Pneumologie最新文献_第10页

[Statement paper on the implementation of a national organized program in Germany for the early detection of lung cancer in risk populations using low-dose CT screening including management of screening findings]. [关于在德国实施国家组织的使用低剂量CT筛查早期检测风险人群肺癌癌症的计划的声明文件，包括筛查结果的管理]。

IF 1.2

Pneumologie Pub Date : 2024-01-01 Epub Date: 2023-10-10 DOI: 10.1055/a-2175-4580

Torsten Gerriet Blum, Jens Vogel-Claussen, Stefan Andreas, Torsten T Bauer, Jörg Barkhausen, Volker Harth, Hans-Ulrich Kauczor, Wulf Pankow, Katrin Welcker, Rudolf Kaaks, Hans Hoffmann

引用次数: 0

Horse allergy: Curly Horses can mediate immune tolerance. 马过敏：卷曲的马可以介导免疫耐受。

IF 1.2

Pneumologie Pub Date : 2024-01-01 Epub Date: 2023-10-12 DOI: 10.1055/a-2101-9533

Alexandra Mitlehner, Caspar Mitlehner, Monika Reißmann, Peter Stoll, Ines Swoboda, Wolfgang Mitlehner

{"title":"Horse allergy: Curly Horses can mediate immune tolerance.","authors":"Alexandra Mitlehner, Caspar Mitlehner, Monika Reißmann, Peter Stoll, Ines Swoboda, Wolfgang Mitlehner","doi":"10.1055/a-2101-9533","DOIUrl":"10.1055/a-2101-9533","url":null,"abstract":"American Bashkir Curly Horses are claimed to be hypoallergenic, but this has not been clinically proven. In the present study, the effect of exposure to Curly Horses was investigated in 141 patients allergic to horses by measuring their lung function and nasal patency during Curly Horse contact. Continuous contact with Curly Horses, including riding and brushing, decreased the allergic riders' reactivity as measured by FEV1, PEF, and PNIF. Subsequent visits (up to 40 or more hours of riding) further reduced reactivity to the Curly Horses. Allergic events to horses occurred only in 72 out of 1312 riding hours, mainly in the first ten riding hours.In 41 out of the 141 patients, it was further investigated whether repeated exposure to Curly Horses could induce tolerance to other horses. Patients in the tolerance induction study were tested annually for horse allergy using a nasal provocation test. The tolerance induction study showed that exposure to Curly Horses induced immune tolerance to other horses in 88% of patients who completed the study.To understand the mechanism causing hypoallergenicity, we performed IgE immunoblots to determine whether Curly Horse hairs contain IgE binding proteins. However, no differences in IgE reactivity were found between Curly and non-Curly Horses. Moreover, the immune tolerance induction study patients did not show decreased IgE reactivity to hairs from Curly or non-Curly Horses even though patients had developed tolerance. However, we did find increasing levels of anti-horse IgG antibodies in the study patients.Overall, our data strongly suggests that continuous exposure to Curly Horses can induce immune tolerance, rendering these patients non-reactive to horses. The reason for the reduced clinical allergenicity of Curly Horses remains unclear, but the data suggest that blocking IgG antibodies may be of importance for immune tolerance development.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":" ","pages":"47-57"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41209959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E-cigarette use-associated lung injury (EVALI). 电子烟使用相关肺损伤（EVALI）。

IF 1.2

Pneumologie Pub Date : 2024-01-01 Epub Date: 2023-10-19 DOI: 10.1055/a-2161-0105

Nathaly Yessenia Tituana, Claudia Gabriela Clavijo, Evelyn Fernanda Espinoza, Viviana Alexandra Tituana

{"title":"E-cigarette use-associated lung injury (EVALI).","authors":"Nathaly Yessenia Tituana, Claudia Gabriela Clavijo, Evelyn Fernanda Espinoza, Viviana Alexandra Tituana","doi":"10.1055/a-2161-0105","DOIUrl":"10.1055/a-2161-0105","url":null,"abstract":"The prevalence of vaping has overtaken conventional cigarettes as the most frequent form of nicotine consumption among 15-24-year olds. There are currently a large number of both legitimate and illegitimate products and suppliers offering more than 8000 different flavors of vape on the market, whose additives are not tested, studied or regulated and whose safety and toxicity profile remains unknown. In vitro studies have demonstrated a dose-dependent decrease in the viability of normal human bronchial epithelial cells after exposure to vapor from electronic vape devices.Short- and medium-term studies to date indicate that vapor-induced pulmonary lesions are the most serious and commonly reported side effect; such lesions include bilateral ground glass opacities in lung bases with subpleural preservation, bilateral infiltrates, pleural effusion, pneumomediastinum and nodular opacities. Cases of EVALI have been described in patients with daily exposure, as well as in users who reported having been exposed to these substances at least once a month. The most frequently inhaled substances are THC, flavored liquids of unknown content, and nicotine.The clinical manifestations of dyspnea and cough are the most frequent respiratory symptomatology, in addition to constitutional manifestations such as fever and chills, and gastrointestinal manifestations such as vomiting, nausea, abdominal pain and diarrhea. To these can be added the presence of tachypnea, tachycardia, elevated blood pressure, hypoxia, leukocytosis with neutrophilia and elevated ESR.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":" ","pages":"58-69"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Treatment of MDR, pre-XDR, XDR and rifampicin resistant tuberculosis or in case of intolerance to at least rifampicin in Austria, Germany and Switzerland - Amendment dated 19.09.2023 to the Sk2-Guideline: Tuberculosis in adulthood of the German Central Committee against Tuberculosis (DZK) on behalf of the German Respiratory Society (DGP)]. 【在奥地利、德国和瑞士治疗耐多药、广泛耐药前、广泛耐药和利福平耐药性结核病，或在至少对利福平不耐受的情况下——德国中央结核病防治委员会（DZK）代表德国呼吸学会（DGP）于2023年9月19日修订的Sk2指南：成年期结核病】。

IF 1.2

Pneumologie Pub Date : 2024-01-01 Epub Date: 2023-11-06 DOI: 10.1055/a-2182-1609

Ralf Otto-Knapp, Torsten Bauer, Folke Brinkmann, Cornelia Feiterna-Sperling, Inna Friesen, Hilte Geerdes-Fenge, Pia Hartmann, Brit Häcker, Barbara Hauer, Walter Haas, Jan Heyckendorf, Martin Kuhns, Christoph Lange, Florian P Maurer, Albert Nienhaus, Martin Priwitzer, Elvira Richter, Helmut J F Salzer, Otto Schoch, Nicolas Schönfeld, Tom Schaberg

{"title":"[Treatment of MDR, pre-XDR, XDR and rifampicin resistant tuberculosis or in case of intolerance to at least rifampicin in Austria, Germany and Switzerland - Amendment dated 19.09.2023 to the Sk2-Guideline: Tuberculosis in adulthood of the German Central Committee against Tuberculosis (DZK) on behalf of the German Respiratory Society (DGP)].","authors":"Ralf Otto-Knapp, Torsten Bauer, Folke Brinkmann, Cornelia Feiterna-Sperling, Inna Friesen, Hilte Geerdes-Fenge, Pia Hartmann, Brit Häcker, Barbara Hauer, Walter Haas, Jan Heyckendorf, Martin Kuhns, Christoph Lange, Florian P Maurer, Albert Nienhaus, Martin Priwitzer, Elvira Richter, Helmut J F Salzer, Otto Schoch, Nicolas Schönfeld, Tom Schaberg","doi":"10.1055/a-2182-1609","DOIUrl":"10.1055/a-2182-1609","url":null,"abstract":"In December 2022, based on the assessment of new evidence, the World Health Organization (WHO) updated its guidelines for the treatment of drug-resistant tuberculosis (TB). The evaluation of both, these recommendations, and the latest study data, makes it necessary to update the existing guidelines on the treatment of at least rifampicin-resistant tuberculosis for the German-speaking region, hereby replacing the respective chapters. A shortened MDR-TB treatment of at least 6 month using the fixed and non-modifiable drug combination of bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM) is now also recommended for Germany, Austria, and Switzerland under certain conditions. This recommendation applies to TB cases with proven rifampicin resistance, including rifampicin monoresistance. For treatment of pre-extensively drug resistant TB (pre-XDR-TB), an individualized treatment for 18 months adjusted to resistance data continues to be the primary recommendation. The non-modifiable drug combination of bedaquiline, pretomanid, and linezolid (BPaL) may be used alternatively in pre-XDR TB if all prerequisites are met. The necessary prerequisites for the use of BPaLM and BPaL are presented in this amendment to the S2k guideline for 'Tuberculosis in adulthood'.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":" ","pages":"35-46"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hinweise auf die Rolle von Autoantikörpern für den IPF-Progress 自身抗体在 IPF 进展过程中发挥作用的证据

IF 1.2

Pneumologie Pub Date : 2023-12-01 DOI: 10.1055/a-2111-0727

引用次数: 0

[Early detection of lung cancer - current status and implementation scenarios]. [肺癌早期检测--现状和实施方案]。

IF 1.2

Pneumologie Pub Date : 2023-12-01 Epub Date: 2023-12-13 DOI: 10.1055/a-1531-0131

Rudolf M Huber

{"title":"[Early detection of lung cancer - current status and implementation scenarios].","authors":"Rudolf M Huber","doi":"10.1055/a-1531-0131","DOIUrl":"https://doi.org/10.1055/a-1531-0131","url":null,"abstract":"The prognosis of conventionally diagnosed lung cancer patients is still rather poor. Two large, randomized trials using screening by low dose CT could demonstrate that early detection in persons with smoking as risk factor can improve this prognosis. Early detection of lung cancer can be achieved by structured screening programs using low dose CT for persons at increased risk, but in addition also by consequent management of incidental pulmonary nodules, which are seen on imaging for other reasons. Integral part of these programs should be prevention measures, especially a consequent, repeated, low-threshold offer of a service for smoking cessation. Programs for lung cancer screening for persons at increased risk are only beneficial for the screenees and cost-effective, if the various parts of the program are optimally integrated and coordinated and all necessary disciplines (especially respiratory medicine, radiology, pathology, thoracic surgery, radiotherapy) are included in a multidisciplinary manner. For Germany the certified lung cancer centres in structured cooperation with physicians in private practice (respiratory physicians, radiologists, general practitioners) would be a good option. It is essential that there is a good perception for the need of early detection of lung cancer in politics and the public and that the persons at risk are reached, contacted and motivated by various methods.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":"77 12","pages":"1016-1026"},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138808877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19: Algorithmus zur Risikoprognose während der Omicron-Welle COVID-19：欧米克隆波期间的风险预测算法

IF 1.2

Pneumologie Pub Date : 2023-12-01 DOI: 10.1055/a-2204-5227

引用次数: 0

Cystische Fibrose (CF): Dreifachtherapie verbessert Monozytenfunktion 囊性纤维化（CF）：三联疗法可改善单核细胞功能

IF 1.2

Pneumologie Pub Date : 2023-12-01 DOI: 10.1055/a-2110-2231

引用次数: 0

[Tuberculosis Infection Control & Hygiene - Recommendations of the DZK]. [结核病感染控制和卫生-DZK的建议]。

IF 1.2

Pneumologie Pub Date : 2023-12-01 Epub Date: 2023-10-13 DOI: 10.1055/a-2172-9575

Peter Witte, Mardjan Arvand, Stefanie Barth, Roland Diel, Inna Friesen, Petra Gastmeier, Brit Häcker, Barbara Hauer, Martin Kuhns, Albert Nienhaus, Ralf Otto-Knapp, Elvira Richter, Nicoletta Wischnewski, Renate Ziegler, Torsten Bauer

{"title":"[Tuberculosis Infection Control & Hygiene - Recommendations of the DZK].","authors":"Peter Witte, Mardjan Arvand, Stefanie Barth, Roland Diel, Inna Friesen, Petra Gastmeier, Brit Häcker, Barbara Hauer, Martin Kuhns, Albert Nienhaus, Ralf Otto-Knapp, Elvira Richter, Nicoletta Wischnewski, Renate Ziegler, Torsten Bauer","doi":"10.1055/a-2172-9575","DOIUrl":"10.1055/a-2172-9575","url":null,"abstract":"Preventing the spread of the disease is an essential goal in the care and treatment of tuberculosis. In addition to early diagnosis and effective therapies, isolation of infectious patients and adequate hygiene measures are of particular importance for infection prevention. The present recommendations replace the previous recommendations \"tuberculosis infection control\" from 2012 and take into account the current national and international recommendations and as well as new scientific findings. After a description of the infection and the transmission pathways, the necessary prevention and hygiene measures in health care facilities are comprehensively presented. Since the last revision of the recommendations on infection prevention, international recommendations and the KRINKO recommendation on ending isolation have been changed. In accordance with this, under certain conditions in the case of sensitive tuberculosis, de-isolation in health care facilities can take place after 14 days without taking the sputum findings into account. The second part of the recommendations explains in detail the measures to be taken in special situations and areas, such as general practitioners, ambulance services and care facilities. Here, the recommendations on respiratory protection have been simplified; for staff, an FFP2 mask is now generally considered sufficient.","PeriodicalId":20197,"journal":{"name":"Pneumologie","volume":" ","pages":"983-1000"},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41209958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Gedenken an Dr. med. Robert Kropp 17. November 1931 – 10. September 2023 纪念医学博士罗伯特-克罗普 1931 年 11 月 17 日 - 2023 年 9 月 10 日

IF 1.2

Pneumologie Pub Date : 2023-12-01 DOI: 10.1055/a-2210-0362

引用次数: 0