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Multiparametric analysis of proteolytic enzyme activity using mass cytometry 利用质谱仪对蛋白水解酶活性进行多参数分析
Postepy biochemii Pub Date : 2023-06-30 DOI: 10.18388/pb.2021_477
Katarzyna Małgorzata Groborz
{"title":"Multiparametric analysis of proteolytic enzyme activity using mass cytometry","authors":"Katarzyna Małgorzata Groborz","doi":"10.18388/pb.2021_477","DOIUrl":"https://doi.org/10.18388/pb.2021_477","url":null,"abstract":"<p><p></p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The biological role of neuronostatin, a hormone encoded by the somatostatin gene 神经生长抑素的生物学作用，一种由生长抑素基因编码的激素
Postepy biochemii Pub Date : 2023-06-30 DOI: 10.18388/pb.2021_476
Małgorzata Krążek, Adrian Ligęza, Tatiana Wojciechowicz, Marek Skrzypski
{"title":"The biological role of neuronostatin, a hormone encoded by the somatostatin gene","authors":"Małgorzata Krążek,&nbsp;Adrian Ligęza,&nbsp;Tatiana Wojciechowicz,&nbsp;Marek Skrzypski","doi":"10.18388/pb.2021_476","DOIUrl":"https://doi.org/10.18388/pb.2021_476","url":null,"abstract":"<p><p>Neuronostatin is a peptide hormone encoded by the somatostatin gene. Neuronostatin was discovered in 2008 using bioinformatics methods. Studies in rodents have shown that it exerts a widespread effects in the central nervous system, as well as in peripheral tissues. It was demonstrated that neuronostatin reduces food and water intake, delays gastrointestinal transit, and may have important role in adipogenesis. It also increases glucagon secretion from pancreatic islet alpha cells. In addition, it has been proven that neuronostatin can affect cardiac contractility and blood pressure, and may be involved in processes related to memory, pain sensation and anxiety. In addition neuronostatin can induce a depression-like effect. In this article we review the literature addressing the biological role of neuronostatin in the organism.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 2","pages":"89-95"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of the glucosinolates in cancer epigenetics 硫代葡萄糖苷在癌症表观遗传学中的作用
Postepy biochemii Pub Date : 2023-06-30 DOI: 10.18388/pb.2023_478
Julia Anchimowicz, Zbigniew Wyżewski, Weronika Świtlik
{"title":"Role of the glucosinolates in cancer epigenetics","authors":"Julia Anchimowicz,&nbsp;Zbigniew Wyżewski,&nbsp;Weronika Świtlik","doi":"10.18388/pb.2023_478","DOIUrl":"https://doi.org/10.18388/pb.2023_478","url":null,"abstract":"<p><p>It has been known for years that diet impacts human health, including the risk of cancer development. Food components can both increase and reduce the risk of carcinogenesis. Thereby, a wisely composed diet can extend life span and improve life quality. The favourable effect on health exert glucosinolates (GSLs), a group of secondary plant metabolites found in vegetables of the Brassicaceae family, such as broccoli, cauliflower, cabbage, and kohlrabi. Hydrolysis of GSLs results in the formation of compounds, like sulforaphane (SFN), phenylethyl isothiocyanate (PEITC) and 3,3′-Diindolylmethane (DIM), which are known for versatile anti-cancer activity. This review highlights advances on the role of the chosen GSLs on selected epigenetic mechanisms, i.e. DNA methylation, histone acetylation and microRNAs expression in cancer treatment.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 2","pages":"96-103"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
W Świecie Nauk Bio. 在生物科学的世界里。
Postepy biochemii Pub Date : 2023-06-19
Teresa Wesołowska
{"title":"W Świecie Nauk Bio.","authors":"Teresa Wesołowska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>W Świecie Nauk Bio.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 2","pages":"122-134"},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9875746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
W świecie nauk BIO. 在有机科学的世界里。
Postepy biochemii Pub Date : 2023-04-26
Teresa Wesołowska
{"title":"W świecie nauk BIO.","authors":"Teresa Wesołowska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>W Świecie Nauk Bio.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 1","pages":"65-80"},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors responsible for the modulation of microbiota and their impact on course of inflammation in inflammatory bowel disease – selected aspects 负责调节微生物群的因素及其对炎症性肠病炎症过程的影响-选择方面
Postepy biochemii Pub Date : 2023-03-31 DOI: 10.18388/pb.2021_479
Natalia Fabisiak, Jakub Fichna
{"title":"Factors responsible for the modulation of microbiota and their impact on course of inflammation in inflammatory bowel disease – selected aspects","authors":"Natalia Fabisiak,&nbsp;Jakub Fichna","doi":"10.18388/pb.2021_479","DOIUrl":"https://doi.org/10.18388/pb.2021_479","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBD) is a group of chronic digestive tract diseases of characterized by periods of exacerbation and remission. The pathophysiology of IBD is multifactorial and includes microbiological, immunological, genetic and environmental factors. In recent years, the significant role of the intestinal microbiome in the development of these entities has been emphasized. In the article we discussed the impact of selected factors: antimicrobial peptides, vitamin D and iron on the composition of the intestinal microbiota and their role in the immune response and pathogenesis of IBD.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 1","pages":"54-62"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effect of curcumin and its potential use in the treatment of neurodegenerative diseases 姜黄素的神经保护作用及其在神经退行性疾病治疗中的潜在应用
Postepy biochemii Pub Date : 2023-03-31 DOI: 10.18388/pb.2021_472
Mikołaj Górka, Natalia Białoń, Dominika Bieczek, Dariusz Górka
{"title":"Neuroprotective effect of curcumin and its potential use in the treatment of neurodegenerative diseases","authors":"Mikołaj Górka,&nbsp;Natalia Białoń,&nbsp;Dominika Bieczek,&nbsp;Dariusz Górka","doi":"10.18388/pb.2021_472","DOIUrl":"https://doi.org/10.18388/pb.2021_472","url":null,"abstract":"<p><p>The development of methods used in molecular biology has allowed a milestone in medical and pharmaceutical sciences. Progress has also been made in the field of pharmacognosy, which places substances of natural origin contained in plant raw materials at the center of attention. The beneficial effects of some of them have been known for years, while scientific evidence of their health-promoting properties was lacking for a long time. This was also the case with curcumin and the long road from its isolation in pure form in 1842 to the knowledge of its chemical structure in 1910. Due to the chemical properties of the molecule, curcumin is attributed with many health-promoting properties. These affect many organ systems including the skin, visual pathway, respiratory system, circulatory system, digestive system and nervous system. One of the complications that follow nerve damage is the loss of locomotor function in the animal and the development of inflammation within it. Curcumin has anti-inflammatory properties. This is confirmed by its inhibition of nuclear factor κB, a mediator in inflammatory processes. In addition, a very important field associated with neuronal dysfunction is the aging process. This is caused, among other things, by the presence of reactive oxygen species. The neuroprotective effect of curcumin allows to reduce their concentration caused by the accumulation of mutations within the mitochondrial DNA. The beneficial effect on the nervous system is due to the penetration of curcumin across the blood-brain barrier. However, its poor solubility significantly limits the therapeutic properties resulting from curcumin supplementation. Methods are currently being developed to increase its bioavailability using nanoparticles.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 1","pages":"18-25"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10234562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lycopene – the impact of supplementation on the skin aging process 番茄红素——补充对皮肤衰老过程的影响
Postepy biochemii Pub Date : 2023-03-31 DOI: 10.18388/pb.2021_482
Dariusz Wawrzyniak, Katarzyna Rolle, Jan Barciszewski
{"title":"Lycopene – the impact of supplementation on the skin aging process","authors":"Dariusz Wawrzyniak,&nbsp;Katarzyna Rolle,&nbsp;Jan Barciszewski","doi":"10.18388/pb.2021_482","DOIUrl":"https://doi.org/10.18388/pb.2021_482","url":null,"abstract":"<p><p>The skin aging process is affected by multiple different factors (including sun exposure, smoking, poor diet) and reactive oxygen species (ROS). Under their influence, the skin becomes weaker, mainly elastin and collagen fibers are damaged. The amount of lipids is also reduced, leading to the death of the skin cells. The presence of free radicals also blocks the natural ability of the epidermis to regenerate. Each of these factors determines the acceleration of the signs of aging. To some extent, our body is able to deal with the free radicals by producing antioxidants. Regular supplementation is also a beneficial solution. Lycopene is a red pigment naturally found in tomatoes and is a known antioxidant. Among the carotenoids, it is the strongest singlet oxygen quencher and scavenger of peroxygen radicals, making it an important defense mechanism in the human body. The aim of this paper is to present the biological properties of lycopene in relation to its beneficial effect on the aging process of the skin.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Searching for non-canonical functions of aminoacyl-tRNA synthases based on mutations carried by Charcot-Marie-Tooth patients 基于Charcot-Marie-Tooth患者携带的突变寻找氨基酰基- trna合酶的非规范功能
Postepy biochemii Pub Date : 2023-03-31 DOI: 10.18388/pb.2021_481
Julia O Misiorek
{"title":"Searching for non-canonical functions of aminoacyl-tRNA synthases based on mutations carried by Charcot-Marie-Tooth patients","authors":"Julia O Misiorek","doi":"10.18388/pb.2021_481","DOIUrl":"https://doi.org/10.18388/pb.2021_481","url":null,"abstract":"<p><p>Charcot-Marie-Tooth (CMT) is a genetic, incurable neurodegenerative disease which etiology is linked to mutations in almost hundred different genes. The disease affects peripheral nerves which control muscle work and their myelin sheath resulting in progressive muscular dystrophy. The most remarkable genes which mutations are associated with CMT phenotype, are genes encoding aminoacyl-tRNA synthases (aaRS). These proteins are enzymes which common role is to catalyze the reaction of amino acids transfer into tRNA molecules and thereby, to participate in translation of genetic code into the language of proteins. aaRS have been gaining new functions resulting from the mutations acquired in the course of evolution. These functions remain unidentified, despite unraveling the binding partners of aaRS. However, the ongoing molecular studies, which focus on mutations carried by CMT patients and model organisms, bring the researchers closer to unravel the novel functions of aaRS and their potential key role in CMT pathogenesis.</p>","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 1","pages":"42-46"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How I Met Odo Feliks Kazimierz Bujwid 我是如何认识Odo Feliks Kazimierz Bujwid的
Postepy biochemii Pub Date : 2023-03-31 DOI: 10.18388/pb.2021_474
Martyna Pietrzak, Agnieszka Pękala-Safińska
{"title":"How I Met Odo Feliks Kazimierz Bujwid","authors":"Martyna Pietrzak,&nbsp;Agnieszka Pękala-Safińska","doi":"10.18388/pb.2021_474","DOIUrl":"https://doi.org/10.18388/pb.2021_474","url":null,"abstract":"","PeriodicalId":20335,"journal":{"name":"Postepy biochemii","volume":"69 1","pages":"63-64"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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