Pediatric Gastroenterology, Hepatology & Nutrition最新文献_第6页

Serum Eosinophilic Cationic Protein as a Useful Noninvasive Marker of Eosinophilic Gastrointestinal Disease in Children. 血清嗜酸性粒细胞阳离子蛋白是儿童嗜酸性粒细胞性胃肠病的有效无创标记物

IF 1.9

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-03-01 Epub Date: 2024-03-04 DOI: 10.5223/pghn.2024.27.2.79

Hae Ryung Kim, Youie Kim, Jin Soo Moon, Jae Sung Ko, Hye Ran Yang

{"title":"Serum Eosinophilic Cationic Protein as a Useful Noninvasive Marker of Eosinophilic Gastrointestinal Disease in Children.","authors":"Hae Ryung Kim, Youie Kim, Jin Soo Moon, Jae Sung Ko, Hye Ran Yang","doi":"10.5223/pghn.2024.27.2.79","DOIUrl":"10.5223/pghn.2024.27.2.79","url":null,"abstract":"Purpose: Recently, the prevalence of eosinophilic gastrointestinal disease (EGID) has shown an increasing trend worldwide. As the diagnosis of EGID requires invasive endoscopy with biopsy, noninvasive markers for detecting EGID in suspected patients, particularly children, are urgently needed. Therefore, this study aimed to evaluate the diagnostic accuracy of serum eosinophil cationic protein (ECP) beyond peripheral eosinophil counts in pediatric patients with EGID.Methods: Overall, 156 children diagnosed with EGID were enrolled and 150 children with functional abdominal pain disorder (FAPD) were recruited as controls. All participants underwent endoscopic biopsy in each segment of the gastrointestinal (GI) tract and serum ECP measurement, as well as peripheral eosinophil percent and absolute eosinophil count.Results: Comparing EGID (n=156) with FAPD (n=150) patients, serum ECP levels were significantly higher in pediatric patients with EGID than in those with FAPD (25.8±28.6 µg/L vs. 19.5±21.0 µg/L, p=0.007), while there was no significant difference in peripheral eosinophil percent and absolute eosinophil counts between the two groups. Serum ECP levels were correlated with peripheral eosinophil percent (r=0.593, p<0.001) and the absolute eosinophil count (r=0.660, p<0.001). The optimal cutoff value of serum ECP for pediatric EGID was 10.5 µg/mL, with a sensitivity of 69.9% and a specificity of 43.4% with an area under the receiver operating characteristic curve of 0.562.Conclusion: The combination of serum ECP levels and peripheral eosinophil counts, when employed with appropriated thresholds, could serve as a valuable noninvasive biomarker to distinguish between EGID and FAPD in pediatric patients manifesting GI symptoms.","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 2","pages":"79-87"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of Pyloric Length Measurement for Detecting Severe Metabolic Alkalosis in Infants with Hypertrophic Pyloric Stenosis. 幽门长度测量对检测肥厚性幽门狭窄婴儿严重代谢性碱中毒的实用性

IF 1.9

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-03-01 Epub Date: 2024-03-04 DOI: 10.5223/pghn.2024.27.2.88

Hyun Jin Kim

{"title":"Utility of Pyloric Length Measurement for Detecting Severe Metabolic Alkalosis in Infants with Hypertrophic Pyloric Stenosis.","authors":"Hyun Jin Kim","doi":"10.5223/pghn.2024.27.2.88","DOIUrl":"10.5223/pghn.2024.27.2.88","url":null,"abstract":"Purpose: Infantile hypertrophic pyloric stenosis (IHPS) is a common gastrointestinal disease in neonates and hypochloremia metabolic alkalosis is a typical laboratory finding in affected patients. This study aimed to analyze the clinical characteristics of infants with IHPS and evaluate the association of clinical and laboratory parameters with ultrasonographic findings.Methods: Infants diagnosed with IHPS between January 2017 and July 2022 were retrospectively evaluated.Results: A total of 67 patients were included in the study. The mean age at diagnosis was 40.5±19.59 days, and the mean symptom duration was 11.97±9.91 days. The mean pyloric muscle thickness and pyloric canal length were 4.87±1.05 mm and 19.6±3.46 mm, respectively. Hyponatremia and metabolic alkalosis were observed in five (7.5%) and 36 (53.7%) patients, respectively. Serum sodium (p=0.011), potassium (p=0.023), and chloride levels (p=0.015) were significantly lower in patients with high bicarbonate levels (≥30 mmol/L). Furthermore, pyloric canal length was significantly higher in patients with high bicarbonate levels (p=0.015). To assess metabolic alkalosis in IHPS patients, the area under the receiver operating characteristic curve of pyloric canal length was 0.910 and the optimal cutoff value of the pyloric canal length was 23.5 mm.Conclusion: We found a close association between laboratory and ultrasonographic findings of IHPS. Clinicians should give special consideration to patients with pyloric lengths exceeding 23.5 mm and appropriate fluid rehydration should be given to these patients.","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 2","pages":"88-94"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which Alarm Symptoms Are Associated With Abnormal Gastrointestinal Endoscopy Among Thai Children? 哪些报警症状与泰国儿童消化道内窥镜检查异常有关？

IF 1.9

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-03-01 Epub Date: 2024-03-04 DOI: 10.5223/pghn.2024.27.2.113

Anundorn Wongteerasut

{"title":"Which Alarm Symptoms Are Associated With Abnormal Gastrointestinal Endoscopy Among Thai Children?","authors":"Anundorn Wongteerasut","doi":"10.5223/pghn.2024.27.2.113","DOIUrl":"10.5223/pghn.2024.27.2.113","url":null,"abstract":"Purpose: Alarm symptoms (red flag signs) are crucial indications for management decisions on pediatric gastrointestinal endoscopy. We aimed to identify items in the alarm symptoms and pre-endoscopic investigations that predict abnormal endoscopy results.Methods: A retrospective descriptive study was conducted among children aged under 18 years undergoing endoscopy. The patients were classified into normal and abnormal endoscopic groups. The incidence of alarm symptoms and pre-endoscopic investigations were compared between the groups. Univariate and multivariate logistic regression analyses were performed to determine independent risk factors for abnormal endoscopy.Results: Of 148 participants, 66 were classified in the abnormal endoscopy group. Compared with the normal group, the abnormal group had a significantly higher prevalence of alarm symptoms. Moreover, hematemesis/hematochezia, anemia, low hemoglobin level, hypoalbuminemia, rising erythrocyte sedimentation rate, increased serum lipase, and blood urea nitrogen/creatinine ratio were significantly higher in the abnormal endoscopy group than in the normal group. Multivariate logistic regression analysis indicated that hematemesis/hematochezia and low hemoglobin level were independent risk factors for abnormal endoscopy.Conclusion: The alarm symptoms and pre-endoscopic investigations were evaluated using predictive factors for abnormal pediatric endoscopic findings. According to multivariate logistic regression analysis, hematemesis/hematochezia and low hemoglobin levels were independent risk factors for abnormal endoscopy.","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 2","pages":"113-124"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Profile and Outcomes of Children with Acute Liver Failure in a Tertiary Care Center in South India: A Retrospective Study. 印度南部一家三级医疗中心急性肝衰竭患儿的临床概况和预后：回顾性研究

IF 1.3

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-01-01 Epub Date: 2024-01-09 DOI: 10.5223/pghn.2024.27.1.43

Anitha Abimannane, Bobbity Deepthi, Rohit Bhowmick, Narayanan Parameswaran

{"title":"Clinical Profile and Outcomes of Children with Acute Liver Failure in a Tertiary Care Center in South India: A Retrospective Study.","authors":"Anitha Abimannane, Bobbity Deepthi, Rohit Bhowmick, Narayanan Parameswaran","doi":"10.5223/pghn.2024.27.1.43","DOIUrl":"10.5223/pghn.2024.27.1.43","url":null,"abstract":"Purpose: In this study, we investigated the clinical profile, survival at discharge, and proportion of children with acute liver failure (ALF) meeting the criteria for, yet surviving without, liver transplantation (LT).Methods: Medical case records of children aged >28 days to ≤15 years over a period of 7 years, identified from pediatric admission and discharge registers, were screened. Children satisfying the criteria for ALF were included in this study.Results: A total of 71 records meeting the pediatric ALF (PALF) criteria were included. The survival rate at discharge was 61% (n=44). A considerable proportion of children satisfied the King's College Criteria (KCC) (56.3%) and the European Association for the Study of the Liver (EASL) criteria (7%) for LT at admission. Nonetheless, the survival rate in the absence of LT was 42.5% in children who satisfied the KCC and 20% in those who met the EASL criteria. Infection (29.5%) and paracetamol overdose (19.7%) were the major identifiable causes of PALF. Hepatitis A was the most common infection identified. No significant predictors of poor outcomes were identified in multivariable analysis.Conclusion: Our study highlights the changing survival rates and the clinical and etiological profiles of patients with PALF. In areas with poor access to LT services, survival in these children could be improved through early referral to centers with adequate intensive care facilities. Preventing ALF and referring patients to LT services are paramount to reducing mortality.","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 1","pages":"43-52"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Impact of the Coronavirus Disease 2019 Pandemic on Pediatric Gastrointestinal Endoscopy: A Questionnaire-based Internet Survey of 162 Institutional Experiences in Asia Pacific. 更正：2019年冠状病毒疾病大流行对儿科消化道内窥镜检查的影响：对亚太地区 162 家机构经验的问卷式互联网调查。

IF 1.9

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-01-01 Epub Date: 2024-01-09 DOI: 10.5223/pghn.2024.27.1.77

Andy Darma, Katsuhiro Arai, Jia-Feng Wu, Nuthapong Ukarapol, Shin-Ichiro Hagiwara, Seak Hee Oh, Suporn Treepongkaruna

引用次数: 0

Outcomes of Portosystemic Shunts in Children with and without Liver Transplantation. 肝移植和未接受肝移植的儿童门静脉分流的效果。

IF 1.3

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-01-01 Epub Date: 2024-01-09 DOI: 10.5223/pghn.2024.27.1.37

Hamza Hassan Khan, Stuart S Kaufman, Nada A Yazigi, Khalid M Khan

{"title":"Outcomes of Portosystemic Shunts in Children with and without Liver Transplantation.","authors":"Hamza Hassan Khan, Stuart S Kaufman, Nada A Yazigi, Khalid M Khan","doi":"10.5223/pghn.2024.27.1.37","DOIUrl":"10.5223/pghn.2024.27.1.37","url":null,"abstract":"Purpose: Limited data exist regarding outcome and morbidity associated with portosystemic shunts in the pediatric transplant population. Our study assesses the outcomes of pediatric patients who underwent a portosystemic shunt procedure, both with and without liver transplantation (LT).Methods: This study retrospectively reviewed the medical records of pediatric patients aged 0-19 years who underwent shunt placement between 2003 and 2017 at a tertiary care center. The analysis included cases of shunt placement with or without LT.Results: A total of 13 pediatric patients were included in the study with median age of 8.8 years. Among the cases, 11 out of 13 (84.6%) underwent splenorenal shunt, 1 (7.7%) underwent a mesocaval shunt, and another 1 (7.7%) underwent a Modified Rex (mesoportal) shunt. Additionally, 5 out of 13 (38.5%) patients had LT, with 4 out of 5 (80.0%) receiving the transplant before shunt placement, and 1 out of 5 (20.0%) receiving it after shunt placement. Gastrointestinal bleeding resulting from portal hypertension was the indication in all cases. A total of 10 complications were reported in 5 patients; the most common complication was anemia in 3 (23.1%) patients. At the most recent follow-up visit, the shunts were functional without encephalopathy, and no deaths were reported.Conclusion: Shunt placement plays a crucial role in the management of patients with portal hypertension. Our study demonstrates favorable long-term outcomes in pediatric patients who underwent shunt placement. Long term shunt outcomes were similar and unremarkable in patients with LT and without LT.","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 1","pages":"37-42"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Probiotics in the Treatment and Prevention of Common Gastrointestinal Conditions in Children. 益生菌在治疗和预防儿童常见胃肠道疾病中的作用。

IF 1.3

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-01-01 Epub Date: 2024-01-09 DOI: 10.5223/pghn.2024.27.1.1

Iva Hojsak, Sanja Kolaček

引用次数: 0

Mucosal Immunity Related to CD8⁺ T Lymphocytes in Children with Helicobacter pylori Gastritis. 幽门螺杆菌胃炎患儿与 CD8+ T 淋巴细胞有关的粘膜免疫。

IF 1.3

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-01-01 Epub Date: 2024-01-09 DOI: 10.5223/pghn.2024.27.1.26

Da Hee Yang, Ha Young Lee, Woohyuk Choi, Chang-Lim Hyun, Ki Soo Kang

{"title":"Mucosal Immunity Related to CD8+ T Lymphocytes in Children with Helicobacter pylori Gastritis.","authors":"Da Hee Yang, Ha Young Lee, Woohyuk Choi, Chang-Lim Hyun, Ki Soo Kang","doi":"10.5223/pghn.2024.27.1.26","DOIUrl":"10.5223/pghn.2024.27.1.26","url":null,"abstract":"Purpose: We investigated the role of CD8+T cells as host immune factors in pediatric patients with Helicobacter pylori gastritis.Methods: Gastric mucosal tissue and blood samples were collected from 39 children, including 11 children with H. pylori infection and 28 children as controls. Anti-CD8 and anti-T-bet antibodies were used for immunohistochemistry of the gastric mucosa. For the cell surface and intracellular staining, peripheral blood mononuclear cells were stained with anti-IL7Rα, anti-CX3CR1, anti-CD8, anti-T-bet, and anti-IFN-γ antibodies. Cytokines of sera such as tumor necrosis factor alpha (TNF-α) and CX3CL1 were analyzed using enzyme- linked immunosorbent assay (ELISA).Results: In the immunohistochemistry of gastric mucosa, the frequency of CD8+ and T-bet+ T cells cells was higher in the H. pylori-positive group than in the control group (26.9± 7.8% vs. 16.9±3.3%, p<0.001; 5.0±2.5% vs. 2.2±0.7%, p=0.001). Between the control and H. pylori-positive groups, the frequency of IL-7RαlowCX3CR1+ CD8+ and T-bet+ INF-γ+ CD8+ T cells were not significantly different between surface and intracellular staining, respectively (40.4±24.0% vs. 38.2±17.8%, p=0.914; 40.4±24.0% vs. 38.2±17.8%, p=0.914). In the ELISA, no significant differences in TNF-α and CX3CL1 concentrations were observed between the control and H. pylori-positive groups (34.3±12.1 pg/mL vs. 47.0±22.6 pg/mL, p=0.114/0.5± 0.1 pg/mL vs. 0.5±0.1 pg/mL, p=0.188).Conclusion: CD8+ T and Th1 cells, which secrete IFN-γ, might play important roles in the mucosal immunity of the stomach in children with H. pylori infection.","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 1","pages":"26-36"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Use of Bortezomib for Recurrent Progressive Familial Intrahepatic Cholestasis Type II After Liver Transplantation: A Pediatric Case with a 9-Year Follow-Up. 硼替佐米成功治疗肝移植后复发的进行性家族性肝内胆汁淤积症II型：一个随访 9 年的儿科病例。

IF 1.3

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-01-01 Epub Date: 2024-01-09 DOI: 10.5223/pghn.2024.27.1.71

Yu Gyoung Bak, Ho Jung Choi, Yeong Eun Kim, Seak Hee Oh, Kyung Mo Kim

引用次数: 0

Histopathological Study and Expression of Beta-Catenin in Congenital Choledochal Cyst in a Tertiary Care Pediatric Referral Center in South India. 印度南部一家三级儿科转诊中心对先天性胆总管囊肿的组织病理学研究和 Beta-Catenin 的表达。

IF 1.3

Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-01-01 Epub Date: 2024-01-09 DOI: 10.5223/pghn.2024.27.1.62

Rashmi Tresa Philpose, Abdul Aleem Mohammed, Ashrith Reddy Gowni

{"title":"Histopathological Study and Expression of Beta-Catenin in Congenital Choledochal Cyst in a Tertiary Care Pediatric Referral Center in South India.","authors":"Rashmi Tresa Philpose, Abdul Aleem Mohammed, Ashrith Reddy Gowni","doi":"10.5223/pghn.2024.27.1.62","DOIUrl":"10.5223/pghn.2024.27.1.62","url":null,"abstract":"Purpose: Choledochal cysts are congenital anomalies that occur as localized cystic or fusiform dilatations of the biliary tree. Reflux and stasis of pancreatic enzymes in the biliary duct may relate to the development of intestinal metaplasia which might be an important factor related to the carcinogenesis of choledochal cyst, thus the expression of beta-catenin in the metaplastic epithelium might be associated with malignant transformation of choledochal cyst epithelium.Methods: This study was conducted at a tertiary care pediatric center between October 2014 and March 2017. Forty patients were evaluated for epithelial lining, mural ulceration, fibrosis, inflammation, and metaplasia.Results: Out of 40, 12 cases (30.0%) were the infantile age group and 28 cases (70.0%) were in the classic pediatric group. Ulceration was classified as grade 0 (14 cases, 35.0%), grade 1 (17 cases, 42.5%), or grade 2 (nine cases, 22.5%). Inflammation was classified as grade 0 (2 cases, 5.0%), grade 1 (26 cases, 65.0%), or grade 2 (12 cases, 30.0%). Fibrosis was classified as grade 0 (five cases, 12.5%), grade 1 (11 cases, 27.5%), grade 2 (17 cases, 42.5%), or grade 3 (seven cases, 17.5%). Metaplasia was noted in five (12.5%) out of 40 cases. All choledochal cysts with metaplasia showed beta-catenin nuclear positivity on immunohistochemistry and were followed up.Conclusion: This study emphasizes the importance of detailed histopathological examination and documentation of metaplastic changes. Metaplasia was associated with beta-catenin nuclear positivity. These findings suggest a potential role for beta-catenin as a marker of metaplastic changes in choledochal cysts.","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 1","pages":"62-70"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0