acetylcysteine ​​reversed the changes in the animals' behavior similarly to aripiprazole. At the biochemical level, both drugs significantly reduced the elevated concentration of bound sulfane sulfur in the hippocampus of model rats. Recent studies indicate that in the neurodevelopmental pathophysiology of schizophrenia, disturbances in the homeostasis of sulfur compounds play an important role, which are corrected by the action of drugs.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 3","pages":"228-237"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of peroxisome proliferator-activated receptors (PPARs) in the male gonad and prostate 过氧化物酶体增殖激活受体（PPARs）在男性性腺和前列腺中的作用
Postepy biochemii Pub Date : 2025-10-01 DOI: 10.18388/pb.2021_611
Ewelina Górowska-Wójtowicz, Maja Kudrycka
{"title":"The role of peroxisome proliferator-activated receptors (PPARs) in the male gonad and prostate","authors":"Ewelina Górowska-Wójtowicz, Maja Kudrycka","doi":"10.18388/pb.2021_611","DOIUrl":"10.18388/pb.2021_611","url":null,"abstract":"<p><p>So far, three types of peroxisome proliferator-activated receptors have been characterized: PPARα, PPARβ (also known as δ) and PPARγ, each characterized by different expression, localization and role. PPAR receptors regulate a number of processes, including lipid and glucose metabolism, adipogenesis and inflammation. Literature data also indicate their key role in maintaining the balance of sex hormone levels and the function of the male reproductive system. The involvement of PPAR in the male gonad has been demonstrated by their effect on the testis morphology as well as steroidogenesis, spermatogenesis, spermiogenesis and sperm motility. In the prostate, PPAR regulate lipid synthesis, mitochondrial biogenesis and the maintenance of prostate secretory functions. Disruption of PPAR signaling in the male gonad and prostate results in its structural and functional changes, which can even lead to carcinogenesis. Importantly, further exploration of the molecular mechanisms of PPAR action in the male reproductive system may contribute to understanding the course of certain pathologies and developing methods for their treatment.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 3","pages":"208-219"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomedical applications of metallic nanoparticles and their green synthesis 金属纳米粒子的生物医学应用及其绿色合成
Postepy biochemii Pub Date : 2025-10-01 DOI: 10.18388/pb.2021_621
Monika Asztemborska, Romuald Stęborowski, Małgorzata Jakubiak
{"title":"Biomedical applications of metallic nanoparticles and their green synthesis","authors":"Monika Asztemborska, Romuald Stęborowski, Małgorzata Jakubiak","doi":"10.18388/pb.2021_621","DOIUrl":"https://doi.org/10.18388/pb.2021_621","url":null,"abstract":"<p><p>The maim goal of modern medicine is early and accurate disease diagnosis and effective treatment with minimal side effects. Nanotechnology offers great potential in this area. Nanomaterials exhibit unique properties – biocompatibility, anti-inflammatory and antibacterial effects - due to their size, chemical composition, and large surface to mass ratio. Metal nanoparticles are used in diagnostics to improve imaging precision and in therapy to enhance drug delivery and control their release. These properties can be tailored during synthesis for specific applications. A promising approach is green synthesis, which uses plant-derived metabolites and enzymes as natural bioreductants and stabilizers. This method produces biocompatible nanoparticles with functional surface coatings suitable for medical use. The article discusses the key properties of nanoparticles that make them valuable in medicine, outlines selected diagnostic ant therapeutic applications of metallic nanomaterial, and highlights the role of plants in the controlled, eco-friendly synthesis of nanoparticles for medical and pharmaceutical purposes.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 3","pages":"260-270"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KLF1 (Krüppel-like factor 1) variants in the pathogenesis of hematological diseases KLF1 （kr<s:1> ppel样因子1）变异在血液病发病机制中的作用
Postepy biochemii Pub Date : 2025-06-25 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_614
Klaudia Kulczynska-Figurny, Mirosława Siatecka
{"title":"KLF1 (Krüppel-like factor 1) variants in the pathogenesis of hematological diseases","authors":"Klaudia Kulczynska-Figurny, Mirosława Siatecka","doi":"10.18388/pb.2021_614","DOIUrl":"https://doi.org/10.18388/pb.2021_614","url":null,"abstract":"<p><p>KLF1 (Krüppel-like factor 1) is an erythroid transcription factor involved in various stages of red blood cell formation. KLF1 plays key functions at the megakaryocyte-erythrocyte progenitor stage, where it is involved in the development of the erythrocyte lineage. It participates in the global expression of erythrocyte genes, playing a direct role in globin switching. KLF1 also participates in the final maturation of erythrocytes, controlling exit from the cell cycle and the enucleation process. KLF1 has a domain structure: N-terminal transactivation domain and C-terminal DNA-binding domain. Many variants (mutations) have been described in the KLF1 gene, which lead to the development of a whole spectrum of phenotypes: from clinically insignificant morphological changes, through mild changes, to severe pathological conditions. Two mutations are dominant. One occurs in mice and causes neonatal anemia with congenital spherocytosis (Nan), the other in humans and leads to congenital dyserythropoietic anemia type IV (CDA).</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"153-161"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meldonium: current and emerging therapeutic applications 美度铵：当前和新出现的治疗应用
Postepy biochemii Pub Date : 2025-06-25 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_605
Halszka Ponamarczuk, Marcin Popielarski
{"title":"Meldonium: current and emerging therapeutic applications","authors":"Halszka Ponamarczuk, Marcin Popielarski","doi":"10.18388/pb.2021_605","DOIUrl":"https://doi.org/10.18388/pb.2021_605","url":null,"abstract":"<p><p>Meldonium functions as an inhibitor of γ-butyrobetaine hydroxylase, the enzyme responsible for catalyzing the biosynthesis of L-carnitine. By inhibiting mitochondrial β-oxidation of fatty acids under hypoxic conditions, meldonium exerts cytoprotective effects on cardiac, hepatic, and pulmonary tissues. Meldonium attenuates the deleterious effects of myocardial infarction, arrhythmias, and diabetes. It is recognized as a promising therapeutic agent for neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, as well as painful neuropathies. Its neuroprotective properties are attributed to its ability to mitigate age-related alterations in the central nervous system by reducing oxidative stress and inflammation. Moreover, it inhibits neuronal apoptosis and facilitates cognitive functions, particularly learning and memory processes. Meldonium has been designated as a prohibited doping agent by the World Anti-Doping Agency (WADA), and its use is strictly banned in professional sports. Recent scientific investigations indicate that meldonium may exhibit additional therapeutic potential beyond its currently recognized clinical applications.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"127-144"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of mitochondria as therapeutic targets in the treatment of pancreatic ductal adenocarcinoma: opportunities and challenges 线粒体作为治疗靶点在胰腺导管腺癌治疗中的作用：机遇与挑战
Postepy biochemii Pub Date : 2025-06-25 Print Date: 2025-06-30 DOI: 10.18388/pb.2021_597
Julia Lis, Jakub Fichna, Aleksandra Tarasiuk-Zawadzka
{"title":"The role of mitochondria as therapeutic targets in the treatment of pancreatic ductal adenocarcinoma: opportunities and challenges","authors":"Julia Lis, Jakub Fichna, Aleksandra Tarasiuk-Zawadzka","doi":"10.18388/pb.2021_597","DOIUrl":"https://doi.org/10.18388/pb.2021_597","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause of cancer-related deaths worldwide. This is due to its complex microenvironment and high resistance to treatment. One of the key factors contributing to this resistance is the altered function of mitochondria in tumor cells, including high levels of oxidative phosphorylation (OXPHOS), a predominance of mitochondrial fusion processes, and increased autophagy, all of which are closely linked to cancer cell metabolism. The literature suggests three main therapeutic approaches: OXPHOS inhibition, modulation of mitochondrial dynamics, and autophagy suppression. Studies indicate that both reducing OXPHOS activity and inhibiting autophagy sensitize tumors to chemotherapy. Moreover, modulating mitochondrial dynamics effectively suppresses further tumor growth. Despite promising research on targeting mitochondria as a therapeutic strategy for PDAC, further studies are needed to determine the efficacy and safety of these approaches in humans.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"71 2","pages":"103-108"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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