Pediatric Gastroenterology, Hepatology & Nutrition最新文献

{"title":"Positioning the Cu/Zn Ratio within the Diagnostic Framework of Wilson Disease: Methodological and Conceptual Considerations.","authors":"Mehmet Akif Ağır","doi":"10.5223/pghn.2025.28.5.332","DOIUrl":"10.5223/pghn.2025.28.5.332","url":null,"abstract":"","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 5","pages":"332-334"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation of 2'-Fucosyllactose in Formula-Fed Infants Has Potential Benefits to Reduce the Risks of Infantile Colic and Atopic Dermatitis in Infancy.","authors":"Yao-Jong Yang, Hsiao-Yu Lo, Shu-Ching Huang","doi":"10.5223/pghn.2025.28.5.291","DOIUrl":"10.5223/pghn.2025.28.5.291","url":null,"abstract":"<p><strong>Purpose: </strong>Human milk oligosaccharides (HMOs) are non-digestible carbohydrates found in breast milk, with 2'-fucosyllactose (2'-FL) being a prominent type. This study examined the effects of HMOs on the incidence of infantile colic (IC) and atopic dermatitis (AD) in full-term infants who were breastfed (BM), formula-fed (FF), or fed formula supplemented with 2'-fucosyllactose (FF_2'-FL) for 1 year.</p><p><strong>Methods: </strong>This open-label, prospective clinical trial enrolled 338 full-term infants from 2020 to 2024. IC was diagnosed using the ROME IV criteria, and AD was assessed with the PO-SCORAD.The study evaluated the incidence of IC and AD, infant growth, and risk factors for IC and AD.</p><p><strong>Results: </strong>A total of 113 infants were in the BM group, 111 in the FF group, and 114 in the FF_2'-FL group. Maternal baseline characteristics, including delivery age (<i>p</i>=0.001) and delivery type (<i>p</i>=0.013), differed significantly among the three groups. The incidence of IC in the FF_2'-FL group was comparable to that in the BM group (10.5% vs. 8.8%; odds ratio [OR], 1.21; 95% confidence interval [CI], 0.501-2.929; <i>p</i>=0.795) and lower than in the FF group (10.5% vs. 15.3%, OR, 0.65; 95% CI, 0.295-1.434; <i>p</i>=0.120). Similarly, the incidence of AD in the FF_2'-FL group was close to that in the BM group and lower than in the FF group.</p><p><strong>Conclusion: </strong>This study suggests that supplementation with 2'-fucosyllactose may help reduce the risk of IC and AD. These findings have important implications for pediatric healthcare and support the development of preventive strategies for IC and AD beyond breastfeeding.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 5","pages":"291-301"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium and Phosphorus Intake in Very Low Birth Weight Preterm Infants: Implications for Osteopenia Prevention and Growth.","authors":"Piyarat Kajohntridach, Premsak Laoyookhong, Tippawan Siritientong","doi":"10.5223/pghn.2025.28.5.320","DOIUrl":"10.5223/pghn.2025.28.5.320","url":null,"abstract":"<p><strong>Purpose: </strong>Sufficient calcium and phosphorus supplementation in preterm infants may ensure proper bone growth and reduce the risk of osteopenia. This study aimed to assess-in comparison to controls-the calcium and phosphorus intake via both enteral and parenteral routes, as well as growth, of preterm infants with very low birth weight (VLBW) who were diagnosed with osteopenia. Assessment took place during the first 28 days of life; infants were followed throughout hospitalization.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective study of preterm infants weighing <1,500 g who were admitted to a tertiary healthcare center between January 1, 2017 and June 30, 2022.</p><p><strong>Results: </strong>The study included 55 infants with osteopenia (case group) and 220 control infants (control group). The average weekly calcium intake in the case group during the first 4 weeks after birth was significantly lower than that of the control group, with values of 1.45, 1.98, 3.06, and 4.02 mEq/kg/day versus 1.64, 3.10, 4.89, and 5.69 mEq/kg/day, respectively (<i>p</i><0.05). Similarly, phosphorus intake was significantly lower in the case group (0.75, 1.24, 1.29, and 1.45 mmoL/kg/day) compared to the control group (0.75, 1.38, 1.62, and 1.79 mmoL/kg/day; <i>p</i><0.05). Preterm infants with VLBW and osteopenia exhibited lower average daily weight gain (19.03 g vs. 21.45 g; <i>p</i><0.001) and a smaller gain in head circumference (0.57 cm vs. 0.68 cm; <i>p</i><0.001) compared to controls.</p><p><strong>Conclusion: </strong>This findings highlight the necessity for timely provision of calcium and phosphorus to prevent osteopenia and promote optimal growth in this vulnerable population.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 5","pages":"320-331"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Disorders of Gut-Brain Interaction in Indonesian Adolescents: Has It Increased during the Coronavirus Disease Pandemic?","authors":"Andy Darma, Ni Nyoman Metriani Nesa, Khadijah Rizky Sumitro, Evi Rokhayati, Budiyanto, Karolina Trigemayanti Tallo, Novi Rahayu Ariyanti, Lucia Pudyastuti Retnaningtyas, Dian Dwi Sari Mustika Febryani, Imanuel Yulius Malino, Herwina Brahmantya, Wenas Wenas, Alpha Fardah Athiyyah, Reza Gunadi Ranuh, Subijanto Marto Sudarmo","doi":"10.5223/pghn.2025.28.5.302","DOIUrl":"10.5223/pghn.2025.28.5.302","url":null,"abstract":"<p><strong>Purpose: </strong>The prevalence of disorders of gut-brain interaction (DGBI), previously known as functional gastrointestinal disorders, has increased among children and adolescents, impacting their quality of life. Lifestyle changes during the coronavirus disease (COVID-19) pandemic, such as decreased physical activity and altered dietary habits, may have contributed to this increase rise. This study aimed to assess the prevalence of DGBIs among Indonesian adolescents during the COVID-19 pandemic using the Rome IV diagnostic criteria.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted from March 2022 to April 2023 involving 5,247 adolescents (aged 13-18 years) from nine provinces in Indonesia (Riau, Riau Islands, Central Java, East Java, Bali, South Kalimantan, East Kalimantan, East Nusa Tenggara, and Papua). Data were collected via online and offline versions of the Rome IV questionnaire and analyzed descriptively to determine DGBI prevalence rates by age, sex, and region.</p><p><strong>Results: </strong>The prevalence of DGBIs was greater in females than males and among adolescents living in urban areas. We found that 28.4% of adolescents were diagnosed with at least one DGBI, with functional constipation being the most prevalent (21.8%), followed by functional dyspepsia (4.5%). Additionally, 13.5% of respondents experienced two overlapping DGBIs, and 1.3% suffered from three overlapping DGBIs simultaneously. The prevalence rate of DGBI varied significantly across the participating provinces.</p><p><strong>Conclusion: </strong>DGBIs are highly prevalent among Indonesian adolescents after the COVID-19 pandemic. These findings can guide public health strategies to address adolescent gastrointestinal health in Indonesia and other regions.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 5","pages":"302-311"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Duodenal Strictures Between Crohn's and Non-Crohn's Diseases in Children.","authors":"Ji Won Youn, Jong Woo Hahn, Hye Ran Yang","doi":"10.5223/pghn.2025.28.5.280","DOIUrl":"10.5223/pghn.2025.28.5.280","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the clinical features and laboratory findings of duodenal strictures caused by Crohn's disease (CD) with those of other etiologies in children.</p><p><strong>Methods: </strong>We recruited children diagnosed with duodenal strictures through a full investigation. Clinical, laboratory, endoscopic, and radiological data at diagnosis were collected retrospectively.</p><p><strong>Results: </strong>Of the 11 included patients, four were diagnosed with CD, four with eosinophilic gastrointestinal disorder (EGID), and the other three were grouped together (<i>Helicobacter-</i>associated in one and idiopathic disease in two). Serum anti-<i>Saccharomyces cerevisiae</i> antibody (ASCA) was positive in four of four (100%) CD cases, four of four (100%) EGID cases, and none (0%) of the other cases (<i>p</i>=0.011). The median fecal calprotectin concentration was 994 mg/kg in the CD group (range: 626-2,118 mg/kg), 548 mg/kg in the EGID group (range: 458-1,056 mg/kg), and 124 mg/kg in one patient in the other group (<i>p</i>=0.313). Surgery for duodenal obstruction was performed in four patients (one with CD and three with idiopathic and <i>Helicobacter</i>-associated conditions) (<i>p</i>=0.021), and balloon dilation was performed in one patient with CD and one other patient.</p><p><strong>Conclusion: </strong>Although acquired duodenal strictures are rare in children, they can develop in pediatric patients with CD or EGID. The measurement of serum ASCA and fecal calprotectin levels before endoscopic and histopathological investigations may identify the presence of organic causes of duodenal strictures in children.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 5","pages":"280-290"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Oral Nutritional Supplements in Improving the Condition of Children with Diarrhea: A Systematic Review.","authors":"Kamiar Mahmoudifar, Mehrara Hashempoor, Fateme Asadi Touranlou, Mitra Rezaie","doi":"10.5223/pghn.2025.28.5.267","DOIUrl":"10.5223/pghn.2025.28.5.267","url":null,"abstract":"<p><p>Despite advances in the understanding of disease pathogenesis and treatment, diarrhea remains the primary cause of death among children around the world. Nutrition plays a significant role in treating diarrheal diseases. Malnourished children who have infectious diarrhea are at great risk of developing prolonged and more severe symptoms. The objective of this study was to review the effects of oral nutritional supplements on children with diarrhea. A systematic search for information was conducted using specific keywords in several databases. The results showed that oral food supplements are effective in reducing the symptoms of diarrhea, and the success rate with some formulations reached 100%. The rate of success and failure of formulas of oral nutritional supplements is dependent on the ingredients and foods used: Supplements high in zinc and fiber, as well as the foods yogurt and lactose-free milk, had the greatest impact on the success rate. Oral nutritional supplements are an effective way to reduce the duration and symptoms of diarrhea and can be used to treat diarrhea.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 5","pages":"267-279"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Bone Morphogenic Protein-4 and Visceral-Central Adiposity.","authors":"Sedanur Tekin Can, Filiz Tubaş, Nuriye Gökçe, Aslıhan Kiraz, Funda İpekten, Zehra Filiz Karaman, Derya Altay, Ülkü Gül Şiraz, Yusuf Özkul, Dinçer Göksülük","doi":"10.5223/pghn.2025.28.5.312","DOIUrl":"10.5223/pghn.2025.28.5.312","url":null,"abstract":"<p><strong>Purpose: </strong>Excessive fat accumulation can adversely affect vital organs, primarily because of energy imbalance. Hepatosteatosis is characterized by visceral fat accumulation, whereas obesity is associated with central fat deposition. This study aimed to determine the differences in bone morphogenetic protein 4 (BMP-4) levels according to the presence of obesity and hepatosteatosis.</p><p><strong>Methods: </strong>A total of 84 volunteers evaluated at the Erciyes University Faculty of Medicine Child Health and Diseases Polyclinic were included. Pediatric radiological assessments were conducted for hepatosteatosis, and BMP-4 gene expression analysis was performed at the Erciyes University Genome and Stem Cell Center, using patient records and RNA extracted from peripheral blood samples. Subsequently, groups were formed based on obesity and hepatosteatosis status, and BMP-4 expression levels were compared between groups.</p><p><strong>Results: </strong>The mean BMP-4 expression coefficient in the entire cohort was 1.3. Based on the BMI percentile groups, BMP-4 expression was highest in normal-weight individuals and lowest in overweight individuals, showing a statistically significant difference (<i>p</i>=0.024). In children with obesity, a weak positive correlation was noted between BMP-4 and glucose levels (r=0.315) and between BMP-4 and gamma-glutamyl transpeptidase levels (r=0.328).</p><p><strong>Conclusion: </strong>BMP-4 may play a role in the modulation of obesity and hepatosteatosis. These findings suggest that BMP-4 expression decreases during initial weight gain, but increases in obese individuals. This suggests that BMP-4 increases with the onset of obesity. An increase in BMP-4 levels at the onset of obesity initiates the activation of resistance mechanisms.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 5","pages":"312-319"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Polyethylene Glycol 3350+Electrolytes vs. Polyethylene Glycol 4000 for Fecal Disimpaction in Pediatric Functional Constipation: A Double-Blind Randomized Controlled Trial.","authors":"Kalpana Panda, J Bikrant Kumar Prusty, Mrutunjay Dash, Basudev Biswal, Mamata Devi Mohanty, Prasant Kumar Saboth","doi":"10.5223/pghn.2025.28.4.233","DOIUrl":"10.5223/pghn.2025.28.4.233","url":null,"abstract":"<p><strong>Purpose: </strong>Polyethylene glycol (PEG) is recommended as the first-line laxative for fecal disimpaction in pediatric functional constipation. PEG 3350+electrolyte (E) and PEG 4000 are the most commonly available formulations. PEG 3350+E and PEG 4000 have hypothesized benefits of lower risk of electrolyte imbalance and better palatability, respectively. However, a head-to-head comparison of these two formulations for fecal disimpaction remains lacking. This study aimed to compare the efficacy, tolerability, and acceptability of PEG 3350+E vs. PEG 4000 for fecal disimpaction in pediatric functional constipation.</p><p><strong>Methods: </strong>This double-blind, randomized controlled intention-to-treat trial included pediatric patients with functional constipation (as per ROME IV) and fecal impaction. Patients with organic constipation, h/o prior to gastrointestinal surgery, and those who were already receiving PEG/lactulose were excluded. Computer-generated block randomization was performed. Colorless liquid formulations of study medication were provided by investigator (JBK) as per treatment allocation in identical opaque bottles @1.5 gm/kg/dayx6 days or until fecal impaction resolution (passage of clear liquid stool), whichever is earlier.</p><p><strong>Results: </strong>One hundred patients were randomized in a 1:1 ratio (50 patients in each arm). Efficacy of PEG 3350+E vs. PEG 4000 was similar (84% vs. 86%; <i>p</i>=0.9). Similarly, no significant differences were noted in the adverse event rates between two groups. Abdominal discomfort and vomiting were the most common adverse effects. PEG 4000 showed better palatability than PEG 3350+E (<i>p</i>=0.044). However, there was no significant difference in the compliance rate.</p><p><strong>Conclusion: </strong>PEG 3350+E and PEG 4000 showed similar efficacies for fecal disimpaction, with minor side effects. PEG 4000 had better palatability; however, both were well tolerated by children.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 4","pages":"233-244"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Variants and Long-Term Outcomes in Korean Children with Progressive Familial Intrahepatic Cholestasis.","authors":"Shinjie Choi, Yeji Kim, Sunwoo Park, Jeong Eun Ahn, Lia Kim, Minsoo Shin, Kyung Jae Lee, Jin Soo Moon, Jae Sung Ko","doi":"10.5223/pghn.2025.28.4.245","DOIUrl":"10.5223/pghn.2025.28.4.245","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to elucidate the genetic variants associated with progressive familial intrahepatic cholestasis (PFIC), a rare class of disorders driven by pathogenic monogenic variants in bile acid transporters. Furthermore, the long-term clinical outcomes of PFIC patients were evaluated.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at Seoul National University Hospital and included pediatric patients diagnosed with PFIC and confirmed by genetic testing between January 2000 and October 2024. Genetic testing, encompassing either single-gene testing or a neonatal cholestasis 34-gene panel, was performed for all patients.</p><p><strong>Results: </strong>Six patients were identified, including five with PFIC2, classified as bile salt export pump deficiency, and one with PFIC3, classified as multidrug resistance protein 3 deficiency. The median age of symptom onset was 3 months. The genetic analyses revealed no widely known variants associated with PFIC. However, a novel frameshift variant (c.589dup, p.(Glu197GlyfsTer8)) was detected in the <i>ABCB11</i> gene. Additionally, a missense variant (c.3812T>A, p.(Ile1271Asn)) was commonly identified in the same gene. All patients ultimately underwent liver transplantation; two patients who developed hepatocellular carcinoma (HCC) were diagnosed at a median age of 1.6 years. Notably, all patients survived without recurrence after transplantation, with a median follow-up duration of 12.0 years.</p><p><strong>Conclusion: </strong>This study is the first documented case of PFIC3 in a Korean child. Genotype is not associated with the risk of developing HCC. Given the early diagnosis of HCC observed in some patients, routine surveillance for HCC is strongly recommended in all patients with PFIC2.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 4","pages":"245-255"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreign Body Ingestion in Children: A 16-year Experience.","authors":"Andrea Di Siena, Paola Melli, Federica Rodofile, Chiara Rodaro, Marco Marino, Luigi Castriotta, Yvonne Beorchia, Antonio Pedduzza, Angelo Di Giorgio, Paola Cogo","doi":"10.5223/pghn.2025.28.4.215","DOIUrl":"10.5223/pghn.2025.28.4.215","url":null,"abstract":"<p><strong>Purpose: </strong>Foreign body (FB) ingestion is a common health problem that affects children. It requires endoscopic removal in up to 20% of cases. In this study, we reviewed all our pediatric cases of FB ingestion requiring endoscopy and compared their management to the published guidelines.</p><p><strong>Methods: </strong>Retrospective study of children (aged 0-16 years) who were admitted to the emergency pediatric service department and underwent endoscopy for FB ingestion from January 2007 to December 2022. All statistical analyses were performed using STATA software version 17.0 (StataCorp LP).</p><p><strong>Results: </strong>Of a total of 962 children diagnosed with FB ingestion, 62 of them (median age 4 years; interquartile range 2-8 years) underwent endoscopies and were included in this study. Of these, 39 (62.9%) were symptomatic and 23 (37.1%) were asymptomatic. The most common symptoms were vomiting (24.2%), pain (24.2%), sialorrhea (22.6%). In most patients, FBs were located in the esophagus (56.2%), with coins being the most common type (42.0%). The occurrence of at least one symptom was found to be associated with the FBs located in the upper-middle esophagus (compared to all other anatomical regions) (<i>p</i><0.001). NASPGHAN and ESPGHAN guidelines were met in 68.8% of patients, while SIGENP guidelines were met in 72.9%.</p><p><strong>Conclusion: </strong>FB ingestion is common in children. Coins are the most frequently encountered objects, typically located in the esophagus or stomach. An association was observed between the presence of at least one symptom and FBs located in the upper-middle esophagus. Performing endoscopies within 2 hours of FB ingestion is challenging in some cases.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 4","pages":"215-223"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}