Pediatric Gastroenterology, Hepatology & Nutrition最新文献

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Is a Training Program in Pediatric Abdominal Ultrasonography Necessary for Pediatricians? 儿科医生有必要参加小儿腹部超声波检查培训课程吗?
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.5223/pghn.2024.27.6.333
Soon Chul Kim
{"title":"Is a Training Program in Pediatric Abdominal Ultrasonography Necessary for Pediatricians?","authors":"Soon Chul Kim","doi":"10.5223/pghn.2024.27.6.333","DOIUrl":"10.5223/pghn.2024.27.6.333","url":null,"abstract":"<p><p>Despite being an essential specialty, pediatrics in South Korea faces the threat of collapse. While the declining birth rate is an important contributor to the decrease in the pediatric population, a more critical issue lies in the dysfunctional healthcare system. Primary care pediatricians are troubled by the lack of patients, whereas tertiary care specialists are concerned about the shortage of doctors. Although the absolute number of pediatric specialists is not small, there is a scarcity of doctors willing to specialize in pediatrics. Recently, pediatric abdominal ultrasonography has been conducted in tertiary hospitals. However, there is an argument that this responsibility should be shifted to primary care pediatricians. As someone who has been performing pediatric abdominal ultrasound examinations for years, I am committed to educating pediatric specialists in this field. My aim is to contribute, albeit modestly, to improving the South Korean healthcare system.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 6","pages":"333-335"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1-14 Years with Chronic Gastric Acid-Related Disease. 更正:日本 1-14 岁患有慢性胃酸相关疾病的儿科患者长期服用埃索美拉唑的有效性和安全性。
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.5223/pghn.2024.27.6.383
Masaaki Mori, Yoshiko Nakayama, Shigeo Nishimata, Tadafumi Yokoyama, Ryo Matsuoka, Reiko Hatori, Masaki Shimizu, Katsuhiro Arai, Yuri Etani, Tsuyoshi Sogo, Tomoko Ishizu, Masahiro Nii, Ryosuke Nakashima, Toshiaki Shimizu
{"title":"Correction: Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1-14 Years with Chronic Gastric Acid-Related Disease.","authors":"Masaaki Mori, Yoshiko Nakayama, Shigeo Nishimata, Tadafumi Yokoyama, Ryo Matsuoka, Reiko Hatori, Masaki Shimizu, Katsuhiro Arai, Yuri Etani, Tsuyoshi Sogo, Tomoko Ishizu, Masahiro Nii, Ryosuke Nakashima, Toshiaki Shimizu","doi":"10.5223/pghn.2024.27.6.383","DOIUrl":"https://doi.org/10.5223/pghn.2024.27.6.383","url":null,"abstract":"<p><p>[This corrects the article on p. 274 in vol. 27, PMID: 39319279.].</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 6","pages":"383-384"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Factors associated with Bowel Dysfunctions after Pull-Through Surgery in Children Diagnosed with Hirschsprung Disease. 被诊断患有赫氏prung 病的儿童接受拉通手术后肠道功能障碍的发生率和相关因素。
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.5223/pghn.2024.27.6.372
Maliwan Surasen, Palittiya Sintusek, Nimmita Srisan, Katawaetee Decharun, Paisarn Vejchapipat
{"title":"Prevalence and Factors associated with Bowel Dysfunctions after Pull-Through Surgery in Children Diagnosed with Hirschsprung Disease.","authors":"Maliwan Surasen, Palittiya Sintusek, Nimmita Srisan, Katawaetee Decharun, Paisarn Vejchapipat","doi":"10.5223/pghn.2024.27.6.372","DOIUrl":"10.5223/pghn.2024.27.6.372","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the prevalence of bowel dysfunction and associated factors after pull-through surgery.</p><p><strong>Methods: </strong>The medical records of children under 18 years old diagnosed with Hirschsprung disease (HD) based on histopathology between 2004 and 2022 were reviewed. Bowel dysfunction after pull-through surgery was categorized into Hirschsprung-associated enterocolitis (HAEC), constipation, and fecal incontinence.</p><p><strong>Results: </strong>Among 97 children diagnosed with HD, the median age at presentation was 3 (2-15) days (84.54% male). The clinical manifestations included abdominal distension (58.76%), constipation (17.52%), bilious vomiting (17.52%), nonbilious vomiting (14.43%), and enterocolitis (12.37%). HDs were classified by the location of aganglionosis: short segments (74.23%), long segments (8.25%), total colonic (12.37%), and small intestinal (5.15%). Excluding surgical complications, the prevalence of bowel dysfunction was 64.95% during an average follow-up of 8.33 years. HAEC was the most common issue (46.39%), followed by nonretentive incontinence (22.68%), constipation (20.62%), and retentive incontinence (15.46%). Preoperative HAEC was significantly associated with post-surgery HAEC (adjusted odds ratio [aOR] 18.31; 95% confidence interval [CI], 1.30-257.73; <i>p</i>=0.031). The Duhamel operation was associated with constipation and retentive incontinence (aOR 62.15; 95% CI, 1.64-2,349.13; <i>p</i>=0.026). Age under 6 months at pull-through surgery was associated with nonretentive fecal incontinence after 4 years (aOR 8.83; 95% CI, 1.11-70.39; <i>p</i>=0.040).</p><p><strong>Conclusion: </strong>The prevalence of bowel dysfunction in children with HD remains high despite successful surgical correction. Preoperative HAEC, Duhamel operation, and pull-through surgery before the age of 6 months were found to be independent factors associated with bowel dysfunction after pull-through surgery.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 6","pages":"372-382"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Nutrition During Continuous Albuterol for Pediatric Critical Asthma: A Matched Cohort Study. 小儿重症哮喘患者在持续服用阿布特罗期间的口服营养:匹配队列研究
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.5223/pghn.2024.27.6.364
Maya Antionette Root, Carolyn Maria Ibrahim Pavlich, Anthony Alexander Sochet, Alexa Rae Roberts, Brett Walter Russi
{"title":"Oral Nutrition During Continuous Albuterol for Pediatric Critical Asthma: A Matched Cohort Study.","authors":"Maya Antionette Root, Carolyn Maria Ibrahim Pavlich, Anthony Alexander Sochet, Alexa Rae Roberts, Brett Walter Russi","doi":"10.5223/pghn.2024.27.6.364","DOIUrl":"10.5223/pghn.2024.27.6.364","url":null,"abstract":"<p><strong>Purpose: </strong>The practice of withholding oral nutrition for children hospitalized for critical asthma receiving continuous albuterol is not evidence based. We sought to characterize oral nutrition practices in this population and estimate the frequency of aspiration-related respiratory failure.</p><p><strong>Methods: </strong>We performed a single-center retrospective, matched cohort study of children 3-17 years of age admitted to a pediatric intensive care unit from Oct 2020 to May 2023 for critical asthma receiving continuous albuterol. Cases provided oral nutrition were matched 1:2 to controls withheld nutrition by age and National Heart Lung and Blood Institute asthma severity classification. The primary outcome was aspiration-related respiratory failure defined as any respiratory support escalation following observed aspiration. Descriptive data included demographics, anthropometrics, pediatric asthma severity scores, adjunct asthma interventions, continuous albuterol duration, mortality, and length of stay.</p><p><strong>Results: </strong>Of 36 cases and 72 matched controls, the mean age was 9.1±3.9 years and 66.7% had moderate-severe persistent asthma. Cases and controls had comparable anthropometrics and admission pediatric asthma severity scores. No aspiration-related respiratory failure events were observed even among those receiving nutrition concurrent to noninvasive ventilation. Compared to controls, cases experienced a longer continuous albuterol duration (median: 1.1 [interquartile range: 0.7-1.8] versus 0.7 [interquartile range: 0.3-1.3] days, <i>p</i><0.001). No differences in length of stay, adjunct interventions, endotracheal intubation rates, and mortality were observed between cases and controls.</p><p><strong>Conclusion: </strong>For children hospitalized for critical asthma, oral nutrition during continuous nebulized albuterol appeared well tolerated. While prospective validation is required, the practice of withholding oral nutrition for continuous albuterol administration may be unwarranted.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 6","pages":"364-371"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence, Management, and Outcomes of Non-Invasive Helicobacter pylori Testing in Children at a Tertiary Paediatric Hospital in Singapore. 新加坡一家三级儿科医院对儿童进行非侵入性幽门螺杆菌检测的患病率、管理和结果。
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.5223/pghn.2024.27.6.336
Charanya Rajan, Fang Kuan Chiou, Christopher Wen Wei Ho
{"title":"Prevalence, Management, and Outcomes of Non-Invasive <i>Helicobacter pylori</i> Testing in Children at a Tertiary Paediatric Hospital in Singapore.","authors":"Charanya Rajan, Fang Kuan Chiou, Christopher Wen Wei Ho","doi":"10.5223/pghn.2024.27.6.336","DOIUrl":"10.5223/pghn.2024.27.6.336","url":null,"abstract":"<p><strong>Purpose: </strong><i>Helicobacter pylori</i> infections differ between children and adults. The Pediatric society practice guidelines recommend against a test-and-treat approach, characterized by the use of non-invasive tests for diagnosis (e.g. urea breath test [UBT] or stool antigen test). However, significant variations exist in clinical practice. This study examined the use of non-invasive testing for the screening and diagnosis of <i>H. pylori</i> infection in children at a tertiary pediatric hospital in Singapore, reviewing both management decisions and patient outcomes.</p><p><strong>Methods: </strong>A retrospective review was conducted on children between the ages of 0 and 18 years who were tested for <i>H. pylori</i> infection using either a stool antigen test or UBT between January 2018 and June 2020.</p><p><strong>Results: </strong>Among the 1,397 children tested, 117 (8.4%) had a positive stool <i>H. pylori</i> antigen result, and 5 out of 85 tested (5.9%) had a positive UBT. Abdominal pain was the predominant symptom (n=98; 80.3%). Only 7 treatment-naïve children had biopsy-proven disease. Tissue biopsies for <i>H. pylori</i> culture were sent to 2 children, with 1 negative result. A total of 111 children (91.0%) received treatment, wherein proton pump inhibitor, amoxicillin, and clarithromycin for 14 days was the most common therapeutic regimen. Symptom resolution was observed in 62 children (50.8%).</p><p><strong>Conclusion: </strong>A test-and-treat strategy was more widely utilized than endoscopy-based testing, showing a low compliance to existing guidelines for the management of <i>H. pylori</i> infections in children at our center and significant false-positive rates.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 6","pages":"336-344"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of IL-7RαlowCX3CR1+ CD8+ T Cells and α4β7 Integrin Tagged T Cells Related to Mucosal Immunity in Children with Inflammatory Bowel Disease. 炎症性肠病患儿中与粘膜免疫相关的 IL-7RαlowCX3CR1+ CD8+ T 细胞和 α4β7 Integrin 标记 T 细胞的表达。
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.5223/pghn.2024.27.6.345
Da Hee Yang, Hyo Jin Kim, Duong Thi Thuy Dinh, Jiwon Yang, Chang-Lim Hyun, Youngheun Jee, Naeun Lee, Min Sun Shin, Insoo Kang, Ki Soo Kang
{"title":"Expression of IL-7Rα<sup>low</sup>CX3CR1<sup>+</sup> CD8<sup>+</sup> T Cells and α4β7 Integrin Tagged T Cells Related to Mucosal Immunity in Children with Inflammatory Bowel Disease.","authors":"Da Hee Yang, Hyo Jin Kim, Duong Thi Thuy Dinh, Jiwon Yang, Chang-Lim Hyun, Youngheun Jee, Naeun Lee, Min Sun Shin, Insoo Kang, Ki Soo Kang","doi":"10.5223/pghn.2024.27.6.345","DOIUrl":"10.5223/pghn.2024.27.6.345","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to investigate the recruiting of T lymphocytes including IL-7Rα<sup>low</sup> CX3CR1<sup>+</sup> effector memory (EM) CD8<sup>+</sup> T cells and α4β7 integrin tagged T cells to inflamed intestinal mucosa.</p><p><strong>Methods: </strong>Whole blood and mucosal tissues of intestine were collected from 40 children with or without inflammatory bowel disease (IBD). T cell surface staining and immunohistochemistry were done with several antibodies in peripheral blood mononuclear cells (PBMCs) and intestinal mucosa, respectively. Serum levels of cytokines were measured by ELISA.</p><p><strong>Results: </strong>The frequency of IL-7Rα<sup>low</sup>CX3CR1<sup>+</sup> EM CD8<sup>+</sup> T cells in the PBMC was significantly higher in the ulcerative colitis group than in the control group (57.9±17.80% vs. 33.9±15.70%, <i>p</i>=0.021). The frequency of integrin α4β7<sup>+</sup> CD4<sup>+</sup> T cells in the PBMC was significantly lower in the ulcerative colitis group than in the control group (53.2±27.6% vs. 63.9±13.2%, <i>p</i>=0.022). Serum concentration of TNF-α was higher in the Crohn's disease group than in the control group (26.13±5.01 pg/mL vs. 19.65±6.07 pg/mL, <i>p</i>=0.008). Of the three groups, the ulcerative colitis group had the highest frequency of integrin α4β7<sup>+</sup> T cells based on immunohistochemistry analyses for intestinal tissues, followed by the Crohn's disease group and the control group (4.63±1.29 cells vs. 2.0±0.57 cells vs. 0.84±0.52 cells, <i>p</i><0.001).</p><p><strong>Conclusion: </strong>Trafficking immune cells with effector memory CD8<sup>+</sup> T cells clarified by IL-7Rα<sup>low</sup>CX3CR1<sup>+</sup> and integrin α4β7<sup>+</sup> CD4<sup>+</sup> T cells might be highly associated with the pathogenesis of ulcerative colitis.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 6","pages":"345-354"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment and Characterization of Patient-Derived Intestinal Organoids from Pediatric Crohn's Disease Patients. 从小儿克罗恩病患者中建立患者衍生肠组织细胞并确定其特征
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.5223/pghn.2024.27.6.355
Sunghyun An, Homin Huh, Jae Sung Ko, Jin Soo Moon, Ky Young Cho
{"title":"Establishment and Characterization of Patient-Derived Intestinal Organoids from Pediatric Crohn's Disease Patients.","authors":"Sunghyun An, Homin Huh, Jae Sung Ko, Jin Soo Moon, Ky Young Cho","doi":"10.5223/pghn.2024.27.6.355","DOIUrl":"10.5223/pghn.2024.27.6.355","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to establish and characterize patient-derived intestinal organoids (PDOs) from children with Crohn's disease (CD).</p><p><strong>Methods: </strong>To generate PDOs, endoscopic biopsy specimens were obtained from non-inflamed duodenal bulbs of normal controls and CD patients. To verify the presence of PDOs, histological staining and quantitative reverse transcription polymerase chain reaction (RT-qPCR) analyses were performed.</p><p><strong>Results: </strong>PDOs were successfully established in normal controls (n=2) and CD patients (n=2). Hematoxylin and eosin staining of formalin-fixed, paraffin-embedded PDO sections revealed crypt and villus structures, whereas immunofluorescence staining with EpCAM and DAPI confirmed the epithelial-specific architecture of the PDOs. RT-qPCR results revealed a significant increase in <i>Lgr5</i>, <i>Si</i>, and <i>Chga</i> gene expression and a decrease in <i>Olfm4</i> and <i>Muc2</i> expression in CD patients compared to normal controls, suggesting altered stem cell activity and mucosal barrier function (<i>p</i><0.05).</p><p><strong>Conclusion: </strong>We successfully established and characterized PDOs in children with CD, providing a valuable tool for understanding the pathophysiology of the disease and evaluating potential therapeutic approaches. The differential gene expression of PDOs in CD patients might be caused by the complex interplay between epithelial adaptation and inflammation in the intestinal epithelium.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 6","pages":"355-363"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Dilemmas for the Diagnosis and Treatment of Helicobacter pylori Infection in Children: From Guideline to Practice. 诊断和治疗儿童幽门螺旋杆菌感染的临床难题:从指南到实践。
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI: 10.5223/pghn.2024.27.5.267
Susanne Jenneke Van Veen, Elvira Ingrid Levy, Koen Huysentruyt, Yvan Vandenplas
{"title":"Clinical Dilemmas for the Diagnosis and Treatment of <i>Helicobacter pylori</i> Infection in Children: From Guideline to Practice.","authors":"Susanne Jenneke Van Veen, Elvira Ingrid Levy, Koen Huysentruyt, Yvan Vandenplas","doi":"10.5223/pghn.2024.27.5.267","DOIUrl":"https://doi.org/10.5223/pghn.2024.27.5.267","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> infection is often acquired in early childhood. While most infected children remain asymptomatic, <i>H. pylori</i> can cause chronic gastritis, gastric ulceration, and, in the long term, gastric cancer. This article aimed to review different diagnostic and treatment options and discuss the challenges associated with applying the current guidelines in the real world. Relevant articles published from 2015 to August 2023 in the English language in PubMed and Medline electronic databases were extracted using subject headings and keywords of interest to the topic. References of interest in the selected articles were also considered. Invasive and noninvasive diagnostic tests have advantages but also disadvantages and limitations according to the clinical setting and age of the child. Guidelines recommend not performing diagnostic testing in children with long-lasting or recurrent abdominal complaints or cases of a family history of severe disease caused by <i>H. pylori</i>. However, parents regularly consult with the explicit demand to test for <i>H. pylori</i> because of them or a close family member experiencing severe gastric disease caused by <i>H. pylori</i>. In some situations, it may be challenging for the healthcare professional to stick to evidence-based guidelines and not consider \"patient-centered care,\" with the risk of putting a trustful relationship in danger. Physicians may find it challenging not to perform diagnostic tests for <i>H. pylori</i> and prescribe eradication treatment in specific clinical settings when maintaining a trusting patient-physician relationship by applying this \"patient-centered care\" method when evidence-based guidelines recommend differently.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 5","pages":"267-273"},"PeriodicalIF":1.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Valganciclovir in Congenital Cytomegalovirus Infection with Isolated Intrahepatic Cholestasis: A Randomized Controlled Trial. 缬更昔洛韦治疗先天性巨细胞病毒感染伴孤立性肝内胆汁淤积症的有效性和安全性:随机对照试验
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI: 10.5223/pghn.2024.27.5.298
Salahuddin Mahmud, Tanzila Farhana, Ataul Mustufa Anik, Fayaza Ahmed, Mashud Parvez, Madhabi Baidya, Rafia Rashid, Farhana Tasneem, Ahmed Rashidul Hasan, Mohammad Jahangir Alam, Shafi Ahmed Muaz
{"title":"Efficacy and Safety of Valganciclovir in Congenital Cytomegalovirus Infection with Isolated Intrahepatic Cholestasis: A Randomized Controlled Trial.","authors":"Salahuddin Mahmud, Tanzila Farhana, Ataul Mustufa Anik, Fayaza Ahmed, Mashud Parvez, Madhabi Baidya, Rafia Rashid, Farhana Tasneem, Ahmed Rashidul Hasan, Mohammad Jahangir Alam, Shafi Ahmed Muaz","doi":"10.5223/pghn.2024.27.5.298","DOIUrl":"https://doi.org/10.5223/pghn.2024.27.5.298","url":null,"abstract":"<p><strong>Purpose: </strong>Cytomegalovirus (CMV) infection affects the hepatic, neurologic, hematopoietic, respiratory, gastrointestinal, and other organs, resulting in a high mortality rate and long-term sequelae. It may cause acute or chronic hepatitis, or even lead to hepatic cirrhosis. Valganciclovir (VGCV) is an effective, safe, and well-tolerated treatment for congenital CMV infection, without any serious adverse effects. This study was conducted to evaluate the clinical, biochemical, and virological profiles of infants with CMV with intrahepatic cholestasis and to determine the outcomes with or without treatment with VGCV.</p><p><strong>Methods: </strong>Twenty infants aged <6 months diagnosed with congenital CMV infection with evidence of intrahepatic cholestasis were included in this study. Randomization was used to divide the study participants into 2 groups. The control group (n=10) was treated with only supportive management, and the intervention group (n=10) was treated with oral VGCV at 16 mg/kg/dose 12 hours a day for 6 weeks plus supportive treatments. Physical examinations and biochemical, serological, and virological tests were performed at the time of diagnosis and at the end of 6 weeks and 6 months.</p><p><strong>Results: </strong>The control and intervention groups were compared in terms of clinical and laboratory parameters such as jaundice, dark urine, pale stool, hepatomegaly, total bilirubin, aminotransferases, gamma-glutamyl transferase, alkaline phosphatase, and CMV polymerase chain reaction load, which showed a significant reduction after treatment in the intervention group (<i>p</i><0.05) with oral VGCV, with very few side effects, whereas the control group showed no significant changes.</p><p><strong>Conclusion: </strong>Oral VGCV can be used to effectively treat CMV infection with intrahepatic cholestasis without notable side effects.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 5","pages":"298-312"},"PeriodicalIF":1.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1-14 Years with Chronic Gastric Acid-Related Disease. 日本 1-14 岁患有慢性胃酸相关疾病的儿科患者长期服用埃索美拉唑的有效性和安全性
IF 1.3
Pediatric Gastroenterology, Hepatology & Nutrition Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI: 10.5223/pghn.2024.27.5.274
Masaaki Mori, Yoshiko Nakayama, Shigeo Nishimata, Tadafumi Yokoyama, Ryo Matsuoka, Reiko Hatori, Masaki Shimizu, Katsuhiro Arai, Yuri Etani, Tsuyoshi Sogo, Tomoko Ishizu, Masahiro Nii, Ryosuke Nakashima, Toshiaki Shimizu
{"title":"Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1-14 Years with Chronic Gastric Acid-Related Disease.","authors":"Masaaki Mori, Yoshiko Nakayama, Shigeo Nishimata, Tadafumi Yokoyama, Ryo Matsuoka, Reiko Hatori, Masaki Shimizu, Katsuhiro Arai, Yuri Etani, Tsuyoshi Sogo, Tomoko Ishizu, Masahiro Nii, Ryosuke Nakashima, Toshiaki Shimizu","doi":"10.5223/pghn.2024.27.5.274","DOIUrl":"10.5223/pghn.2024.27.5.274","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate prolonged esomeprazole use in Japanese pediatric patients for reflux esophagitis (RE) maintenance therapy and prevention of gastric (GU) and/or duodenal ulcers (DU) while using non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA).</p><p><strong>Methods: </strong>This multicenter, open-label, parallel-group, phase III study (NCT03553563) included patients who were administered esomeprazole according to body weight (10 mg/day [Groups 1 and 3] and up to 20 mg/day [Groups 2 and 4] for patients weighing 10-20 kg and ≥20 kg, respectively). Efficacy outcomes for Groups 1 and 2 (maintenance therapy for healed RE) and Groups 3 and 4 (prevention of long-term NSAID/LDA use-associated GU/DU) were the presence/absence of RE relapse and GU/DU recurrence, respectively.</p><p><strong>Results: </strong>Esomeprazole as maintenance therapy was associated with a low RE recurrence rate, independent of body weight or dosage. Recurrence rates of RE were 0.0% and 5.3% for Groups 1 and 2, respectively. In patients previously diagnosed with GU and/or DU due to long-term NSAID/LDA use, the recurrence rates of GU/DU during weeks 0-32 were 11.1% and 0.0% in Groups 3 and 4, respectively.</p><p><strong>Conclusion: </strong>Long-term use of 10- or 20-mg, once-daily esomeprazole demonstrated a favorable benefit-risk balance in preventing RE and suppressing recurrence of GU and/or DU secondary to NSAID or LDA therapy in Japanese pediatric patients. No new safety concerns were identified. Esomeprazole may be a viable option for managing RE and preventing GU and DU in Japanese pediatric patients.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"27 5","pages":"274-285"},"PeriodicalIF":1.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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