PneumologiePub Date : 2024-06-01Epub Date: 2024-02-13DOI: 10.1055/a-2182-1907
Carsten Schwarz, Jutta Bend, Helge Hebestreit, Michael Hogardt, Christian Hügel, Stephan Illing, Jochen G Mainz, Ernst Rietschel, Sebastian Schmidt, Bernhard Schulte-Hubbert, Helmut Sitter, Marc Oliver Wielpütz, Jutta Hammermann, Ingo Baumann, Frank Brunsmann, Doris Dieninghoff, Ernst Eber, Helmut Ellemunter, Patience Eschenhagen, Caroline Evers, Saskia Gruber, Assen Koitschev, Julia Ley-Zaporozhan, Uta Düesberg, Hans-Joachim Mentzel, Thomas Nüßlein, Felix C Ringshausen, Ludwig Sedlacek, Christina Smaczny, Olaf Sommerburg, Sivagurunathan Sutharsan, Ralf-Peter Vonberg, Ann-Katrin Weber, Jovita Zerlik
{"title":"[CF Lung Disease - a German S3 Guideline: Pseudomonas aeruginosa].","authors":"Carsten Schwarz, Jutta Bend, Helge Hebestreit, Michael Hogardt, Christian Hügel, Stephan Illing, Jochen G Mainz, Ernst Rietschel, Sebastian Schmidt, Bernhard Schulte-Hubbert, Helmut Sitter, Marc Oliver Wielpütz, Jutta Hammermann, Ingo Baumann, Frank Brunsmann, Doris Dieninghoff, Ernst Eber, Helmut Ellemunter, Patience Eschenhagen, Caroline Evers, Saskia Gruber, Assen Koitschev, Julia Ley-Zaporozhan, Uta Düesberg, Hans-Joachim Mentzel, Thomas Nüßlein, Felix C Ringshausen, Ludwig Sedlacek, Christina Smaczny, Olaf Sommerburg, Sivagurunathan Sutharsan, Ralf-Peter Vonberg, Ann-Katrin Weber, Jovita Zerlik","doi":"10.1055/a-2182-1907","DOIUrl":"10.1055/a-2182-1907","url":null,"abstract":"<p><p>Cystic Fibrosis (CF) is the most common autosomal recessive genetic multisystemic disease. In Germany, it affects at least 8000 people. The disease is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene leading to dysfunction of CFTR, a transmembrane chloride channel. This defect causes insufficient hydration of the airway epithelial lining fluid which leads to reduction of the mucociliary clearance.Even if highly effective, CFTR modulator therapy has been available for some years and people with CF are getting much older than before, recurrent and chronic infections of the airways as well as pulmonary exacerbations still occur. In adult CF life, <i>Pseudomonas aeruginosa</i> (PA) is the most relevant pathogen in colonisation and chronic infection of the lung, leading to further loss of lung function. There are many possibilities to treat PA-infection.This is a S3-clinical guideline which implements a definition for chronic PA-infection and demonstrates evidence-based diagnostic methods and medical treatment in order to give guidance for individual treatment options.</p>","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumologiePub Date : 2024-05-23DOI: 10.1055/a-2313-4137
Johanna Eggeling, Barbara Kalsdorf, Dagmar Schaub, Stefanie Schierholz, Peter Hammerl, Dennis Nowak, Christoph Lange
{"title":"[Everything under control?]","authors":"Johanna Eggeling, Barbara Kalsdorf, Dagmar Schaub, Stefanie Schierholz, Peter Hammerl, Dennis Nowak, Christoph Lange","doi":"10.1055/a-2313-4137","DOIUrl":"10.1055/a-2313-4137","url":null,"abstract":"<p><p>A 43-year-old quarry worker, after being exposed to fine quartz dust for 16 years in a German quarry, is on the waiting list for a lung transplant. The inhalation of the fine dust irreversibly damaged his lungs and facilitated the occurrence of fulminant mycobacterial and fungal infections, which have already led to a unilateral pneumonectomy and increasing respiratory failure. Despite regular monitoring by the occupational health and safety board, this dramatic development of silicosis could not be prevented.</p>","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumologiePub Date : 2024-05-01DOI: 10.1055/a-2253-4388
{"title":"Atezolizumab als Erstlinientherapie bei älteren Patienten mit NSCLC","authors":"","doi":"10.1055/a-2253-4388","DOIUrl":"https://doi.org/10.1055/a-2253-4388","url":null,"abstract":"","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumologiePub Date : 2024-05-01DOI: 10.1055/a-2284-6770
{"title":"Durvalumab zeigt bei operablem NSCLC deutliche Überlebensvorteile","authors":"","doi":"10.1055/a-2284-6770","DOIUrl":"https://doi.org/10.1055/a-2284-6770","url":null,"abstract":"","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141032756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumologiePub Date : 2024-05-01Epub Date: 2024-05-17DOI: 10.1055/a-2298-6312
Katharina Buschulte, Erik Büscher, Klaas Franzen, Armin Frille, Espen Groth, Julia Hoffmann, Andreas Knaack, Johannes Krönig, Christoph Lederer, Gabriela Leuschner, Eva Pappe, Nina Sicker, Finn Wilkens, Christoph Fisser
{"title":"Highlights vom DGP-Kongress 2024 aus Sicht der YoungDGP.","authors":"Katharina Buschulte, Erik Büscher, Klaas Franzen, Armin Frille, Espen Groth, Julia Hoffmann, Andreas Knaack, Johannes Krönig, Christoph Lederer, Gabriela Leuschner, Eva Pappe, Nina Sicker, Finn Wilkens, Christoph Fisser","doi":"10.1055/a-2298-6312","DOIUrl":"https://doi.org/10.1055/a-2298-6312","url":null,"abstract":"","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PneumologiePub Date : 2024-05-01DOI: 10.1055/a-2295-5809
{"title":"Nachruf: Dr. med. Martin Bachmann","authors":"","doi":"10.1055/a-2295-5809","DOIUrl":"https://doi.org/10.1055/a-2295-5809","url":null,"abstract":"","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}