Pituitary最新文献

{"title":"Patient-reported outcomes in a Pituitary Tumor Center of Excellence (PTCOE)-aligned pituitary clinic compared with general endocrinology care.","authors":"Ali Nail Yagci, Aslihan Pekmezci, Meliha Melin Uygur, Sebnem Burhan, Melda Celik, Fatma Aktas Yagci, Mazhar Muslum Tuna, Mutlu Niyazoglu, Esra Hatipoglu","doi":"10.1007/s11102-026-01692-8","DOIUrl":"10.1007/s11102-026-01692-8","url":null,"abstract":"<p><strong>Purpose: </strong>Pituitary Tumor Centers of Excellence (PTCOE) were developed to standardize multidisciplinary care for pituitary disorders; however, their impact on patient-reported outcomes remains insufficiently characterized. This study aimed to compare health-related quality of life, illness perception, and outpatient satisfaction between patients followed in a PTCOE-aligned, though not formally accredited, specialized pituitary clinic and those managed in general endocrinology clinics, and to identify organizational factors associated with these outcomes.</p><p><strong>Methods: </strong>In this cross-sectional study, 175 adults with prolactinoma (n = 70), non-functioning pituitary adenoma (n = 54), acromegaly (n = 35) and Cushing's disease (n = 16) were evaluated across two tertiary endocrinology centers. Patient-reported outcomes were assessed using validated Turkish versions of the SF-36, Illness Perception Scale, and Outpatient Satisfaction Scale.</p><p><strong>Results: </strong>Certain baseline clinical profiles differed significantly between the two groups, with patients in the specialized clinic exhibiting higher rates of pituitary surgery (63.9% vs. 32.1%, p = 0.001) and hypopituitarism (28.9% vs. 14.1%, p = 0.02). Patients in the specialized clinic showed significantly lower SF-36 Role Physical, Role Emotional, Social Functioning, and Bodily Pain scores (all p ≤ 0.03). Illness-perception patterns also diverged, with higher Timeline, Consequences, and Treatment Control scores in the specialized clinic. Outpatient satisfaction, however, was consistently higher across all subscales in the specialized clinic (all p ≤ 0.006). In multivariable analyses, clinic type, sex, hypopituitarism, surgical history, and follow-up duration independently contributed to variation in multiple patient-reported outcome domains.</p><p><strong>Conclusion: </strong>PTCOE-aligned specialized care was associated with more favorable illness representations and higher patient satisfaction, even among cases with greater disease burden. This underscores the need for integrating patient-reported outcomes into the evaluation and refinement of pituitary care models.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of remission and recurrence following transsphenoidal surgery for prolactinoma: a single-center experience.","authors":"William M Burns, Gurkirat Kohli, Lu Wang, George Kassis, Nicholas Contento, Prasanth Romiyo, Samia Lopa, Ismat Shafiq, G Edward Vates","doi":"10.1007/s11102-026-01678-6","DOIUrl":"10.1007/s11102-026-01678-6","url":null,"abstract":"<p><strong>Purpose: </strong>To identify clinical, radiographic, and biochemical predictors of acute surgical remission (ASR), long-term remission (LTR), and recurrence in patients undergoing endoscopic transsphenoidal surgery (ETSS) for prolactinoma.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 52 patients who underwent ETSS for histologically confirmed prolactinoma at a single center between 2010 and 2022.</p><p><strong>Results: </strong>Remission was more likely in patients with microadenomas (ASR 72.2% vs. 41.2% macroadenomas, p = 0.03; LTR 44.4% vs. 17.6%, p = 0.052), Knosp 0-1 tumors (ASR 66.7% vs. 18.8% Knosp 2-4, p = 0.001; LTR 38.9% vs. 0%, p = 0.004), absence of cavernous sinus invasion (ASR 62.2% vs. 26.7%, p = 0.02; LTR 37.8% vs. 0%, p = 0.005), completely resected tumors (ASR 75.0% vs. 25.0%, p < 0.001; LTR 50.0% vs. 0%, p < 0.001). Patients achieving LTR had lower postoperative prolactin (4.5 vs. 28.0 ng/mL, p = 0.01). Median follow-up duration was 5.6 years, and median time to recurrence was 2.6 years. Recurrence was associated with higher peak prolactin (HR 1.003 per ng/mL, 95% CI: 1.001-1.01, p = 0.01), Knosp 2-4 tumors (HR 5.64, 95% CI: 1.40-22.80, p = 0.02), cavernous sinus invasion (HR 3.97, 95% CI: 1.15-13.64, p = 0.03), subtotal resection (HR 0.19 for GTR, 95% CI: 0.06-0.60, p = 0.01), and higher postoperative prolactin (HR 1.13 per ng/mL, 95% CI: 1.04-1.23, p = 0.01).</p><p><strong>Conclusion: </strong>Tumor size, invasiveness, extent of resection, and prolactin levels are key predictors of remission and recurrence. These findings underscore risk-stratified decision-making and long-term surveillance.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcaneal quantitative ultrasound parameters strongly correlate with DXA measurements in patients with acromegaly.","authors":"Claudia Campana, Andrea Casabella, Anna Arecco, Maurizio Cutolo, Serena Tonelli, Elvis Hysa, Lara Vera, Francesca Bertaina, Jessica Amarù, Diego Ferone, Sabrina Paolino, Federico Gatto","doi":"10.1007/s11102-026-01696-4","DOIUrl":"10.1007/s11102-026-01696-4","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with acromegaly have increased skeletal fragility. To date, dual-energy X-ray absorptiometry (DXA) and vertebral morphometry are the recommended examinations to evaluate bone health in these patients, despite known limitation. Calcaneal quantitative ultrasound (cQUS) is a less expensive and less invasive method to evaluate bone status compared to DXA. We aimed to investigate bone status by cQUS in a cohort of patients with acromegaly and to evaluate its ability to detect bone impairment.</p><p><strong>Methods: </strong>Observational cohort study including 56 patients with acromegaly (acromegaly group, AG) and 59 healthy subjects matched for age, sex and BMI (control group, CG). DXA and cQUS assessment were performed in both AG and CG; detailed clinical data were collected for the AG.</p><p><strong>Results: </strong>All cQUS parameters showed a good correlation with the DXA-derived T-score values (p<0.001) in both AG and CG. The cQUS-derived T-score was not significantly different in the AG compared to the CG (AG: 0.40 [IQR -1.60 to 1.50]; CG: -1,30 [IQR -1.65 to 0.95], p= 0.068). The cQUS-derived T-score showed a good discriminatory ability for the presence of osteopenia in the AG (AUC 0.833 [CI 0.721-0.945]). This discriminatory ability of the cQUS-derived T-score was similar between the AG and the CG (p=0.325).</p><p><strong>Conclusions: </strong>cQUS parameters showed a good correlation with DXA evaluation in patients with acromegaly, comparable to the observation in the general population. cQUS-derived T-score can accurately discriminate osteopenia in patients with acromegaly.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormonal staining patterns and clinical outcomes in acromegaly: a 15-year single-center study.","authors":"Sinem Başak Tan Öksüz, Esra Eraslan Aydemir, Aylin Okçu Heper, Cevriye Cansız Ersöz, Murat Faik Erdoğan, Rıfat Emral, Mustafa Şahin, Özgür Demir, Asena Gökçay Canpolat, Sevim Güllü","doi":"10.1007/s11102-026-01688-4","DOIUrl":"10.1007/s11102-026-01688-4","url":null,"abstract":"<p><strong>Purpose: </strong>Acromegaly is most commonly caused by pituitary somatotroph adenomas, a substantial proportion of which exhibit prolactin (PRL) expression on immunohistochemistry. However, the clinical relevance and prognostic implications of this pathological phenotype remain controversial. We aimed to compare pathological features and treatment outcomes of growth hormone/prolactin (GH/PRL)-positive adenomas with GH-only adenomas.</p><p><strong>Methods: </strong>We retrospectively analyzed 90 patients with acromegaly who underwent transsphenoidal surgery between 2010 and 2025. Adenomas were classified according to immunohistochemical staining as GH-only, GH/PRL, or other subtypes. Clinical, biochemical, radiological, and treatment outcomes were compared across groups.</p><p><strong>Results: </strong>Of 90 adenomas, 47 (52.2%) were GH-only, 39 (43.3%) GH/PRL, and 4 (4.4%) other PIT-1 lineage adenomas. Postoperative remission was achieved in 32 patients (35.6%), with no significant difference between GH-only and GH/PRL adenomas. In multivariable analysis, optic chiasm compression was independently associated with lower odds of remission (OR 0.212, 95% CI 0.049-0.910; p = 0.037). Among 45 patients receiving SSA therapy, 25 (55.6%) achieved biochemical response. Perinuclear CK8/18 staining (OR 4.839, 95% CI 1.198-19.540; p = 0.027) and T2-weighted MRI hypointensity (OR 5.464, 95% CI 1.284-23.250; p = 0.022) were independently associated with SSA response. Although Ki-67 was higher in GH/PRL adenomas, it was not associated with treatment outcomes.</p><p><strong>Conclusion: </strong>Despite higher proliferative activity, GH/PRL adenomas did not demonstrate inferior surgical or medical outcomes compared with GH-only adenomas. Prognosis appears to be driven primarily by anatomical features and cytokeratin patterns, supporting individualized treatment strategies.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impulse control disorders and their relationship with psychopathology in patients treated with cabergoline for hyperprolactinaemia.","authors":"Luigi Zerbinati, Giulia Cristilli, Beatrice Valier, Francesca Braccia, David Okai, Tommaso Toffanin, Martina Verrienti, Antonella Giampietro, Luigi Grassi, Maria Chiara Zatelli, Maria Rosaria Ambrosio","doi":"10.1007/s11102-026-01693-7","DOIUrl":"10.1007/s11102-026-01693-7","url":null,"abstract":"<p><strong>Purpose: </strong>Dopamine agonists (DAs), such as cabergoline (CAB), are first-line treatments for hyperprolactinaemia but have been associated with impulse control disorders (ICD). This observational study aimed to investigate the prevalence, severity, and clinical characteristics of ICD in CAB-treated patients compared with controls, using a combined clinician-administered and multimethod self-report assessment.</p><p><strong>Methods: </strong>A total of 126 participants were included: 63 patients with prolactin-secreting pituitary adenomas receiving cabergoline (CAB) and 63 controls (CG). ICD were evaluated using the Parkinson's Impulse Control Scale (PICS) as the reference diagnostic measure, alongside self-report questionnaires assessing ICD-related behaviors. Psychiatric comorbidity was assessed using the Mini International Neuropsychiatric Interview (MINI), and general psychopathology using the Brief Symptom Inventory-53 (BSI-53).</p><p><strong>Results: </strong>ICD were identified in 15.9% of CAB-treated patients and 6.3% of controls, indicating a more than twofold higher prevalence and greater severity in the CAB group, although differences were not statistically significant. When restricted to CAB-related cases, prevalence decreased to 12.7%. The Questionnaire for Impulsive-Compulsive Disorders (QUIP) showed moderate sensitivity (71.4%) but low positive predictive value (41.7%). Within the CAB group, ICD-positive patients had shorter treatment duration and lower weekly doses. No significant differences emerged in MINI or BSI-53 results, although psychiatric comorbidity was present in ~ 50% of ICD cases.</p><p><strong>Conclusion: </strong>CAB therapy was associated with a modest but clinically meaningful increase in ICD. Screening tools may support early identification, but positive findings require confirmation through comprehensive clinical assessment.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term endocrine trajectories and reoperation risk after surgery for Rathke's cleft cysts: a single-center cohort study of 177 patients.","authors":"Natalia Kremenevski, Waseem Masalha, Daniel Delev, Roland Coras, Arnd Doerfler, Dieter Henrik Heiland, Oliver Schnell","doi":"10.1007/s11102-026-01698-2","DOIUrl":"10.1007/s11102-026-01698-2","url":null,"abstract":"<p><strong>Purpose: </strong>To characterise endocrine trajectories after surgery for Rathke's cleft cysts (RCCs) and identify factors associated with pituitary hormonal dysfunction and reoperation.</p><p><strong>Methods: </strong>Retrospective single-centre cohort of 177 patients undergoing RCC surgery (2004-2023). Preoperative MRI volumetry, cyst location, histopathology, and longitudinal endocrine assessments were analysed. Early postoperative MRI defined residual cyst status. Reoperation-free survival was assessed by Kaplan-Meier and multivariable Cox regression.</p><p><strong>Results: </strong>Patients were 67.8% women (mean age 44.8 ± 17.0 years); median follow-up was 38.5 months. Preoperatively, 50.3% had anterior pituitary dysfunction, 33.3% hyperprolactinaemia, and 9.0% arginine vasopressin deficiency (AVP-D). Larger cyst volume was independently associated with hyperprolactinaemia and gonadal axis dysfunction, whereas age and sex showed axis-specific associations. Cyst location had limited explanatory value. An inflammatory-metaplastic cyst-wall phenotype was associated with more frequent pituitary hormonal dysfunction at presentation. Postoperatively, hyperprolactinaemia resolved in 78.0% of affected patients. AVP-D increased to 24.3% early after surgery and persisted in 22.0% at last follow-up. Gross total resection was achieved in 82.9%, and reoperation occurred in 15.8%. In landmark analysis, residual cyst on early postoperative MRI remained strongly associated with subsequent reoperation after adjustment for age, sex, cyst volume, and location.</p><p><strong>Conclusion: </strong>Larger cyst volume and an inflammatory-metaplastic cyst-wall phenotype were associated with more frequent pituitary hormonal dysfunction at diagnosis. Most clinically relevant net endocrine changes occurred within the first three postoperative months, supporting standardised reassessment at this time point as a pragmatic early follow-up milestone. Early postoperative MRI residual was strongly associated with reoperation, supporting a function-preserving surgical strategy and risk-adapted follow-up.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary adenoma and intracerebral aneurysms: case series, systematic review and meta-analysis.","authors":"Valentino Marino Picciola, Michela Borghesi, Vanessa Trombin, Serena Chirico, Maria Rosaria Ambrosio, Maria Chiara Zatelli","doi":"10.1007/s11102-026-01690-w","DOIUrl":"10.1007/s11102-026-01690-w","url":null,"abstract":"<p><strong>Purpose: </strong>Intracranial aneurysms (IAs) and Pituitary Adenoma (PA) coexistence has been reported for decades, yet available evidence remains fragmented. We performed a systematic review and meta-analysis following PRISMA 2020 guidelines to assess clinical features of patients with both conditions and quantify the prevalence of IAs in PA patients.</p><p><strong>Methods: </strong>PubMed and Embase were searched up to December 15, 2025. Studies reporting coexistence of IAs and PAs were included. Individual patient-level data (Group 1) and aggregate prevalence data (Group 2) were analyzed separately. Risk of bias (RoB) was assessed using Joanna Briggs Institute tools. All analyses were performed using metaprop function from the meta package in R software.</p><p><strong>Results: </strong>Seventy-one studies met inclusion criteria. Most studies have a low RoB. In Group 1 (74 patients), PAs were predominantly macroadenomas (91.9%), most frequently non-functioning (40.5%). IAs were mainly in the cavernous segment of the internal carotid artery (33%). IA diagnosis occurred significantly later than PA diagnosis (p < 0.01). In Group 2 (5264 patients), the pooled prevalence of IAs among PAs was 4% (95% CI 2-4%; I² = 92.1%, τ² = 1.1050, p < 0.0001). Sex-stratified prevalence was 8% (95% CI: 6%-9%) in females and 6% (95% CI: 4%-7%) in males. IAs sex-specific prevalence was significantly higher in both male and female PA patients as compared to the general population (p < 0.01).</p><p><strong>Conclusion: </strong>Patients with PAs show a higher IAs prevalence compared with the general population, likely reflecting combined hemodynamic, anatomical, and endocrine influences.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological features and outcomes of immature PIT-1 lineage tumors: A high-risk pituitary neuroendocrine tumor/pituitary adenoma subtype per WHO 2022.","authors":"Aysel Unver Ozkahraman, Aslihan Pekmezci, Huseyin Karatay, Ebubekir Akpinar, Buruc Erkan, Mehmet Karagulle, Burak Kocak, Mutlu Niyazoglu, Esra Hatipoglu","doi":"10.1007/s11102-026-01691-9","DOIUrl":"10.1007/s11102-026-01691-9","url":null,"abstract":"<p><strong>Purpose: </strong>Immature PIT-1 lineage tumors are classified as high-risk pituitary adenomas/pituitary neuroendocrine tumors (PitNETs) under the 2022 WHO Classification, yet clinical outcome data remain scarce. This study aimed to characterize clinicopathological features and treatment outcomes of this rare entity.</p><p><strong>Methods: </strong>We retrospectively analyzed 13 patients with pathologically confirmed immature PIT-1 lineage tumors who underwent surgery at our tertiary center between January 2022 and December 2024. Diagnoses were established according to WHO 2022 criteria using comprehensive transcription factor (TF) immunohistochemistry. Clinical, radiological, histopathological, treatment, and follow-up data were evaluated.</p><p><strong>Results: </strong>Immature PIT-1 lineage tumors accounted for 4% (21/525) of surgically treated pituitary adenomas, of whom 13 with complete follow-up data constituted the primary analysis cohort. Median age was 37 years (range: 25-73), with female predominance (61.5%). Notably, 61.5% presented with hormonal hypersecretion: acromegaly (38.5%), TSH-secreting tumors (15.4%), and GH-PRL co-secretion (7.7%). All patients had macroadenomas (median diameter 28 mm (range: 15-59 mm)); 38.5% demonstrated cavernous sinus invasion (Knosp grades 3-4). Immunohistochemically defined plurihormonal phenotype was present in 77% of cases; cytologic atypia was identified in all cases. Despite maximal surgical resection, residual disease persisted in 46% and 31% required reoperation at 16-month follow-up (range: 4-51 months). The median Ki-67 proliferation index was 4% (IQR: 2-10%; range: 1-35%), and the median mitotic count was 4 per 2 mm² (IQR: 1-8; range: 1-20).</p><p><strong>Conclusion: </strong>Immature PIT-1 lineage tumors exhibit aggressive behavior with high residual disease rates, with 31% of patients requiring reoperation, 23% receiving adjuvant radiotherapy, and somatostatin analogue resistance observed in two patients. Routine TF immunohistochemistry is essential for accurate diagnosis; management requires maximal safe surgical resection and intensive long-term surveillance.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in the understanding of psychological complications of acromegaly: toward a longitudinal clinical phenotype.","authors":"Gabriella Martino, Orlando Silvestro, Francesco Ferraù, Salvatore Cannavò","doi":"10.1007/s11102-026-01685-7","DOIUrl":"10.1007/s11102-026-01685-7","url":null,"abstract":"<p><p>Acromegaly is a chronic endocrine disorder where biochemical remission often fails to ensure psychological recovery. Drawing on cross‑sectional, longitudinal and registry evidence, this paper proposes a longitudinal clinical phenotype to reconcile divergence between hormonal control and patient‑reported outcomes. Psychological burden unfolds along a temporal gradient, where HR‑QoL captures persistent functional and somatic sequelae, emotional distress reflects adaptive strain during disease transitions, and psychiatric morbidity emerges from cumulative dysfunction. Treatment burden, chronic pain/arthropathy and subtle cognitive deficits are highlighted as mediators that sustain or worsen psychological outcomes. This framework supports routine longitudinal psychological assessment and integrated management of residual structural burden and psychosocial adaptation to improve lived recovery.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical clarification of neurological outcome estimates after pediatric suprasellar tumor surgery.","authors":"Zhanyun Liu","doi":"10.1007/s11102-026-01689-3","DOIUrl":"10.1007/s11102-026-01689-3","url":null,"abstract":"","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"29 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}