Nienke Knockaert, Koen Huysentruyt, Badriul Hegar, Jackeline Motta Franco, Victor Ravel Santos Macedo, Sarah Cristina Fontes Vieira, Yvan Vandenplas
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The median (interquartile range) CoMiSS was 1.5 (0-4); the 95th percentile was 7. In Sergipe, 101 infants (60.4% boys) were included. The median (interquartile range) CoMiSS was 4 (4-6); the 95th centile was 10.9. Age (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94-0.99; <i>p</i><0.001) and country (OR, 2.40; 95% CI, 2.06-2.79; <i>p</i><0.001) were significant independent predictors of changes in mean CoMiSS in a linear regression model (r<sup>2</sup>=0.27).</p><p><strong>Conclusion: </strong>Median CoMiSS in healthy infants differed between Jakarta and Sergipe (1.5 vs. 4.0). These findings highlight that the perceived normality of parents may be region-dependent.</p>","PeriodicalId":19989,"journal":{"name":"Pediatric Gastroenterology, Hepatology & Nutrition","volume":"28 2","pages":"124-134"},"PeriodicalIF":1.3000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919533/pdf/","citationCount":"0","resultStr":"{\"title\":\"Difference in Cow's Milk-Related Symptom Score (CoMiSS<sup>TM</sup>) Among Presumed Healthy Infants in Indonesia and Brazil.\",\"authors\":\"Nienke Knockaert, Koen Huysentruyt, Badriul Hegar, Jackeline Motta Franco, Victor Ravel Santos Macedo, Sarah Cristina Fontes Vieira, Yvan Vandenplas\",\"doi\":\"10.5223/pghn.2025.28.2.124\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The Cow's Milk-related Symptom Score (CoMiSS) improves the recognition of cow milk allergy (CMA) symptoms. 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引用次数: 0
摘要
目的：牛奶相关症状评分（CoMiSS）提高对牛奶过敏（CMA）症状的识别。≥10分应提高对CMA的认识。方法：在印度尼西亚（雅加达）和巴西（塞尔吉佩）各一家医院进行了一项前瞻性横断面研究。对12个月大的健康婴儿进行CoMiSS评估。结果：雅加达共纳入286例婴儿，其中男孩占50.7%。CoMiSS中位数（四分位间距）为1.5 (0-4)；第95百分位是7。在Sergipe， 101名婴儿（60.4%为男孩）被纳入研究。CoMiSS中位数（四分位间距）为4 (4-6)；第95百分位为10.9。年龄(优势比[OR]， 0.96；95%置信区间[CI]， 0.94-0.99；pp2 = 0.27)。结论：雅加达和Sergipe健康婴儿的中位CoMiSS存在差异（1.5 vs. 4.0）。这些发现强调，父母的正常感知可能是地区依赖的。
Difference in Cow's Milk-Related Symptom Score (CoMiSSTM) Among Presumed Healthy Infants in Indonesia and Brazil.
Purpose: The Cow's Milk-related Symptom Score (CoMiSS) improves the recognition of cow milk allergy (CMA) symptoms. A score of ≥10 should raise awareness of CMA. The median CoMiSS in healthy European infants aged <6 months is 3. This study aimed to determine the impact of different regions on CoMiSS in healthy infants aged <12 months to evaluate regional and age-related differences.
Methods: A prospective cross-sectional study was conducted at one hospital each in Indonesia (Jakarta) and Brazil (Sergipe). CoMiSS was assessed in healthy infants aged -12 months old.
Results: In Jakarta, a total of 286 infants (50.7% boys) were included. The median (interquartile range) CoMiSS was 1.5 (0-4); the 95th percentile was 7. In Sergipe, 101 infants (60.4% boys) were included. The median (interquartile range) CoMiSS was 4 (4-6); the 95th centile was 10.9. Age (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94-0.99; p<0.001) and country (OR, 2.40; 95% CI, 2.06-2.79; p<0.001) were significant independent predictors of changes in mean CoMiSS in a linear regression model (r2=0.27).
Conclusion: Median CoMiSS in healthy infants differed between Jakarta and Sergipe (1.5 vs. 4.0). These findings highlight that the perceived normality of parents may be region-dependent.
期刊介绍：
Pediatric Gastroenterology, Hepatology and Nutrition (Pediatr Gastroenterol Hepatol Nutr), an official journal of The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition, is issued bimonthly and published in English. The aim of Pediatr Gastroenterol Hepatol Nutr is to advance scientific knowledge and promote child healthcare by publishing high-quality empirical and theoretical studies and providing a recently updated knowledge to those practitioners and scholars in the field of pediatric gastroenterology, hepatology and nutrition. Pediatr Gastroenterol Hepatol Nutr publishes review articles, original articles, and case reports. All of the submitted papers are peer-reviewed. The journal covers basic and clinical researches on molecular and cellular biology, pathophysiology, epidemiology, diagnosis, and treatment of all aspects of pediatric gastrointestinal diseases and nutritional health problems.
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