Pediatric Gastroenterology, Hepatology & Nutrition最新文献

{"title":"Comparing the Effect of Oil Massage on Phototherapy Efficacy in Term Neonates with Hyperbilirubinemia: A Randomized Controlled Trial.","authors":"Dinesh Kumar, Durgesh Kumar, Pankaj Kumar Arya, Muniba Alim, Indra Kumar Sharma, Rajesh Kumar Yadav, Nishant Sharma","doi":"10.5223/pghn.2025.28.2.93","DOIUrl":"10.5223/pghn.2025.28.2.93","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the efficacy of oil massage as an adjunct therapy for neonatal jaundice during phototherapy.</p><p><strong>Methods: </strong>A total of 160 neonates with unconjugated hyperbilirubinemia were enrolled and randomly allocated into two study groups using a computer-generated random number table. Group 1 (Intervention Group) consisted of 84 patients who received both phototherapy and massage therapy, while Group 2 (Control Group) consisted of 76 patients who received only phototherapy. The intervention group underwent massage therapy three times daily for 20 minutes over two consecutive days. Transcutaneous bilirubin levels were measured every eight hours. Additionally, the total duration of phototherapy and the 24-hour stool and urine output frequency were recorded in both groups.</p><p><strong>Results: </strong>There were no significant differences in the demographic characteristics between the two groups. However, stool frequency and urine output were significantly higher in the intervention group. The average duration of phototherapy was 19.4±4.17 hours in the intervention group compared to 28.4±6.58 hours in the control group (<i>p</i><0.001). The rate of Transcutaneous bilirubin reduction was significantly higher in the intervention group during the first 24 hours. A rebound increase in bilirubin levels was observed at 40 and 48 hours in both groups after phototherapy was discontinued.</p><p><strong>Conclusion: </strong>Phototherapy combined with massage significantly reduced total bilirubin levels in newborns with neonatal hyperbilirubinemia, making it a valuable adjunct treatment for the rapid reduction of bilirubin in neonates.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 2","pages":"93-100"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Percutaneous Transhepatic Biliary Drainage in Pediatric Patients following Liver Transplantation.","authors":"Thorben Pape, Ulrich Baumann, Eva-Doreen Pfister, Florian W R Vondran, Nicolas Richter, Jens Dingemann, Anna M Hunkemöller, Tabea von Garrel, Heiner Wedemeyer, Andrea Schneider, Henrike Lenzen, Klaus Stahl","doi":"10.5223/pghn.2025.28.2.113","DOIUrl":"10.5223/pghn.2025.28.2.113","url":null,"abstract":"<p><strong>Purpose: </strong>Cholestatic complications remain a primary cause of post-liver transplantation (LTX) morbidity in pediatric patients. Standard biliary access by endoscopic retrograde cholangioscopy may not be feasible due to modified biliary drainage. Percutaneous transhepatic biliary drainage (PTCD) may be performed alternatively. However, systematic data concerning safety and efficacy of PTCD in these patients are scarce.</p><p><strong>Methods: </strong>In this retrospective study, procedural and safety characteristics of PTCD in pediatric patients following LTX were analyzed. We compared laboratory indicators of inflammation, cholestasis, and graft function before and at 6 and 12 months after the first PTCD insertion. Efficacy was analyzed by percentage of patients without cholangitis, need for surgical biliary re-intervention and re-transplantation during a follow-up period of 60 months.</p><p><strong>Results: </strong>Over a decade, PTCD was attempted in a total of 15 patients, with technical success (93.3%) in 14 patients. Periprocedural complications, including bleeding (7.1%) and cholangitis (21.4%) were observed in patients. During follow-up, both MELD-score (baseline: 13 [8-15] vs. 12 months: 8 [7-8], <i>p</i><0.001) and parameters of cholestasis (GGT: baseline: 286 [47-458] U/L vs. 12 months: 105 [26-147] U/L, <i>p</i>=0.024) decreased. Prior to PTCD, cholangitis (64.3%) and cholangiosepsis (21.4%) were common complications. In contrast, following PTCD, cholangitis occurred in only one patient (7.1%). Five patients (35.7%) needed surgical biliary re-intervention and two (14.3%) required re-transplantation.</p><p><strong>Conclusion: </strong>PTCD in pediatric patients following LTX had an acceptable safety profile, demonstrating a biochemical improvement of both cholestasis and graft function and may prevent cholestatic complications, thus reducing the need for surgical re-intervention and re-transplantation.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 2","pages":"113-123"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in Cow's Milk-Related Symptom Score (CoMiSS^TM) Among Presumed Healthy Infants in Indonesia and Brazil.","authors":"Nienke Knockaert, Koen Huysentruyt, Badriul Hegar, Jackeline Motta Franco, Victor Ravel Santos Macedo, Sarah Cristina Fontes Vieira, Yvan Vandenplas","doi":"10.5223/pghn.2025.28.2.124","DOIUrl":"10.5223/pghn.2025.28.2.124","url":null,"abstract":"<p><strong>Purpose: </strong>The Cow's Milk-related Symptom Score (CoMiSS) improves the recognition of cow milk allergy (CMA) symptoms. A score of ≥10 should raise awareness of CMA. The median CoMiSS in healthy European infants aged <6 months is 3. This study aimed to determine the impact of different regions on CoMiSS in healthy infants aged <12 months to evaluate regional and age-related differences.</p><p><strong>Methods: </strong>A prospective cross-sectional study was conducted at one hospital each in Indonesia (Jakarta) and Brazil (Sergipe). CoMiSS was assessed in healthy infants aged -12 months old.</p><p><strong>Results: </strong>In Jakarta, a total of 286 infants (50.7% boys) were included. The median (interquartile range) CoMiSS was 1.5 (0-4); the 95th percentile was 7. In Sergipe, 101 infants (60.4% boys) were included. The median (interquartile range) CoMiSS was 4 (4-6); the 95th centile was 10.9. Age (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94-0.99; <i>p</i><0.001) and country (OR, 2.40; 95% CI, 2.06-2.79; <i>p</i><0.001) were significant independent predictors of changes in mean CoMiSS in a linear regression model (r²=0.27).</p><p><strong>Conclusion: </strong>Median CoMiSS in healthy infants differed between Jakarta and Sergipe (1.5 vs. 4.0). These findings highlight that the perceived normality of parents may be region-dependent.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 2","pages":"124-134"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Local Food Sources in a Sustainable Healthy Diet System and Psychosocial Care to Reduce Malnutrition.","authors":"Lestari Octavia, Nia Novita Wirawan, Intan Ria Nirmala, Verawati Sudarma, Patricia Budihartanti Liman, Fitrianingsih, Wahyu Rahardjo, Rahmi Nurdiani, Wiralis","doi":"10.5223/pghn.2025.28.2.135","DOIUrl":"10.5223/pghn.2025.28.2.135","url":null,"abstract":"<p><p>The magnitude of the problem of stunting is high in low- to middle-income countries, including Indonesia. The government of Indonesia has implemented specific and sensitive intervention programs to reduce this problem. This public health problem requires multidisciplinary management with suitable approaches and programs. In the first 1000 days of life, the quality of life is determined by conception and delivery until two years old. The requirement and fulfillment of nutrients during this period would benefit the growth and development of children. Indonesia is an archipelago country with 100,000 km of coastline and 16,771 islands with great potential for fishing. In coastal areas, optimizing protein consumption from the sea and enhancing educational programs in psychosocial care are appropriate intervention programs that will benefit stunting eradication. The complexity of the stunting problem puts authorities and other stakeholders together to formulate and design appropriate comprehensive intervention programs to improve the quality of life of the next generation.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 2","pages":"135-140"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effect of Table Salt on Gastrostomy Granulomas in Pediatric Patients: A Prospective Study.","authors":"Jack J Hachem, Thu Pham, Ankona Banerjee, James Noel","doi":"10.5223/pghn.2025.28.2.86","DOIUrl":"10.5223/pghn.2025.28.2.86","url":null,"abstract":"<p><strong>Purpose: </strong>Gastrostomy granulomas frequently occur in pediatric patients with gastrostomy tubes, yet there is a notable lack of comprehensive data on the efficacy and safety of various treatment modalities. Commonly used treatments, such as silver nitrate, are often painful and require frequent clinic visits, posing challenges for patients and families. Additionally, research on home-based treatments is limited, despite their potential to offer more convenient and less painful alternatives. This study addresses the need for well-designed comparisons of different treatment options.</p><p><strong>Methods: </strong>We conducted a prospective, open-label study at the Children's Hospital of San Antonio, enrolling 36 pediatric patients aged 6 months to 17 years with gastrostomy tubes. Patients were randomized into two groups: one treated with topical silver nitrate and the other with table salt, excluding those on chemotherapy or with immunologic disorders. Granuloma sizes were measured at the study's start with blinded physicians analyzing photographs to assess size reduction, and parent satisfaction surveys were conducted to evaluate treatment acceptability and side effects.</p><p><strong>Results: </strong>The median reduction in granuloma size was significantly greater in the table salt group (3.12 mm) compared to the silver nitrate group (2.25 mm) (Wilcoxon <i>p</i>-value=0.04). Parental satisfaction and confidence were high in both groups, with minor, self-limited skin irritation reported as a side effect.</p><p><strong>Conclusion: </strong>The study suggests that table salt could be a feasible, non-inferior, and cost-effective alternative to silver nitrate for treating gastrostomy granulomas in pediatric patients. Further research with a larger sample size is necessary to validate these findings.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 2","pages":"86-92"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Eosinophilic Cell-free Granules Based on Expression of CCR3 and MBP Markers in Esophageal Biopsy Specimens of Patients with Suspected and Confirmed Eosinophilic Esophagitis.","authors":"Saba Ebrahimi, Saghi Khatami, Fatemeh Elham Mahjoub, Maryam Monajemzadeh, Azizollah Yousefi, Amirhossein Hosseini, Majid Khoshmirsafa, Fatemeh S Mousavinasab, Mahboubeh Mansouri, Mehdi Shabani, Mehrnaz Mesdaghi","doi":"10.5223/pghn.2025.28.1.19","DOIUrl":"10.5223/pghn.2025.28.1.19","url":null,"abstract":"<p><strong>Purpose: </strong>Eosinophilic esophagitis (EoE) is the most well-known eosinophilic gastrointestinal disorder (EGID) characterized by the presence of a high number eosinophils within the esophageal epithelium and the clinical signs. Biopsies of patients with suspected EoE may not show a high number of eosinophils, however the presence of granules may help with the diagnosis. This study aims to evaluate the presence of cell-free eosinophil granules in the esophageal tissue of patients with suspected and confirmed EoE to accelerate the diagnosis and treatment of patients with low eosinophil count.</p><p><strong>Methods: </strong>Fifteen patients with confirmed EoE and 15 suspected of EoE were included in this study. Patients' esophageal tissue biopsies were stained using immunohistochemistry (IHC) to identify eosinophils and their cell-free granules. For testing, anti-major basic protein (MBP) and anti-chemokine receptor type 3 (CCR3) were used as primary antibodies and a double-staining kit containing secondary antibodies conjugated to the enzyme and related chromogens were used.</p><p><strong>Results: </strong>Cell-free granules with different degrees were observed in 53.3% and 93.3% of suspected and confirmed EoE samples, respectively. Furthermore, in esophageal biopsy of 73.3% of patients with suspected and 93.3% of patients with a definitive diagnosis of EoE, basal layer hyperplasia (BLH) was recognized.</p><p><strong>Conclusion: </strong>The results of the present study showed that IHC can be applied to detect cell-free eosinophil granules in esophageal tissue. Observation of granules and basal cell hyperplasia in biopsies of suspected EoE patients whose eosinophil count is below the threshold can be valuable findings to make a definitive diagnosis for these patients.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 1","pages":"19-26"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet Count at Diagnosis Is Associated with Endoscopic Activity in Pediatric Patients with Crohn's Disease.","authors":"Sang-Yoon Lee","doi":"10.5223/pghn.2025.28.1.46","DOIUrl":"10.5223/pghn.2025.28.1.46","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to evaluate the association between platelet count and endoscopy activity in pediatric patients with Crohn's disease (CD).</p><p><strong>Methods: </strong>This single center retrospective study included children and adolescents aged <19 years who were newly diagnosed with CD. Comparison of baseline characteristics at diagnosis between two groups divided according to the presence and absence of thrombocytosis were conducted. Factors associated with moderate-to-severe endoscopic activity was also conducted.</p><p><strong>Results: </strong>A total of 50 were included. Thirty-five patients (70.0%) were male, and the mean age±standard deviation was 13.7±2.5 years. Among patients without thrombocytosis, endoscopic activity was mild in 9 patients (42.9%), moderate in 11 (52.4%), and severe in 1 (4.8%), while among patients with thrombocytosis, endoscopic activity was mild in 3 (10.3%), moderate in14 (48.3%), and severe in 12 (41.4%) (<i>p</i>=0.003). According to multivariate analysis with stepwise selection, platelet count (odds ratio [OR], 1.01; 95% confidence interval [CI], 1.00-1.02; <i>p</i>=0.021) and albumin (OR, 0.15; 95% CI, 0.02-0.98; <i>p</i>=0.045) were significantly associated with moderate-to-severe endoscopic activity at diagnosis. According to the receiver operating characteristic (ROC) curve analysis, the optimal platelet count cut-off level associated with moderate-to-severe endoscopic activity was 456,000/µL with an area under the ROC curve of 0.752 (95% CI, 0.598-0.906; sensitivity, 55.3%; specificity, 91.7%; postitive predictive value, 95.5%; negative predictive value, 39.3%; <i>p</i><0.001).</p><p><strong>Conclusion: </strong>Pediatric patients with CD that present with thrombocytosis at diagnosis are likely to have a moderate-to-severe endoscopic activity.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 1","pages":"46-53"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance and Related Factors of <i>Helicobacter pylori</i> Infection in Children with Dyspepsia.","authors":"Hyun Jin Kim","doi":"10.5223/pghn.2025.28.1.38","DOIUrl":"10.5223/pghn.2025.28.1.38","url":null,"abstract":"<p><strong>Purpose: </strong><i>Helicobacter pylori</i> is a Gram-negative bacterium that is associated with peptic ulcer disease (PUD) and gastric cancer. However, studies on the endoscopic finding and factors related to <i>H. Pylori</i> infection in children are lacking. This study aimed to evaluate the prevalence and factors associated with <i>H. pylori</i> infection in children with dyspepsia.</p><p><strong>Methods: </strong>We retrospectively analyzed the medical records of patients aged <18 years who underwent upper endoscopy for dyspepsia between January 2015 and December 2022. <i>H. pylori</i> was diagnosed using a rapid urease test, and the dyspeptic symptoms included postprandial fullness, early satiation, epigastric pain, and nausea.</p><p><strong>Results: </strong>Among 185 patients, the prevalence of <i>H. pylori</i> infection was 16.2%. Obesity and a family history of <i>H. pylori</i> infection were more frequently observed in patients with <i>H. pylori</i> infection than in those without. Anemia was also more common in patients with <i>H. pylori</i> infection than in those without. <i>H. pylori</i> was detected in six (18.8%) patients with PUD (n=32). All six patients had duodenal ulcers and anemia, and complications such as obstruction and bleeding were significantly more common among patients with PUD who were positive for <i>H. pylori</i> infection than among those without.</p><p><strong>Conclusion: </strong>We observed a low prevalence of <i>H. pylori</i> infection in children with dyspepsia; however, these children exhibited a more severe clinical course. Therefore, caution should be exercised in detecting <i>H. pylori</i> infection in children, especially, who had obesity or family history of <i>H. pylori</i> infection.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 1","pages":"38-45"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Health and Immunity of Milk Formula Supplemented with a Prebiotic Mixture of Short-Chain Galacto-oligosaccharides and Long-Chain Fructo-Oligosaccharides (9:1) in Healthy Infants and Toddlers: A Systematic Review with Meta-Analysis.","authors":"Muzal Kadim, Andy Darma, Melissa Stephanie Kartjito, Charisma Dilantika, Ray Wagiu Basrowi, Veli Sungono, Juandy Jo","doi":"10.5223/pghn.2025.28.1.1","DOIUrl":"10.5223/pghn.2025.28.1.1","url":null,"abstract":"<p><p>Prebiotics are substrates selectively utilized by microorganisms to confer health benefits to their hosts. Various prebiotics have been supplemented in standard milk formulas for infants who cannot be exclusively breastfed, aiming to provide benefits similar to those of breast milk. One of the most commonly used prebiotics is a mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS [9:1]). Systematic review and meta-analysis were conducted to determine the effectiveness of scGOS:lcFOS (9:1) supplementation in standard milk formula for improving gastrointestinal health and immunity among healthy infants and toddlers, using parameters such as stool pH and intestinal colonization with beneficial bacteria. This systematic review was prepared in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Randomized clinical trials comparing scGOS/lcFOS (9:1)-supplemented formula versus placebo- or non-supplemented formula milk were eligible for inclusion. Related studies on gastrointestinal health and immunity among healthy infants up to five years old were searched from the earliest available date until February 29, 2024. Eighteen publications (number of participants=1,675) were selected for the systematic review, of which 11 were subsequently subjected to a meta-analysis. Results showed that the standard formula supplemented with scGOS/lcFOS (9:1) was well tolerated and conferred various gastrointestinal health and immunity to healthy infants and toddlers. These findings support the supplementation of standard milk formula with scGOS/lcFOS (9:1) for healthy infants and toddlers.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 1","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>Helicobacter pylori</i> Infection with Pediatric Asthma in Palestine.","authors":"Alaa S Hrizat, Amal A Shahin, Banan M Mafarjeh, Mohammad A Atawneh, Kamel Gharaibeh, Nisreen Rumman, Mutaz Sultan","doi":"10.5223/pghn.2025.28.1.27","DOIUrl":"10.5223/pghn.2025.28.1.27","url":null,"abstract":"<p><strong>Purpose: </strong>Significant debate exists on the association between <i>Helicobacter pylori</i> infection and childhood asthma. We aimed to explore this association in a cohort of children in Palestine while estimating the prevalence of <i>H. pylori</i> in this population.</p><p><strong>Methods: </strong>We conducted a prospective case-control study among children aged 6-15 years in Palestine, including 44 asthma cases diagnosed by pediatric pulmonologists and 99 age-matched healthy controls recruited through cluster sampling from schools. <i>H. pylori</i> status was determined using a stool antigen test. Asthma severity was assessed using the International Study of Asthma and Allergies in Childhood questionnaire. Data on recent antibiotic use, which could affect <i>H. pylori</i> status, were collected for both groups. Multiple logistic regression analyzed the association between <i>H. pylori</i> and asthma, adjusting for age and sex. The chi-square test assessed the impact of antibiotic use on <i>H. pylori</i> status.</p><p><strong>Results: </strong>The prevalence of <i>H. pylori</i> infection in the study population was 45%. Children with asthma had a lower prevalence of <i>H. pylori</i> infection compared to healthy controls (32% vs. 51%, adjusted odds ratios, 0.46; 95% confidence interval, 0.22-0.99; <i>p</i>=0.04). Antibiotic use in the past month or year did not significantly impact <i>H. pylori</i> status. Among children with asthma, <i>H. pylori</i> infection rates did not vary by asthma severity (<i>p</i>=0.05).</p><p><strong>Conclusion: </strong><i>H. pylori</i> infection is associated with a reduced risk of asthma in children, suggesting a potential protective role. Further prospective cohort studies are warranted to clarify the mechanisms underlying this association.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 1","pages":"27-37"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}