Pleura and Peritoneum最新文献

{"title":"Visceral adipose tissue is associated with occult synchronous peritoneal metastasis in colorectal cancer.","authors":"Bei-Bei Zhang, Han-Bing Xie, Ping-Ping Liu, Le Liu, Xue-Meng Li, Lin Zhao, Guang-Yu Wang, Rui-Tao Wang","doi":"10.1515/pp-2024-0030","DOIUrl":"10.1515/pp-2024-0030","url":null,"abstract":"<p><strong>Objectives: </strong>Synchronous peritoneal metastasis (PM) represents an advanced stage of colorectal cancer (CRC), indicating extensive tumor spread. Visceral adipose tissue (VAT) has been linked to cancer development and progression. This study aims to explore the relationship between VAT and occult synchronous PM in CRC patients before surgery.</p><p><strong>Methods: </strong>We enrolled 681 CRC patients, with 419 in the primary cohort (356 non-metastatic and 63 with PM) and 262 in the validation cohort (239 non-metastatic and 23 with PM). Clinical characteristics and laboratory measurements were collected prior to surgery. Adipose and muscle tissues were delineated on preoperative contrast-enhanced computed tomography (CT) images. The association between visceral adipose tissue and synchronous PM was assessed using univariate and multivariate logistic regression analyses.</p><p><strong>Results: </strong>In the primary cohort, 419 patients were diagnosed with CRC, with 63 presenting with PM. Patients with PM had higher visceral adipose tissue index (VATI) levels compared to those without PM. Additionally, there was a trend towards increased PM incidence with elevated VATI. Multivariate logistic regression analysis confirmed that higher VATI was independently associated with PM. These findings were consistent in the validation cohort.</p><p><strong>Conclusions: </strong>VATI is an independent risk factor for occult synchronous PM in patients with CRC.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"10 2","pages":"81-88"},"PeriodicalIF":1.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate postoperative effects of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy using carboplatin on peritoneal tissue inflammatory and ischemic responses: an explorative porcine study.","authors":"Elisabeth Krogsgaard Petersen, Mats Bue, Christina Harlev, Andrea René Jørgensen, Pelle Hanberg, Lone Kjeld Petersen, Maiken Stilling","doi":"10.1515/pp-2025-0001","DOIUrl":"10.1515/pp-2025-0001","url":null,"abstract":"<p><strong>Objectives: </strong>This explorative porcine study investigated the immediate postoperative response of inflammatory protein markers and ischemic metabolites in peritoneal abdominal wall tissue during and after hyperthermic intraperitoneal chemotherapy (HIPEC) assessed by microdialysis.</p><p><strong>Methods: </strong>Eight cancer-free female pigs underwent imitation cytoreductive surgery (CRS) followed by HIPEC (90 min) using a carboplatin dosage of 800 mg/m². A subperitoneal microdialysis catheter was placed in the abdominal wall to sample inflammatory protein markers and ischemic metabolites. During and after HIPEC, dialysates and blood samples were collected over 8 h. Inflammatory protein expression levels were quantified using Proximity Extension Assay (Olink Target 96 Inflammation panel). In addition, concentrations of ischemic metabolites were quantified using a CMA600 microdialysis analyzer.</p><p><strong>Results: </strong>An immediate response of 27 proteins, including proteins from the TNF family, early inflammatory chemokines, pro- and anti-inflammatory proteins, was found within the first 30 min after HIPEC initiation. This was followed by a modest and relatively constant inflammatory response. Glycerol concentrations tended to decrease during the sampling period, while glucose showed more stable levels. Constant hyperlactatemia exceeding the plasma levels was seen during and after HIPEC, with no significant tissue ischemia as indicated by the lactate/pyruvate ratios.</p><p><strong>Conclusions: </strong>In a porcine model, CRS with HIPEC leads to an immediate and relatively constant increased inflammatory and ischemic peritoneal tissue short-time response. The explorative findings contribute to the debate on the value of HIPEC in combination with CRS and call for future studies to further investigate the inflammatory and metabolic tissue responses.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"10 2","pages":"69-80"},"PeriodicalIF":1.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressurised intraperitoneal aerosol chemotherapy (PIPAC): the first Australian experience.","authors":"Katarina Foley, Jessica Reid, Suzanne Edwards, Timothy Price, Allan Zimet, Susan Woods, Markus Trochsler, Andrew Craig Lynch, Peter Hewett","doi":"10.1515/pp-2024-0028","DOIUrl":"https://doi.org/10.1515/pp-2024-0028","url":null,"abstract":"<p><strong>Objectives: </strong>Pressurised intraperitoneal aerosol chemotherapy (PIPAC) is a novel surgical technique for patients with peritoneal metastases not amenable to curative treatment. PIPAC delivers pressurised aerosolised chemotherapy using a hyperbaric capnoperitonem established laparoscopically. This study sought to investigate the feasibility and safety of PIPAC in an Australian population.</p><p><strong>Methods: </strong>We undertook a cohort analysis of prospectively-collected data on patients undergoing PIPAC across two Australian hospitals. Participants were planned to have three PIPAC procedures, each 6 weeks apart. Study outcomes included post-operative complications including 30-day mortality, length of stay (LOS) and patient quality of life (EORTC QLQ-C30 scores).</p><p><strong>Results: </strong>18 patients underwent 50 completed procedures. 13 patients had two or more PIPACs. The most common primary malignancy was colorectal cancer (n=8), followed by gastric cancer (n=4), appendiceal cancer (n=4) and mesothelioma (n=2). One grade four but no grade five complications occurred, with zero 30-day mortality. Median LOS was 1 day. Mean EORTC QLQ-C30 score increased from 47.8 at baseline to 53 post second PIPAC. Due to the heterogeneity of our cohort, survival analysis and statistical comparisons were unable to be made.</p><p><strong>Conclusion: </strong>PIPAC is feasible, safe and well tolerated in an Australian population with a lack of severe complications and zero 30 day mortality. Due to the small number of patients and the heterogeneity of our study's sample, it was not possible to perform survival analysis. The study is nonetheless valuable as the first investigation of implementation of PIPAC in Australia.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"10 1","pages":"25-31"},"PeriodicalIF":1.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can inter-observer consistency be achieved in the laparoscopic assessment of the peritoneal carcinomatosis index score in peritoneal metastasis? A pilot study.","authors":"Audrey Astruc, Valérie Seegers, Frederic Dumont, Cécile Loaec, Emilie Thibaudeau, Charlotte Bourgin, Romuald Wernert, Noémie Body, Valeria De Franco","doi":"10.1515/pp-2024-0015","DOIUrl":"https://doi.org/10.1515/pp-2024-0015","url":null,"abstract":"<p><strong>Objectives: </strong>The main prognostic factor for peritoneal metastasis (PM) is the complete resection of the disease during cytoreductive surgery. Accurate patient selection is therefore essential for determining eligibility for this type of surgery. The peritoneal carcinomatosis index (PCI) is a widely used tool for assessing the extent of carcinomatosis. This study aimed to evaluate the inter-observer reproducibility of PCI assessments via laparoscopy and identify factors influencing this reproducibility.</p><p><strong>Methods: </strong>Between November 2020 and November 2022, 25 laparoscopic PCI assessment videos were reviewed by six surgeons from two centers. The total PCI score, regional PCI scores, and the number of visualized PCI areas were recorded. Inter-observer concordance was analyzed.</p><p><strong>Results: </strong>The median PCI score was 12 out of 39 (range 0-39), and the median number of visualized PCI regions was 10 out of 13 (range 1-13). The intraclass correlation coefficient (ICC) for the total PCI score was 0.846 (95 % CI 0.738, 0.927). A history of abdominal surgery significantly impacted PCI assessment reproducibility (p=0.029).</p><p><strong>Conclusions: </strong>This study found a high inter-observer concordance in laparoscopic PCI assessments. Previous abdominal surgery negatively affected reproducibility, highlighting a challenge in evaluating the PCI in these patients.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"10 1","pages":"19-23"},"PeriodicalIF":1.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal melanomatosis due to primary anorectal melanoma.","authors":"Aras Emre Canda, Semra Demirli Atici, Evren Kadioglu, Cem Terzi","doi":"10.1515/pp-2025-0002","DOIUrl":"https://doi.org/10.1515/pp-2025-0002","url":null,"abstract":"","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"10 1","pages":"33-34"},"PeriodicalIF":1.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging gastric cancer metastasis progression in an organotypic, three-dimensional functional model of the human peritoneum.","authors":"Arianna Castagna, Frank-Jürgen Weinreich, Andreas Brandl, Janine Spreuer, Nicola Herold, Birgit Schittek, Marc André Reymond, Wiebke Solass","doi":"10.1515/pp-2024-0020","DOIUrl":"https://doi.org/10.1515/pp-2024-0020","url":null,"abstract":"<p><strong>Objectives: </strong>Despite the introduction of multimodal treatment regimens, the prognosis of gastric cancer peritoneal metastasis (GCPM) remains poor. To establish efficient therapies, a deeper understanding of pathophysiological mechanisms in the development of GCPM is necessary and this requires adequate functional models. Therefore, we established a three-dimensional model to study tumor adhesion, invasion and growth.</p><p><strong>Methods: </strong>A co-culture of peritoneal mesothelial cells with fibroblasts and collagen I was cultivated to further seed human gastric cancer cell lines on the surface. Different imaging techniques (optical microscopy, immunohistochemistry, scanning (SEM) and transmission (TEM) electron microscopy) served as tools to proof the sustainability of the model.</p><p><strong>Results: </strong>We demonstrated the feasibility of creating a robust GCPM model. We showed that the model is reproducible under various conditions (6-, 12-, and 24-wells) and pre-analytical processing is possible. The imaging was feasible and allowed the comparison of morphological changes on the GCPM model to normal human peritoneum.</p><p><strong>Conclusions: </strong>We established a reproducible and robust organotypic model of GCPM which can be used to generate deeper knowledge on the pathophysiology of GCPM and might serve as a platform for testing different chemotherapy schemes in order to establish a personalized treatment for patients with GCPM.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"10 1","pages":"11-17"},"PeriodicalIF":1.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific 3D-tissue slices from peritoneal metastases - An <i>in vitro</i> model for individual susceptibility analysis.","authors":"Christian Etzold, Orestis Lyros, Matthias Mehdorn, Robert Nowotny, Stefan Niebisch, Boris Jansen-Winkeln, Katrin Schierle, Ines Gockel, René Thieme","doi":"10.1515/pp-2024-0012","DOIUrl":"https://doi.org/10.1515/pp-2024-0012","url":null,"abstract":"<p><strong>Objectives: </strong>The prognosis of patients with peritoneal metastases (PM) is poor, and these patients have a brief overall survival. Most patients with advanced PM receive palliative therapy to maintain their quality of life. In our current study, we investigated whether patient-specific 3D-tissue slices from patients with PM subjected to pressurized intraperitoneal aerosol chemotherapy could be cultured <i>in vitro</i>.</p><p><strong>Methods: </strong>Biopsies from gastric cancer patients with PM were characterized for cytokeratin-positive tumor cells and the proliferation marker Ki-67. Biopsies from seven patients were cut to 350 µM thick slices in a standardized manner, cultured with 10 µM 5-fluorouracil, doxorubicin, cisplatin, oxaliplatin, or irinotecan for 96 h, and then examined histopathologically and via immunohistochemistry for persistent cytokeratin and Ki-67 expression.</p><p><strong>Results: </strong><i>In vitro</i> cultured slices revealed a similar morphology to un-cultured specimens, and Ki-67-positive tumor cell areas were present after 96 h. The total amount of tumor cells per slice was determined by pan-cytokeratin staining. In the doxorubicin-treated slices, the cytokeratin-positive tumor cell fraction and proliferative (Ki-67pos) cells were decreased. Patient-specific 3D-tissue-slice cultures from peritoneal biopsies were cultured <i>in vitro</i> for up to 4 days.</p><p><strong>Conclusions: </strong>Potentially, these cultures are a reliable model to evaluate the chemosensitivity of patients with PM. Further investigation is needed to match the chemosensitivity with the clinical course of these patients.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"10 1","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"14^th PSOGI-ISSPP International congress on Peritoneal Surface Malignancies*: Lyon, 26 - 28^TH September 2024.","authors":"","doi":"10.1515/pp-2024-0031","DOIUrl":"https://doi.org/10.1515/pp-2024-0031","url":null,"abstract":"","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"9 Suppl1","pages":"A1-A199"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Questioning the role of HIPEC in patients with granulosa cell ovarian tumours.","authors":"Luis Felipe Falla-Zuniga, Armando Sardi, Mary Caitlin King, Vadim Gushchin","doi":"10.1515/pp-2024-0025","DOIUrl":"10.1515/pp-2024-0025","url":null,"abstract":"","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"9 4","pages":"157-158"},"PeriodicalIF":1.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Questioning the role of HIPEC in patients with granulosa cell ovarian tumours.","authors":"Christos Iavazzo, Ioannis D Gkegkes","doi":"10.1515/pp-2024-0002","DOIUrl":"10.1515/pp-2024-0002","url":null,"abstract":"","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"9 4","pages":"155"},"PeriodicalIF":1.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}