Planta medica最新文献_第9页

Phytochemicals as Radioprotective and Radiosensitizing Agents in Cancer Radiotherapy: Advances, Challenges, and Future Perspectives. 植物化学物质在癌症放射治疗中的放射防护和放射增敏作用：进展、挑战和未来展望。

IF 2 4区医学

Planta medica Pub Date : 2026-01-01 Epub Date: 2025-10-14 DOI: 10.1055/a-2654-6072

Tuward J Dweh, Marylin Taye, Dhritismita Deka, Suman Kumar Samanta, Narayan C Talukdar

{"title":"Phytochemicals as Radioprotective and Radiosensitizing Agents in Cancer Radiotherapy: Advances, Challenges, and Future Perspectives.","authors":"Tuward J Dweh, Marylin Taye, Dhritismita Deka, Suman Kumar Samanta, Narayan C Talukdar","doi":"10.1055/a-2654-6072","DOIUrl":"10.1055/a-2654-6072","url":null,"abstract":"Radiation therapy (RT) remains a fundament of cancer treatment, yet its effectiveness is often hindered by normal tissue toxicity and radiation-induced fibrosis. Recent research has highlighted the promise of bioactive-phytochemicals in enhancing the therapeutic index of RT-sensitizing tumor cells to radiation while safeguarding healthy tissues. This reflects a growing interest in integrating natural compounds with conventional cancer therapies to achieve synergistic effects. To summarize recent advances, identify the research gaps, and evaluate future directions, a comprehensive review was conducted using data from the NCBI and PubChem databases, focusing on preclinical and clinical studies exploring the role of phytochemicals in cancer radiotherapy. The findings stated that the phytochemicals such as curcumin, resveratrol, quercetin, genistein, and EGCG have been shown to sensitize cancer cells to radiation by amplifying DNA damage, promoting apoptosis, and inhibiting key signaling pathways including PI3K/Akt, ATM, and NF-κB. Simultaneously, these compounds exhibit protective effects on normal tissues by activating antioxidant responses (e.g., Nrf2/ARE), reducing oxidative stress, and alleviating radiation-induced fibrosis through modulation of CTGF and TGF-β pathways. Emerging agents like astilbin, puerarin, and isorhamnetin have also demonstrated notable radiosensitizing and antifibrotic potential. However, challenges such as poor bioavailability, dose inconsistencies, and patient-specific variability remain significant barriers to clinical translation. In conclusion, the dual context-dependent actions of phytochemicals emphasize the need for personalized therapeutic strategies, optimized dosing, and advanced delivery systems. Furthermore, integrating nanotechnology may hold particular promise for enhancing the precision and effectiveness of phytochemical-based interventions in radiation oncology.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"11-32"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NMR Chemical Shifts of Common Flavonoids. 常见类黄酮的核磁共振化学位移。

IF 2 4区医学

Planta medica Pub Date : 2026-01-01 Epub Date: 2025-10-29 DOI: 10.1055/a-2706-7473

Žarko Kulić, Valentin J N Steiner, Andreas Butterer

引用次数: 0

Ovatodiolide: Recent Advances in Pharmacological Activities and Mechanisms. 卵黄内酯：药理活性和机制的最新进展。

IF 2 4区医学

Planta medica Pub Date : 2026-01-01 Epub Date: 2025-09-05 DOI: 10.1055/a-2696-1032

Yingying Zhou, Jianguo Zhang, Qingqing Xia, Lingmin Zhang, Miaomiao Zhang, Lijun Lu, Zaixing Yang, Jie Li

引用次数: 0

In Vitro Evaluation of the Angiogenic Potential of Plantago Major Extract in Enhancing the Wound-Healing Process. 车前草提取物促进创面愈合血管生成潜能的体外评价。

IF 2 4区医学

Planta medica Pub Date : 2026-01-01 Epub Date: 2025-08-19 DOI: 10.1055/a-2686-4040

Latifa Amalia, Retno Murwanti, Triana Hertiani, Kurnia Rahayu Purnomo Sari

{"title":"In Vitro Evaluation of the Angiogenic Potential of Plantago Major Extract in Enhancing the Wound-Healing Process.","authors":"Latifa Amalia, Retno Murwanti, Triana Hertiani, Kurnia Rahayu Purnomo Sari","doi":"10.1055/a-2686-4040","DOIUrl":"10.1055/a-2686-4040","url":null,"abstract":"Plantago major extracts have demonstrated considerable efficacy in promoting wound healing. However, there is limited research evaluating the angiogenic potential of P. major extract using Matrigel-based assays alongside gene expression analysis of key angiogenic markers such as vascular endothelial growth factor A and vascular endothelial growth factor receptor 2. This study evaluated the angiogenic effects of P. major extracts obtained by several extraction techniques: ultrasound-assisted extraction for leaves and both ultrasound-assisted extraction and maceration for non-leaf components using in vitro human umbilical vein endothelial cells. Aucubin content was analyzed using an HPTLC-densitometer, revealing the highest aucubin content in the non-leaves extract obtained from ultrasound-assisted extraction (16.75%). Furthermore, an in vitro experiment with human umbilical vein endothelial cells was conducted to assess P. major extract's effect on cell viability, migration, and the formation of capillary-like structures (tube formation). All extracts maintained cell viability above 80% at concentrations below 250 µg/mL. The leaves extract obtained from ultrasound-assisted extraction at 31.25 µg/mL showed the greatest wound closure (80.29%) and the highest branching length (2756.41 cm). However, gene expression of vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 showed no significant upregulation in the leaves extract obtained from ultrasound-assisted extraction-treated group, and low replication numbers limited some assays. These findings suggest that P. major leaf extract may promote angiogenesis through mechanisms beyond vascular endothelial growth factor signaling, but further studies with higher statistical power and broader mechanistic approaches are warranted.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"33-42"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Influencing Clinical Trials of Herbal Medicinal Products - Using Ginger as Example. 影响中药临床试验的因素——以生姜为例

IF 2 4区医学

Planta medica Pub Date : 2025-12-01 Epub Date: 2025-09-08 DOI: 10.1055/a-2686-6315

Ingrid Hook, Liselotte Krenn, Barbara Steinhoff, Evelyn Wolfram

引用次数: 0

Cupressuflavone Isolated from Cupressus torulosa Ameliorates Diabetic Nephropathy by Inhibiting Oxidative Stress and Inflammation Through Nrf-2/NF-κB Signalling Axis. 从托鲁沙柏树中提取的柏素黄酮通过Nrf-2/ NF-κB信号轴抑制氧化应激和炎症，改善糖尿病肾病。

IF 2 4区医学

Planta medica Pub Date : 2025-12-01 Epub Date: 2025-08-19 DOI: 10.1055/a-2686-3928

Kishan Singh, Karan Singh Yadav, Arti Shukla, Vipin Kumar Singh, Narayan Prasad Yadav, Madhav Nilakanth Mugale, Kapil Dev

{"title":"Cupressuflavone Isolated from Cupressus torulosa Ameliorates Diabetic Nephropathy by Inhibiting Oxidative Stress and Inflammation Through Nrf-2/NF-κB Signalling Axis.","authors":"Kishan Singh, Karan Singh Yadav, Arti Shukla, Vipin Kumar Singh, Narayan Prasad Yadav, Madhav Nilakanth Mugale, Kapil Dev","doi":"10.1055/a-2686-3928","DOIUrl":"10.1055/a-2686-3928","url":null,"abstract":"Cupressuflavone (CTM-01), a potential biflavonoid isolated from Cupressus torulosa exhibited antimicrobial, analgesic, cytotoxic and wound-healing properties. The present study aims to evaluate the renoprotective effects through in vitro and in vivo models as well as elucidate the underlying mechanisms of its nephroprotective action under diabetic conditions. The in vitro effects of CTM-01 on cell viability (25, 50, and 100 µM) and intracellular ROS production were evaluated in cultured normal rat proximal epithelial cells (NRK-52E) grown under high glucose conditions (30 mM) while streptozotocin (STZ) induced rats were treated with CTM-01 at 25 mg/kg for four weeks and the effects on different biochemical, histological, and molecular parameters were studied. The oral administration of CTM-01 (25 mg/kg) in diabetic rats restored the fasting blood glucose to normal control levels and markedly ameliorated renal dysfunction as evidenced by a significant decrease in serum creatinine, urea, and albumin. Additionally, CTM-01-treated rats exhibited a significant increase in the levels of renal antioxidants such as SOD, CAT, and GSH as well as decreased MDA content against diabetic control rats and restored kidney damage in CTM-01-treated diabetic rats. Moreover, CTM-01 significantly increased the level of Nrf-2 and downregulated the expression of p-NF-κB. This novel study provides strong evidence to support the potent anti-oxidative and renoprotective properties of CTM-01 in alleviating oxidative damage and inflammation through the suppression of the Nrf-2/NF-κB signalling axis for the effective management of diabetic nephropathy.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"913-922"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Farnesiferol B and Kamolonol Isolated from Ferula assa-foetida are Potent BACE1 Inhibitors with Neuroprotective Effects. 从阿魏中分离的法尼铁醇B和卡莫洛酚是有效的BACE1抑制剂，具有神经保护作用。

IF 2 4区医学

Planta medica Pub Date : 2025-12-01 Epub Date: 2025-08-25 DOI: 10.1055/a-2689-8035

Jong Min Oh, Woong-Hee Shin, Bomi Kim, Eonmi Kim, Hyun Ju Son, Hoon Kim

{"title":"Farnesiferol B and Kamolonol Isolated from Ferula assa-foetida are Potent BACE1 Inhibitors with Neuroprotective Effects.","authors":"Jong Min Oh, Woong-Hee Shin, Bomi Kim, Eonmi Kim, Hyun Ju Son, Hoon Kim","doi":"10.1055/a-2689-8035","DOIUrl":"10.1055/a-2689-8035","url":null,"abstract":"Five compounds were isolated from Ferula assa-foetida and their beta-secretase 1 inhibitory activities were evaluated. Farnesiferol B and kamolonol showed potent beta-secretase 1 inhibitory activity with IC50 values of 8.11 and 1.00 µM and competitive inhibition patterns against beta-secretase 1 with Ki values of 6.51 and 0.41 µM, respectively. In silico pharmacokinetics showed that farnesiferol B was predicted to have high gastrointestinal absorption and blood-brain barrier permeability. In cell studies, farnesiferol B and kamolonol were nontoxic to normal Madin-Darby canine kidney and neuroblastoma cells, and both showed protective effects on neuroblastoma cells for Aβ42-induced neurotoxicity. In molecular docking simulations, we found that the efficacy of the compounds may be related to their interaction with the flap region and hydrogen bonding with ARG368. In addition, molecular dynamics simulation of kamolonol showed the ligand maintained its stability in interaction with the loop residues. These results show that farnesiferol B and kamolonol are potent beta-secretase 1 inhibitors with neuroprotective effects, suggesting that they are potential candidates for the treatment of neurodegenerative disorders, such as Alzheimer's disease.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"933-942"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo, Ex Vivo, and In Vitro Antihyperglycemic Evaluation of Croton ehrenbergii. 巴豆在体内、离体和体外的抗高血糖作用评价。

IF 2 4区医学

Planta medica Pub Date : 2025-12-01 Epub Date: 2025-09-04 DOI: 10.1055/a-2689-5059

Mónica Aideé Díaz-Román, Maria Yolanda Rios, Juan-José Acevedo-Fernández, A Berenice Aguilar-Guadarrama

{"title":"In Vivo, Ex Vivo, and In Vitro Antihyperglycemic Evaluation of Croton ehrenbergii.","authors":"Mónica Aideé Díaz-Román, Maria Yolanda Rios, Juan-José Acevedo-Fernández, A Berenice Aguilar-Guadarrama","doi":"10.1055/a-2689-5059","DOIUrl":"10.1055/a-2689-5059","url":null,"abstract":"Various Croton species have been traditionally used to treat diabetes; however, the antidiabetic potential and safety of many of these species remain poorly understood. This study evaluated the chemical composition, antihyperglycemic activity, insulin-sensitizing effect, and acute oral toxicity of C. ehrenbergii. Dichloromethane, ethyl acetate, n-butanol, and aqueous residue fractions were obtained via liquid-liquid extraction from the hydroalcoholic extract obtained via maceration of the aerial parts. The primary compounds isolated from the fractions using column chromatography and identified by 1D nuclear magnetic resonance spectroscopy were 7,4'-di-O-methylnaringenin, β-sitosterol, tiliroside, rutin, nicotiflorin, isoquercetin, and l-quebrachitol. The in vivo antihyperglycemic activity of these compounds was assessed using oral sucrose and glucose tolerance tests, and the most active fractions were evaluated ex vivo to explore the mechanisms of action. The extract, fractions, and compounds were tested in vitro for their ability to inhibit α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) as well as for their agonistic activity on PPAR-γ. Tiliroside and nicotiflorin moderately inhibited PTP1B and α-glucosidase; whereas, l-quebrachitol acted as a PPAR-γ agonist. Acute oral toxicity studies indicated that the extract was safe at the tested dose. These results provide the first scientific evidence of the antihyperglycemic properties and preliminary safety of C. ehrenbergii.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"923-932"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Olive Polyphenol Hydroxytyrosol Enhances Autophagy and Heme Oxygenase-1 Expression in Aortic Endothelial Cells and Reduces Arterial Stiffness ex vivo. 橄榄多酚羟基酪醇增强主动脉内皮细胞自噬和血红素加氧酶-1表达，降低动脉僵硬度。

IF 2 4区医学

Planta medica Pub Date : 2025-12-01 Epub Date: 2025-08-22 DOI: 10.1055/a-2662-9672

Stef Lauwers, Melissa Van Praet, Bieke Steenput, Anne-Sophie Weyns, Cédric H G Neutel, Emmy Tuenter, Nina Hermans, Lynn Roth

{"title":"The Olive Polyphenol Hydroxytyrosol Enhances Autophagy and Heme Oxygenase-1 Expression in Aortic Endothelial Cells and Reduces Arterial Stiffness ex vivo.","authors":"Stef Lauwers, Melissa Van Praet, Bieke Steenput, Anne-Sophie Weyns, Cédric H G Neutel, Emmy Tuenter, Nina Hermans, Lynn Roth","doi":"10.1055/a-2662-9672","DOIUrl":"10.1055/a-2662-9672","url":null,"abstract":"Age-related arterial stiffening is a hallmark of vascular ageing and a key driver of cardiovascular disease. Oxidative stress, impaired autophagy, and extracellular matrix remodelling play an important role in the progression of aortic stiffening. Hydroxytyrosol (HT), a phenolic compound in olives, has demonstrated antioxidant properties and the ability to modulate autophagy, positioning it as a potential therapeutic for vascular ageing. In this study, we investigated the effects of HT on autophagy flux and antioxidant protein expression in human aortic endothelial cells (HAoECs). In parallel, we examined the impact of HT on arterial stiffness ex vivo using isolated aortic segments from wild-type (WT) and Fbn1C1039G+/- mice, a model of elastin fragmentation.HT treatment (50 and 100 µM; 18 h) enhanced autophagy flux in HAoECs, evidenced by increased LC3-II and p62 turnover, and reduced mTOR activity. Additionally, HT upregulated heme oxygenase-1 (HO-1), a key antioxidant enzyme. Ex vivo treatment of aortic segments from WT and Fbn1C1039G+/- mice with HT (50 µM; 18 h) restored IP3-mediated contractions and reduced aortic stiffness in Fbn1C1039G+/- aortas, as demonstrated by a decreased Peterson's modulus. Although HT did not significantly affect collagen or elastin content or elastic fibre breaks in the aortic wall, it notably increased HO-1 protein levels in Fbn1C1039G+/- aortas.These findings demonstrate the potential of HT to mitigate oxidative stress, enhance autophagy, and reduce arterial stiffness, making it a promising nutraceutical for addressing age-related vascular dysfunction. Further long-term studies are needed to elucidate the molecular mechanisms and evaluate its sustained benefits in vivo.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"899-912"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144965105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Therapeutic Potential of Topically Applied Essential Oils in Preventing or Treating Early Borrelia burgdorferi Infection: A Review. 局部应用精油预防或治疗早期伯氏疏螺旋体感染的治疗潜力：综述。

IF 2 4区医学

Planta medica Pub Date : 2025-12-01 Epub Date: 2025-06-20 DOI: 10.1055/a-2640-4274

Keren Dolan, John Courie, Michael Tims

{"title":"The Therapeutic Potential of Topically Applied Essential Oils in Preventing or Treating Early Borrelia burgdorferi Infection: A Review.","authors":"Keren Dolan, John Courie, Michael Tims","doi":"10.1055/a-2640-4274","DOIUrl":"10.1055/a-2640-4274","url":null,"abstract":"Lyme disease, caused by Borrelia burgdorferi, presents significant diagnostic challenges, often leading to delayed treatment and decreased therapeutic response to conventional antibiotics. This review aims to evaluate the potential of plant essential oils, known for their bacteriostatic, bactericidal, and anti-quorum sensing properties, as prophylactic, adjunct, or complementary treatments during the early stages of B. burgdorferi infection. The authors explore how these essential oils can target adaptive mechanisms and interactions of B. burgdorferi, including complement regulator-acquiring surface proteins (CRASPs), immune modulation, motility, chemotaxis, biofilm formation, efflux-pump mechanisms, and cyst formation. The authors identify current research gaps and propose frameworks to substantiate the clinical efficacy of essential oils for Lyme disease treatment. This review indicates that essential oils have multifaceted therapeutic potential and could provide a viable option for early intervention in Lyme disease. Further research is necessary to confirm their clinical applicability and safety.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"866-879"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0