ACS Materials Letters最新文献_第10页

A Synergistic Nanoplatform for Chemodynamic and Sonodynamic Cancer Therapy 化学动力学和声动力学癌症治疗的协同纳米平台

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-06 DOI: 10.1021/acsmaterialslett.6c00397

Jingguang Wang, Nantian Duan, Yutao Lin, Tao Wang, Yi Qian, Jiayue Xie, Zhenze Xie, Chang Du

{"title":"A Synergistic Nanoplatform for Chemodynamic and Sonodynamic Cancer Therapy","authors":"Jingguang Wang, Nantian Duan, Yutao Lin, Tao Wang, Yi Qian, Jiayue Xie, Zhenze Xie, Chang Du","doi":"10.1021/acsmaterialslett.6c00397","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00397","url":null,"abstract":"The development of non-invasive, synergistic therapeutic strategies remains a critical challenge in cancer treatment due to tumor heterogeneity and the limitations of monotherapies. Herein, we report a multifunctional zirconium-based metal–organic framework nanoplatform Zr-MOF-NH2@Pt@PEI, which was synthesized by the solvothermal method, followed by in situ growth of ultrasmall platinum (Pt) within the MOF matrix and subsequent surface modification with polyethyleneimine (PEI). A Schottky-type heterojunction was formed at the Pt-MOF interface, significantly enhancing charge separation, inhibiting electron-hole recombination, and maximizing reactive oxygen species generation under mild stimuli. The PEI coating conferred a strong positive surface charge, promoting cellular uptake via electrostatic interactions with cancer cell membranes while maintaining excellent hemocompatibility and cytocompatibility. Upon exposure to tumor microenvironmental H2O2 and ultrasound stimulation, Zr-MOF-NH2@Pt@PEI effectively activated the synergistic anticancer effect of chemodynamic therapy and sonodynamic therapy. In conclusion, Zr-MOF-NH2@Pt@PEI is a promising candidate for non-invasive multimodal cancer therapy, providing a strategy for precise nanomedicine.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2255–2263"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atomic-Scale Aluminum Oxyfluoride-Confined Nanoporous Carbons for Exceptional Aging-Resistant Propylene/Propane Separation 原子级氧化氟化铝限制纳米多孔碳用于特殊耐老化的丙烯/丙烷分离

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-06-29 DOI: 10.1021/acsmaterialslett.6c00439

Leiqing Hu, Won-Il Lee, Kai Chen, Yang Jiao, Erda Deng, Kim Kisslinger, Yugang Zhang, Xiao Tong, Jaejun Lee, Qingyue Yu, Rajan Jain, Yifu Ding, Miao Yu, Zhongbiao Wu, Chang-Yong Nam, Haiqing Lin

{"title":"Atomic-Scale Aluminum Oxyfluoride-Confined Nanoporous Carbons for Exceptional Aging-Resistant Propylene/Propane Separation","authors":"Leiqing Hu, Won-Il Lee, Kai Chen, Yang Jiao, Erda Deng, Kim Kisslinger, Yugang Zhang, Xiao Tong, Jaejun Lee, Qingyue Yu, Rajan Jain, Yifu Ding, Miao Yu, Zhongbiao Wu, Chang-Yong Nam, Haiqing Lin","doi":"10.1021/acsmaterialslett.6c00439","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00439","url":null,"abstract":"Carbon molecular sieves (CMSs) offer a promising alternative to energy-intensive cryogenic distillation for gas separations such as C3H6/C3H8. However, they suffer from physical aging that reduces gas permeability and from a trade-off between size-sieving capability and mechanical stability. Herein, we address both challenges by engineering robust nanoporous carbons via an integrated low-temperature carbonization and vapor-phase infiltration (VPI) strategy. A 6FDA-DAM polyimide is carbonized at 500 °C to form mechanically resilient carbons and then subjected to VPI treatment to generate sub-nanometer aluminum oxyfluoride onto internal pore walls. The inorganic coating rigidifies carbon nanostructures, enhancing their resistance to physical aging, and narrows pore sizes, thereby increasing size-sieving ability. 6-Cycle VPI treatment of a CMS increases C3H6/C3H8 selectivity from 16 to 43 with stable separation properties over 90 days, outperforming most leading CMSs and polymers. The VPI process enables atom-by-atom tuning of micropores and provides a scalable route to enhance membrane separation efficiency.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2291–2299"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-Organic Coordination Nanotubes as Advanced Architectures for Efficient Ammonia Electrosynthesis via Pure Nitrate Reduction in Neutral Media 金属-有机配位纳米管作为中性介质中纯硝酸盐还原高效氨电合成的先进结构

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-07 DOI: 10.1021/acsmaterialslett.6c00317

Miao Wang, Qian Teng, Qianchuan Yu, Heng Zhou, Shuaikang Yang, Tianyu Shen, Huaizhu Wang, Zuoao Wu, Zuoxiu Tie, Shuangming Chen, Li-Min Zheng, Zhong Jin

{"title":"Metal-Organic Coordination Nanotubes as Advanced Architectures for Efficient Ammonia Electrosynthesis via Pure Nitrate Reduction in Neutral Media","authors":"Miao Wang, Qian Teng, Qianchuan Yu, Heng Zhou, Shuaikang Yang, Tianyu Shen, Huaizhu Wang, Zuoao Wu, Zuoxiu Tie, Shuangming Chen, Li-Min Zheng, Zhong Jin","doi":"10.1021/acsmaterialslett.6c00317","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00317","url":null,"abstract":"Metal-organic coordination materials have emerged as promising candidates for electrocatalytic nitrate reduction reaction (NITRR), but the molecular-level engineering required for constructing high-efficiency electrocatalysts remains challenging. This study addresses this gap by developing a class of metal-organic coordination nanotubes (MONTs) as atomically precise single-site electrocatalysts, including Fe-MONTs, Co-MONTs, and Ni-MONTs. Benefited from the unique coordination structure, the Co-MONT electrode exhibited superior electrocatalytic performances for the NITRR, achieving an ammonia production Faradaic efficiency of 89.9% at −0.7 V (vs reversible hydrogen electrode) and an ammonia yield rate of 231.3 mmol h−1 g−1cat. in pure nitrate solution. Through combining in situ characterizations and theoretical simulations, the electrocatalysis mechanisms and active site configurations were elucidated. This work establishes MONTs as an intriguing platform for electrochemical wastewater purification and sustainable ammonia synthesis, providing promising design principles for advanced electrocatalysts.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2194–2202"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient CO2 Capture and Conversion from Flue Gas Enabled by an Indolo[3,2-b]carbazole-Based Copper Metal–Organic Framework 吲哚[3,2-b]咔唑基铜金属有机骨架实现烟气中CO2的高效捕集和转化

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-21 DOI: 10.1021/acsmaterialslett.6c00577

Hang-Ou Qi, Xiao-Han Li, Ze-Jiu Diao, Fan Li, Xiaoyu Wu, Lifeng Ding, Guoliang Liu, Lin-Bing Sun

{"title":"Efficient CO2 Capture and Conversion from Flue Gas Enabled by an Indolo[3,2-b]carbazole-Based Copper Metal–Organic Framework","authors":"Hang-Ou Qi, Xiao-Han Li, Ze-Jiu Diao, Fan Li, Xiaoyu Wu, Lifeng Ding, Guoliang Liu, Lin-Bing Sun","doi":"10.1021/acsmaterialslett.6c00577","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00577","url":null,"abstract":"The capture of CO2 from flue gas and its subsequent conversion into value-added chemicals is essential for carbon neutrality. Herein, we report NUT-90, an nbo type metal–organic framework assembled from Cu ions and indolo[3,2-b]carbazole (ICZ)-functionalized ligands, which serves this dual function. NUT-90 shows strong affinity for CO2, with an adsorption capacity of 95.1 cm3 g–1 and an IAST selectivity of 114.7 (CO2/N2 = 15/85, 298 K). Density functional theory calculations indicate that ICZ groups and unsaturated Cu sites act cooperatively as Lewis base-acid pairs for CO2 binding. Moreover, as a heterogeneous catalyst at 328 K, NUT-90 converts CO2 from flue gas with bromopropylene oxide into cyclic carbonate, achieving up to 99% yield and maintaining activity over four cycles. This work demonstrates NUT-90 as a viable material platform for integrated CO2 capture and utilization.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2373–2379"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Microwave Synthesis of Co–Mn–Ni–Pd–Pt High-Entropy Alloy Nanoparticles with Engineered Twin Boundaries for Alkaline Hydrogen Evolution Reaction 微波快速合成用于碱氢析氢反应的Co-Mn-Ni-Pd-Pt高熵合金纳米颗粒

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-02 DOI: 10.1021/acsmaterialslett.6c00370

Athira M. Chandran, Risana M. Jasmin, Ramya B. Prabhu, Bhagavatula L.V. Prasad, Ashutosh K. Singh

{"title":"Rapid Microwave Synthesis of Co–Mn–Ni–Pd–Pt High-Entropy Alloy Nanoparticles with Engineered Twin Boundaries for Alkaline Hydrogen Evolution Reaction","authors":"Athira M. Chandran, Risana M. Jasmin, Ramya B. Prabhu, Bhagavatula L.V. Prasad, Ashutosh K. Singh","doi":"10.1021/acsmaterialslett.6c00370","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00370","url":null,"abstract":"Breaking conventional catalytic scaling relations remains a major challenge in designing efficient electrocatalysts for the hydrogen evolution reaction (HER). Here, we report an ultrafast microwave-assisted strategy for scalable synthesis of nanostructured Co–Mn–Ni–Pd–Pt high-entropy alloy (HEA) electrocatalysts within 5 min. Volumetric microwave heating enables synchronized reduction of multiple metals, producing phase-pure HEA nanoparticles (∼5 nm) with homogeneous elemental distribution. The complex atomic configuration induces significant lattice distortion and hierarchical twinning defects, which may modulate the d-band center and tailor hydrogen intermediate (H*) adsorption energetics.1−3 The optimized HEA catalyst on functionalized carbon delivers outstanding alkaline HER performance, requiring only 28.7 mV overpotential at –10 mA cm–2, outperforming commercial Pt/C at substantially lower noble-metal loading. The catalyst further demonstrates excellent activity in simulated and natural seawater with long-term stability over 100 h. This work establishes microwave-driven synthesis of defect-engineered HEAs as a rapid, scalable platform for next-generation electrocatalysts.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2241–2248"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-Based Recyclable Thermosets: From Renewable Sources to Circular Materials 生物基可回收热固性材料：从可再生资源到循环材料

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-02 DOI: 10.1021/acsmaterialslett.6c00126

Xiaotong Fan, Wendy Rusli, Claire Yu Qing Neo, Enyi Ye, Dan Kai, Zibiao Li, Xian Jun Loh, Jie Zheng

{"title":"Bio-Based Recyclable Thermosets: From Renewable Sources to Circular Materials","authors":"Xiaotong Fan, Wendy Rusli, Claire Yu Qing Neo, Enyi Ye, Dan Kai, Zibiao Li, Xian Jun Loh, Jie Zheng","doi":"10.1021/acsmaterialslett.6c00126","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00126","url":null,"abstract":"Integrating dynamic covalent networks with bio-based resources offers a powerful strategy to create recyclable thermosets while mitigating environmental and resource-related risks, advancing materials development toward a circular economy. Beyond sustainability, the structural diversity and functionality of renewable feedstock provide unique opportunities to design bio-based thermosets with tailored properties and advanced performance. This review summarizes recent progress in bio-based recyclable thermosetting polymers, with particular emphasis on the rational selection of renewable building blocks and their incorporation into recyclable, reprocessable, and high-performance networks. Key bio-derived functional motifs are discussed in terms of their reactivity, availability, and compatibility with dynamic covalent chemistries. Representative examples demonstrate closed-loop recycling, self-healing, stress relaxation, and shape reconfiguration without sacrificing mechanical integrity. Applications in carbon-fiber-reinforced polymer composites, flame-retardant materials, adhesives, and foams are highlighted to illustrate translational potential. Finally, remaining challenges and future opportunities are discussed, providing design principles for next-generation sustainable thermosets.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2091–2113"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148666316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn3O4 Nanoparticles Modulate Redox Homeostasis to Mitigate Nanoplastic-Induced Phytotoxicity Mn3O4纳米颗粒调节氧化还原稳态以减轻纳米塑料诱导的植物毒性

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-06 DOI: 10.1021/acsmaterialslett.6c00515

Shengmei Kang, Fan Wang, Jiawei Chen, Yong Yan, Sheng Cheng, Izabela Jośko, Feng Wang

{"title":"Mn3O4 Nanoparticles Modulate Redox Homeostasis to Mitigate Nanoplastic-Induced Phytotoxicity","authors":"Shengmei Kang, Fan Wang, Jiawei Chen, Yong Yan, Sheng Cheng, Izabela Jośko, Feng Wang","doi":"10.1021/acsmaterialslett.6c00515","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00515","url":null,"abstract":"Nanoplastics are emerging stressors to terrestrial plants, yet effective mitigation strategies remain limited. Here, representative oxide nanoparticles (SiO2, TiO2, Fe3O4, and Mn3O4) were compared for alleviating nanoplastic-induced phytotoxicity. Mn3O4 showed the strongest protective effects against polystyrene nanoplastics (PS-NPs) with distinct surface charges, which induced oxidative stress, impaired photosystem II function, and weakened antioxidant defenses. Mn3O4 mitigated these effects by modulating reactive oxygen species levels and spatial distribution at the nanoplant interface, rather than acting solely as a passive radical scavenger. Physiological analyses showed improved photosynthetic efficiency, reduced lipid peroxidation, and enhanced antioxidant capacity. Transcriptomic profiling further revealed redox-related, metabolic, and structural adjustments consistent with an adaptive stress response. The protective effects of Mn3O4 were validated across multiple plant species and cultivation systems, highlighting a nanomaterial-enabled strategy for improving plant resilience under nanoplastic stress.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2354–2363"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148666322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-Azolate Metal−Organic Framework as Cathode Material for Electrocatalytic CO2 Reduction within a Zero-Gap Electrolyzer 铜-偶氮酸盐金属-有机骨架作为零间隙电解槽内电催化CO2还原的正极材料

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-09 DOI: 10.1021/acsmaterialslett.6c00309

Francesca Greenwell, Chenxi Li, Stefano Magliocco, Alice Pellegrino, Amol Kumar, Anna Wach, Wojciech Błachucki, Erik Svensson Grape, Mårten Ahlquist, Sascha Ott

{"title":"Copper-Azolate Metal−Organic Framework as Cathode Material for Electrocatalytic CO2 Reduction within a Zero-Gap Electrolyzer","authors":"Francesca Greenwell, Chenxi Li, Stefano Magliocco, Alice Pellegrino, Amol Kumar, Anna Wach, Wojciech Błachucki, Erik Svensson Grape, Mårten Ahlquist, Sascha Ott","doi":"10.1021/acsmaterialslett.6c00309","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00309","url":null,"abstract":"Electrochemical CO2 reduction (eCO2R) is a sustainable strategy for converting CO2 into value-added chemicals. Here, we report the Cu-azolate metal−organic framework (MOF) CuBBTA (Cu2Cl2-bbta, MAF-X29) as a stable electrocatalyst for eCO2R in a zero-gap electrolyzer. CuBBTA was spray-coated onto carbon paper using either PTFE or Nafion binders to form gas diffusion electrodes that achieved Faradaic efficiencies of up to 50% for carbon-containing products (CH4, C2H4, and CO) at current densities as high as 100 mA cm−2 under a flow of CO2. Post-electrolysis studies confirmed retention of the MOF structure. DFT calculations reveal that CO2 reduction proceeds via COOH* and CO* intermediates, with a thermodynamically favourable and kinetically accessible CO*−CO* dimerization pathway for ethylene formation. Importantly, polymer binder selection significantly influences product selectivity. While PTFE favours methane formation, Nafion shifts selectivity toward CO, highlighting the critical yet underexplored role of electrode environment in MOF-based eCO2R catalysis.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2186–2193"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Atomic Composition through Transmetalation for Isostructural Multimetallic Metal–Organic Frameworks 等结构多金属金属-有机框架的金属转化可编程原子组成

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-02 DOI: 10.1021/acsmaterialslett.6c00458

Alyson S. Plaman, Haley Wellman, R. J. Cassem, Kent O. Kirlikovali, Omar K. Farha

{"title":"Programmable Atomic Composition through Transmetalation for Isostructural Multimetallic Metal–Organic Frameworks","authors":"Alyson S. Plaman, Haley Wellman, R. J. Cassem, Kent O. Kirlikovali, Omar K. Farha","doi":"10.1021/acsmaterialslett.6c00458","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00458","url":null,"abstract":"Heterometallic metal–organic frameworks (MOFs) offer properties unachievable in monometallic systems, yet their rational synthesis remains limited by thermodynamic biases that favor a narrow set of inorganic node geometries. Here, we report a generalizable post-synthetic strategy to construct isostructural multimetallic MOFs through controlled transmetalation of NU-3001. We incorporate metals spanning distinct regions of the periodic table, including transition metals (Fe, Zr), lanthanides (Ho), and actinides (Th). Comprehensive characterization confirms uniform metal incorporation while preserving the parent MOF topology, crystallinity, and porosity. Time-dependent studies reveal metal-dependent exchange preferences; variable-temperature diffraction and sorption measurements demonstrate comparable thermal stability across derivatives, with some maintaining crystallinity up to 450 °C and porosity up to 300 °C. We show that analogous materials cannot be accessed through de novo synthesis methods, underscoring the essential role of transmetalation in overcoming thermodynamic preferences. This work establishes NU-3001 as a versatile platform for constructing compositionally programmable multimetallic MOFs.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2308–2316"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148675488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymerization-Induced Electrostatic Self-Assembly Enables Noncytotoxic Polyplex Formation for Gene Delivery 聚合诱导的静电自组装使基因传递的非细胞毒性多聚体形成

IF 8.6 1区化学

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-04-15 DOI: 10.1021/acsmaterialslett.6c00077

Maria A. Castillo, Jungyeon Kim, Francesca Patel-Burrows, Xueyuan Li, Antony Adamson, Lee A. Fielding, Samuel T. Jones

{"title":"Polymerization-Induced Electrostatic Self-Assembly Enables Noncytotoxic Polyplex Formation for Gene Delivery","authors":"Maria A. Castillo, Jungyeon Kim, Francesca Patel-Burrows, Xueyuan Li, Antony Adamson, Lee A. Fielding, Samuel T. Jones","doi":"10.1021/acsmaterialslett.6c00077","DOIUrl":"https://doi.org/10.1021/acsmaterialslett.6c00077","url":null,"abstract":"Gene delivery is a cornerstone of both basic researchand genetherapy, where it holds the key to treating genetic disorders at theirsource. However, it does not adhere to one-size-fits-all solutions.Cargo-tailored and time-saving approaches are urgently needed fordifferent applications. Photoinduced electron/energy transfer reversibleaddition-fragmentation chain-transfer (PET-RAFT) polymerization isa technique that enables the synthesis of a wide range of well-definedpolymers, allowing for rapid reaction condition screening in smallvolumes. In this work, polymerization-induced electrostatic self-assembly(PIESA) based on PET-RAFT polymerization is demonstrated to facilitatethe simultaneous synthesis and assembly of pDNA polyplexes for transfection.The as-prepared polyplexes are shown to be less cytotoxic than theirconventionally assembled counterparts and act as more effective genedelivery vehicles in transfection trials. This strategy provides aversatile platform that facilitates rapid screening of cell-compatiblecopolymer nanoparticle compositions for gene delivery in ultralowvolumes.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"8 8","pages":"2139–2147"},"PeriodicalIF":8.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0