Histopathological Study and Expression of Beta-Catenin in Congenital Choledochal Cyst in a Tertiary Care Pediatric Referral Center in South India.

IF 1.3 Q3 PEDIATRICS
Rashmi Tresa Philpose, Abdul Aleem Mohammed, Ashrith Reddy Gowni
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引用次数: 0

Abstract

Purpose: Choledochal cysts are congenital anomalies that occur as localized cystic or fusiform dilatations of the biliary tree. Reflux and stasis of pancreatic enzymes in the biliary duct may relate to the development of intestinal metaplasia which might be an important factor related to the carcinogenesis of choledochal cyst, thus the expression of beta-catenin in the metaplastic epithelium might be associated with malignant transformation of choledochal cyst epithelium.

Methods: This study was conducted at a tertiary care pediatric center between October 2014 and March 2017. Forty patients were evaluated for epithelial lining, mural ulceration, fibrosis, inflammation, and metaplasia.

Results: Out of 40, 12 cases (30.0%) were the infantile age group and 28 cases (70.0%) were in the classic pediatric group. Ulceration was classified as grade 0 (14 cases, 35.0%), grade 1 (17 cases, 42.5%), or grade 2 (nine cases, 22.5%). Inflammation was classified as grade 0 (2 cases, 5.0%), grade 1 (26 cases, 65.0%), or grade 2 (12 cases, 30.0%). Fibrosis was classified as grade 0 (five cases, 12.5%), grade 1 (11 cases, 27.5%), grade 2 (17 cases, 42.5%), or grade 3 (seven cases, 17.5%). Metaplasia was noted in five (12.5%) out of 40 cases. All choledochal cysts with metaplasia showed beta-catenin nuclear positivity on immunohistochemistry and were followed up.

Conclusion: This study emphasizes the importance of detailed histopathological examination and documentation of metaplastic changes. Metaplasia was associated with beta-catenin nuclear positivity. These findings suggest a potential role for beta-catenin as a marker of metaplastic changes in choledochal cysts.

印度南部一家三级儿科转诊中心对先天性胆总管囊肿的组织病理学研究和 Beta-Catenin 的表达。
目的:胆总管囊肿是一种先天性畸形,表现为胆管局部囊性或纺锤形扩张。胆管中胰酶的反流和淤积可能与肠化生的发生有关,而肠化生可能是胆总管囊肿癌变的一个重要因素,因此β-catenin在化生上皮中的表达可能与胆总管囊肿上皮的恶性转化有关:本研究于2014年10月至2017年3月在一家三级儿科中心进行。对40例患者的上皮内膜、壁溃疡、纤维化、炎症和变性进行了评估:在40例患者中,12例(30.0%)为婴儿年龄组,28例(70.0%)为典型儿科组。溃疡分为 0 级(14 例,35.0%)、1 级(17 例,42.5%)或 2 级(9 例,22.5%)。炎症分为 0 级(2 例,5.0%)、1 级(26 例,65.0%)或 2 级(12 例,30.0%)。纤维化分为 0 级(5 例,12.5%)、1 级(11 例,27.5%)、2 级(17 例,42.5%)或 3 级(7 例,17.5%)。在 40 例病例中,有 5 例(12.5%)出现了变性。所有伴有变性的胆总管囊肿在免疫组化中均显示β-catenin核阳性,并进行了随访:本研究强调了详细组织病理学检查和记录变性变化的重要性。变性与β-catenin核阳性有关。这些研究结果表明,β-catenin可能是胆总管囊肿变性的标志物。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
43
期刊介绍: Pediatric Gastroenterology, Hepatology and Nutrition (Pediatr Gastroenterol Hepatol Nutr), an official journal of The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition, is issued bimonthly and published in English. The aim of Pediatr Gastroenterol Hepatol Nutr is to advance scientific knowledge and promote child healthcare by publishing high-quality empirical and theoretical studies and providing a recently updated knowledge to those practitioners and scholars in the field of pediatric gastroenterology, hepatology and nutrition. Pediatr Gastroenterol Hepatol Nutr publishes review articles, original articles, and case reports. All of the submitted papers are peer-reviewed. The journal covers basic and clinical researches on molecular and cellular biology, pathophysiology, epidemiology, diagnosis, and treatment of all aspects of pediatric gastrointestinal diseases and nutritional health problems.
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